WO1998056939A1 - Souche de streptomyces avermitilis, procede de separation de complexes d'avermectine et preparations destinees a la protection d'animaux et de vegetaux - Google Patents

Souche de streptomyces avermitilis, procede de separation de complexes d'avermectine et preparations destinees a la protection d'animaux et de vegetaux Download PDF

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Publication number
WO1998056939A1
WO1998056939A1 PCT/RU1997/000183 RU9700183W WO9856939A1 WO 1998056939 A1 WO1998056939 A1 WO 1998056939A1 RU 9700183 W RU9700183 W RU 9700183W WO 9856939 A1 WO9856939 A1 WO 9856939A1
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WO
WIPO (PCT)
Prior art keywords
avermectin
complexes
preparations
aversectin
separating
Prior art date
Application number
PCT/RU1997/000183
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English (en)
Russian (ru)
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WO1998056939A8 (fr
Inventor
Vladimir Alexandrovich Mosin
Elena Borisovna Kruglyak
Nadezhda Evgenievna Berezkina
Tamara Samuilovna Novik
Viktor Antonovich Drinyaev
Vasily Andreevich Jurkiv
Vasily Trofimovich Lisovenko
Galina Nikolaevna Tenkova
Original Assignee
Vladimir Alexandrovich Mosin
Elena Borisovna Kruglyak
Nadezhda Evgenievna Berezkina
Tamara Samuilovna Novik
Viktor Antonovich Drinyaev
Vasily Andreevich Jurkiv
Lisovenko Vladimir Trofimovich
Galina Nikolaevna Tenkova
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vladimir Alexandrovich Mosin, Elena Borisovna Kruglyak, Nadezhda Evgenievna Berezkina, Tamara Samuilovna Novik, Viktor Antonovich Drinyaev, Vasily Andreevich Jurkiv, Lisovenko Vladimir Trofimovich, Galina Nikolaevna Tenkova filed Critical Vladimir Alexandrovich Mosin
Priority to AU41397/97A priority Critical patent/AU4139797A/en
Priority to PCT/RU1997/000183 priority patent/WO1998056939A1/fr
Publication of WO1998056939A1 publication Critical patent/WO1998056939A1/fr
Publication of WO1998056939A8 publication Critical patent/WO1998056939A8/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/20—Bacteria; Substances produced thereby or obtained therefrom
    • A01N63/28—Streptomyces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/08—Oxygen as only ring hetero atoms containing a hetero ring of at least seven ring members, e.g. zearalenone, macrolide aglycons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Definitions

