WO1998017262A1 - Pansement contenant des huiles essentielles - Google Patents

Pansement contenant des huiles essentielles Download PDF

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Publication number
WO1998017262A1
WO1998017262A1 PCT/GB1997/002901 GB9702901W WO9817262A1 WO 1998017262 A1 WO1998017262 A1 WO 1998017262A1 GB 9702901 W GB9702901 W GB 9702901W WO 9817262 A1 WO9817262 A1 WO 9817262A1
Authority
WO
WIPO (PCT)
Prior art keywords
oil
dressing
aromatherapy
remedy
oils
Prior art date
Application number
PCT/GB1997/002901
Other languages
English (en)
Inventor
Madeleine Le Gall
Original Assignee
De Boissezon, Lucia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9622109.8A external-priority patent/GB9622109D0/en
Application filed by De Boissezon, Lucia filed Critical De Boissezon, Lucia
Priority to AU47150/97A priority Critical patent/AU4715097A/en
Priority to EP97909470A priority patent/EP0949913A1/fr
Priority to CA002269599A priority patent/CA2269599A1/fr
Publication of WO1998017262A1 publication Critical patent/WO1998017262A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/38—Clusiaceae, Hypericaceae or Guttiferae (Hypericum or Mangosteen family), e.g. common St. Johnswort
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy

