WO1998030218A1 - Substituted bis-acridines and related compounds as ccr5 receptor ligands, anti-inflammatory agents and anti-viral agents - Google Patents

Substituted bis-acridines and related compounds as ccr5 receptor ligands, anti-inflammatory agents and anti-viral agents Download PDF

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Publication number
WO1998030218A1
WO1998030218A1 PCT/US1998/000489 US9800489W WO9830218A1 WO 1998030218 A1 WO1998030218 A1 WO 1998030218A1 US 9800489 W US9800489 W US 9800489W WO 9830218 A1 WO9830218 A1 WO 9830218A1
Authority
WO
WIPO (PCT)
Prior art keywords
bis
chloro
methoxy
acridinyl
4alkyl
Prior art date
Application number
PCT/US1998/000489
Other languages
English (en)
French (fr)
Inventor
William E. Bondinell
Valerie A. Reader
Thomas Wen Fu Ku
Original Assignee
Smithkline Beecham Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corporation filed Critical Smithkline Beecham Corporation
Priority to CA002276525A priority Critical patent/CA2276525A1/en
Priority to AU60208/98A priority patent/AU6020898A/en
Priority to EP98903437A priority patent/EP0979078A4/en
Priority to US09/341,171 priority patent/US6242459B1/en
Priority to JP53117498A priority patent/JP2001509152A/ja
Publication of WO1998030218A1 publication Critical patent/WO1998030218A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9
    • C07D219/12—Amino-alkylamino radicals attached in position 9
PCT/US1998/000489 1997-01-08 1998-01-08 Substituted bis-acridines and related compounds as ccr5 receptor ligands, anti-inflammatory agents and anti-viral agents WO1998030218A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002276525A CA2276525A1 (en) 1997-01-08 1998-01-08 Substituted bis-acridines and related compounds as ccr5 receptor ligands, anti-inflammatory agents and anti-viral agents
AU60208/98A AU6020898A (en) 1997-01-08 1998-01-08 Substituted bis-acridines and related compounds as ccr5 receptor ligands, anti-inflammatory agents and anti-viral agents
EP98903437A EP0979078A4 (en) 1997-01-08 1998-01-08 SUBSTITUTED BIS-ACRIDINE AND THEIR RELATED COMPOUNDS AS CCR5 RECEPTOR LIGANDS, ANTI-FLAMMABILITY AND ANTIVIRAL AGENTS
US09/341,171 US6242459B1 (en) 1997-01-08 1998-01-08 Substituted bis-acridines and related compounds as CCR5 receptor ligands, anti-inflammatory agents and anti-viral agents
JP53117498A JP2001509152A (ja) 1997-01-08 1998-01-08 Ｃｃｒ５受容体リガンド、抗炎症薬および抗−ウイルス薬としての置換ビス−アクリジンおよび関連化合物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3514897P 1997-01-08 1997-01-08
US60/035,148 1997-01-08

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09/341,171 A-371-Of-International US6242459B1 (en) 1997-01-08 1998-01-08 Substituted bis-acridines and related compounds as CCR5 receptor ligands, anti-inflammatory agents and anti-viral agents
US09/833,044 Division US20010031763A1 (en) 1997-01-08 2001-04-11 Substituted bis-acridines and related compounds as CCR5 receptor ligands, anti-inflammatory agents and anti-viral agents

Publications (1)

Publication Number Publication Date
WO1998030218A1 true WO1998030218A1 (en) 1998-07-16

Family

ID=21880954

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/000489 WO1998030218A1 (en) 1997-01-08 1998-01-08 Substituted bis-acridines and related compounds as ccr5 receptor ligands, anti-inflammatory agents and anti-viral agents

Country Status (9)

