WO1999005266A3 - Transfert de noyau entre des especes differentes - Google Patents
Transfert de noyau entre des especes differentes Download PDFInfo
- Publication number
- WO1999005266A3 WO1999005266A3 PCT/US1998/015387 US9815387W WO9905266A3 WO 1999005266 A3 WO1999005266 A3 WO 1999005266A3 US 9815387 W US9815387 W US 9815387W WO 9905266 A3 WO9905266 A3 WO 9905266A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nuclear transfer
- trans
- donor cells
- species nuclear
- oocytes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
- C12N15/877—Techniques for producing new mammalian cloned embryos
- C12N15/8771—Bovine embryos
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Developmental Biology & Embryology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU85875/98A AU8587598A (en) | 1997-07-26 | 1998-07-24 | Trans-species nuclear transfer |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5310397P | 1997-07-26 | 1997-07-26 | |
US60/053,103 | 1997-07-26 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO1999005266A2 WO1999005266A2 (fr) | 1999-02-04 |
WO1999005266A3 true WO1999005266A3 (fr) | 1999-04-15 |
WO1999005266B1 WO1999005266B1 (fr) | 1999-09-23 |
Family
ID=21981947
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/015387 WO1999005266A2 (fr) | 1997-07-26 | 1998-07-24 | Transfert de noyau entre des especes differentes |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU8587598A (fr) |
WO (1) | WO1999005266A2 (fr) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9517780D0 (en) * | 1995-08-31 | 1995-11-01 | Roslin Inst Edinburgh | Biological manipulation |
US7696404B2 (en) | 1996-08-19 | 2010-04-13 | Advanced Cell Technology, Inc. | Embryonic or stem-like cell lines produced by cross species nuclear transplantation and methods for enhancing embryonic development by genetic alteration of donor cells or by tissue culture conditions |
NZ334016A (en) * | 1996-08-19 | 2000-08-25 | Univ Massachusetts | Embryonic stem cell lines produced by cross species nuclear transplantation |
EP1060243A4 (fr) * | 1998-03-02 | 2005-03-09 | Univ Massachusetts | Lignees cellulaires embryonnaires ou de type souche produites par transplantation nucleaire d'especes croisees |
EP1067834A4 (fr) * | 1998-03-16 | 2002-01-23 | Garelag Pty Ltd | Transfert de noyau de cellules porcines |
AU782286B2 (en) | 1999-06-30 | 2005-07-14 | Advanced Cell Technology, Inc. | Cytoplasmic transfer to de-differentiate recipient cells |
JP2003503045A (ja) * | 1999-06-30 | 2003-01-28 | ワン,ウー−サク | 異種間核移植技術を用いたクローントラの生産方法 |
RU2216591C2 (ru) * | 1999-06-30 | 2003-11-20 | Воо-Сук ХВАНГ | Способ получения клонированных эмбрионов человека путем применения способа межвидовой трансплантации ядер |
CA2334382A1 (fr) * | 1999-06-30 | 2001-01-04 | Woo-Suk Hwang | Procede de production de vaches clonees |
BR0013999A (pt) * | 1999-09-14 | 2002-05-21 | Univ Massachusetts Public Inst | Linhagens de célula embriÈnicas ou semelhantes a células tronco produzidas por transplante nuclear de espécies cruzadas e métodos para melhorar o desenvolvimento embriÈnico por alteração genética de células doadoras ou por condições de cultura de tecido |
MXPA02006093A (es) * | 1999-12-20 | 2004-08-23 | Univ Massachusetts | Celulas tipo madre o embrionicas producidas por transplante nuclear de especies de cruza. |
WO2003018767A2 (fr) | 2001-08-27 | 2003-03-06 | Advanced Cell Technology, Inc. | Transdifferenciation et redifferenciation de cellules somatiques et production de cellules pour therapies cellulaires |
ES2933478T3 (es) | 2005-08-03 | 2023-02-09 | Astellas Inst For Regenerative Medicine | Métodos mejorados de reprogramación de células somáticas animales |
WO2013010045A1 (fr) | 2011-07-12 | 2013-01-17 | Biotime Inc. | Nouveaux procédés et formulations pour thérapie cellulaire orthopédique |
SG11201508028QA (en) | 2013-04-16 | 2015-10-29 | Regeneron Pharma | Targeted modification of rat genome |
CN105980568B (zh) | 2013-12-11 | 2019-12-03 | 瑞泽恩制药公司 | 用于靶向修饰基因组的方法和组合物 |
DK3080279T3 (en) | 2013-12-11 | 2018-11-05 | Regeneron Pharma | METHODS AND COMPOSITIONS FOR TARGETED MODIFICATION OF A GENOM |