Definitions

  • the present application relates to a dressing for topical delivery of aromatherapy oils and to the use of aromatherapy oils in such a dressing.
  • Aromatherapy is one such "alternative" therapy and involves the use of aromatherapy oils which either individually or in combination act to stimulate or alleviate specific physical or mental conditions.
  • inhalation may be achieved by placing a few drops of the oil onto a patient's handkerchief or by diffusing the oils into the atmosphere surrounding the patient, usually by means of a diffuser which causes the oils to vaporise.
  • massage may be more appropriate than inhalation. Both methods result in aromatherapy oils being ingested either via the lungs or transdermally. The most effective treatment will often be prescribed by qualified personnel, particularly by aromatherapists.
  • Inhaling oils from a handkerchief or topical application of oils by massage results in a relatively sudden, concentrated dosage. In some circumstances, it may be more beneficial to receive a more sustained exposure to the oils. Moreover, it is not easy to massage all parts of the body without the assistance of a masseuse.
  • aromatherapy oils are perfectly safe when prescribed by qualified personnel, care must always be exercised because accidental exposure to certain oils can be positively harmful. For example, some oils used in aromatherapy can cause spontaneous abortion of a foetus. In addition, some oils can have a deleterious effect on fabrics, causing discoloration and even destruction of the fabric over a period of time. Extreme care must therefore be taken when administering aromatherapy oils by diffusion.
  • aromatherapy oils can also be used to provide other benefits.
  • peppermint oil to combat fatigue or increase alertness is well documented. Since driver fatigue is a common factor in the majority of road accidents, systems for delivering bursts of peppermint oil to drivers to refresh and revive them are being developed.
  • the present invention resides in a dressing for the topical administration of an aromatherapy oil comprising a reservoir containing an aromatherapy oil, wherein application of the dressing to the skin of a wearer results in transfer of the oil to the skin.
  • the invention resides in the use of an aromatherapy oil in a dressing for the topical application of the oil to the skin.
  • an aromatherapy delivery device comprising a dressing containing an aromatherapy oil adapted to deliver the oil to the skin of a wearer of the device.
  • a dressing containing an aromatherapy oil adapted to deliver the oil to the skin of a wearer of the device.
  • Application of such dressings to a person's skin enables the aromatherapy oil to migrate through the dressing, more especially from the reservoir, whereupon the oil comes into contact with and is absorbed through the skin.
  • a further advantage of the present invention is that a high percentage of the aromatherapy oil contained in the dressing is actually ingested by the body, whereas previous methods of applying aromatherapy oils, namely by massage or inhalation, involve a significant loss of oil to the atmosphere. Consequently, the present invention offers a much more effective and efficient means of delivering aromatherapy oil to the body.
  • aromatherapy oil contained in the dressing according to the invention may comprise a single oil or a blend of two or more different oils.
  • the aromatherapy oil will comprise one or more essential oils.
  • essential oils is well-known in the art and is used to refer to volatile oils derived from the leaves, stems, flowers, or twigs of plants, and which usually carry the essence odour and flavour of the plant. Some essential oils are nearly pure single compounds, while others are mixtures of compounds. Some essential oils are extremely expensive to extract but can be produced synthetically, so for present purposes, the term “essential oils” covers both the natural and synthetic varieties.
  • the aromatherapy oil used in the dressings of the invention preferably comprises a blend of two or more essential oils.
  • the top note is generally supplied by a light, volatile oil which evaporates relatively quickly;
  • the middle note comprises the bulk of heart of the blend and gives the blend its intrinsic character, it emerges or evaporates more slowly than the oil supplying the top note; and
  • the base note is derived from a rich and heavy oil which evaporates even more slowly and therefore has a lingering presence.
  • the base note usually acts as a "fixer" for the other notes.
  • Aromatherapy oils which are particularly useful in the present invention include, but are not limited to, bergamot, peppermint, basil, eucalyptus, grapefruit, lavender, geranium, roman chamomile, frankincense, calendula, rose, vetiver, sweet marjoram, rosemary and clary sage oils.
  • Vetiver oil is especially favoured in formulations and acts as a fixer for other oils, in other words, vetiver provides the base note for a variety of formulations.
  • the aromatherapy oil carried by the dressing preferably comprises at least one carrier oil.
  • the carrier oil is used as a base oil for other active essential oils mixed therewith.
  • the invention resides in an aromatherapy oil comprising a synergistic blend of at least one essential oil and at least one carrier oil. More especially, the invention resides in an aromatherapy delivery device comprising a dressing containing an aromatherapy oil adapted to deliver the oil to the skin of a wearer, wherein the aromatherapy oil comprises a synergistic blend of at least one essential oil and at least one carrier oil.
  • the carrier oil is present to provide a base for a more active oil, such as a essential oil
  • the carrier oil is preferably present in an amount of 2 ml to 1 drop of active oil (1 drop approximates to 0.05 ml)). This represents a concentration of active oil which is generally safe for most purposes. However, the concentration of active oil can be increased above this level in appropriate circumstances.
  • the aromatherapy oil contained in the dressing according to the invention may comprise blends of two or more carrier oils. Such blends are appropriate, for example, when the beneficial properties of more than one carrier oil are required, or to adjust the viscosity of the carrier oil thereby to influence or control the rate of penetration of the oil into the body.
  • the rate of penetration of the aromatherapy oil into the body is an important aspect to be considered in formulating the components of the oil in the dressing.
  • a "quick fix" of aromatherapy oil may be all that is required
  • one of the objects of the invention is to provide a means whereby the body may ingest an aromatherapy oil over a prolonged period, in which case the dressings are required to remain active over several hours at least.
  • Such prolonged activity may be achieved by adjusting not only the volume of aromatherapy oil contained in the dressing but also the viscosity, which in turn may be at least partly achieved by the choice or blend of carrier oil.
  • the carrier oil preferably comprises a fine oil, such an oil being easily absorbed by the skin and therefore an ideal agent for carrying the other oils, such as the essential oils, into the body.
  • Particularly preferred fine oils for use as carrier oils in the dressings of the invention include sweet almond oil, borage seed oil and jojoba oil. While none of these oils are themselves essential oils, they may each contribute towards the beneficial properties of the dressing.
  • sweet almond oil which is usually obtained by pressing the kernels of both the sweet and bitter almond tree contains glucosides, vitamins and minerals and is also rich in protein. Not only is sweet almond oil able to relieve soreness, dryness and inflammation of the skin, but it also helps relieve muscular aches and pains. In addition, it can be used safely on both adults and babies and is generally easily absorbed by all types of skin, irrespective of ethnic origin. For all these reasons, sweet almond oil is particularly preferred as a carrier or base oil.
  • Borage oil can act as a tonic and a reviver and is therefore particularly suitable as a carrier oil in dressings intended for increasing alertness of an individual or for reducing the effects of jet lag.
  • aromatherapy oils begin to evaporate upon exposure to the atmosphere, they are also sensitive to oxygen and begin to lose their potency, so it is important therefore to prevent the oil from coming into contact with air until such time as the dressing is to be applied.
  • This may be achieved, for example, by housing the dressing in a sealed pack. The seal of the pack may be broken and the dressing removed just prior to use.
  • a further benefit achieved by sealing the dressing in a pack is that the dressing can be kept sterile until application to the skin.
