WO1998055626A3 - Recombinant porcine reproductive and respiratory syndrome virus (prrsv) for use as a vaccine - Google Patents

Recombinant porcine reproductive and respiratory syndrome virus (prrsv) for use as a vaccine Download PDF

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Publication number
WO1998055626A3
WO1998055626A3 PCT/US1998/012141 US9812141W WO9855626A3 WO 1998055626 A3 WO1998055626 A3 WO 1998055626A3 US 9812141 W US9812141 W US 9812141W WO 9855626 A3 WO9855626 A3 WO 9855626A3
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WO
WIPO (PCT)
Prior art keywords
prrsv
vaccine
respiratory syndrome
porcine reproductive
virus
Prior art date
Application number
PCT/US1998/012141
Other languages
French (fr)
Other versions
WO1998055626A2 (en
Inventor
Stephen J Spatz
Paul M Coussens
John David Reilly
Original Assignee
Origen Inc
Stephen J Spatz
Paul M Coussens
John David Reilly
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Origen Inc, Stephen J Spatz, Paul M Coussens, John David Reilly filed Critical Origen Inc
Priority to AU79605/98A priority Critical patent/AU7960598A/en
Publication of WO1998055626A2 publication Critical patent/WO1998055626A2/en
Publication of WO1998055626A3 publication Critical patent/WO1998055626A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to a recombinant Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) vaccine comprising PRRSV structural genes linked to a heterologous polymerase gene and the method for constructing the recombinant virus. Specifically, the recombinant virus comprises the genes encoding open reading frames 1a and 1b from Equine Arteritis Virus (EAV) and the genes encoding open reading frames 2 through 7 from PRRSV. The invention is useful for producing PRRSV vaccines that are resistant to mutaions that currently occur during propagation of PRRSV for vaccines. Furthermore, the invention provides a means for distinguishing swine vaccinated with the aforementioned invention from swine naturally infected with PRRSV.
PCT/US1998/012141 1997-06-05 1998-06-05 Recombinant porcine reproductive and respiratory syndrome virus (prrsv) for use as a vaccine WO1998055626A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU79605/98A AU7960598A (en) 1997-06-05 1998-06-05 Recombinant porcine reproductive and respiratory syndrome virus (prrsv) for use as a vaccine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4866297P 1997-06-05 1997-06-05
US60/048,662 1997-06-05

Publications (2)

Publication Number Publication Date
WO1998055626A2 WO1998055626A2 (en) 1998-12-10
WO1998055626A3 true WO1998055626A3 (en) 1999-03-04

Family

ID=21955759

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/012141 WO1998055626A2 (en) 1997-06-05 1998-06-05 Recombinant porcine reproductive and respiratory syndrome virus (prrsv) for use as a vaccine

Country Status (2)

Country Link
AU (1) AU7960598A (en)
WO (1) WO1998055626A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106399313A (en) * 2016-09-29 2017-02-15 西北农林科技大学 Anti-PRRSV (porcine reproductive and respiratory syndrome virus) microRNA (ribonucleic acid)-like virus small RNA sequence and application and detection method thereof