CA2950173C (fr) | 2014-06-06 | 2023-10-10 | Regeneron Pharmaceuticals, Inc. | Procedes et compositions pour la modification d'un locus cible |
RU2771532C2 (ru) | 2014-06-26 | 2022-05-05 | Регенерон Фармасьютикалз, Инк. | Способы и композиции для нацеленных генетических модификаций и способы их применения |
CN113444747A (zh) | 2014-11-21 | 2021-09-28 | 瑞泽恩制药公司 | 使用成对向导rna进行靶向遗传修饰的方法和组合物 |
CN107208113A (zh) | 2014-12-19 | 2017-09-26 | 瑞泽恩制药公司 | 用于通过单步多重靶向进行靶向遗传修饰的方法和组合物 |
SG11201706809WA (en) | 2015-03-16 | 2017-09-28 | Regeneron Pharma | Non-human animal exhibiting diminished upper and lower motor neuron function and sensory perception |
ES2784360T3 (es) | 2015-05-29 | 2020-09-24 | Regeneron Pharma | Animales no humanos que tienen una interrupción en un locus C9ORF72 |
CN109195443A (zh) | 2016-02-16 | 2019-01-11 | 雷杰纳荣制药公司 | 具有突变型犬尿氨酸酶基因的非人动物 |
EP3457840B1 (fr) | 2016-05-20 | 2024-04-10 | Regeneron Pharmaceuticals, Inc. | Procédés pour briser la tolérance immunologique à l'aide de multiples arn de guidage |
JP2019523009A (ja) | 2016-07-29 | 2019-08-22 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | C末端切断型フィブリリン−1の発現をもたらす変異を有するマウス |
MX2019003745A (es) | 2016-09-30 | 2019-12-11 | Regeneron Pharma | Animales no humanos que tienen una expansion de repeticiones de hexanucleotidos en un locus c9orf72. |
ES2953875T3 (es) | 2017-02-27 | 2023-11-16 | Regeneron Pharma | Modelos de retinosquisis en roedor |
EP3644722A1 (fr) | 2017-06-27 | 2020-05-06 | Regeneron Pharmaceuticals, Inc. | Animaux non humains comprenant un locus asgr1 |
EP3585159A1 (fr) | 2017-07-31 | 2020-01-01 | Regeneron Pharmaceuticals, Inc. | Cellules souches embryonnaires de souris transgéniques cas et souris et leurs utilisations |
AU2018309714A1 (en) | 2017-07-31 | 2020-01-30 | Regeneron Pharmaceuticals, Inc. | Assessment of CRISPR/Cas-induced recombination with an exogenous donor nucleic acid in vivo |
BR112020001996A2 (pt) | 2017-07-31 | 2020-08-18 | Regeneron Pharmaceuticals, Inc. | animal não humano, e, métodos para testar e para otimizar a capacidade de uma crispr/cas nuclease de excisar um ácido nucleico genômico in vivo, para testar a recombinação induzida por crispr/cas de um ácido nucleico genômico com um ácido nucleico de doador exógeno in vivo e para otimizar a capacidade de crispr/cas de induzir a recombinação de um ácido nucleico genômico com um ácido nucleico de doador exógeno in vivo. |
JP7139419B2 (ja) | 2017-09-29 | 2022-09-20 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化ttr遺伝子座を含む非ヒト動物および使用方法 |
CN111565566B (zh) | 2017-11-10 | 2022-10-21 | 瑞泽恩制药公司 | 包含slc30a8突变的非人动物及使用方法 |
US11419318B2 (en) | 2017-11-30 | 2022-08-23 | Regeneran Pharmaceuticals, Inc. | Genetically modified rat comprising a humanized TRKB locus |
CN111885915B (zh) | 2018-03-19 | 2023-04-28 | 瑞泽恩制药公司 | 使用crispr/cas系统对动物进行转录调制 |
CA3112612C (fr) | 2018-09-13 | 2024-02-27 | Regeneron Pharmaceuticals, Inc. | Rat a invalidation genique de facteur h de complement en tant que modele de glomerulopathie c3 |
MX2021007400A (es) | 2018-12-20 | 2021-07-15 | Regeneron Pharma | Expansion de repeticiones mediada por nucleasas. |
ES2966625T3 (es) | 2019-04-04 | 2024-04-23 | Regeneron Pharma | Roedores que comprenden un locus del factor de coagulación 12 humanizado |
CA3137761A1 (fr) | 2019-06-04 | 2020-12-10 | Regeneron Pharmaceuticals, Inc. | Animaux non humains comprenant un locus ttr humanise ayant une mutation beta-slip et procedes d'utilisation |
EP3796776A1 (fr) | 2019-06-07 | 2021-03-31 | Regeneron Pharmaceuticals, Inc. | Animaux non humains comprenant un locus d'albumine humanisé |
CN114008193A (zh) | 2019-06-27 | 2022-02-01 | 瑞泽恩制药公司 | Tdp-43蛋白病的建模 |
WO2021108363A1 (fr) | 2019-11-25 | 2021-06-03 | Regeneron Pharmaceuticals, Inc. | Régulation à la hausse médiée par crispr/cas d'un allèle ttr humanisé |
US20210227812A1 (en) | 2020-01-28 | 2021-07-29 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized pnpla3 locus and methods of use |
