WO1998033808A3 - Procede stoechiometrique reversible servant a la conjugaison de biomolecules - Google Patents

Procede stoechiometrique reversible servant a la conjugaison de biomolecules Download PDF

Info

Publication number
WO1998033808A3
WO1998033808A3 PCT/US1998/002007 US9802007W WO9833808A3 WO 1998033808 A3 WO1998033808 A3 WO 1998033808A3 US 9802007 W US9802007 W US 9802007W WO 9833808 A3 WO9833808 A3 WO 9833808A3
Authority
WO
WIPO (PCT)
Prior art keywords
reversible
stoichiometric process
conjugating biomolecules
conjugating
biomolecules
Prior art date
Application number
PCT/US1998/002007
Other languages
English (en)
Other versions
WO1998033808A2 (fr
Inventor
Hubert Koster
Original Assignee
Hubert Koster
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hubert Koster filed Critical Hubert Koster
Priority to EP98906096A priority Critical patent/EP1000081A2/fr
Priority to JP53319598A priority patent/JP2001526776A/ja
Priority to CA002284463A priority patent/CA2284463A1/fr
Priority to DE19882066T priority patent/DE19882066T1/de
Priority to AU61416/98A priority patent/AU748806B2/en
Publication of WO1998033808A2 publication Critical patent/WO1998033808A2/fr
Publication of WO1998033808A3 publication Critical patent/WO1998033808A3/fr
Priority to NO993746A priority patent/NO993746L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne des compositions renfermant au moins deux biopolymères (p. ex. des acides nucléiques ou des polypeptides), qui sont conjugués à un support insoluble par deux liaisons réversibles différentes, ces liaisons pouvant être coupées dans des conditions sélectives. L'invention concerne également des procédés et des composants destinés à la production de ces compositions.
PCT/US1998/002007 1997-02-04 1998-02-04 Procede stoechiometrique reversible servant a la conjugaison de biomolecules WO1998033808A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP98906096A EP1000081A2 (fr) 1997-02-04 1998-02-04 Procede stoechiometrique reversible servant a la conjugaison de biomolecules
JP53319598A JP2001526776A (ja) 1997-02-04 1998-02-04 生体分子を結合するための可逆性化学量論的工程
CA002284463A CA2284463A1 (fr) 1997-02-04 1998-02-04 Procede stoechiometrique reversible servant a la conjugaison de biomolecules
DE19882066T DE19882066T1 (de) 1997-02-04 1998-02-04 Reversibles stöchiometrisches Verfahren zum Konjugieren von Biomolekülen
AU61416/98A AU748806B2 (en) 1997-02-04 1998-02-04 A reversible stoichiometric process for conjugating biomolecules
NO993746A NO993746L (no) 1997-02-04 1999-08-03 En reversibel, stökiometrisk prosess for konjugering av biomolekyler

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3716597P 1997-02-04 1997-02-04
US60/037,165 1997-02-04

Publications (2)

Publication Number Publication Date
WO1998033808A2 WO1998033808A2 (fr) 1998-08-06
WO1998033808A3 true WO1998033808A3 (fr) 1999-02-25

Family

ID=21892797

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/002007 WO1998033808A2 (fr) 1997-02-04 1998-02-04 Procede stoechiometrique reversible servant a la conjugaison de biomolecules

Country Status (7)

Country Link
EP (1) EP1000081A2 (fr)
JP (1) JP2001526776A (fr)
AU (1) AU748806B2 (fr)
CA (1) CA2284463A1 (fr)
DE (1) DE19882066T1 (fr)
NO (1) NO993746L (fr)
WO (1) WO1998033808A2 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8975082B2 (en) 2008-05-13 2015-03-10 University Of Kansas Metal abstraction peptide (MAP) tag and associated methods
US9034798B2 (en) 2003-01-16 2015-05-19 Caprotec Bioanalytics Gmbh Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
US9187735B2 (en) 2012-06-01 2015-11-17 University Of Kansas Metal abstraction peptide with superoxide dismutase activity
US9249456B2 (en) 2004-03-26 2016-02-02 Agena Bioscience, Inc. Base specific cleavage of methylation-specific amplification products in combination with mass analysis
US9394565B2 (en) 2003-09-05 2016-07-19 Agena Bioscience, Inc. Allele-specific sequence variation analysis