  • the invention is not subject to the manufacture of biologically active substances in the form of an invasive substance.
  • P ⁇ edshes ⁇ vuyuschy u ⁇ ven ⁇ e ⁇ ni ⁇ i Izves ⁇ n ⁇ , ch ⁇ a ⁇ in ⁇ mitse ⁇ Zge ⁇ tusez a ⁇ egt ⁇ Y ⁇ ⁇ i ⁇ u- l ⁇ ivi ⁇ vanii in ⁇ isu ⁇ s ⁇ vii is ⁇ chni ⁇ v ugle ⁇ da, ae ⁇ a and ⁇ s ⁇ a ⁇ i ⁇ s ⁇ yann ⁇ y ae ⁇ atsin ⁇ dutsi ⁇ ue ⁇ v ⁇ sem blie ⁇ ⁇ s ⁇ eni ⁇ vesches ⁇ v, naevanny ⁇ ave ⁇ me ⁇ nnamn, ⁇ ye ⁇ bladayu ⁇ ⁇ ee ⁇ vy ⁇ azhe- nym an ⁇ i ⁇ a ⁇ azi ⁇ a ⁇ nym deys ⁇ viem ⁇ a ⁇ en ⁇ ⁇ Z ⁇ 1573955, 1980.
  • All amethysts are chemically 16-membered and macrolides and are distinguished by alternates from 5 and 26 carbon atoms.
  • the most active gins are Avemectins ⁇ , especially ⁇ &.
  • PRODUCTIVITY STRAIN 51GER-HOSE OF AUGUSTUS LIIS-51 (Patent No. 2048250, 1995) is 700 mcg / ml. Strain 5-June-Augustus augustus with IIIS-54 has already been producing 1,500 mg / ml of amecretins (patent No. 2054483, 1996), with an average of 35%.
  • the goal is achieved by the receipt of strain 5 “Lérgé” with the help of August 3, 003, which is produced in the average 2300 mcg / ml of amectine and 2000 ml / ml.
  • the variability of the investigations was 50-140%; 49-130% ⁇ 78-143%, which corresponded to the production of 900-2500 mkg / ml; 950-2500 mcg / ml and 1650-3000 mcg / ml avermectin.
  • the maximum accumulation of apertures is 7-8 days at a rate of an increase in acid of 1.0-1.3 mol ug / l-min and a temperature of 28 ° ⁇ .
  • Dispensary range ° C 20 4- 28 + 37 + / - 50
  • a dry mass is used, which is obtained by increasing the accrue to a good condition.
  • Aeration of biomass ave- mexins is carried out by a mixture consisting of water and low- and high-leveling pollutants, which is mixed with non-impaired water.
  • ⁇ ⁇ aches ⁇ ve niz ⁇ - ⁇ i ⁇ yaschi ⁇ is ⁇ lzuyu ⁇ ⁇ as ⁇ v ⁇ i ⁇ eli with ⁇ em ⁇ e ⁇ a ⁇ u ⁇ y ⁇ i ⁇ eniya not ⁇ e- Witzlaus ⁇ em ⁇ e ⁇ a ⁇ u ⁇ u ⁇ i ⁇ eniya v ⁇ dy, na ⁇ ime ⁇ , e ⁇ il ⁇ vy, and me ⁇ il ⁇ vy iz ⁇ il ⁇ vy s ⁇ i ⁇ y or atse ⁇ n in ⁇ aches ⁇ ve vys ⁇ n ⁇ yaschi ⁇ - ⁇ lie ⁇ ilengli ⁇ l with m ⁇ le ⁇ ulya ⁇ n ⁇ y maes ⁇ y 200 (PEG-200), with ⁇ lie ⁇ ilengli ⁇ l m ⁇ le ⁇ ulya ⁇ n ⁇ y mass ⁇ y 400 (PEG-400) seed dime ⁇ ilsul ⁇ - (D ⁇ S0 "> n d ⁇ .
  • PARTICULAR FORMS on basic electro- tives also include auxiliary and physical substances.
  • 5 Injectable industrial veterinary medicine contains one of the Amec- tecine compounds (Averesecin C, Averasec- 7 tyne ⁇ , or Electrotecin ⁇ at a concentration of 0.9-1.1%) in the distributor, which supplies a complete mixture of ethanol, polyethylene glycol and water in the case (5-7):
  • Opportunistic applications include a combination of 0.1% to 0.3% of the hard drive, and use or reassign.
  • the preparation for the protection of plants against gallant nematodes also contains one of the complexes of amec- teins at a concentration of 0, 1-0, 3 in case of neglect or neglect. 5.
  • the storms of Z. Augustus :1: . ⁇ 1 ⁇ -003 ⁇ were cultivated on the Ostagany agar for 10 days 27–29 ° C.
  • the bulk of the agar was transported into the pumping flasks with a capacity of 750 ml, containing 75 ml of the medium of the following composition,%: glucose - 4.0; soybean flour - 0.6; protein and vitamin ratio - 0.8; gourmet extract - 0.4; CaS ⁇ z - 0.1; ⁇ 2 ⁇ 4 - 0.05; WATER WATER.
  • They glucose was sterilized separately at 0.6 and 30 minutes, and they were introduced into the flasks of the sowing before it was immediately. Other components sterilized at 1.0 and 40 minutes.
  • the ⁇ value for sterilization is 6.2–6.4.
  • Bulbs were installed on a download with a number of 220 units per minute and inoculated at 27-29 ° C for 36 hours. Then, in the amount of 5?, They were transferred to a flask with a fragment of the following medium,%: glucose - 7.0; soybean flour - 0.6; protein-vitamin concentrate - 0.8; gourmet extract - 0.4; CaS ⁇ z - 0.1; ⁇ - 0.05; WATER WATER. The ⁇ value before sterilization is 6.2–6.4. Glucose was sterilized separately at 0.6 and 30 minutes, and the remaining components at 1.0 and 40 minutes. Glitches were introduced into the flasks of an unintentionally injured person by sowing the medium.
  • the process was carried out for 192 hours at 28 ° C on a download with a total of 220 per minute.
  • the trays washed 500 ml of 96% ethanol. Received 7, 15 l of a purified and processed product (7.5 mg / ml, 99.4% yield), they drove the product and consume 55% of the water. The stock in the flask, heated to 65 ° C, was placed in a separate office for separation of the lipid fraction.
  • the preparation was administered in the following doses of 50, 70, 84, 90, 110, and 150 mg / kg body weight.