  • the aromatherapy oil itself may be accommodated in an impervious enclosure from where the oil is released as the dressing is to be applied.
  • the oil may be contained within a sealed plastics membrane which is punctured or otherwise opened as the dressing is about to be applied.
  • the aromatherapy oil in the dressing is not overly exposed to the atmosphere before the dressing is applied to the skin, the oil should not lose much potency.
  • the blending of a quantity of wheatgerm oil with the aromatherapy oil has been found to help preserve the potency of the oils.
  • the dressings of the invention may be formulated with blends of specific aromatherapy oils according to their intended purpose. When a plurality of oils are used, it is important that they are thoroughly blended before applying to the dressing.
  • the dressing according to the invention may comprise an elongate member, such as a bandage, but more conveniently is in the form of a plaster or "skin patch".
  • the dressing is advantageously provided with an adhesive layer for fixing the dressing to the skin.
  • the dressing includes an impermeable barrier layer which forms an outer layer of the dressing in use. In this way, loss of the aromatherapy oils from the dressing due to evaporation or absorption into any clothing overlying the dressing can be reduced or substantially eliminated.
  • the dressing preferably further comprises a permeable or semi-permeable skin contacting layer which lies against the skin of the wearer in use.
  • Aromatherapy oil contained in the dressing is able to diffuse through the skin contacting layer and onto the skin of the wearer.
  • the aromatherapy oil is interposed between an outer impermeable layer and a permeable or semi-permeable skin contacting layer.
  • the aromatherapy oil may be conveniently impregnated into an absorbent pad or gauze which forms part of the dressing, ideally interposed between an outer impermeable layer and an inner, permeable or semi-permeable skin contacting layer.
  • the dressings according to the invention are advantageously provided with a releasable protective layer covering at least the surface of the dressing which is to be applied to the skin.
  • a releasable protective layer avoids loss of aromatherapy oil from the dressing and may be removed just prior to use.
  • the aforementioned dressings carrying aromatherapy oils and the more specific forms of dressings as described hereinafter are most conveniently provided in the form of skin patches.
  • Such skin patches are generally provided with an adhesive portion, preferably in a layer around their perimeter like a sticking plaster, to readily adhere the patch to the wearer.
  • the skin patches are stored in sealed packages ready for use.
  • the invention will now be more particularly described in relation to the alleviation or stimulation of certain conditions .
  • aromatherapy oils can assist in bringing the body back into synchronisation, but to be most effective, the oils need to be applied and ingested over a prolonged period. Ideally, ingestion of the oils should begin prior to the start of the journey and should continue for at least the journey itself.
  • the dressing In order not to overload the dressing with aromatherapy oils and to spread the dosage more evenly over the required period, it is desirable to charge the reservoir of the dressing with sufficient oil to last for several hours, five hours being a practical optimum period.
  • the dressing may be replaced when its supply of oil has been or is about to become exhausted.
  • the invention resides in an anti-jet-lag remedy comprising a dressing for application to the body, wherein the dressing contains an aromatherapy oil.
  • a first formulation may be applied prior to and/or during the bulk of the journey (a so-called “Take-Off' remedy) and a second or further formulation may be applied during the latter stages of the journey and for a period afterwards (a so-called “Recovery” remedy).
  • the anti-jet-lag remedy comprises a dressing including one or more essential oils selected from peppermint, eucalyptus, grapefruit, lavender, geranium oils, roman chamomile, geranium, sweet marjoram, rosemary, basil or clary sage oils.
  • one formulation constituting the "Take-Off' remedy comprises at least one oil selected from peppermint, eucalyptus and grapefruit oil
  • another formulation constituting the "Recovery" remedy comprises at least one oil selected from lavender, geranium and grapefruit oil. It is particularly advantageous to include an amount of all three of the listed oils for each formulation, such mixtures providing maximum synergy.
  • one formulation constituting the "Take-Off remedy may be a "Sleep” remedy and comprise at least one oil selected from lavender, roman chamomile, clary sage, geranium and sweet marjoram
  • another formulation constituting the "Recovery” remedy may be an "Alert” remedy and comprise at least one oil selected from rosemary, peppermint, grapefruit and basil. It is particularly advantageous to include an amount of all four of the listed oils for each formulation, such mixtures providing maximum synergy.
  • vetiver oil as the fixer or base oil for each of the abovementioned anti-jet-lag remedies.
  • the aforementioned essential oils are most preferably blended with a carrier oil prior to their incorporation in the dressing.
  • sweet almond oil is a particularly suitable carrier oil, its combination with the other essential oils resulting in a mixture displaying synergistic effects in alleviating jet-lag symptoms as compared to the effects which each individual oil would normally display.
  • aromatherapy oils can help alleviate is that of general tiredness or drowsiness.
  • drowsiness is frequently a factor in motor accidents, some drivers do not realise the extent of their tiredness until it is too late.
  • a means of keeping a driver alert over extended periods of time would therefore be extremely be worthwhile.
  • such means would be useful in many other situations, one such example being for keeping security guards alert who are required to monitor VDU screens.
  • the invention resides in a remedy for increasing alertness comprising a dressing for application to the body, wherein the dressing contains an aromatherapy oil.
  • the dressing of the alertness or "Awake” remedy comprises an aromatherapy oil containing one or more of the following oils; namely, bergamot, peppermint and basil (sweet) oils.
  • the dressing of the "Awake” remedy may comprise an aromatherapy oil containing one or more of the following oils; namely, rosemary, peppermint and sweet basil and grapefruit oils. While each of these essential oils individually is capable of increasing alertness, it is desirable to use a blend or mix of one or more of these oils.
  • the remedy may further include an amount of vetiver oil as the fixer or base oil. For enhanced effectiveness, it is further preferred to blend the active oils with a carrier oil, more especially with sweet almond oil.
  • the alertness remedy by means of the dressing even before the onset of drowsiness. Since the dressing may contain sufficient aromatherapy oil to last for several hours at a time, the remedy can often remain effective over the entire length of a journey.
  • the liver is particularly receptive to treatment by means of an aromatherapy dressing or patch.
  • the invention resides in a liver rejuvenation remedy comprising a dressing for application to the body, wherein the dressing contains an aromatherapy oil.
  • the liver rejuvenation remedy is applied externally to the body in the vicinity of the liver.
  • the liver rejuvenation remedy comprises a dressing including one or more essential oils selected from chamomile, especially German chamomile, lavender, frankincense, calendula and rose oils.
  • chamomile especially German chamomile, lavender, frankincense, calendula and rose oils.
  • a combination of one or more of the aforementioned essential oils is particularly preferred.
  • Sweet almond oil and borage seed oil are especially suitable for use as a carrier oil for the liver rejuvenation remedy, most preferably a mixture of these two oils are used.
  • Jet Lag Take-off Formula 1 drop of an essential oil mixture of peppermint, eucalyptus, grapefruit and vetiver oils blended with 2ml of a carrier oil mixture of sweet almond oil and wheatgerm oil.
  • Jet Lag "Sleep” Formula an essential oil mixture comprising 20ml of lavender, 5ml of roman chamomile, 10ml of clary sage, 5ml of geranium and 10ml of sweet marjoram, blended a carrier oil of 100ml of sweet almond oil.
  • Jet Lag "Alert” Formula an essential oil mixture of 15ml of rosemary, 5ml of peppermint, 15ml of grapefruit and 15ml of basil (linalol type), blended in a carrier oil of 100ml of sweet almond oil.
  • dressings containing specific formulations may be produced for relieving anxiety, insomnia, heartburn and premenstrual tension, for detoxification, revitalising and energising of the body, or for improving lung capacity to name but a few.

