WO1999006439A3 - Est 5' pour proteines secretees exprimees dans l'endoderme - Google Patents

Est 5' pour proteines secretees exprimees dans l'endoderme Download PDF

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Publication number
WO1999006439A3
WO1999006439A3 PCT/IB1998/001233 IB9801233W WO9906439A3 WO 1999006439 A3 WO1999006439 A3 WO 1999006439A3 IB 9801233 W IB9801233 W IB 9801233W WO 9906439 A3 WO9906439 A3 WO 9906439A3
Authority
WO
WIPO (PCT)
Prior art keywords
ests
secreted proteins
endoderm
proteins expressed
sequences
Prior art date
Application number
PCT/IB1998/001233
Other languages
English (en)
Other versions
WO1999006439A2 (fr
Inventor
Milne Edwards Jean-Bapti Dumas
Aymeric Duclert
Bruno Lacroix
Original Assignee
Genset Sa
Dumas Milne Edwards Jean Bapti
Aymeric Duclert
Bruno Lacroix
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genset Sa, Dumas Milne Edwards Jean Bapti, Aymeric Duclert, Bruno Lacroix filed Critical Genset Sa
Priority to AU85552/98A priority Critical patent/AU8555298A/en
Priority to CA002296398A priority patent/CA2296398A1/fr
Priority to JP2000505194A priority patent/JP2001512005A/ja
Priority to EP98936591A priority patent/EP0994899A2/fr
Publication of WO1999006439A2 publication Critical patent/WO1999006439A2/fr
Publication of WO1999006439A3 publication Critical patent/WO1999006439A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4728—Calcium binding proteins, e.g. calmodulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne des séquences EST 5' (marqueurs séquentiels exprimés) dérivés d'ARNm codant des protéines sécrétées. Les EST 5' peuvent être utilisés pour la production d'ADNc et d'ADN génomiques correspondant aux EST 5'. Les EST 5' peuvent également être utilisés dans le diagnostic, la médecine légale, la thérapie génique et les procédures de cartographie des gènes. Des séquences de régulation d'amont peuvent également être produites au moyen des EST 5'. Les EST 5' peuvent également être utilisés pour la mise au point de vecteurs d'expression et de vecteurs de sécrétion.
PCT/IB1998/001233 1997-08-01 1998-07-31 Est 5' pour proteines secretees exprimees dans l'endoderme WO1999006439A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU85552/98A AU8555298A (en) 1997-08-01 1998-07-31 5' ests for secreted proteins expressed in endoderm
CA002296398A CA2296398A1 (fr) 1997-08-01 1998-07-31 Est 5' pour proteines secretees exprimees dans l'endoderme
JP2000505194A JP2001512005A (ja) 1997-08-01 1998-07-31 内胚葉において発現する分泌タンパク質の５’ｅｓｔ
EP98936591A EP0994899A2 (fr) 1997-08-01 1998-07-31 Est 5' pour proteines secretees exprimees dans l'endoderme

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90446897A 1997-08-01 1997-08-01
US08/904,468 1997-08-01

Publications (2)

Publication Number Publication Date
WO1999006439A2 WO1999006439A2 (fr) 1999-02-11
WO1999006439A3 true WO1999006439A3 (fr) 1999-04-08

Family

ID=25419217

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1998/001233 WO1999006439A2 (fr) 1997-08-01 1998-07-31 Est 5' pour proteines secretees exprimees dans l'endoderme

Country Status (5)

