WO1998033808A2 - Procede stoechiometrique reversible servant a la conjugaison de biomolecules - Google Patents

Procede stoechiometrique reversible servant a la conjugaison de biomolecules Download PDF

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Publication number
WO1998033808A2
WO1998033808A2 PCT/US1998/002007 US9802007W WO9833808A2 WO 1998033808 A2 WO1998033808 A2 WO 1998033808A2 US 9802007 W US9802007 W US 9802007W WO 9833808 A2 WO9833808 A2 WO 9833808A2
Authority
WO
WIPO (PCT)
Prior art keywords
functionality
nucleic acid
composition according
chelate
comprised
Prior art date
Application number
PCT/US1998/002007
Other languages
English (en)
Other versions
WO1998033808A3 (fr
Inventor
Hubert Koster
Andreas Ruppert
Original Assignee
Hubert Koster
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hubert Koster filed Critical Hubert Koster
Priority to EP98906096A priority Critical patent/EP1000081A2/fr
Priority to AU61416/98A priority patent/AU748806B2/en
Priority to CA002284463A priority patent/CA2284463A1/fr
Priority to JP53319598A priority patent/JP2001526776A/ja
Priority to DE19882066T priority patent/DE19882066T1/de
Publication of WO1998033808A2 publication Critical patent/WO1998033808A2/fr
Publication of WO1998033808A3 publication Critical patent/WO1998033808A3/fr
Priority to NO993746A priority patent/NO993746L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes

Abstract

L'invention concerne des compositions renfermant au moins deux biopolymères (p. ex. des acides nucléiques ou des polypeptides), qui sont conjugués à un support insoluble par deux liaisons réversibles différentes, ces liaisons pouvant être coupées dans des conditions sélectives. L'invention concerne également des procédés et des composants destinés à la production de ces compositions.
PCT/US1998/002007 1997-02-04 1998-02-04 Procede stoechiometrique reversible servant a la conjugaison de biomolecules WO1998033808A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP98906096A EP1000081A2 (fr) 1997-02-04 1998-02-04 Procede stoechiometrique reversible servant a la conjugaison de biomolecules
AU61416/98A AU748806B2 (en) 1997-02-04 1998-02-04 A reversible stoichiometric process for conjugating biomolecules
CA002284463A CA2284463A1 (fr) 1997-02-04 1998-02-04 Procede stoechiometrique reversible servant a la conjugaison de biomolecules
JP53319598A JP2001526776A (ja) 1997-02-04 1998-02-04 生体分子を結合するための可逆性化学量論的工程
DE19882066T DE19882066T1 (de) 1997-02-04 1998-02-04 Reversibles stöchiometrisches Verfahren zum Konjugieren von Biomolekülen
NO993746A NO993746L (no) 1997-02-04 1999-08-03 En reversibel, stökiometrisk prosess for konjugering av biomolekyler

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3716597P 1997-02-04 1997-02-04
US60/037,165 1997-02-04

Publications (2)

Publication Number Publication Date
WO1998033808A2 true WO1998033808A2 (fr) 1998-08-06
WO1998033808A3 WO1998033808A3 (fr) 1999-02-25

Family

ID=21892797

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/002007 WO1998033808A2 (fr) 1997-02-04 1998-02-04 Procede stoechiometrique reversible servant a la conjugaison de biomolecules

Country Status (7)

Country Link
EP (1) EP1000081A2 (fr)
JP (1) JP2001526776A (fr)
AU (1) AU748806B2 (fr)
CA (1) CA2284463A1 (fr)
DE (1) DE19882066T1 (fr)
NO (1) NO993746L (fr)
WO (1) WO1998033808A2 (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6225061B1 (en) 1999-03-10 2001-05-01 Sequenom, Inc. Systems and methods for performing reactions in an unsealed environment
US6730517B1 (en) 1999-04-02 2004-05-04 Sequenom, Inc. Automated process line
EP1485707A2 (fr) * 2001-07-16 2004-12-15 HK Pharmaceuticals, Inc. Composes de capture, recueils de ceux-ci et procedes d'analyse du proteome et compositions complexes
SG153699A1 (en) * 2003-01-16 2009-07-29 Caprotec Bioanalytics Gmbh Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
US7917301B1 (en) 2000-09-19 2011-03-29 Sequenom, Inc. Method and device for identifying a biological sample
US8315805B2 (en) 2001-04-20 2012-11-20 Sequenom, Inc. Systems and methods for testing a biological sample
US8975082B2 (en) 2008-05-13 2015-03-10 University Of Kansas Metal abstraction peptide (MAP) tag and associated methods
US9187735B2 (en) 2012-06-01 2015-11-17 University Of Kansas Metal abstraction peptide with superoxide dismutase activity
WO2019081680A1 (fr) * 2017-10-25 2019-05-02 Institut Pasteur Immobilisation d'acides nucléiques à l'aide d'un mimétique d'étiquette histidine enzymatique pour des applications de diagnostic

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005024068A2 (fr) 2003-09-05 2005-03-17 Sequenom, Inc. Analyse de variations de sequences alleles specifiques
EP2395098B1 (fr) 2004-03-26 2015-07-15 Agena Bioscience, Inc. Division spécifique de base de produits d'amplification spécifique à la méthylation en combinaison avec une analyse de masse

