WO1998039358B1 - Lipides cationiques oligomeres - Google Patents

Lipides cationiques oligomeres

Info

Publication number
WO1998039358B1
WO1998039358B1 PCT/US1998/004344 US9804344W WO9839358B1 WO 1998039358 B1 WO1998039358 B1 WO 1998039358B1 US 9804344 W US9804344 W US 9804344W WO 9839358 B1 WO9839358 B1 WO 9839358B1
Authority
WO
WIPO (PCT)
Prior art keywords
cationic lipids
oligomeric cationic
oligomeric
present
compositions
Prior art date
Application number
PCT/US1998/004344
Other languages
English (en)
Other versions
WO1998039358A9 (fr
WO1998039358A1 (fr
Filing date
Publication date
Priority claimed from US08/812,775 external-priority patent/US5877220A/en
Application filed filed Critical
Priority to AU66879/98A priority Critical patent/AU6687998A/en
Publication of WO1998039358A1 publication Critical patent/WO1998039358A1/fr
Publication of WO1998039358B1 publication Critical patent/WO1998039358B1/fr
Publication of WO1998039358A9 publication Critical patent/WO1998039358A9/fr

Links

Abstract

La présente invention concerne de nouveaux lipides cationiques oligomères. La présente invention concerne également des compositions de ces nouveaux lipides cationiques avec des macromolécules anioniques, des méthodes d'interférence avec une expression de protéines dans une cellule faisant appel à ces compositions, ainsi qu'une trousse destinée à leur préparation.
PCT/US1998/004344 1997-03-06 1998-03-05 Lipides cationiques oligomeres WO1998039358A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU66879/98A AU6687998A (en) 1997-03-06 1998-03-05 Oligomeric cationic lipids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/812,775 US5877220A (en) 1997-03-06 1997-03-06 Amide-based oligomeric cationic lipids
US08/812,775 1997-03-06

Publications (3)

Publication Number Publication Date
WO1998039358A1 WO1998039358A1 (fr) 1998-09-11
WO1998039358B1 true WO1998039358B1 (fr) 1998-11-26
WO1998039358A9 WO1998039358A9 (fr) 1999-02-25

Family

ID=25210592

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/004344 WO1998039358A1 (fr) 1997-03-06 1998-03-05 Lipides cationiques oligomeres

Country Status (3)

Country Link
US (1) US5877220A (fr)
AU (1) AU6687998A (fr)
WO (1) WO1998039358A1 (fr)

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AU2001247697B2 (en) * 2000-03-22 2006-06-22 Solulink, Incorporated Hydrazine-based and carbonyl-based bifunctional crosslinking reagents
US7102024B1 (en) 2000-08-01 2006-09-05 Schwartz David A Functional biopolymer modification reagents and uses thereof
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US7803397B2 (en) 2003-09-15 2010-09-28 Protiva Biotherapeutics, Inc. Polyethyleneglycol-modified lipid compounds and uses thereof
US7158353B2 (en) * 2003-11-06 2007-01-02 Seagate Technology Llc Magnetoresistive sensor having specular sidewall layers
MY144231A (en) * 2003-12-17 2011-08-15 Wyeth Corp Aß IMMUNOGENIC PEPTIDE CARRIER CONJUGATES AND METHODS OF PRODUCING SAME
SG182163A1 (en) * 2003-12-17 2012-07-30 Wyeth Corp Immunogenic peptide carrier conjugates and methods of producing same
AU2005252273B2 (en) * 2004-06-07 2011-04-28 Arbutus Biopharma Corporation Lipid encapsulated interfering RNA
EP2199298A1 (fr) * 2004-11-17 2010-06-23 Protiva Biotherapeutics Inc. Petits ARN interférents éteignant l'apolipoprotéine B
US8101741B2 (en) 2005-11-02 2012-01-24 Protiva Biotherapeutics, Inc. Modified siRNA molecules and uses thereof
ES2535419T3 (es) * 2007-12-27 2015-05-11 Protiva Biotherapeutics Inc. Silenciamiento de expresión de quinasa tipo polo usando ARN interferente
WO2009086558A1 (fr) * 2008-01-02 2009-07-09 Tekmira Pharmaceuticals Corporation Compositions et procédés améliorés pour la délivrance d'acides nucléiques
HUE034483T2 (en) 2008-04-15 2018-02-28 Protiva Biotherapeutics Inc New lipid preparations for introducing a nucleic acid
EP2350043B9 (fr) 2008-10-09 2014-08-20 TEKMIRA Pharmaceuticals Corporation Lipides aminés améliorés et procédés d'administration d'acides nucléiques
US9023820B2 (en) 2009-01-26 2015-05-05 Protiva Biotherapeutics, Inc. Compositions and methods for silencing apolipoprotein C-III expression
US9018187B2 (en) 2009-07-01 2015-04-28 Protiva Biotherapeutics, Inc. Cationic lipids and methods for the delivery of therapeutic agents
WO2011000107A1 (fr) 2009-07-01 2011-01-06 Protiva Biotherapeutics, Inc. Formulations lipidiques inédites permettant l'administration d'agents thérapeutiques en direction de tumeurs solides
US8569256B2 (en) 2009-07-01 2013-10-29 Protiva Biotherapeutics, Inc. Cationic lipids and methods for the delivery of therapeutic agents
WO2011011447A1 (fr) 2009-07-20 2011-01-27 Protiva Biotherapeutics, Inc. Compositions et méthodes pour rendre silencieuse l’expression du gène du virus ebola
WO2011084721A2 (fr) * 2009-12-21 2011-07-14 Agave Pharma Inc Molécule cationique et procédé d'utilisation
US8455455B1 (en) 2010-03-31 2013-06-04 Protiva Biotherapeutics, Inc. Compositions and methods for silencing genes involved in hemorrhagic fever
WO2012000104A1 (fr) 2010-06-30 2012-01-05 Protiva Biotherapeutics, Inc. Systèmes non liposomaux pour une administration d'acide nucléique
US8466122B2 (en) 2010-09-17 2013-06-18 Protiva Biotherapeutics, Inc. Trialkyl cationic lipids and methods of use thereof
US9035039B2 (en) 2011-12-22 2015-05-19 Protiva Biotherapeutics, Inc. Compositions and methods for silencing SMAD4
US11013905B2 (en) 2017-05-11 2021-05-25 Tci Llc Thermal interconnect for implantable blood pump
EP4251170A1 (fr) 2020-11-25 2023-10-04 Akagera Medicines, Inc. Nanoparticules lipidiques utilisées pour l'administration d'acides nucléiques, et méthodes d'utilisation associées
WO2023230587A2 (fr) 2022-05-25 2023-11-30 Akagera Medicines, Inc. Nanoparticules lipidiques pour l'administration d'acides nucléiques et leurs procédés d'utilisation

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