WO1998011927A1 - Expulsion member for advancing the stopper of a syringe ampoule and a corresponding stopper - Google Patents

Expulsion member for advancing the stopper of a syringe ampoule and a corresponding stopper Download PDF

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Publication number
WO1998011927A1
WO1998011927A1 PCT/CH1996/000325 CH9600325W WO9811927A1 WO 1998011927 A1 WO1998011927 A1 WO 1998011927A1 CH 9600325 W CH9600325 W CH 9600325W WO 9811927 A1 WO9811927 A1 WO 9811927A1
Authority
WO
WIPO (PCT)
Prior art keywords
plug
driven member
characterized
stopper
according
Prior art date
Application number
PCT/CH1996/000325
Other languages
German (de)
French (fr)
Inventor
Jürg Steck
Christoph Renggli
Original Assignee
Disetronic Licensing Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Disetronic Licensing Ag filed Critical Disetronic Licensing Ag
Priority to PCT/CH1996/000325 priority Critical patent/WO1998011927A1/en
Publication of WO1998011927A1 publication Critical patent/WO1998011927A1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M5/31515Connection of piston with piston rod

Abstract

This invention concerns an expulsion member (1) for advancing the stopper (2) of a syringe ampoule (3) to administer liquid medicament (4). The stopper (2) has no orifice with an internal thread for taking up a drawing rod. The end of the expulsion member (1) is for seating against the tampon (2) is provided with elements (5, 6, 7, 8, 10, 12, 13) which make possible a frictional and/or interlocking connection with the stopper (2) with the exception of a threaded connection. This makes it possible to have the advantage of being able to easily use pre-filled ampoules with stoppers (2) without a threaded orifice for a drawing rod in an infusion apparatus.

Description

Driven member for advancing a plug of an injection ampoule and plug this.

The invention relates to a Abtriebεglied for the feed of a plug of an injection ampoule according to the preamble of claim 1 and a mating plug according to the preamble of patent claim 10.

Ξpritzampullen are substantially hollow-cylindrical containers which are closed on one side with a movable piston and on the other side by a Auslaεsstück.

From the prior art Infuεionεsysteme are known which support the drug to be administered in an injection -Ampulle, in which the drug is located between a movable plug and a piercing membrane. An output member moves the stopper towards the needle, characterized drug is joined by a connecting needle into the catheter. Once this catheter is filled with medicament, the front end of the catheter is directed into the body of an organism and an accurate dose drug may be administered.

The disadvantages of this arrangement are that can empty the vial by the force of the water column even in a certain height difference between the ampoule and the lower end of the catheter. This risk can be counteracted by designing the stopper of the injection ampoule, either by the friction between the wall of the glass ampoule and the plug is increased or the stopper is held in any way. The enlargement of the friction is not useful, because otherwise the infusion system has to spend too much energy to move the plug to encounter this up towards the needle. If the plug but kept from the output member, this drain can not enter by the force of the water column as the output member holds the plug in position.

There are also known plug rear holders for infusion devices in which the driven member being connectable with the stopper, that the stopper, for example, has a cylindrical opening at its rear end, in which the driven member can be inserted and connected. It concerns with the cylindrical opening drilled into a thread, so that the ampoule by means of a plunger rod can be filled first. If the ampoule filled, the plunger rod is screwed off and the ampoule in the infusion device (pump) is inserted and connected to the output member. In some of these known pump systems, the dispensing mechanism operates such that the threaded rod is rotatably and axially slidably, while the threaded nut is rotationally fixed and axially fixed. The rotating threaded rod is connected to the stopper such that a connecting element is placed onto the threaded rod, which is opposite the threaded rod rotatably but axially fixed, so that, although the threaded rod rotates, but not the connection element in the plug.

The situation is different in ampoules, which are used in an injection device. These ampoules are usually filled in advance so that there is no reason to provide the plug with a threaded bore for a plunger rod. Now if such a prefilled vial are used in an infusion device, there is no connectivity driven member stopper.

The invention aims to provide a remedy. The invention has for its object to provide a driven member for a plug, so that a frictional and / or positive retaining connection can be produced between the stopper of a vial and an output member. Furthermore the invention is based to provide a plug for frictional and / or form-locking connection with a driven member according to the invention the task. The invention solves the task with an output member, comprising the features of claim 1, and a plug which demonstration of the features of claim 10.

The advantage is achieved that pre-filled vials whose plugs have not threaded bore for a plunger rod can also be used in an infusion device without difficulty.

The invention and further developments of the invention are explained below with reference to the partially schematic illustrations of several embodiments thereof in more detail. Show it:

Figure l is a longitudinal section through a pre-filled injection ampoule with a plug without a thread bore. -

Figure 2 is an inventive driven member with a mandrel for the stopper of the injection ampoule of FIG. 1.