WO2021158883A1 (fr) | 2020-02-07 | 2021-08-12 | Regeneron Pharmaceuticals, Inc. | Animaux non humains comprenant un locus klkb1 humanisé et procédés d'utilisation |
US20230102342A1 (en) | 2020-03-23 | 2023-03-30 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized ttr locus comprising a v30m mutation and methods of use |
WO2021263146A2 (fr) | 2020-06-26 | 2021-12-30 | Regeneron Pharmaceuticals, Inc. | Animaux non humains comprenant un locus d'ace2 humanisé |
AU2022381205A1 (en) | 2021-11-04 | 2024-03-28 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a modified cacng1 locus |
AU2022408167A1 (en) | 2021-12-08 | 2024-06-06 | Regeneron Pharmaceuticals, Inc. | Mutant myocilin disease model and uses thereof |
CN113943712B (zh) * | 2021-12-20 | 2022-03-22 | 南京岚轩生物科技有限公司 | 一种电融合缓冲液、其制备方法及电融合方法 |
WO2023122506A1 (fr) | 2021-12-20 | 2023-06-29 | Regeneron Pharmaceuticals, Inc. | Animaux non humains comprenant des loci ace2 et tmprss humanisés |
WO2023150798A1 (fr) | 2022-02-07 | 2023-08-10 | Regeneron Pharmaceuticals, Inc. | Compositions et procédés permettant de définir des délais de traitement optimaux dans le cadre d'une maladie lysosomale |
US20230257432A1 (en) | 2022-02-11 | 2023-08-17 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for screening 4r tau targeting agents |
WO2023235677A1 (fr) | 2022-05-31 | 2023-12-07 | Regeneron Pharmaceuticals, Inc. | Modèle animal de protéinopathie tdp-43 |
WO2024026488A2 (fr) | 2022-07-29 | 2024-02-01 | Regeneron Pharmaceuticals, Inc. | Animaux non humains comprenant un locus de récepteur de transférrine modifié |
WO2024031053A1 (fr) | 2022-08-05 | 2024-02-08 | Regeneron Pharmaceuticals, Inc. | Variants de tdp-43 résistants à l'agrégation |
US20240130341A1 (en) | 2022-09-29 | 2024-04-25 | Regeneron Pharmaceuticals, Inc. | Correction of hepatosteatosis in humanized liver animals through restoration of il6/il6r/gp130 signaling in human hepatocytes |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5496720A (en) * | 1993-02-10 | 1996-03-05 | Susko-Parrish; Joan L. | Parthenogenic oocyte activation |
WO1997007669A1 (fr) * | 1995-08-31 | 1997-03-06 | Roslin Institute (Edinburgh) | Populations de cellules quiescentes pour transfert de noyau |
WO1998007841A1 (fr) * | 1996-08-19 | 1998-02-26 | University Of Massachusetts | Lignees de cellules embryonnaires ou de type souche produites par transplantation nucleaire croisee d'especes |
WO1998030683A2 (fr) * | 1997-01-10 | 1998-07-16 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts | Transfert nucleaire au moyen de cellules donneuses foetales et adultes differentiees |
-
1998
- 1998-07-24 AU AU85875/98A patent/AU8587598A/en not_active Abandoned
- 1998-07-24 WO PCT/US1998/015387 patent/WO1999005266A2/fr active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5496720A (en) * | 1993-02-10 | 1996-03-05 | Susko-Parrish; Joan L. | Parthenogenic oocyte activation |
WO1997007669A1 (fr) * | 1995-08-31 | 1997-03-06 | Roslin Institute (Edinburgh) | Populations de cellules quiescentes pour transfert de noyau |
WO1998007841A1 (fr) * | 1996-08-19 | 1998-02-26 | University Of Massachusetts | Lignees de cellules embryonnaires ou de type souche produites par transplantation nucleaire croisee d'especes |
WO1998030683A2 (fr) * | 1997-01-10 | 1998-07-16 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts | Transfert nucleaire au moyen de cellules donneuses foetales et adultes differentiees |
Non-Patent Citations (6)
Title |
---|
CHESNE P ET AL: "NUCLEAR TRANSFER IN CATTLE: BIRTH OF CLONED CALVES AND ESTIMATION OF BLASTOMERE TOTIPOTENCY IN MORULAE USED AS A SOURCE OF NUCLEI", LIFE SCIENCES, vol. 316, 1993, pages 487 - 491, XP000197855 * |
HEYMAN Y ET AL: "CLONING OF DOMESTIC SPECIES", ANIMAL REPRODUCTION SCIENCE, vol. 42, no. 1/04, 1996, pages 427 - 436, XP000671884 * |
SIMS M ET FIRST: "PRODUCTION OF CALVES BY TRANSFER OF NUCLEI FROM CULTURED INNER CELL MASS CELLS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 90, no. 13, June 1993 (1993-06-01), pages 6143 - 6147, XP000604993 * |