  • White infertile mice weighing 25-30 g of Averasecin C were administered in doses of 7, 10, 25, 40, 50 and 60 mg / kg. Each dose to the rounds and mice was tested on 6 hours.
  • To calculate the average lethal dose we used the method of bit analysis for Litchfield and Wilkson (see, for example, Belenky L., The elements are neglected).
  • the results of the determination of the simple toxicity of Avectin C for bats and mice are shown in Table 5.
  • the extract is highly concentrated as in Example 2. After the release of the waste water, the waste was transferred to a separate business. After quenching, two layers were obtained: the lower layer was PEG-200, containing 40 g of aversine C, and the upper one was a lipid fraction. The lower layers of the slower and peremeshivanin were poured into 1.37 liters of water. The sprayed plant was divided on a filter, washed and dried, and dried in a vacuum drying oven. Received 38.4 g of EVERYtin C from the following composition. in%: simplifyectin ⁇ ⁇ . - 11 ⁇ . - 38 ⁇ ⁇ tracks ⁇ ggi - 3.1
  • Example 5 200 ml of the Avessecin C solution in PEG-400, as shown in Example 2 (76 mg / ml Avessecin C), was added at a concentration of 400 ml. The mixture was stirred for another 1 hour and set aside for installation at a room temperature for 10 hours.
  • Broken-down Crystals 11 Wash through a glass and a clean filter before vacuum, the crystals on the filter wash 50 ml of chilled water up to 10 ° C and dry up to 60% of the weight.
  • males are 70 and 20 mg / kg, respectively.
  • Example 5 Example 5 was vaporized in a vacuum, as was the case in Example 2. The waste was transferred to a separation business. After the standstill, two layers were learned. The lower layer, the Averasectin solution réellerier redesign in PEG-400, was poured into 600 ml of water. The sprayed plant was divided into a filter and dried. Received 12, 6 g of the preparation - ⁇ vereectin ⁇ .
  • Averesin C A decrease in the content of Averesin C below 0.9 leads to a decrease in the effective coefficient of activity of the drugs.
  • An increase in the content of averesectin C is higher than 1.1%, without changing the efficiency of the com- pact, it increases its strength and prolongs the elimination from the organism.
  • auxiliary substances ensures the optimal viscosity of the composites, the growth of the property of C, and the property of the property is independent of the property.
  • auxiliary substances instead of Malawitoctin C, you can also enter Avectoctin réelle convinced or Avectoctin crizillus at the same rate as the concentrate.
  • Each of the transceiver is effective when it comes to ecto- and endoparaeitis.
  • you receive a medicine you receive a medicinal form of community.
  • the Avessecin ⁇ is more preferable to doing so, since there is a death in the case of an invasion (on the 5th day), there is a sinking of the
  • ⁇ id zhiv ⁇ ny ⁇ name D ⁇ ea ⁇ a ⁇ n ⁇ s ⁇ ⁇ emya zab ⁇ levaniya ml / 50 ⁇ g administration ⁇ b ⁇ ab ⁇ i ⁇ vsh es ⁇ e 1.0 ⁇ dn ⁇ a ⁇ n ⁇ ⁇ yab ⁇ -n ⁇ yab ⁇ mel ⁇ ag ⁇ e 1.0 ⁇ dn ⁇ a ⁇ n ⁇ ⁇ ⁇ aeaniyam di ⁇ i ⁇ aulee, ⁇ s ⁇ n- 1.0 ⁇ dn ⁇ a ⁇ n ⁇ ⁇ e ⁇ ed ⁇ s ⁇ an ⁇ v- gilee, ⁇ lle ⁇ i ⁇ z, bus ⁇ m ⁇ z, ⁇ y on s ⁇ yl ⁇ v ⁇ e ⁇ i ⁇ s ⁇ ngildy , ⁇ abe ⁇ i ⁇ e s ⁇ de ⁇ zhanie and weight ee ⁇ ag ⁇ s ⁇ m ⁇ s, s ⁇ ngil ⁇ - n ⁇ y ⁇ e ⁇ ed vy
  • Ruminants ( ⁇ u ⁇ ny ⁇ ga ⁇ y s ⁇ , ⁇ vtsy, ⁇ zy, ve ⁇ b- Luda, zub ⁇ y) Di ⁇ i ⁇ aulez, gem ⁇ n ⁇ z, ⁇ s ⁇ e ⁇ agi ⁇ z, nema ⁇ di- Pe ⁇ ed ⁇ s ⁇ an ⁇ v ⁇ y on ⁇ z, ma ⁇ shallagi ⁇ z, ⁇ - s ⁇ yl ⁇ v ⁇ e s ⁇ de ⁇ zhanie ⁇ e ⁇ i ⁇ z, ⁇ abe ⁇ i ⁇ z, ee ⁇ - ⁇ senyu and vesn ⁇ ⁇ e- ⁇ ag ⁇ s ⁇ m ⁇ z, bun ⁇ s ⁇ - It is advantageous for the spare part. 100 biscuits
  • the drug containing 0.2% of the substance used, is used for the treatment and treatment of maternal, aromatic, and rheumatoid diseases.
  • the product is used for all kinds of livestock and poultry mixed with dry or moistened food in the morning for two or seven days before eating, 9 days a week.
  • the general dose of food with the appliance should not increase the amount of the required quantity of food to the patient.
  • the efficiency of the product is at least 35%.
  • the product is based on the main part ⁇ and the recession and the whole will be more preferable and not on the contrary, and on the basis the main part ⁇ - due to the outcome.
  • the product that contains Avessetin C will be more preferable and generally more convenient for horsemans.
  • the human health center on the basis of the recession and the whole independence of the Aversecine group, will be effective in dealing with galley munitions. The differences between them will be in the realm of sustainable activities.
  • the period of the protective action (during the processing of the preparation for the first galls) is at least 4 months.