Country Link
EP (1) EP0994899A2 (fr)
JP (1) JP2001512005A (fr)
AU (1) AU8555298A (fr)
CA (1) CA2296398A1 (fr)
WO (1) WO1999006439A2 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2216176T3 (es) * 1996-11-27 2004-10-16 Schering Corporation Quimioquinas de mamiferos.
EP1352962A1 (fr) * 1997-03-07 2003-10-15 Human Genome Sciences, Inc. 186 protéines secrétées humaines
US20020198149A1 (en) * 1997-06-16 2002-12-26 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO1999018126A1 (fr) 1997-10-07 1999-04-15 Ono Pharmaceutical Co., Ltd. POLYPEPTIDE, ADNc LE CODANT ET LEUR UTILISATION
US6548633B1 (en) 1998-12-22 2003-04-15 Genset, S.A. Complementary DNA's encoding proteins with signal peptides
KR20010033385A (ko) 1997-12-22 2001-04-25 오노 야꾸힝 고교 가부시키가이샤 펩티드, 사람 펩시노겐 ⅱ 또는 사람 펩신 ⅱ의 측정 방법및 측정용 키트
JPH11187882A (ja) * 1997-12-26 1999-07-13 Ono Pharmaceut Co Ltd 新規なポリペプチド、その製造方法、そのポリペプチドをコードするｃＤＮＡ、そのｃＤＮＡからなるベクター、そのベクターで形質転換された宿主細胞、そのポリペプチドの抗体、およびそのペプチドまたは抗体を含有する薬学的組成物
US6306653B1 (en) * 1998-01-20 2001-10-23 Codon Diagnostics, Llc Detection and treatment of breast disease
AU5312699A (en) * 1998-06-25 2000-01-10 Millennium Pharmaceuticals, Inc. Novel mp-7 protein and nucleic acid molecules and uses therefor
AU3382800A (en) * 1999-02-26 2000-09-14 Millennium Pharmaceuticals, Inc. Secreted proteins and uses thereof
US7083793B2 (en) 1999-02-26 2006-08-01 Millennium Pharmaceuticals, Inc. Tango 243 polypeptides and uses thereof
US6277574B1 (en) * 1999-04-09 2001-08-21 Incyte Genomics, Inc. Genes associated with diseases of the kidney
US6262247B1 (en) * 1999-08-30 2001-07-17 Incyte Genomics, Inc. Polycyclic aromatic hydrocarbon induced molecules
ES2349679T3 (es) 1999-10-28 2011-01-10 Agensys, Inc. Antígeno tumoral secretado.
FR2800750B1 (fr) * 1999-11-05 2003-01-31 Centre Nat Rech Scient Proteines membranaires ctl (choline transporter like) impliquees dans le transport de la choline
US6833241B2 (en) 2000-03-23 2004-12-21 Novartis Mammary gland chemokine
AU2001264819A1 (en) * 2000-05-26 2001-12-11 Indiana University Advanced Research And Technology Institute Placc, a novel human c-c chemokine isolated from placenta
CA2443123A1 (fr) 2001-04-10 2002-10-24 Agensys, Inc. Acides nucleiques et proteines correspondantes utiles pour la detection et le traitement de divers cancers
US7927597B2 (en) 2001-04-10 2011-04-19 Agensys, Inc. Methods to inhibit cell growth
WO2012170977A1 (fr) * 2011-06-10 2012-12-13 President And Fellows Of Harvard College Modulation de la prolifération des cellules bêta du pancréas

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0625572A1 (fr) * 1992-09-25 1994-11-23 The Kanagawa Academy Of Science And Technology Foundation PROCEDE POUR SYNTHETISER UN ADNc DE LONGUEUR COMPLETE, PROCEDE POUR PRODUIRE UN INTERMEDIAIRE DE CET ADNc, ET PROCEDE POUR PRODUIRE UN VECTEUR DE RECOMBINAISON CONTENANT CET ADNc
WO1996034981A2 (fr) * 1995-05-02 1996-11-07 Genset Sa METHODE DE COUPLAGE SPECIFIQUE DE LA COIFFE DE L'EXTREMITE 5' D'UN FRAGMENT D'ARNm ET PREPARATION D'ARNm ET D'ADNc COMPLET
WO1997007198A2 (fr) * 1995-08-11 1997-02-27 Genetics Institute, Inc. Sequences d'adn et proteines secretees codees par celles-ci
WO1998042738A1 (fr) * 1997-03-21 1998-10-01 Human Genome Sciences, Inc. 87 proteines humaines secretees