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6225061B1 (en) 1999-03-10 2001-05-01 Sequenom, Inc. Systems and methods for performing reactions in an unsealed environment
US20020009394A1 (en) 1999-04-02 2002-01-24 Hubert Koster Automated process line
US7917301B1 (en) 2000-09-19 2011-03-29 Sequenom, Inc. Method and device for identifying a biological sample
US20020155587A1 (en) 2001-04-20 2002-10-24 Sequenom, Inc. System and method for testing a biological sample
WO2003092581A2 (fr) * 2001-07-16 2003-11-13 Hk Pharmaceuticals, Inc. Composes de capture, recueils de ceux-ci et procedes d'analyse du proteome et compositions complexes
WO2019081680A1 (fr) * 2017-10-25 2019-05-02 Institut Pasteur Immobilisation d'acides nucléiques à l'aide d'un mimétique d'étiquette histidine enzymatique pour des applications de diagnostic

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985004674A1 (fr) * 1984-04-05 1985-10-24 Life Technologies, Inc. Immobilisation d'acides nucleiques
DE3644346A1 (de) * 1986-12-19 1987-05-21 Saeulentechnik Dr Ing Herbert Matrixgebundene kronenetherliganden als trennmaterial in der affinitaetschromatographie von nukleinsaeuren
WO1989005616A1 (fr) * 1987-12-24 1989-06-29 Bio-Metric Systems, Inc. Revetements biocompatibles
WO1990001564A1 (fr) * 1988-08-09 1990-02-22 Microprobe Corporation Procedes d'analyse a cibles multiples par hybridation d'acides nucleiques
US5410068A (en) * 1989-10-23 1995-04-25 Perseptive Biosystems, Inc. Succinimidyl trityl compounds and a process for preparing same
US5547835A (en) * 1993-01-07 1996-08-20 Sequenom, Inc. DNA sequencing by mass spectrometry
US5582981A (en) * 1991-08-14 1996-12-10 Gilead Sciences, Inc. Method for identifying an oligonucleotide aptamer specific for a target
WO1998020020A2 (fr) * 1996-11-06 1998-05-14 Sequenom, Inc. Immobilisation haute densite d'acides nucleiques

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985004674A1 (fr) * 1984-04-05 1985-10-24 Life Technologies, Inc. Immobilisation d'acides nucleiques
DE3644346A1 (de) * 1986-12-19 1987-05-21 Saeulentechnik Dr Ing Herbert Matrixgebundene kronenetherliganden als trennmaterial in der affinitaetschromatographie von nukleinsaeuren
WO1989005616A1 (fr) * 1987-12-24 1989-06-29 Bio-Metric Systems, Inc. Revetements biocompatibles
WO1990001564A1 (fr) * 1988-08-09 1990-02-22 Microprobe Corporation Procedes d'analyse a cibles multiples par hybridation d'acides nucleiques
US5410068A (en) * 1989-10-23 1995-04-25 Perseptive Biosystems, Inc. Succinimidyl trityl compounds and a process for preparing same
US5582981A (en) * 1991-08-14 1996-12-10 Gilead Sciences, Inc. Method for identifying an oligonucleotide aptamer specific for a target
US5547835A (en) * 1993-01-07 1996-08-20 Sequenom, Inc. DNA sequencing by mass spectrometry
WO1998020020A2 (fr) * 1996-11-06 1998-05-14 Sequenom, Inc. Immobilisation haute densite d'acides nucleiques

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ARSHADY E: "BEADED POLYMER SUPPORTS AND GELS II. PHYSICO-CHEMICAL CRITERIA AND FUNCTIONALIZATION", JOURNAL OF CHROMATOGRAPHY, vol. 586, no. 2, 22 November 1991 (1991-11-22), pages 199 - 219, XP000247969 *
P.D.GERSHON ET AL.: "Stable Chelating Linkage for Reversible Immobilization of Oligohistidine Tagged Proteins in the BIAcore Surface Plasmon Resonance Detector.", JOURNAL OF IMMUNOLOGICAL METHODS, vol. 183, 1995, pages 65 - 76, XP002081778 *
PON R T ET AL: "DERIVATIZATION OF CONTROLLED PORE GLASS BEADS FOR SOLID PHASE OLIGONUCLEOTIDE SYNTHESIS", BIOTECHNIQUES, vol. 6, no. 8, 1 January 1988 (1988-01-01), pages 768 - 770, 773 - 775, XP000562920 *
SCOUTEN W H ET AL: "REVERSIBLE IMMOBILIZATION OF ANTIBODIES ON MAGNETIC BEADS", ANALYTICAL BIOCHEMISTRY, vol. 205, no. 2, 1 September 1992 (1992-09-01), pages 313 - 318, XP000296795 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9034798B2 (en) 2003-01-16 2015-05-19 Caprotec Bioanalytics Gmbh Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
US9394565B2 (en) 2003-09-05 2016-07-19 Agena Bioscience, Inc. Allele-specific sequence variation analysis
US9249456B2 (en) 2004-03-26 2016-02-02 Agena Bioscience, Inc. Base specific cleavage of methylation-specific amplification products in combination with mass analysis
US8975082B2 (en) 2008-05-13 2015-03-10 University Of Kansas Metal abstraction peptide (MAP) tag and associated methods
US9096652B2 (en) 2008-05-13 2015-08-04 University Of Kansas Metal abstraction peptide (MAP) tag and associated methods
US9187735B2 (en) 2012-06-01 2015-11-17 University Of Kansas Metal abstraction peptide with superoxide dismutase activity

