WO1998037092A3 - Utilisation d'une nouvelle proteine metalloprotease disintegrine, mutants, fragments et analogues de ladite proteine - Google Patents

Utilisation d'une nouvelle proteine metalloprotease disintegrine, mutants, fragments et analogues de ladite proteine Download PDF

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Publication number
WO1998037092A3
WO1998037092A3 PCT/US1998/003490 US9803490W WO9837092A3 WO 1998037092 A3 WO1998037092 A3 WO 1998037092A3 US 9803490 W US9803490 W US 9803490W WO 9837092 A3 WO9837092 A3 WO 9837092A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein
provides
metalloprotease
disintegrin
binding
Prior art date
Application number
PCT/US1998/003490
Other languages
English (en)
Other versions
WO1998037092A2 (fr
Inventor
Michael Howard Tindal
Tariq Mehmood Haqqi
Original Assignee
Procter & Gamble
Univ Case Western Reserve
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1997/003217 external-priority patent/WO1997031931A1/fr
Application filed by Procter & Gamble, Univ Case Western Reserve filed Critical Procter & Gamble
Priority to HU0100780A priority Critical patent/HUP0100780A2/hu
Priority to BR9807766-0A priority patent/BR9807766A/pt
Priority to AU61817/98A priority patent/AU6181798A/en
Priority to JP53694698A priority patent/JP2001514494A/ja
Priority to EP98906648A priority patent/EP0977775A2/fr
Priority to CA002281085A priority patent/CA2281085A1/fr
Publication of WO1998037092A2 publication Critical patent/WO1998037092A2/fr
Publication of WO1998037092A3 publication Critical patent/WO1998037092A3/fr
Priority to NO994056A priority patent/NO994056L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La présente invention concerne un procédé permettant d'identifier des composés susceptibles de se fixer à la protéine disintégrine, et de déterminer la quantité et l'affinité d'un composé susceptible de se fixer à la protéine disintégrine dans un échantillon. L'invention concerne également une cellule hôte contenant un vecteur d'expression recombinant à la protéine disintégrine et un vecteur d'expression recombinant codant la protéine disintégrine, la protéine humaine métalloprotéase disintégrine, son mutant et son fragment. Ladite cellule est utilisée pour répondre aux objectifs de la présente invention. L'invention concerne enfin un procédé in vivo ou in vitro, qui permet de dépister l'ostéo-arthrite dégénérative et d'autres maladies provoquées par la métalloprotéase, et est susceptible d'être fabriqué et utilisé sous la forme d'un kit.
PCT/US1998/003490 1997-02-25 1998-02-25 Utilisation d'une nouvelle proteine metalloprotease disintegrine, mutants, fragments et analogues de ladite proteine WO1998037092A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
HU0100780A HUP0100780A2 (hu) 1997-02-25 1998-02-25 Új dezintegrin metalloproteáz, mutánsai, fragmentumai és hasonlók alkalmazása
BR9807766-0A BR9807766A (pt) 1997-02-25 1998-02-25 Uso de metaloprotease de disintegrina, mutantes, fragmentos e semelhantes
AU61817/98A AU6181798A (en) 1997-02-25 1998-02-25 Use of a novel disintegrin metalloprotease, mutants, fragments and the ike
JP53694698A JP2001514494A (ja) 1997-02-25 1998-02-25 新規なジスインテグリンメタロプロテアーゼ、変異体、フラグメントなどの使用
EP98906648A EP0977775A2 (fr) 1997-02-25 1998-02-25 Utilisation d'une nouvelle proteine metalloprotease disintegrine, mutants, fragments et analogues de ladite proteine
CA002281085A CA2281085A1 (fr) 1997-02-25 1998-02-25 Emploi d'une nouvelle desintegrine metalloprotease, ses mutants, fragments, etc
NO994056A NO994056L (no) 1997-02-25 1999-08-23 Anvendelse av disintegrin metalloprotease samt mutanter og fragmenter derav

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US81015397A 1997-02-25 1997-02-25
US08/810,153 1997-02-25
PCT/US1997/003217 WO1997031931A1 (fr) 1996-03-01 1997-02-28 Nouvelle disintegrine-metalloprotease et procedes d'utilisation
USPCT/US97/03217 1997-02-28

Publications (2)

Publication Number Publication Date
WO1998037092A2 WO1998037092A2 (fr) 1998-08-27
WO1998037092A3 true WO1998037092A3 (fr) 1998-11-05

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/003490 WO1998037092A2 (fr) 1997-02-25 1998-02-25 Utilisation d'une nouvelle proteine metalloprotease disintegrine, mutants, fragments et analogues de ladite proteine

Country Status (7)

Country Link
EP (1) EP0977775A2 (fr)
JP (1) JP2001514494A (fr)
AU (1) AU6181798A (fr)
CA (1) CA2281085A1 (fr)
HU (1) HUP0100780A2 (fr)
NO (1) NO994056L (fr)
WO (1) WO1998037092A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6436629B1 (en) 2000-10-27 2002-08-20 The Regents Of The University Of California Modulating angiogenesis

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996041624A1 (fr) * 1995-06-08 1996-12-27 Immunex Corporation Enzyme de conversion du facteur de necrose tumorale alpha
WO1997031931A1 (fr) * 1996-03-01 1997-09-04 The Procter & Gamble Company Nouvelle disintegrine-metalloprotease et procedes d'utilisation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996041624A1 (fr) * 1995-06-08 1996-12-27 Immunex Corporation Enzyme de conversion du facteur de necrose tumorale alpha
WO1997031931A1 (fr) * 1996-03-01 1997-09-04 The Procter & Gamble Company Nouvelle disintegrine-metalloprotease et procedes d'utilisation

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HOWARD L ET AL: "MOLECULAR CLONING OF MADM: A CATALYTICALLY ACTIVE MAMMALIAN", BIOCHEMICAL JOURNAL, vol. 317, no. 1, 1 July 1996 (1996-07-01), pages 45 - 50, XP002046451 *
MCGEEHAN G M ET AL: "REGULATION OF TUMOUR NECROSIS FACTOR-ALPHA PROCESSING BY A METALLOPROTEINASE INHIBITOR", NATURE, vol. 370, no. 6490, 18 August 1994 (1994-08-18), pages 558 - 561, XP000574095 *
ROSENDAHL, M.S. ET AL.: "Identification and characterization of a pro-tumor necrosis factor-alpha-processing enzyme from the ADAM family of zinc metalloproteases.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 39, 26 September 1997 (1997-09-26), pages 24588 - 93, XP002073972 *

Also Published As

Publication number Publication date
WO1998037092A2 (fr) 1998-08-27
NO994056L (no) 1999-10-25
JP2001514494A (ja) 2001-09-11
HUP0100780A2 (hu) 2001-06-28
NO994056D0 (no) 1999-08-23
EP0977775A2 (fr) 2000-02-09
CA2281085A1 (fr) 1998-08-27
AU6181798A (en) 1998-09-09

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