STICE S L ET AL: "PLURIPOTENT BOVINE EMBRYONIC CELL LINES DIRECT EMBRYONIC DEVELOPMENT FOLLOWING NUCLEAR TRANSFER", BIOLOGY OF REPRODUCTION, vol. 54, no. 1, January 1996 (1996-01-01), pages 100 - 110, XP000671718 * |
WOLFE, B.A. ET AL.: "Embryos produced by the transfer of caprine nuclei to enucleated bovine oocytes are capable of cleavage but not to develop to blastocysts", BIOLOGY OF REPRODUCTION, vol. 50, no. suppl. 1, 1994 - 1972, pages 72, XP002092259 * |
ZAWADA, W.M. ET AL.: "Somatic cell cloned transgenic bovine neurons for transplantation in Parkinsonian rats", NATURE MEDICINE, vol. 4, no. 5, May 1998 (1998-05-01), pages 569 - 574, XP002092260 * |
Also Published As
Publication number | Publication date |
---|---|
WO1999005266A2 (fr) | 1999-02-04 |
WO1999005266B1 (fr) | 1999-09-23 |
AU8587598A (en) | 1999-02-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO1999005266A3 (fr) | Transfert de noyau entre des especes differentes | |
WO1998030683A3 (fr) | Transfert nucleaire au moyen de cellules donneuses foetales et adultes differentiees | |
EP1017423A4 (fr) | Clonage de porcs a l'aide de noyaux donneurs a partir de cellules differenciees | |
AU1595195A (en) | Embryonic stem cells as nuclear donors and nuclear transfer techniques to produce chimeric and transgenic animals | |
ATE318307T1 (de) | Kultur einer zelllinieaus der inneren zellmasse von huftierembryonen. | |
WO2000031237A3 (fr) | Procede de clonage de porcins | |
EP1780263A3 (fr) | Procédé de production de culture de céllules aviaires indifférenciées, au moyen de céllules gérminales primordiales | |
WO2002072762A3 (fr) | Utilisation d'interference de l'arn pour produire des cellules souches de lignee specifique et d'autres cellules non differenciees, et production de cellules differenciees in vitro par coculture | |
GB2350619B (en) | Sex-specific insemination of mammals with low number of sperm cells | |
BR9506652A (pt) | Materiais e métodos para gerenciamento de rejeição hiperaguda em xenotransplante em ser humano | |
EP1045635A4 (fr) | Clonage faisant appel a des noyaux donnes de cellules foetales et adultes differenciees | |
NZ502712A (en) | Medium and method for long term culturing of avian primordial germ cells (PGC) in a tissue culture comprising growth factors | |
EP1088057A4 (fr) | Procede et milieu pour la culture in vitro d'embryons humains | |
WO2001042421A3 (fr) | Compositions pour culture cellulaire a long terme et animaux genetiquement modifies derives de ces compositions | |
MXPA02006094A (es) | Metodos para producir embriones clonadod y adultos a partir de celulas cultivadas. | |
AU695398B2 (en) | Method of production of transgenic plants wholly transformed into To generation, from meristems | |
NO912621L (no) | Fremgangsmaate for innfoering av dna i animalske celler. | |
WO2001049106A3 (fr) | Procede de clonage d'animaux avec modifications genetiques ciblees, par transfert de noyaux cellulaires somatiques males ou femelles a culture a long terme, comprenant des modifications genetiques provoquees artificiellement, dans des cellules receveuses enuclees | |
WO2001068831A3 (fr) | Reprogrammation effective de materiel nucleaire chez des mammiferes | |
NO20006545L (no) | Fremgangsmåte for in vitro modning av humane kjönnsceller | |
AU570954B2 (en) | Propagation of proliferating cell aggregates | |
IE881133L (en) | In-vitro culture of bovine embryos | |
IE890289L (en) | Bovine embryo in vitro culture | |
AU3927599A (en) | Source of nuclei for nuclear transfer | |
AU6292898A (en) | Efficient nuclear transfer using primordial germ cells |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
AK | Designated states |
Kind code of ref document: B1 Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: B1 Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
NENP | Non-entry into the national phase |
Ref country code: KR |
|
WWE | Wipo information: entry into national phase |
Ref document number: 09463276 Country of ref document: US |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
122 | Ep: pct application non-entry in european phase | ||
NENP | Non-entry into the national phase |
Ref country code: CA |