Also Published As

Publication number Publication date
WO1998033808A2 (fr) 1998-08-06
AU6141698A (en) 1998-08-25
DE19882066T1 (de) 2000-01-05
EP1000081A2 (fr) 2000-05-17
NO993746D0 (no) 1999-08-03
CA2284463A1 (fr) 1998-08-06
JP2001526776A (ja) 2001-12-18
AU748806B2 (en) 2002-06-13
NO993746L (no) 1999-10-01

Similar Documents

Publication Publication Date Title
CA2331337A1 (fr) Modification de proteine specifique a un site par mutagenese
DK1053355T3 (da) PNA- og DNA-konjugater og metoder til fremstilling heraf
WO1998033808A3 (fr) Procede stoechiometrique reversible servant a la conjugaison de biomolecules
AU6542598A (en) Site protected protein modification
NO992167D0 (no) Preparater og fremgangsmÕter for immobilisering av nukleinsyrer til faste bµrere
CA2355379A1 (fr) Pousseur de materiau compact universel et methode de fabrication
WO2000012587A8 (fr) Chaines polyamides de longueur precise, procede de fabrication et leur conjugues avec des proteines
NO20020348D0 (no) Peptid acceptor ligeringsmetoder
WO2005050171A3 (fr) Procedes et compositions se rapportant a des reactifs centraux simples
CA2215933A1 (fr) Preparation de produits de recombinaison immunogenes au moyen d'hydrates de carbone solubles actives par l'intermediaire de reactifs organiques de cyanylation
EP1102787A4 (fr) Oligonucleotides 2'-o-aminoethyloxyethyle-modifies
AU5773798A (en) Pegylation process
SI1305329T2 (sl) S-fluorometil ester 6alfa,9alfa-difluoro-17alfa-(2-furanilkarboksil)oksi-11beta-hidroksi- 16alfa-metil-3-okso-androst-1,4-dien-17-karbotiojske kisline kot protivnetno sredstvo
CA2248006A1 (fr) Segments de liaison actives et leurs procedes de fabrication et de purification
WO2002042418A3 (fr) Acide 3-hydroxypropionique et autres composes organiques
WO2003046200A3 (fr) Procedes de decouverte de ligands
WO2002062999A8 (fr) Proteines et acides nucleiques codant pour celles-ci
EP0939124A3 (fr) Séquences de la MBGP1
AU4854999A (en) Methods, compositions and apparatus for making nucleic acid molecules having a selected affinity to a target molecule
WO2005014723A8 (fr) Composes de type cyanine avec bras alkynyle de liaison
NL191466C (nl) Voorlegering op basis van Al-Ti, alswel werkwijze voor de bereiding hiervan.
EP0879888A3 (fr) Polypeptides patched-2 et polynucléotides et leurs procédés de fabrication
CA2395420A1 (fr) Procede de production de n-phosphonomethylglycine
WO2001032864A3 (fr) Nouveaux polypeptides de type gpcr_kd5 et sequences d'adn correspondantes
WO2001004141A3 (fr) Seripancrine

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GW HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
ENP Entry into the national phase

Ref document number: 2284463

Country of ref document: CA

Ref document number: 2284463

Country of ref document: CA

Kind code of ref document: A

Ref document number: 1998 533195

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 1998906096

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 61416/98

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 09355705

Country of ref document: US

RET De translation (de og part 6b)

Ref document number: 19882066

Country of ref document: DE

Date of ref document: 20000105

WWE Wipo information: entry into national phase

Ref document number: 19882066

Country of ref document: DE

WWP Wipo information: published in national office

Ref document number: 1998906096

Country of ref document: EP

WWG Wipo information: grant in national office

Ref document number: 61416/98

Country of ref document: AU

WWW Wipo information: withdrawn in national office

Ref document number: 1998906096

Country of ref document: EP