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne un dispositif conçu pour l'application topique d'huile aromathérapique sur le corps. Ce dispositif comporte un pansement imprégné d'huile aromathérapie ou comprenant de l'huile aromathérapique. L'application de ce pansement sur le corps résulte en un transfert de l'huile à la peau, ce qui permet à l'huile d'être ingérée à travers le derme. Ledit pansement se présente de préférence sous forme d'un disque transdermique adhésif, qui facilite le transfert de l'huile sur de longues périodes et permet d'éviter la perte d'huiles par évaporation. L'huile aromathérapique comprend idéalement une ou plusieurs huiles essentielles, mélangées avec une huile support. Non seulement cette huile facilite la pénétration de l'huile essentielle à travers la peau, mais elle renforce de façon synergique l'effet thérapeutique des huiles essentielles.
PCT/GB1997/002901 1996-10-23 1997-10-21 Pansement contenant des huiles essentielles WO1998017262A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU47150/97A AU4715097A (en) 1996-10-23 1997-10-21 Dressing containing essential oils
EP97909470A EP0949913A1 (fr) 1996-10-23 1997-10-21 Pansement contenant des huiles essentielles
CA002269599A CA2269599A1 (fr) 1996-10-23 1997-10-21 Pansement contenant des huiles essentielles

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9622109.8 1996-10-23
GBGB9622109.8A GB9622109D0 (en) 1996-10-23 1996-10-23 Dressing
GB9720479.6 1997-09-25
GBGB9720479.6A GB9720479D0 (en) 1996-10-23 1997-09-25 Dressing

Publications (1)

Publication Number Publication Date
WO1998017262A1 true WO1998017262A1 (fr) 1998-04-30

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ID=26310277

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1997/002901 WO1998017262A1 (fr) 1996-10-23 1997-10-21 Pansement contenant des huiles essentielles

Country Status (5)