FIG. 2a shows an inventive driven member having a roof-shaped needle for the stopper of the injection ampoule of FIG. 1; Fig. 3 shows a variant of the inventive output member with a suction cup;

Fig. 4 shows a variant of the inventive output member with an adhesive,

Figure 5 is a partial longitudinal section through a pre-filled injection ampoule with a plug with magnet.

6 shows an inventive driven member with a magnet for the stopper of the injection ampoule of FIG. 5.

Figure 7 is a partial longitudinal section through a pre-filled injection ampoule with a plug with Velcro.

Figure 8 shows an inventive driven member with a Velcro closure for the stopper of the injection ampoule of FIG. 7.

9 shows an inventive driven member with a self-tapping screw for the plug of the injection ampoule of FIG. 1.

Figure 10 is a partial longitudinal section through a pre-filled injection ampoule with a plug with a click lock. and Fig. 11 shows an inventive driven member with a snap lock for the stopper of the injection ampoule according to Fig. 10.

The driven member 1 shown in Fig. 2 is used to feed a plug shown in FIG. 1 2 3 a spray ampoule for dispensing a liquid medicament 4, wherein the stopper 2 does not have a bore with an internal thread for receiving a plunger rod.

The particular for bearing against the plug 2 the end of the driven member 1 is provided with means 5, which allow a positive and / or positive connection with the plug 2, with the exception of a threaded connection.

As means 5 are very generally suitable elements having a tip as shown in FIGS. 2 and 2a. The plug 2 of the spray ampoule 3 is normally made of rubber. It is therefore possible to penetrate with a pointed object into the rubber. When the delivering mechanism configured so that the threaded rod in a rotationally fixed and axially displaceable, only the plug 2 to the facing end of the output member with a tip must be designed and the tip are pushed into the plug. 2 Is the delivery mechanism of the infusion system configured such that the threaded rod is rotatable and axially movable, the tip is for connecting the output member with the plug 2 at the, the plug 2 facing the end of the connecting element.

Preferably, the shape of the pointed object is a roof-shaped needle (Fig. 2a). By the roof shape is made possible that the needle during penetration into the plug 2 is not - as would be the case with a one-sided bevel grinding - slides in a certain direction.

A needle is inserted into the rubber stopper, parts of the rubber stopper enter the hollow part of the needle, ie the penetrating displaces only the portion of the plug during a spike, found in the same movement of a needle less displacement instead because rubber parts from entering the needle can. This of course assumes a certain sharpness of the edges of the needle. The displacement of the rubber composition upon penetration of the mandrel causes a force which the spike out of the stopper urges addition (displacement force = V).

The force which drives the mandrel from the plug (V), therefore musε be smaller than the friction (R ^), which exists between the mandrel and rubber paste. At the same time, the friction has to withstand a water column (W) of a certain magnitude. The force of the water column (W) and displacement of the mandrel (V) are to be added and must be less than the friction between the outer surface of the mandrel and rubber stopper (R d) and between the rubber stopper and inner wall of the ampoule (R a):

V + W ≤ (R d) + (R a)

(Fig. 2a) below the tip increases, and then decreases towards the connecting element - is also increased the friction between the rubber stopper and stopper 2 when the outer diameter of the pointed object - as usual at a peak. Accordingly, ideal is a roof-shaped needle whose outer diameter below the roof against which the tip opposite end, decreases.

As shown in FIG. 9 may instead of a mandrel or needle 5, a screw 12 provided as means for connection to the plug 2. The advantage of a self-tapping screw corresponds to that of a nail with respect to a screw, - a separation of the connected portions thereby requires a grδsseren expenditure of force. Conveniently, such a threaded connection is primarily used together with a non-rotatable threaded rod, because the screw 12 is welded to a rotatable Verbindungselernent in a rotatable threaded rod, therefore, in the latter embodiment, the screw could be threaded 12 with additional auxiliary elements in the plug. 2 As shown in Fig. 3, a suction cup 6 can be provided as a means for connection to the plug 2 instead of a Th s or a needle. 5 The advantage of this solution over a pin or a screw, is that neither the plug 2 is violated, yet the user can get hurt. Another advantage of this type of connection is that the suction cup 6, and thus, depending on the connection suction cup-threaded rod, the threaded rod (as opposed to solutions that require adhesive) can be used again.

The maximum outer diameter of the suction cup 6 is slightly smaller than the inside diameter of the ampoule. The surface of the plug 2 should be as smooth as possible.

