WO2001043779A3 - Anti-hiv-1 conjugates for treatment of hiv disease - Google Patents

Anti-hiv-1 conjugates for treatment of hiv disease Download PDF

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Publication number
WO2001043779A3
WO2001043779A3 PCT/US2000/034032 US0034032W WO0143779A3 WO 2001043779 A3 WO2001043779 A3 WO 2001043779A3 US 0034032 W US0034032 W US 0034032W WO 0143779 A3 WO0143779 A3 WO 0143779A3
Authority
WO
WIPO (PCT)
Prior art keywords
hiv
molecule
conjugate
conjugates
provides
Prior art date
Application number
PCT/US2000/034032
Other languages
French (fr)
Other versions
WO2001043779A2 (en
Inventor
Michael Fung
David Thomas
Original Assignee
Tanox Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanox Inc filed Critical Tanox Inc
Priority to AU22657/01A priority Critical patent/AU2265701A/en
Publication of WO2001043779A2 publication Critical patent/WO2001043779A2/en
Publication of WO2001043779A3 publication Critical patent/WO2001043779A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention provides a conjugate of an anti-CD4 molecule and an antichemokine receptor molecule. These molecules may be antibodies. The anti-CD4 molecule may be an antibody that inhibits HIV-1 infection of CD4+ cells and also inhibits syncytia formation between CD4+ cells, but does not cause immunosuppression in humans. The anti-chemokine receptor antibody may be an anti-CCR5 molecule. The invention also provides for conjugate of an anti-CD4 molecule and an HIV-1 fusion inhibiting peptide. Both types of conjugates may be formed by chemical methods and may or may not include a linker. Numerous types of linkers may be used. Both types of conjugates may also be expressed as recombinant proteins with or without linkers. The invention also provides a method of treating HIV-1 disease by providing a conjugate to a subject. The conjugate may be provided by providing the subject with a recombinant nucleic acid in a viral vector.
PCT/US2000/034032 1999-12-16 2000-12-15 Anti-hiv-1 conjugates for treatment of hiv disease WO2001043779A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU22657/01A AU2265701A (en) 1999-12-16 2000-12-15 Anti-hiv-1 conjugates for treatment of hiv disease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17118799P 1999-12-16 1999-12-16
US60/171,187 1999-12-16

Publications (2)

Publication Number Publication Date
WO2001043779A2 WO2001043779A2 (en) 2001-06-21
WO2001043779A3 true WO2001043779A3 (en) 2002-05-10

Family

ID=22622858

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/034032 WO2001043779A2 (en) 1999-12-16 2000-12-15 Anti-hiv-1 conjugates for treatment of hiv disease

Country Status (2)

Country Link
AU (1) AU2265701A (en)
WO (1) WO2001043779A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9504755B2 (en) 2008-08-11 2016-11-29 Nektar Therapeutics Multi-arm polymeric alkanoate conjugates

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1456241B1 (en) * 2001-12-21 2005-03-16 Micromet AG Mono-and dual anti-cd4-rantes chemokine/cytokine constructs
BRPI0514729A (en) * 2004-08-30 2008-06-24 Schering Ag treatment of t-cell modulation hiv infection
TW200720289A (en) 2005-04-01 2007-06-01 Hoffmann La Roche Antibodies against CCR5 and uses thereof
TW200817438A (en) 2006-08-17 2008-04-16 Hoffmann La Roche A conjugate of an antibody against CCR5 and an antifusogenic peptide
AU2007286451A1 (en) * 2006-08-17 2008-02-21 F. Hoffmann-La Roche Ag A conjugate of an antibody against CCR5 and an antifusogenic peptide
BRPI0717512A2 (en) 2006-09-29 2013-11-19 Hoffmann La Roche CCR5 ANTIBODIES AND USES OF THE SAME
US20090143288A1 (en) 2007-03-13 2009-06-04 Roche Palo Alto Llc Peptide-complement conjugates
CL2008002092A1 (en) * 2007-07-20 2009-05-29 Hoffmann La Roche Conjugate containing two or more antifusogenic peptides and an anti-cd-4 antibody; Method of production; pharmaceutical composition comprising it; antifusogenic polypeptides and use of the conjugate to treat viral infections.
WO2010028798A1 (en) * 2008-09-10 2010-03-18 F. Hoffmann-La Roche Ag Multivalent antibodies
WO2010028796A1 (en) * 2008-09-10 2010-03-18 F. Hoffmann-La Roche Ag Trispecific hexavalent antibodies
WO2010028795A1 (en) * 2008-09-10 2010-03-18 F. Hoffmann-La Roche Ag Multivalent antibodies
WO2010028797A1 (en) * 2008-09-10 2010-03-18 F. Hoffmann-La Roche Ag Multivalent antibodies
ES2574988T3 (en) * 2008-10-06 2016-06-23 Yissum Research Development Company Of The Herbrew University Of Jerusalem Ltd. Peptides derived from HIV-1 integrase stimulants that interfere with the Rev-integrase protein
RU2517084C2 (en) 2010-08-06 2014-05-27 Олег Ильич Эпштейн Method and means for inhibiting production or enhancing protein p24 elimination
US10894087B2 (en) 2010-12-22 2021-01-19 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
US20130331443A1 (en) 2010-12-22 2013-12-12 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds
US20140088021A1 (en) 2011-05-27 2014-03-27 Nektar Therapeutics Water-Soluble Polymer-Linked Binding Moiety and Drug Compounds
EP2741777B1 (en) 2011-08-12 2017-01-18 INSERM - Institut National de la Santé et de la Recherche Médicale Methods and pharmaceutical compositions for treatment of pulmonary hypertension
US20160102137A1 (en) * 2014-09-30 2016-04-14 California Institute Of Technology Crosslinked anti-hiv-1 compositions for potent and broad neutralization
US10450368B2 (en) 2015-03-19 2019-10-22 Duke University HIV-1 neutralizing antibodies and uses thereof (CD4bs antibodies)
ES2884267T3 (en) * 2015-04-24 2021-12-10 Viiv Healthcare Uk No 5 Ltd Polypeptides Targeted for HIV Fusion
EP4351647A1 (en) * 2021-06-10 2024-04-17 The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. Antibody-cd4 conjugates and methods of using the same