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985004674A1 (fr) * 1984-04-05 1985-10-24 Life Technologies, Inc. Immobilisation d'acides nucleiques
DE3644346A1 (de) * 1986-12-19 1987-05-21 Saeulentechnik Dr Ing Herbert Matrixgebundene kronenetherliganden als trennmaterial in der affinitaetschromatographie von nukleinsaeuren
WO1989005616A1 (fr) * 1987-12-24 1989-06-29 Bio-Metric Systems, Inc. Revetements biocompatibles
WO1990001564A1 (fr) * 1988-08-09 1990-02-22 Microprobe Corporation Procedes d'analyse a cibles multiples par hybridation d'acides nucleiques
US5410068A (en) * 1989-10-23 1995-04-25 Perseptive Biosystems, Inc. Succinimidyl trityl compounds and a process for preparing same
US5547835A (en) * 1993-01-07 1996-08-20 Sequenom, Inc. DNA sequencing by mass spectrometry
US5582981A (en) * 1991-08-14 1996-12-10 Gilead Sciences, Inc. Method for identifying an oligonucleotide aptamer specific for a target
WO1998020020A2 (fr) * 1996-11-06 1998-05-14 Sequenom, Inc. Immobilisation haute densite d'acides nucleiques

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985004674A1 (fr) * 1984-04-05 1985-10-24 Life Technologies, Inc. Immobilisation d'acides nucleiques
DE3644346A1 (de) * 1986-12-19 1987-05-21 Saeulentechnik Dr Ing Herbert Matrixgebundene kronenetherliganden als trennmaterial in der affinitaetschromatographie von nukleinsaeuren
WO1989005616A1 (fr) * 1987-12-24 1989-06-29 Bio-Metric Systems, Inc. Revetements biocompatibles
WO1990001564A1 (fr) * 1988-08-09 1990-02-22 Microprobe Corporation Procedes d'analyse a cibles multiples par hybridation d'acides nucleiques
US5410068A (en) * 1989-10-23 1995-04-25 Perseptive Biosystems, Inc. Succinimidyl trityl compounds and a process for preparing same
US5582981A (en) * 1991-08-14 1996-12-10 Gilead Sciences, Inc. Method for identifying an oligonucleotide aptamer specific for a target
US5547835A (en) * 1993-01-07 1996-08-20 Sequenom, Inc. DNA sequencing by mass spectrometry
WO1998020020A2 (fr) * 1996-11-06 1998-05-14 Sequenom, Inc. Immobilisation haute densite d'acides nucleiques

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ARSHADY E: "BEADED POLYMER SUPPORTS AND GELS II. PHYSICO-CHEMICAL CRITERIA AND FUNCTIONALIZATION" JOURNAL OF CHROMATOGRAPHY, vol. 586, no. 2, 22 November 1991, pages 199-219, XP000247969 *
P.D.GERSHON ET AL.: "Stable Chelating Linkage for Reversible Immobilization of Oligohistidine Tagged Proteins in the BIAcore Surface Plasmon Resonance Detector." JOURNAL OF IMMUNOLOGICAL METHODS, vol. 183, 1995, pages 65-76, XP002081778 *
PON R T ET AL: "DERIVATIZATION OF CONTROLLED PORE GLASS BEADS FOR SOLID PHASE OLIGONUCLEOTIDE SYNTHESIS" BIOTECHNIQUES, vol. 6, no. 8, 1 January 1988, pages 768-770, 773 - 775, XP000562920 *
SCOUTEN W H ET AL: "REVERSIBLE IMMOBILIZATION OF ANTIBODIES ON MAGNETIC BEADS" ANALYTICAL BIOCHEMISTRY, vol. 205, no. 2, 1 September 1992, pages 313-318, XP000296795 *

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6225061B1 (en) 1999-03-10 2001-05-01 Sequenom, Inc. Systems and methods for performing reactions in an unsealed environment
US6730517B1 (en) 1999-04-02 2004-05-04 Sequenom, Inc. Automated process line
US7917301B1 (en) 2000-09-19 2011-03-29 Sequenom, Inc. Method and device for identifying a biological sample
US8315805B2 (en) 2001-04-20 2012-11-20 Sequenom, Inc. Systems and methods for testing a biological sample
EP1485707A2 (fr) * 2001-07-16 2004-12-15 HK Pharmaceuticals, Inc. Composes de capture, recueils de ceux-ci et procedes d'analyse du proteome et compositions complexes
EP1485707A4 (fr) * 2001-07-16 2005-11-16 Hk Pharmaceuticals Inc Composes de capture, recueils de ceux-ci et procedes d'analyse du proteome et compositions complexes
EP2053406A3 (fr) * 2001-07-16 2009-06-24 caprotec bioanalytics GmbH Composés de capture, collections associées et procédés d'analyse protéomique et compositions complexes
SG153699A1 (en) * 2003-01-16 2009-07-29 Caprotec Bioanalytics Gmbh Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
US8975082B2 (en) 2008-05-13 2015-03-10 University Of Kansas Metal abstraction peptide (MAP) tag and associated methods
US9096652B2 (en) 2008-05-13 2015-08-04 University Of Kansas Metal abstraction peptide (MAP) tag and associated methods
US9187735B2 (en) 2012-06-01 2015-11-17 University Of Kansas Metal abstraction peptide with superoxide dismutase activity
WO2019081680A1 (fr) * 2017-10-25 2019-05-02 Institut Pasteur Immobilisation d'acides nucléiques à l'aide d'un mimétique d'étiquette histidine enzymatique pour des applications de diagnostic

Also Published As

Publication number Publication date
CA2284463A1 (fr) 1998-08-06
NO993746L (no) 1999-10-01
DE19882066T1 (de) 2000-01-05
EP1000081A2 (fr) 2000-05-17
AU748806B2 (en) 2002-06-13
NO993746D0 (no) 1999-08-03
AU6141698A (en) 1998-08-25
JP2001526776A (ja) 2001-12-18
WO1998033808A3 (fr) 1999-02-25

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