WO1998049317A3 - Diagnostic et traitement de troubles lies a la phosphatase ou a la kinase - Google Patents

Diagnostic et traitement de troubles lies a la phosphatase ou a la kinase Download PDF

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Publication number
WO1998049317A3
WO1998049317A3 PCT/US1998/008439 US9808439W WO9849317A3 WO 1998049317 A3 WO1998049317 A3 WO 1998049317A3 US 9808439 W US9808439 W US 9808439W WO 9849317 A3 WO9849317 A3 WO 9849317A3
Authority
WO
WIPO (PCT)
Prior art keywords
phosphatase
kinase
diagnosis
treatment
polypeptides
Prior art date
Application number
PCT/US1998/008439
Other languages
English (en)
Other versions
WO1998049317A2 (fr
Inventor
Greg D Plowman
Douglas Clary
Bahija Jallal
Elior Peles
Susan Onrust
Dave Markby
Sara A Courtneidge
Harald App
Terance H Hui
Original Assignee
Sugen Inc
Greg D Plowman
Douglas Clary
Bahija Jallal
Elior Peles
Susan Onrust
Dave Markby
Sara A Courtneidge
Harald App
Terance H Hui
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sugen Inc, Greg D Plowman, Douglas Clary, Bahija Jallal, Elior Peles, Susan Onrust, Dave Markby, Sara A Courtneidge, Harald App, Terance H Hui filed Critical Sugen Inc
Priority to CA002288221A priority Critical patent/CA2288221A1/fr
Priority to EP98919919A priority patent/EP0979288A2/fr
Priority to JP54724498A priority patent/JP2002513289A/ja
Priority to AU72600/98A priority patent/AU7260098A/en
Publication of WO1998049317A2 publication Critical patent/WO1998049317A2/fr
Publication of WO1998049317A3 publication Critical patent/WO1998049317A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La présente invention concerne des phosphatases et des kinases, des acides nucléiques codant de tels polypeptides, des cellules, des tissus et des animaux contenant de tels acides nucléiques, des anticorps dirigés contre de tels polypeptides, des essais utilisant de tels polypeptides et des procédés se rapportant à ce qui a été énoncé précédemment. L'invention concerne également des procédés permettant de traiter, de diagnostiquer et de rechercher les affections ou états concernés par les phosphatases et les kinases et caractérisés par une interaction anormale entre une phosphatase ou une kinase et son partenaire de liaison.
PCT/US1998/008439 1997-04-28 1998-04-27 Diagnostic et traitement de troubles lies a la phosphatase ou a la kinase WO1998049317A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002288221A CA2288221A1 (fr) 1997-04-28 1998-04-27 Diagnostic et traitement de troubles lies a la phosphatase ou a la kinase
EP98919919A EP0979288A2 (fr) 1997-04-28 1998-04-27 Diagnostic et traitement de troubles lies a la phosphatase ou a la kinase
JP54724498A JP2002513289A (ja) 1997-04-28 1998-04-27 チロシンホスファターゼ関連疾患の診断および治療および関連する方法
AU72600/98A AU7260098A (en) 1997-04-28 1998-04-27 Diagnosis and treatment of phosphatase 0r kinase-related disorders

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US4442897P 1997-04-28 1997-04-28
US60/044,428 1997-04-28
US4722297P 1997-05-20 1997-05-20
US60/047,222 1997-05-20
US4947797P 1997-06-11 1997-06-11
US4975697P 1997-06-11 1997-06-11
US60/049,477 1997-06-11
US60/049,756 1997-06-11
US4991497P 1997-06-18 1997-06-18
US60/049,914 1997-06-18
US6359597P 1997-10-23 1997-10-23
US60/063,595 1997-10-23

Publications (2)

Publication Number Publication Date
WO1998049317A2 WO1998049317A2 (fr) 1998-11-05
WO1998049317A3 true WO1998049317A3 (fr) 1999-02-25

Family

ID=27556472

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/008439 WO1998049317A2 (fr) 1997-04-28 1998-04-27 Diagnostic et traitement de troubles lies a la phosphatase ou a la kinase

Country Status (5)