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0625572A1 (fr) * 1992-09-25 1994-11-23 The Kanagawa Academy Of Science And Technology Foundation PROCEDE POUR SYNTHETISER UN ADNc DE LONGUEUR COMPLETE, PROCEDE POUR PRODUIRE UN INTERMEDIAIRE DE CET ADNc, ET PROCEDE POUR PRODUIRE UN VECTEUR DE RECOMBINAISON CONTENANT CET ADNc
WO1996034981A2 (fr) * 1995-05-02 1996-11-07 Genset Sa METHODE DE COUPLAGE SPECIFIQUE DE LA COIFFE DE L'EXTREMITE 5' D'UN FRAGMENT D'ARNm ET PREPARATION D'ARNm ET D'ADNc COMPLET
WO1997007198A2 (fr) * 1995-08-11 1997-02-27 Genetics Institute, Inc. Sequences d'adn et proteines secretees codees par celles-ci
WO1998042738A1 (fr) * 1997-03-21 1998-10-01 Human Genome Sciences, Inc. 87 proteines humaines secretees

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
ASAKURA K. ET AL.: "A monoclonal autoantibody which promotes central nervous system remyelination is highly polyreactive to multiple known and novel antigens", JOURNAL OF NEUROIMMUNOLOGY, vol. 65, no. 1, March 1996 (1996-03-01), pages 11 - 19, XP002081171 *
CARNINCI P. ET AL.: "High-efficiency full-length cDNA cloning by biotinylated CAP trapper", GENOMICS, vol. 37, no. 3, 1 November 1996 (1996-11-01), pages 327 - 336, XP002081729 *
Database EMBL Emest15, Entry MM68132 Accession number W70681 19 June 1996 81% identity with Seq.ID:38 nt.11-352 *
Database EMBL Emest15, Entry MM70733 Accession number W70707 19 June 1996 82% identity with Seq.ID:38 nt.36-352 *
Database EMBL Emest15, Entry MMA28649 Accession number AA028649 17 August 1996 83% identity with Seq.ID:38 nt.26-352 *
Database EMBL Emest7, Entry HS1150166 Accession number AA232452 6 March 1997 94% identity with Seq.ID:38 nt.39-352 *
HEIJNE VON G.: "A new method for predicting signal sequence cleavage sites", NUCLEIC ACIDS RESEARCH, vol. 14, no. 11, 1986, pages 4683 - 4690, XP002053954 *
KATO S. ET AL.: "Construction of a human full-length cDNA bank", GENE, vol. 150, 1994, pages 243 - 250, XP002081364 *
OZAWA M.: "Cloning of a human homologue of mouse reticulocalbin reveals conservation of structural domains in the novel endoplasmic reticulum resident Ca2+-binding protein with multiple EF-hand motifs", JOURNAL OF BIOCHEMISTRY, vol. 117, 1995, pages 1113 - 1119, XP002070128 *
SCHÄFER B.W. AND HEIZMANN C.W.: "The S100 family of EF-hand calcium-binding proteins: functions and pathology", TIBS TRENDS IN BIOCHEMICAL SCIENCES, vol. 21, no. 4, April 1996 (1996-04-01), pages 134-140, XP004050923 *
TASHIRO K. ET AL.: "Signal sequence trap: a cloning strategy for secreted proteins and type I membrane proteins", SCIENCE, vol. 261, 30 July 1993 (1993-07-30), pages 600 - 603, XP000673204 *
YOKOYAMA-KOBAYASHI M. ET AL.: "A signal sequence detection system using secreted protease activity as an indicator", GENE, vol. 163, 1995, pages 193 - 196, XP002053953 *

Also Published As

Publication number Publication date
JP2001512005A (ja) 2001-08-21
AU8555298A (en) 1999-02-22
WO1999006439A2 (fr) 1999-02-11
EP0994899A2 (fr) 2000-04-26
CA2296398A1 (fr) 1999-02-11

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