WO1999005106A8 - Nouveaux derives benzamides stimulants de la motricite gastrointestinale haute et basse - Google Patents

Nouveaux derives benzamides stimulants de la motricite gastrointestinale haute et basse

Info

Publication number
WO1999005106A8
WO1999005106A8 PCT/FR1998/001640 FR9801640W WO9905106A8 WO 1999005106 A8 WO1999005106 A8 WO 1999005106A8 FR 9801640 W FR9801640 W FR 9801640W WO 9905106 A8 WO9905106 A8 WO 9905106A8
Authority
WO
WIPO (PCT)
Prior art keywords
motricity
benzamide derivatives
novel benzamide
low gastrointestinal
stimulating high
Prior art date
Application number
PCT/FR1998/001640
Other languages
English (en)
Other versions
WO1999005106A1 (fr
Inventor
Christian Jeanpetit
Thierry Bouyssou
Helene Christinaki
Serge Biosa
Olivier Boucheix
Original Assignee
Logeais Labor Jacques
Christian Jeanpetit
Thierry Bouyssou
Helene Christinaki
Serge Biosa
Olivier Boucheix
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Logeais Labor Jacques, Christian Jeanpetit, Thierry Bouyssou, Helene Christinaki, Serge Biosa, Olivier Boucheix filed Critical Logeais Labor Jacques
Priority to EP98940329A priority Critical patent/EP0998458A1/fr
Priority to AU88678/98A priority patent/AU8867898A/en
Publication of WO1999005106A1 publication Critical patent/WO1999005106A1/fr
Publication of WO1999005106A8 publication Critical patent/WO1999005106A8/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

L'invention concerne des composés de formule générale (I), dans laquelle n = 1 ou 2, R1 est un groupe alkyle ou cycloalkyle, R2 et R3 représentent H, OH, ou un groupe cycloalkyle. L'invention concerne également les compositions pharmaceutiques contenant ces composés, et leur utilisation dans le cadre du traitement des dysfonctionnements du tube digestif haut et bas.
PCT/FR1998/001640 1997-07-25 1998-07-24 Nouveaux derives benzamides stimulants de la motricite gastrointestinale haute et basse WO1999005106A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP98940329A EP0998458A1 (fr) 1997-07-25 1998-07-24 Nouveaux derives benzamides stimulants de la motricite gastrointestinale haute et basse
AU88678/98A AU8867898A (en) 1997-07-25 1998-07-24 Novel benzamide derivatives stimulating high and low gastrointestinal motricity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9709477A FR2766484B1 (fr) 1997-07-25 1997-07-25 Nouveaux derives benzamides stimulants de la motricite gastrointestinale haute et basse
FR97/09477 1997-07-25

Publications (2)

Publication Number Publication Date
WO1999005106A1 WO1999005106A1 (fr) 1999-02-04
WO1999005106A8 true WO1999005106A8 (fr) 1999-04-15

Family

ID=9509623

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR1998/001640 WO1999005106A1 (fr) 1997-07-25 1998-07-24 Nouveaux derives benzamides stimulants de la motricite gastrointestinale haute et basse

Country Status (8)

Country Link
EP (1) EP0998458A1 (fr)
AR (1) AR014900A1 (fr)
AU (1) AU8867898A (fr)
CO (1) CO4990994A1 (fr)
FR (1) FR2766484B1 (fr)
TN (1) TNSN98138A1 (fr)
WO (1) WO1999005106A1 (fr)
ZA (1) ZA986633B (fr)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE620543A (fr) *
GB1015921A (en) * 1961-10-06 1966-01-05 Benger Lab Ltd Benzamides
AR216043A1 (es) * 1974-03-21 1979-11-30 Anphar Sa Procedimiento para la preparacion de 1-derivados de benzoilamino-4-piperidina y sus sales fisiologicamente aceptables
EP0248824B1 (fr) * 1985-10-25 1990-01-17 The Upjohn Company L'usage de l'acetamide et de la Benzamide de CIS N- (2-Aminocycloaliphatique) Benzene pour la fabrication des anti-convulsifs
FR2674849B1 (fr) * 1991-04-02 1994-12-23 Logeais Labor Jacques Nouveaux derives de n-cyclohexyl benzamides ou thiobenzamides, leurs preparations et leurs applications en therapeutique.
CA2116024A1 (fr) * 1991-08-20 1993-03-04 Francis David King Antagonistes des recepteurs 5-ht4
WO1995025100A1 (fr) * 1994-03-14 1995-09-21 Sanofi Utilisation d'esters de l'acide 4-amino-5-chloro-2-methoxybenzoique comme 5-ht4 agonistes
FR2735693B1 (fr) * 1995-06-23 1997-09-26 Logeais Labor Jacques Nouvelles applications therapeutiques de n-cyclohexyl benzamides

Also Published As

Publication number Publication date
EP0998458A1 (fr) 2000-05-10
FR2766484B1 (fr) 1999-09-17
ZA986633B (en) 1999-06-15
CO4990994A1 (es) 2000-12-26
AR014900A1 (es) 2001-04-11
WO1999005106A1 (fr) 1999-02-04
FR2766484A1 (fr) 1999-01-29
TNSN98138A1 (fr) 2005-03-15
AU8867898A (en) 1999-02-16

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