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0839912A1 (en) 1996-10-30 1998-05-06 Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
CA2290220C (en) 1998-12-22 2013-11-19 Pfizer Products Inc. An infectious cdna clone of north american porcine reproductive and respiratory syndrome (prrs) virus and uses thereof
US7132106B2 (en) * 1998-12-22 2006-11-07 Pfizer Inc. Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof
US7691389B2 (en) 1998-12-22 2010-04-06 Pfizer Inc Infectious cDNA clone of north american porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof
US7618797B2 (en) 1998-12-22 2009-11-17 Pfizer Inc Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof
CA2366072C (en) * 1999-03-08 2007-07-10 Id-Lelystad, Instituut Voor Dierhouderij En Diergezondheid B.V. Prrsv vaccines
JP4778620B2 (en) 1999-04-22 2011-09-21 ユナイテッド ステイツ デパートメント オブ アグリカルチャー Pig breeding / breathing disorder syndrome vaccine based on isolate JA-142
EP1156111A1 (en) * 2000-05-19 2001-11-21 Stichting Dienst Landbouwkundig Onderzoek Chimeric arterivirus-like particles
KR20030082960A (en) * 2001-03-09 2003-10-23 베링거잉겔하임베트메디카게엠베하 Life attenuated strains of PRRS virus
RU2007101725A (en) 2004-06-18 2008-07-27 Риджентс Оф Дзе Юниверсити Оф Миннесота (Us) IDENTIFICATION OF VIRUS-INFECTED AND VIRUS-VACCINATED ORGANISMS
US7632636B2 (en) 2004-09-21 2009-12-15 Boehringer Ingelheim Vetmedica, Inc. Porcine reproductive and respiratory syndrome isolates and methods of use
DK2369001T3 (en) 2005-06-24 2016-10-24 Univ Minnesota PRRS viruses, infectious clones, mutants thereof and methods of use
WO2008089094A2 (en) 2007-01-12 2008-07-24 The Board Of Trustees Of The University Of Illinois Non-simian cells for growth of porcine reproductive and respiratory syndrome (prrs) virus
AR078253A1 (en) 2009-09-02 2011-10-26 Boehringer Ingelheim Vetmed METHODS TO REDUCE ANTIVIRICAL ACTIVITY IN PCV-2 COMPOSITIONS AND PCV-2 COMPOSITIONS WITH BETTER IMMUNOGENICITY
UA108902C2 (en) 2010-11-10 2015-06-25 NORTH AMERICAN REPRODUCTIVE AND RESPIRATORY PIG SYNDROME (PRRS) VIRUS
CA2827337C (en) 2011-02-17 2019-07-09 Boehringer Ingelheim Vetmedica Gmbh Commercial scale process for production of prrsv
BR112013021076B1 (en) 2011-02-17 2022-11-29 Boehringer Ingelheim Vetmedica Gmbh SWINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS (PRRSV) OF A EUROPEAN TYPE, ITS USE, VACCINE, METHOD FOR THE PREPARATION OF THESE
US9187731B2 (en) 2011-07-29 2015-11-17 Boehringer Ingelheim Vetmedica Gmbh PRRS virus inducing type I interferon in susceptible cells
WO2013017568A1 (en) 2011-07-29 2013-02-07 Boehringer Ingelheim Vetmedica Gmbh INFECTIOUS cDNA CLONE OF EUROPEAN PRRS VIRUS AND USES THEREOF
CA2872789C (en) 2012-05-17 2019-09-03 Zoetis Llc Effective vaccination against porcine reproductive and respiratory syndrome (prrs) virus prior to weaning
US9579373B2 (en) 2013-03-15 2017-02-28 Boehringer Ingelheim Vetmedica, Inc. Porcine reproductive and respiratory syndrome virus, compositions, vaccine and methods of use
RU2683544C1 (en) * 2013-12-12 2019-03-28 Интервет Интернэшнл Б.В. Immortalized macrophage
KR102602018B1 (en) 2016-12-14 2023-11-15 조에티스 서비시즈 엘엘씨 Effective vaccination against european strains of porcine reproductive and respiratory syndrome (prrs) virus prior to weaning

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996004010A1 (en) * 1994-08-05 1996-02-15 Regents Of The University Of Minnesota Vr-2332 viral nucleotide sequence and methods of use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996004010A1 (en) * 1994-08-05 1996-02-15 Regents Of The University Of Minnesota Vr-2332 viral nucleotide sequence and methods of use

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BOON DEN J. A. ET AL.: "EQUINE ARTERITIS VIRUS IS NOT A TOGAVIRUS BUT BELONGS TO THE CORONAVIRUSLIKE SUPERFAMILY", JOURNAL OF VIROLOGY, vol. 65, no. 6, 1 June 1991 (1991-06-01), pages 2910 - 2920, XP000607121 *
BOYER J.-C. ET AL.: "INFECTIOUS TRANSCRIPTS AND CDNA CLONES OF RNA VIRUSES", VIROLOGY, vol. 198, no. 2, 1 February 1994 (1994-02-01), pages 415 - 426, XP002040731 *
CONZELMANN K.-K. ET AL.: "Molecular characterization of Porcine Reproductive and Respiratory Syndrome Virus, a member of the Arterivirus group.", VIROLOGY, vol. 193, 1993, pages 329 - 339, XP002084424 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106399313A (en) * 2016-09-29 2017-02-15 西北农林科技大学 Anti-PRRSV (porcine reproductive and respiratory syndrome virus) microRNA (ribonucleic acid)-like virus small RNA sequence and application and detection method thereof
CN106399313B (en) * 2016-09-29 2019-10-18 西北农林科技大学 A kind of microRNA sample virus tiny RNA sequence of anti-PRRSV and application thereof and detection method

Also Published As

Publication number Publication date
WO1998055626A2 (en) 1998-12-10
AU7960598A (en) 1998-12-21

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