As shown in Fig. 4, a glue 7 can be provided as means for connection to the plug 2. In this solution, the advantage - compared with a pointed object or screw and - the fact that neither the plug 2 is violated, yet the user can get hurt. Preferably, an adhesive 7 is used, which can be connected to different materials. Furthermore, the drug resistance should be guaranteed. In this connection it must be assumed that the threaded rod is not used again because a solution from the plug 2 or only under difficult conditions, is possible. To simplify design the application, the adhesive 7 may be already attached to the threaded rod (or on the plug 2) and secured with a cover prior to dehydration.

5 and 6. As shown in Fig., a magnet can be provided 8 as a means for connection to the plug 2. In principle, it is sufficient if either the threaded rod or the plug 2 is magnetic, while the remaining portion may be magnetic, or even a piece of metal. The magnet 8 - or even just a piece of metal - can be located in or on the plug. 2 The advantage of this design is that the threaded rod can be reused. The threaded rod may itself be magnetic or provided with a further magnet 9 (FIG. 5).

As shown in FIGS. 7 and 8, a hook and loop fastener may be provided as a means 10,11 for connection to the plug 2. The advantage of this design is that the threaded rod can be reused. The above-mentioned adhesive can, the two parts of the hook and loop fastener 10,11 are on the plug 2 and to be attached to the threaded rod. Common Velcro fasteners sold under the trademark VELCRO ™.

10 and 11 as shown in Figs. Klickver- a circuit may be provided as a means 13,14 for connection to the plug 2. Also in this embodiment, the threaded rod can be reused. The snap fastener 13,14 may be implemented in verschiedenster manner. However, should not be forgotten for decoupling the plug 2 and threaded rod that the plug 2 at the lowest end of the ampoule is when the threaded rod to be decoupled. It is therefore primarily axial movement, by which the plug 2 and threaded rod separately. The snap fastener is composed of a 13,14 mounted on the threaded rod 13 and a spherical body attached to the plug 2 concave receptacle body 14 for the ball body. 13

In summary it can be noted that all the solutions, which do not lead to any intrusion of an object into the plug 2, have the advantage that neither stopper 2 yet the user will be injured.

Claims

1. driven member (1) for the feed of a stopper (2) of an injection ampoule (3) for dispensing a liquid drug (4), said plug (2) does not have internally threaded bore for receiving a plunger rod has, characterized in that the to bear against the plug (2) specific end of the driven member (1) is provided with means (5,6,7,8,10,12,13) ​​which has a frictional and / or positive connection with the plug (2) enable, with the exception of Ge indeVerbindung.
2. driven member (1) according to claim 1, characterized in that the means (5,6,7,8,10,12,13) ​​positively connected to the plug (2) can be connected.
3. driven member (1) according to claim 2, characterized in that the means comprise at least one mandrel (5) or a spike or a needle, preferably a roof-shaped needle which is piercable in the plug (2).
4. driven member (1) according to claim 2, characterized in that the means at least one suction cup (6), which the stopper (2) is attachable by vacuum.
5. driven member (1) according to claim 2, characterized in that the means comprise an adhesive (7) with which a Kraftschlusε between the driven member (1) and plug (2) can be produced.
6. driven member (1) according to claim 2, characterized in that the means comprise at least one magnet (8), which is preferably mounted on a plug (2) the second magnet (9) is non-positively connected.
7. driven member (1) according to claim 2, characterized in that said means comprise a Velcro fastener (10) comprise the mounted with a plug at (2) the second hook and loop fastener (11) is non-positively connected.
8. driven member (1) according to claim 1, characterized in that for abutment against the stopper (2) specific end of the driven member (1) with a self-tapping screw (12) is provided which can be screwed into the plug (2).
9. driven member (1) according to claim 1, characterized in that for abutment against the stopper (2) specific end of the driven member (1) is provided with a closure part (13) of a click closure provided, which mounted in a on the plug (2) , corresponding closure part (14) of the click closure is clicked in.
10. plug (2) of an injection ampoule (3) for dispensing a liquid drug (4), said plug (2) does not have internally threaded bore for receiving a plunger rod has, for frictional and / or positive connection with an output member (1 ) according to claim 1 - characterized 9 that the particular the (for abutment against the driven member 1) side of the plug (2) with means (9; 14) is provided, which form-fitting a non-positive and / or; 11 connection with the output member
(I) allow, with the exception of a threaded connection.
11. plug (2) according to claim 10, characterized in that the means (9 * 11 * 14) comprises a magnet (9), a velcro
(II) or a closure member (14) comprise a click closure.
12, plug (2) according to claim 10, characterized in that the means (9; 11; 14) comprise an adhesive (7), with which a frictional connection between the plug (2) and output member (1) can be produced.
PCT/CH1996/000325 1996-09-20 1996-09-20 Expulsion member for advancing the stopper of a syringe ampoule and a corresponding stopper WO1998011927A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/CH1996/000325 WO1998011927A1 (en) 1996-09-20 1996-09-20 Expulsion member for advancing the stopper of a syringe ampoule and a corresponding stopper