Country Link
US (2) US6242459B1 (US06242459-20010605-C00008.png)
EP (1) EP0979078A4 (US06242459-20010605-C00008.png)
JP (1) JP2001509152A (US06242459-20010605-C00008.png)
AR (1) AR011057A1 (US06242459-20010605-C00008.png)
AU (1) AU6020898A (US06242459-20010605-C00008.png)
CA (1) CA2276525A1 (US06242459-20010605-C00008.png)
CO (1) CO4920243A1 (US06242459-20010605-C00008.png)
WO (1) WO1998030218A1 (US06242459-20010605-C00008.png)
ZA (1) ZA9895B (US06242459-20010605-C00008.png)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1001766A1 (en) * 1997-07-03 2000-05-24 Smithkline Beecham Corporation Compounds and methods
WO2001042208A1 (fr) * 1999-12-08 2001-06-14 Teijin Limited Antagonistes du recepteur ccr5 de la cycloamine
US6362177B1 (en) 2000-05-16 2002-03-26 Teijin Limited Cyclic amine derivatives and their use as drugs
US6451842B1 (en) 1997-11-18 2002-09-17 Dupont Pharmaceuticals Company Cyclic amine derivatives and their use as drugs
US6479504B1 (en) * 1999-06-16 2002-11-12 The University Of Iowa Research Foundation Antagonism of immunostimulatory CpG-oligonucleotides by 4-aminoquinolines and other weak bases
US6511826B2 (en) 1995-06-06 2003-01-28 Human Genome Sciences, Inc. Polynucleotides encoding human G-protein chemokine receptor (CCR5) HDGNR10
US6743594B1 (en) 1995-06-06 2004-06-01 Human Genome Sciences, Inc. Methods of screening using human G-protein chemokine receptor HDGNR10 (CCR5)
US7175988B2 (en) 2001-02-09 2007-02-13 Human Genome Sciences, Inc. Human G-protein Chemokine Receptor (CCR5) HDGNR10
US7390830B1 (en) 1999-05-18 2008-06-24 Teijin Limited Remedies or prophylactics for diseases in association with chemokines
US7393934B2 (en) 2001-12-21 2008-07-01 Human Genome Sciences, Inc. Human G-protein chemokine receptor (CCR5) HDGNR10
US7501123B2 (en) 2004-03-12 2009-03-10 Human Genome Sciences, Inc. Human G-protein chemokine receptor (CCR5) HDGNR10
US7576117B1 (en) 1999-08-04 2009-08-18 Teijin Limited Cyclic amine CCR3 antagonist

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6514987B1 (en) * 1997-01-06 2003-02-04 Cerus Corporation Frangible compounds for pathogen inactivation
US7160896B2 (en) 2000-07-07 2007-01-09 Cancer Research Technology Limited Therapeutic acridone and acridine compounds
AU2003207646C1 (en) * 2002-01-22 2008-09-18 Vanderbilt University Treating stress response with chemokine receptor CCR5 modulators
US7473527B2 (en) * 2002-07-02 2009-01-06 The Uab Research Foundation Compounds promoting delivery of genes
US20080108586A1 (en) * 2006-09-06 2008-05-08 Incyte Corporation Combination therapy for human immunodeficiency virus infection
EP2741777B1 (en) 2011-08-12 2017-01-18 INSERM - Institut National de la Santé et de la Recherche Médicale Methods and pharmaceutical compositions for treatment of pulmonary hypertension
US10149830B2 (en) 2016-06-03 2018-12-11 Cushing Academy Pharmaceutical agents and methods relating thereto

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2503899A (en) * 1945-08-29 1950-04-11 Dow Chemical Co Diacridyl diamine derivatives

Family Cites Families (7)

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Publication number Priority date Publication date Assignee Title
FR2314165A1 (fr) 1975-06-13 1977-01-07 Anvar Nouveaux bis (anthryl-9) alcanes et leur preparation
FR2588259B1 (fr) 1985-10-04 1988-01-22 Aix Marseille Universite Bis-acridiniques monopontes et bis-acridiniques bipontes
JPH0688924B2 (ja) 1986-05-28 1994-11-09 ダイセル化学工業株式会社 光記憶材料
DE4014421A1 (de) * 1990-05-05 1991-11-07 Merck Patent Gmbh Aminosaeurederivate
JPH04226467A (ja) 1990-09-13 1992-08-17 Ricoh Co Ltd 電子写真感光体の疲労回復方法
ES2107557T3 (es) * 1991-12-10 1997-12-01 Shionogi & Co Derivado de acido hidroxamico a base de sulfonamida aromatica.
DE4405378A1 (de) * 1994-02-19 1995-08-24 Merck Patent Gmbh Adhäsionsrezeptor-Antagonisten