Citations (6)

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WO1998000535A2 (en) * 1996-06-28 1998-01-08 Dana-Farber Cancer Institute Method for inhibiting hiv-1 infection, drug screens, and methods of diagnosis and prognosis of susceptibility to hiv infection
WO1998015569A1 (en) * 1996-10-09 1998-04-16 Dana-Farber Cancer Institute Gp120 polypeptides having conformational discontinuous chemokine receptor binding sites and methods of inhibiting hiv infection
US5871732A (en) * 1990-11-27 1999-02-16 Biogen, Inc. Anti-CD4 antibody homologs useful in prophylaxis and treatment of AIDS, ARC and HIV infection
WO1999036091A2 (en) * 1998-01-15 1999-07-22 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Method for inhibiting cd95-independent apoptosis in aids
WO2000035409A2 (en) * 1998-12-16 2000-06-22 Progenics Pharmaceuticals, Inc. Hiv-i fusion inhibition compounds
WO2001070262A2 (en) * 2000-03-17 2001-09-27 Panacos Pharmaceuticals, Inc. A method for generating immunogens that elicit neutralizing antibodies against fusion-active regions of hiv envelope proteins

Patent Citations (6)

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US5871732A (en) * 1990-11-27 1999-02-16 Biogen, Inc. Anti-CD4 antibody homologs useful in prophylaxis and treatment of AIDS, ARC and HIV infection
WO1998000535A2 (en) * 1996-06-28 1998-01-08 Dana-Farber Cancer Institute Method for inhibiting hiv-1 infection, drug screens, and methods of diagnosis and prognosis of susceptibility to hiv infection
WO1998015569A1 (en) * 1996-10-09 1998-04-16 Dana-Farber Cancer Institute Gp120 polypeptides having conformational discontinuous chemokine receptor binding sites and methods of inhibiting hiv infection
WO1999036091A2 (en) * 1998-01-15 1999-07-22 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Method for inhibiting cd95-independent apoptosis in aids
WO2000035409A2 (en) * 1998-12-16 2000-06-22 Progenics Pharmaceuticals, Inc. Hiv-i fusion inhibition compounds
WO2001070262A2 (en) * 2000-03-17 2001-09-27 Panacos Pharmaceuticals, Inc. A method for generating immunogens that elicit neutralizing antibodies against fusion-active regions of hiv envelope proteins

Non-Patent Citations (3)

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Title
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ZHANG, HUIZHONG ET AL: "Blocking HIV-1 infection in SupT1 and peripheral blood mononuclear cells by anti-CD4 and anti-CXCR4 antibodies", XP002184173, retrieved from STN Database accession no. 132:346398 *
HOXIE, JAMES A. (1) ET AL: "CD4 -independent utilization of the CXCR4 chemokine receptor by HIV-1 and HIV-2.", JOURNAL OF REPRODUCTIVE IMMUNOLOGY, (DEC., 1998) VOL. 41, NO. 1-2, PP. 197-211., XP001041655 *
XIBAO YU FENZI MIANYIXUE ZAZHI (1999), 15(4), 278-280 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9504755B2 (en) 2008-08-11 2016-11-29 Nektar Therapeutics Multi-arm polymeric alkanoate conjugates

Also Published As

Publication number Publication date
AU2265701A (en) 2001-06-25
WO2001043779A2 (en) 2001-06-21

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