WO1999003993A3 - Suppresseurs de signalement de cytokine et reactifs correspondants - Google Patents

Suppresseurs de signalement de cytokine et reactifs correspondants Download PDF

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Publication number
WO1999003993A3
WO1999003993A3 PCT/US1998/014544 US9814544W WO9903993A3 WO 1999003993 A3 WO1999003993 A3 WO 1999003993A3 US 9814544 W US9814544 W US 9814544W WO 9903993 A3 WO9903993 A3 WO 9903993A3
Authority
WO
WIPO (PCT)
Prior art keywords
suppressors
cytokine signaling
related reagents
reagents
molecules
Prior art date
Application number
PCT/US1998/014544
Other languages
English (en)
Other versions
WO1999003993A2 (fr
Inventor
James A Johnson
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Priority to AU84845/98A priority Critical patent/AU8484598A/en
Publication of WO1999003993A2 publication Critical patent/WO1999003993A2/fr
Publication of WO1999003993A3 publication Critical patent/WO1999003993A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention concerne des gènes purifiés codant des molécules intracellulaires régulatrices d'un être humain, des réactifs de celles-ci comprenant des protéines purifiées, des anticorps spécifiques et des acides nucléiques codant lesdites molécules. La présente invention concerne lesdits réactifs et des kits de diagnostic.
PCT/US1998/014544 1997-07-18 1998-07-17 Suppresseurs de signalement de cytokine et reactifs correspondants WO1999003993A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU84845/98A AU8484598A (en) 1997-07-18 1998-07-17 Suppressors of cytokine signaling; related reagents

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US5315397P 1997-07-18 1997-07-18
US5324497P 1997-07-18 1997-07-18
US60/053,153 1997-07-18
US60/053,244 1997-07-18
US5580497P 1997-08-15 1997-08-15
US5585397P 1997-08-15 1997-08-15
US60/055,853 1997-08-15
US60/055,804 1997-08-15

Publications (2)

Publication Number Publication Date
WO1999003993A2 WO1999003993A2 (fr) 1999-01-28
WO1999003993A3 true WO1999003993A3 (fr) 1999-06-03

Family

ID=27489542

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US1998/014545 WO1999003994A1 (fr) 1997-07-18 1998-07-16 Suppresseurs de signalement de cytokine; socs16 et reactifs correspondants
PCT/US1998/014544 WO1999003993A2 (fr) 1997-07-18 1998-07-17 Suppresseurs de signalement de cytokine et reactifs correspondants

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US1998/014545 WO1999003994A1 (fr) 1997-07-18 1998-07-16 Suppresseurs de signalement de cytokine; socs16 et reactifs correspondants

Country Status (2)

Country Link
AU (2) AU8484698A (fr)
WO (2) WO1999003994A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2308785T3 (es) * 1996-11-01 2008-12-01 The Walter And Eliza Hall Institute Of Medical Research Agentes terapeuticos y diagnosticos capaces de modular la sensibilidad celular a citoquinas.
US6905842B1 (en) 1996-11-01 2005-06-14 The Walter And Eliza Hall Institute Of Medical Research Therapeutic and diagnostic agents
EP0877030A3 (fr) * 1997-05-07 2001-05-23 Smithkline Beecham Corporation Gène en réponse primaire à l'EPO 1 (EPRG1)
EP0970215A1 (fr) * 1997-11-03 2000-01-12 Incyte Pharmaceuticals, Inc. Suppresseur de la signalisation cytokinaire
EP0953636A3 (fr) 1998-03-23 2000-03-29 Smithkline Beecham Plc Régulateurs du signal de cytokines
US7078174B1 (en) 1998-12-21 2006-07-18 The Walter & Eliza Hall Institute Of Medical Research Screening methods using SOCS box-containing peptides
GB9918680D0 (en) * 1999-08-09 1999-10-13 Medical Res Council Polypeptide
JP2003520577A (ja) * 1999-10-21 2003-07-08 スミスクライン・ビーチャム・コーポレイション Ｅｐｏ一次応答遺伝子１、ｅｐｒｇ１
GB2373502A (en) * 2000-11-08 2002-09-25 Smithkline Beecham Corp Suppressor of cytokine signalling 4 (SOCS4)
WO2002055699A2 (fr) * 2000-12-14 2002-07-18 Upjohn Co Nouveau socs (suppresseur de la transmission des signaux par les cytokines)
US20060194275A1 (en) * 2001-04-13 2006-08-31 Incyte Corporation Transporter and ion channels
US7348139B1 (en) 2001-04-13 2008-03-25 The Johns Hopkins University School Of Medicine SOCS-1 gene methylation in cancer
EP1734982A4 (fr) 2004-03-04 2009-08-05 Univ Vanderbilt Polypeptides socs pour inhiber la signalisation induite par la cytokine

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998020023A1 (fr) * 1996-11-01 1998-05-14 The Walter And Eliza Hall Institute Of Medical Research Agents therapeutiques et diagnostiques capables de moduler la receptivite cellulaire aux cytokines

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998020023A1 (fr) * 1996-11-01 1998-05-14 The Walter And Eliza Hall Institute Of Medical Research Agents therapeutiques et diagnostiques capables de moduler la receptivite cellulaire aux cytokines

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
A. YOSHIMURA ET AL: "A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to Tyrosine-phosphorylated interleukin-3 and erythropoietin", EMBO JOURNAL., vol. 14, no. 12, 1995, EYNSHAM, OXFORD GB, pages 2816 - 2826, XP002088456 *
D.J. HILTON ET AL: "Twenty proteins containing a C-terminal SOCS box form five structural classes", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 95, January 1998 (1998-01-01), WASHINGTON US, pages 114 - 119, XP002085497 *
M. MASUHARA ET AL: "Cloning and characterization of novel CIS family genes", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS., vol. 239, October 1997 (1997-10-01), ORLANDO, FL US, pages 439 - 446, XP002088457 *
R. STARR ET AL: "A family of cytokine-inducible inhibitors of signalling", NATURE., vol. 387, no. 6636, 26 June 1997 (1997-06-26), LONDON GB, pages 917 - 921, XP002085491 *
T. NAKA ET AL: "Structure and function of a new STAT-induced STAT inhibitor", NATURE., vol. 387, no. 6636, 26 June 1997 (1997-06-26), LONDON GB, pages 924 - 929, XP002088455 *
T.A ENDO ET AL: "A new protein containing an SH2 domain that inhibits JAK kinases", NATURE., vol. 387, no. 6636, 26 June 1997 (1997-06-26), LONDON GB, pages 921 - 924, XP002085492 *

Also Published As

Publication number Publication date
WO1999003994A1 (fr) 1999-01-28
AU8484598A (en) 1999-02-10
AU8484698A (en) 1999-02-10
WO1999003993A2 (fr) 1999-01-28

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