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  • Pest Control & Pesticides (AREA)
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Abstract

Cette invention concerne la production de préparations antiparasites à base d'avermectines, ainsi qu'une nouvelle souche Streptomyces avermitilis 003FBM produite dans une concentration allant de 2000 à 3000 νg/ml. Cette invention concerne également un procédé permettant de séparer un complexe d'avermectines à partir de la biomasse d'une souche. Ce procédé consiste à effectuer une extraction de cette biomasse à l'aide d'un mélange qui comprend des solvants organiques ayant des températures d'ébullition élevées et basses, et auquel on a ajouté de l'eau. L'extrait est ensuite purifié dans des résines à échange ionique avant d'éliminer la fraction lipide, le produit final étant séparé par cristallisation et/ou précipitation. On utilise du méthanol, de l'éthanol, de l'isopropanol, de l'acétone ou de l'acétonitrile en qualité de solvants ayant une température d'ébullition basse, tandis que l'on utilise du polyéthylèneglycol, du diméthylsulfoxyde ou du polypropylèneglycol en qualité de solvants ayant une température d'ébullition élevée. Ce procédé permet d'obtenir divers complexes tels que de l'aversectine C, de l'aversectine B ou de l'aversectine AB. Ces complexes permettent d'obtenir des préparations vétérinaires antiparasites qui sont administrées par injection ou par voie perorale, et qui assurent également la protection des végétaux contre les nématodes gallicoles.
PCT/RU1997/000183 1997-06-09 1997-06-09 Souche de streptomyces avermitilis, procede de separation de complexes d'avermectine et preparations destinees a la protection d'animaux et de vegetaux WO1998056939A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU41397/97A AU4139797A (en) 1997-06-09 1997-06-09 (streptomyces avermitilis) strain, method for separating avermectin complexe s and preparations for protecting plants and animals
PCT/RU1997/000183 WO1998056939A1 (fr) 1997-06-09 1997-06-09 Souche de streptomyces avermitilis, procede de separation de complexes d'avermectine et preparations destinees a la protection d'animaux et de vegetaux