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CH1996/000325 WO1998011927A1 (en) 1996-09-20 1996-09-20 Expulsion member for advancing the stopper of a syringe ampoule and a corresponding stopper

Publications (1)

Publication Number Publication Date
WO1998011927A1 true WO1998011927A1 (en) 1998-03-26

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EP1078643A1 (en) * 1999-08-13 2001-02-28 CANE' S.r.l. Apparatus for administering drugs to a patient
WO2002096487A1 (en) * 2001-05-30 2002-12-05 Acist Medical Systems, Inc. Medical injection system
EP1455870B1 (en) * 2001-12-06 2007-08-08 Novo Nordisk A/S A medical delivery system
EP1897575A2 (en) * 2000-07-20 2008-03-12 ACIST Medical Systems, Inc. Syringe plunger locking mechanism
WO2008103175A1 (en) * 2007-02-22 2008-08-28 M2 Group Holdings, Inc. Portable infusion pump with flexible piston rod
WO2009153544A1 (en) * 2008-06-19 2009-12-23 Cilag Gmbh International Auto- injector with filling means
US8118781B2 (en) 2006-04-19 2012-02-21 Novo Nordisk A/S Fluid infusion system, a method of assembling such system and drug reservoir for use in the system
US8277414B2 (en) 2004-05-28 2012-10-02 Cilag Gmbh International Injection device
US8313465B2 (en) 2004-05-28 2012-11-20 Cilag Gmbh International Injection device
US8313463B2 (en) 2004-05-28 2012-11-20 Cilag Gmbh International Injection device
US8313464B2 (en) 2004-05-28 2012-11-20 Cilag Gmbh International Injection device
US8343110B2 (en) 2004-05-28 2013-01-01 Cilag Gmbh International Injection device
US8551045B2 (en) 2006-04-19 2013-10-08 Novo Nordisk A/S Fluid infusion system, a method of assembling such system and drug reservoir for use in the system
US8834419B2 (en) 2008-06-19 2014-09-16 Cilag Gmbh International Reusable auto-injector
US8834420B2 (en) 2007-05-21 2014-09-16 Asante Solutions, Inc. Illumination instrument for an infusion pump
US8852141B2 (en) 2007-05-21 2014-10-07 Asante Solutions, Inc. Occlusion sensing for an infusion pump
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US9295777B2 (en) 2002-11-05 2016-03-29 Bigfoot Biomedical, Inc. Disposable wearable insulin dispensing device, a combination of such a device and a programming controller and a method of controlling the operation of such a device
US9308319B2 (en) 2002-11-05 2016-04-12 Bigfoot Biomedical, Inc. Wearable insulin dispensing device, and a combination of such a device and a programming controller
US9314569B2 (en) 2005-09-26 2016-04-19 Bigfoot Biomedical, Inc. Dispensing fluid from an infusion pump system
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US9457141B2 (en) 2013-06-03 2016-10-04 Bigfoot Biomedical, Inc. Infusion pump system and method
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US9539388B2 (en) 2005-09-26 2017-01-10 Bigfoot Biomedical, Inc. Operating an infusion pump system
US9561324B2 (en) 2013-07-19 2017-02-07 Bigfoot Biomedical, Inc. Infusion pump system and method
US9610404B2 (en) 2011-09-07 2017-04-04 Bigfoot Biomedical, Inc. Method for occlusion detection for an infusion pump system
US9629901B2 (en) 2014-07-01 2017-04-25 Bigfoot Biomedical, Inc. Glucagon administration system and methods
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EP1078643A1 (en) * 1999-08-13 2001-02-28 CANE' S.r.l. Apparatus for administering drugs to a patient
EP1897575A3 (en) * 2000-07-20 2008-03-19 ACIST Medical Systems, Inc. Syringe plunger locking mechanism
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EP1455870B1 (en) * 2001-12-06 2007-08-08 Novo Nordisk A/S A medical delivery system
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US9308319B2 (en) 2002-11-05 2016-04-12 Bigfoot Biomedical, Inc. Wearable insulin dispensing device, and a combination of such a device and a programming controller
US9675758B2 (en) 2004-05-28 2017-06-13 Cilag Gmbh International Injection device
US8277414B2 (en) 2004-05-28 2012-10-02 Cilag Gmbh International Injection device
US8313465B2 (en) 2004-05-28 2012-11-20 Cilag Gmbh International Injection device
US8313463B2 (en) 2004-05-28 2012-11-20 Cilag Gmbh International Injection device
US8313464B2 (en) 2004-05-28 2012-11-20 Cilag Gmbh International Injection device
US8343110B2 (en) 2004-05-28 2013-01-01 Cilag Gmbh International Injection device
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