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2503899A (en) * 1945-08-29 1950-04-11 Dow Chemical Co Diacridyl diamine derivatives

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Chemical Abstracts Service (C A S); 1 January 1900 (1900-01-01), XP002912276, Database accession no. 78-71877 *
CHEN T. K., ET AL.: "DIACRIDINES, BIFUNCTIONAL INTERCALATORS, CHEMISTRY AND ANTITUMOR ACTIVITY.", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 21., no. 09., 1 January 1978 (1978-01-01), US, pages 868 - 874., XP002912277, ISSN: 0022-2623, DOI: 10.1021/jm00207a006 *
See also references of EP0979078A4 *

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6511826B2 (en) 1995-06-06 2003-01-28 Human Genome Sciences, Inc. Polynucleotides encoding human G-protein chemokine receptor (CCR5) HDGNR10
US7160546B2 (en) 1995-06-06 2007-01-09 Human Genome Sciences, Inc. Human G-protein chemokine receptor (CCR5) HDGNR10
US6800729B2 (en) 1995-06-06 2004-10-05 Human Genome Sciences, Inc. Human G-Protein chemokine receptor HDGNR10 (CCR5 receptor)
US6759519B2 (en) 1995-06-06 2004-07-06 Human Genome Sciences, Inc. Antibodies to human G-protein chemokine receptor HDGNR10 (CCR5receptor)
US6743594B1 (en) 1995-06-06 2004-06-01 Human Genome Sciences, Inc. Methods of screening using human G-protein chemokine receptor HDGNR10 (CCR5)
US6515027B1 (en) 1997-07-03 2003-02-04 Smithkline Beecham Corp. Substituted benzanilides as CCR5 receptors ligands, antiinflammatory agents and antiviral agents
EP1001766A1 (en) * 1997-07-03 2000-05-24 Smithkline Beecham Corporation Compounds and methods
EP1001766A4 (en) * 1997-07-03 2001-04-04 Smithkline Beecham Corp COMPOSITIONS AND METHODS
US6451842B1 (en) 1997-11-18 2002-09-17 Dupont Pharmaceuticals Company Cyclic amine derivatives and their use as drugs
US7390830B1 (en) 1999-05-18 2008-06-24 Teijin Limited Remedies or prophylactics for diseases in association with chemokines
US6479504B1 (en) * 1999-06-16 2002-11-12 The University Of Iowa Research Foundation Antagonism of immunostimulatory CpG-oligonucleotides by 4-aminoquinolines and other weak bases
US7576117B1 (en) 1999-08-04 2009-08-18 Teijin Limited Cyclic amine CCR3 antagonist
WO2001042208A1 (fr) * 1999-12-08 2001-06-14 Teijin Limited Antagonistes du recepteur ccr5 de la cycloamine
US6410566B1 (en) 2000-05-16 2002-06-25 Teijin Limited Cyclic amine derivatives and their use as drugs
US6362177B1 (en) 2000-05-16 2002-03-26 Teijin Limited Cyclic amine derivatives and their use as drugs
US7175988B2 (en) 2001-02-09 2007-02-13 Human Genome Sciences, Inc. Human G-protein Chemokine Receptor (CCR5) HDGNR10
US7393934B2 (en) 2001-12-21 2008-07-01 Human Genome Sciences, Inc. Human G-protein chemokine receptor (CCR5) HDGNR10
US7501123B2 (en) 2004-03-12 2009-03-10 Human Genome Sciences, Inc. Human G-protein chemokine receptor (CCR5) HDGNR10

Also Published As

Publication number Publication date
AR011057A1 (es) 2000-08-02
US20010031763A1 (en) 2001-10-18
JP2001509152A (ja) 2001-07-10
US6242459B1 (en) 2001-06-05
CA2276525A1 (en) 1998-07-16
EP0979078A4 (en) 2000-06-21
CO4920243A1 (es) 2000-05-29
ZA9895B (en) 1998-07-08
AU6020898A (en) 1998-08-03
EP0979078A1 (en) 2000-02-16

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