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Application Number Priority Date Filing Date Title
PCT/RU1997/000183 WO1998056939A1 (fr) 1997-06-09 1997-06-09 Souche de streptomyces avermitilis, procede de separation de complexes d'avermectine et preparations destinees a la protection d'animaux et de vegetaux

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WO1998056939A1 true WO1998056939A1 (fr) 1998-12-17
WO1998056939A8 WO1998056939A8 (fr) 1999-05-27

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2886640A1 (fr) 2013-12-18 2015-06-24 Riga Technical University Procédé d'isolation pour milbemycine A3 et A4
WO2019164878A1 (fr) * 2018-02-20 2019-08-29 Locus Agriculture Ip Company, Llc Matériaux et procédés d'attraction et de régulation de nématodes pathogènes des plantes
US11963528B2 (en) 2018-02-26 2024-04-23 Locus Solutions Ipco, Llc Materials and methods for control of insect pests using entomopathogenic fungi

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4199569A (en) * 1977-10-03 1980-04-22 Merck & Co., Inc. Selective hydrogenation products of C-076 compounds and derivatives thereof
US4378353A (en) * 1981-02-17 1983-03-29 Merck & Co., Inc. Novel C-076 compounds
SU1011055A3 (ru) * 1979-08-23 1983-04-07 Санкио Компани Лимитед (Фирма) Способ получени вещества,обладающего противоклещевой и глистогонной активностью
SU1560059A3 (ru) * 1985-07-27 1990-04-23 Пфайзер Корпорейшн (Фирма) Способ получени производного авермектина
WO1993019194A1 (fr) * 1992-03-25 1993-09-30 Pfizer Inc. Procedes de production et de culture d'avermectines
WO1995003419A1 (fr) * 1993-07-23 1995-02-02 Pfizer Inc. Methode permettant de precipiter les avermectines naturelles
RU95102462A (ru) * 1995-02-28 1997-03-27 Товарищество с ограниченной ответственностью Научно-производственное объединение "Фармбиомед" Способ получения авермектинового комплекса для создания препаратов для профилактики и комплексного лечения заболеваний, вызванных эндо- и эктопаразитами животных, и препараты на его основе
RU2087535C1 (ru) * 1995-06-09 1997-08-20 Товарищество с ограниченной ответственностью Научно-производственное объединение "Бифидум" Штамм актиномицета streptomyces avermitilis - продуцент авермектинов

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4199569A (en) * 1977-10-03 1980-04-22 Merck & Co., Inc. Selective hydrogenation products of C-076 compounds and derivatives thereof
SU1011055A3 (ru) * 1979-08-23 1983-04-07 Санкио Компани Лимитед (Фирма) Способ получени вещества,обладающего противоклещевой и глистогонной активностью
US4378353A (en) * 1981-02-17 1983-03-29 Merck & Co., Inc. Novel C-076 compounds
SU1560059A3 (ru) * 1985-07-27 1990-04-23 Пфайзер Корпорейшн (Фирма) Способ получени производного авермектина
WO1993019194A1 (fr) * 1992-03-25 1993-09-30 Pfizer Inc. Procedes de production et de culture d'avermectines
WO1995003419A1 (fr) * 1993-07-23 1995-02-02 Pfizer Inc. Methode permettant de precipiter les avermectines naturelles
RU95102462A (ru) * 1995-02-28 1997-03-27 Товарищество с ограниченной ответственностью Научно-производственное объединение "Фармбиомед" Способ получения авермектинового комплекса для создания препаратов для профилактики и комплексного лечения заболеваний, вызванных эндо- и эктопаразитами животных, и препараты на его основе
RU2087535C1 (ru) * 1995-06-09 1997-08-20 Товарищество с ограниченной ответственностью Научно-производственное объединение "Бифидум" Штамм актиномицета streptomyces avermitilis - продуцент авермектинов

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2886640A1 (fr) 2013-12-18 2015-06-24 Riga Technical University Procédé d'isolation pour milbemycine A3 et A4
WO2019164878A1 (fr) * 2018-02-20 2019-08-29 Locus Agriculture Ip Company, Llc Matériaux et procédés d'attraction et de régulation de nématodes pathogènes des plantes
US11963528B2 (en) 2018-02-26 2024-04-23 Locus Solutions Ipco, Llc Materials and methods for control of insect pests using entomopathogenic fungi

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