Country Link
EP (1) EP0979288A2 (fr)
JP (1) JP2002513289A (fr)
AU (1) AU7260098A (fr)
CA (1) CA2288221A1 (fr)
WO (1) WO1998049317A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2220853A1 (fr) * 1998-01-16 1999-07-16 Hsc Research And Development Limited Partnership Tyrosine phosphatase pour tissus lymphoides humains
AU3679400A (en) * 1999-04-16 2000-11-02 Kyowa Hakko Kogyo Co. Ltd. Novel tyrosine phosphatase
EP1046715A1 (fr) * 1999-04-23 2000-10-25 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Interaction de la protéine vasculaire endothelial tyrosine phosphatase et le récepteur Tie-2 d'angiopoietine
EP1254264A1 (fr) * 2000-01-18 2002-11-06 Human Genome Sciences, Inc. Polynucleotides et polypeptides de la protein thyrosine phosphatase humaine, et anticorps
WO2002042435A2 (fr) * 2000-11-27 2002-05-30 Bayer Aktiengesellschaft Regulation de la tyrosine phosphatase humaine
DE60305634T2 (de) * 2003-03-07 2006-09-21 Istituto Nazionale Per Lo Studio E La Cura Dei Tumori Anaplastisches Lymphoma Kinase Testverfahren, Reagenzien und Kompositionen davon
US7456149B2 (en) 2004-03-02 2008-11-25 Acceleron Pharma, Inc. ALK7 and myostatin inhibitors and uses thereof
WO2007037532A1 (fr) * 2005-09-30 2007-04-05 Link Genomics, Inc. Application therapeutique ou diagnostique du gene srms

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993010242A1 (fr) * 1991-11-18 1993-05-27 Cold Spring Harbor Laboratory NOUVEAUX GENES HUMAINS cdc25, PRODUITS CODES ET UTILISATIONS
WO1995006735A2 (fr) * 1993-09-01 1995-03-09 The Ludwig Institute For Cancer Research Sequences nucleotidiques servant a coder de nouvelles tyrosine-phosphatases proteiques
WO1996034985A1 (fr) * 1995-05-05 1996-11-07 Sugen, Inc. Technique et procede de visualisation de transcrit

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993010242A1 (fr) * 1991-11-18 1993-05-27 Cold Spring Harbor Laboratory NOUVEAUX GENES HUMAINS cdc25, PRODUITS CODES ET UTILISATIONS
WO1995006735A2 (fr) * 1993-09-01 1995-03-09 The Ludwig Institute For Cancer Research Sequences nucleotidiques servant a coder de nouvelles tyrosine-phosphatases proteiques
WO1996034985A1 (fr) * 1995-05-05 1996-11-07 Sugen, Inc. Technique et procede de visualisation de transcrit

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
AOKI N. ET AL.: "THE NOVEL PROTEIN-TYROSINE PHOSPHATASE PTP20 IS A POSITIVE REGULATOR OF PC12 CELL NEURONAL DIFFERENTIATION", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 46, 15 November 1996 (1996-11-15), pages 29422 - 29426, XP002053901 *
EMBL database entry HS1185621; accessionnumber AA281242; 4. April 1997; Robert Strausberg: 'National Cancer Institute, Cancer Genome Anatomy Project.' *
MAEKAWA K. ET AL.: "MOLECULAR CLONING OF A NOVEL PROTEIN-TYROSINE PHOSPHATASE CONTAINING A MEMBRANE-BINDING DOMAIN AND glgf REPEATS.", FEBS LETTERS, vol. 337, 1994, pages 200 - 206, XP002076842 *
MATTHEWS R. J. ET AL.: "Characterization of hematopoietic intracellular protein tyrosine phosphatases: Description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences.", MOLECULAR AND CELLULAR BIOLOGY, vol. 12, no. 5, 1992, pages 2396 - 2405, XP002076841 *
SARAS J. ET AL.: "CLONING AND CHARACTERIZATION OF PTPL1, A PROTEIN TYROSINE PHOSPHATASE WITH SIMILARITIES TO CYTOSKELETAL-ASSOCIATED PROTEINS.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 269, no. 39, 1994, pages 24082 - 24089, XP002076840 *

Also Published As

Publication number Publication date
AU7260098A (en) 1998-11-24
EP0979288A2 (fr) 2000-02-16
CA2288221A1 (fr) 1998-11-05
JP2002513289A (ja) 2002-05-08
WO1998049317A2 (fr) 1998-11-05

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