Country Link
EP (1) EP0949913A1 (fr)
AU (1) AU4715097A (fr)
CA (1) CA2269599A1 (fr)
GB (1) GB9720479D0 (fr)
WO (1) WO1998017262A1 (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2340752A (en) * 1998-08-25 2000-03-01 Peter Gordon Dickson A medical dressing for use on wounds and ulcers on the skin
DE19957234A1 (de) * 1999-11-27 2001-06-28 Hexal Ag Pharmazeutisches Pflaster enthaltend ätherische Öle
GB2369055A (en) * 2000-10-25 2002-05-22 Joanna Maw Coloured essential oil skin patch
DE10063378A1 (de) * 2000-12-19 2002-06-20 Labtec Gmbh Aufkleber mit Verflüssigungsmittel für natürliche Atemwegssekrete
WO2002096446A2 (fr) * 2001-05-28 2002-12-05 Bionorica Ag Utilisation de plantes de la famille hypericum pour faciliter la synchronisation d'un rythme circadien
WO2003047557A3 (fr) * 2001-12-07 2003-09-18 Norbert Hoenzelaer Dispositif et timbre pour la liberation controlee de vanilline
US7235257B1 (en) * 1999-12-14 2007-06-26 Rohto Pharmaceutical Co., Ltd. Drugs for relieving hemicrania comprising 1-menthol and essential oils
EP1853247A2 (fr) * 2005-02-17 2007-11-14 Yon Doo Ough Timbre transdermique a parfum de savon et traitement pour le spasme et la douleur musculaire
EP2946775A1 (fr) * 2014-05-20 2015-11-25 LTS LOHMANN Therapie-Systeme AG Système thérapeutique transdermique contenant de l'huile de lavande

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3216609A1 (de) * 1982-05-04 1983-11-10 Dietic Dr. Widmann Pharma + Diät GmbH, 6930 Eberbach Pflaster-inhalat
GB2215208A (en) * 1988-02-01 1989-09-20 Egyt Gyogyszervegyeszeti Gyar Pharmaceutical compositions containing a plant extract
DE29707705U1 (de) * 1997-04-29 1997-07-03 Grueneis Ruediger Depigmentierungsmittel

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3216609A1 (de) * 1982-05-04 1983-11-10 Dietic Dr. Widmann Pharma + Diät GmbH, 6930 Eberbach Pflaster-inhalat
GB2215208A (en) * 1988-02-01 1989-09-20 Egyt Gyogyszervegyeszeti Gyar Pharmaceutical compositions containing a plant extract
DE29707705U1 (de) * 1997-04-29 1997-07-03 Grueneis Ruediger Depigmentierungsmittel

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2340752A (en) * 1998-08-25 2000-03-01 Peter Gordon Dickson A medical dressing for use on wounds and ulcers on the skin
DE19957234A1 (de) * 1999-11-27 2001-06-28 Hexal Ag Pharmazeutisches Pflaster enthaltend ätherische Öle
US7235257B1 (en) * 1999-12-14 2007-06-26 Rohto Pharmaceutical Co., Ltd. Drugs for relieving hemicrania comprising 1-menthol and essential oils
GB2369055A (en) * 2000-10-25 2002-05-22 Joanna Maw Coloured essential oil skin patch
DE10063378A1 (de) * 2000-12-19 2002-06-20 Labtec Gmbh Aufkleber mit Verflüssigungsmittel für natürliche Atemwegssekrete
WO2002096446A2 (fr) * 2001-05-28 2002-12-05 Bionorica Ag Utilisation de plantes de la famille hypericum pour faciliter la synchronisation d'un rythme circadien
WO2002096446A3 (fr) * 2001-05-28 2003-02-27 Bionorica Ag Utilisation de plantes de la famille hypericum pour faciliter la synchronisation d'un rythme circadien
WO2003047557A3 (fr) * 2001-12-07 2003-09-18 Norbert Hoenzelaer Dispositif et timbre pour la liberation controlee de vanilline
EP1853247A2 (fr) * 2005-02-17 2007-11-14 Yon Doo Ough Timbre transdermique a parfum de savon et traitement pour le spasme et la douleur musculaire
EP2946775A1 (fr) * 2014-05-20 2015-11-25 LTS LOHMANN Therapie-Systeme AG Système thérapeutique transdermique contenant de l'huile de lavande
WO2015176801A1 (fr) * 2014-05-20 2015-11-26 Lts Lohmann Therapie-Systeme Ag Système thérapeutique transdermique contenant de l'huile essentielle de lavante
CN107073058A (zh) * 2014-05-20 2017-08-18 Lts勒曼治疗系统股份公司 包含熏衣草油的透皮治疗系统

Also Published As

Publication number Publication date
AU4715097A (en) 1998-05-15
GB9720479D0 (en) 1997-11-26
CA2269599A1 (fr) 1998-04-30
EP0949913A1 (fr) 1999-10-20

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