WO1998003653A3 - Procede de preparation d'organes de mammiferes non humains transgeniques en vue de leur transplantation chez l'homme, et sequences nucleotidiques pour la mise en oeuvre de ce procede - Google Patents

Procede de preparation d'organes de mammiferes non humains transgeniques en vue de leur transplantation chez l'homme, et sequences nucleotidiques pour la mise en oeuvre de ce procede Download PDF

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Publication number
WO1998003653A3
WO1998003653A3 PCT/FR1997/001340 FR9701340W WO9803653A3 WO 1998003653 A3 WO1998003653 A3 WO 1998003653A3 FR 9701340 W FR9701340 W FR 9701340W WO 9803653 A3 WO9803653 A3 WO 9803653A3
Authority
WO
WIPO (PCT)
Prior art keywords
transplantation
nucleotide sequences
humans
transgenic non
human mammalian
Prior art date
Application number
PCT/FR1997/001340
Other languages
English (en)
Other versions
WO1998003653A2 (fr
Inventor
Bernard Vanhove
Christine Pourcel
Jean-Paul Soulillou
Original Assignee
Inst Nat Sante Rech Med
Bernard Vanhove
Christine Pourcel
Soulillou Jean Paul
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Nat Sante Rech Med, Bernard Vanhove, Christine Pourcel, Soulillou Jean Paul filed Critical Inst Nat Sante Rech Med
Priority to EP97935592A priority Critical patent/EP0914434A2/fr
Priority to JP10506648A priority patent/JP2000516804A/ja
Priority to AU38525/97A priority patent/AU3852597A/en
Publication of WO1998003653A2 publication Critical patent/WO1998003653A2/fr
Publication of WO1998003653A3 publication Critical patent/WO1998003653A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/108—Swine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • A01K2267/025—Animal producing cells or organs for transplantation
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention a pour objet l'utilisation de séquences nucléotidiques codant pour des anticorps dirigés contre toute molécule impliquée dans un phénomène de rejet de greffe (encore désignés ci-après anticorps anti-molécules), pour la préparation de cellules transgéniques, ou organes transgéniques, de mammifères non humains, au sein desquels lesdites molécules forment en totalité ou en partie des complexes immuns avec lesdits anticorps anti-molécules, de telle sorte que l'activité desdites molécules dans les phénomènes de rejet de greffe soit totalement ou partiellement inhibée, lesdites cellules ou lesdits organes transgéniques de mammifères non humains étant destinés à être greffés chez un patient.
PCT/FR1997/001340 1996-07-19 1997-07-18 Procede de preparation d'organes de mammiferes non humains transgeniques en vue de leur transplantation chez l'homme, et sequences nucleotidiques pour la mise en oeuvre de ce procede WO1998003653A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP97935592A EP0914434A2 (fr) 1996-07-19 1997-07-18 Procede de preparation d'organes de mammiferes non humains transgeniques en vue de leur transplantation chez l'homme, et sequences nucleotidiques pour la mise en oeuvre de ce procede
JP10506648A JP2000516804A (ja) 1996-07-19 1997-07-18 トランスジェニック非ヒト哺乳動物臓器のヒトへの移植の目的のためのそれらの調製方法およびその方法を実施するためのヌクレオチド配列
AU38525/97A AU3852597A (en) 1996-07-19 1997-07-18 Method for preparing transgenic non-human mammalian organs for transplantation to humans, and nucleotide sequences therefor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9609077A FR2751346A1 (fr) 1996-07-19 1996-07-19 Procede de preparation d'organes de mammiferes non humains transgeniques en vue de leur transplantation chez l'homme, et sequences nucleotidiques pour la mise en oeuvre de ce procede
FR96/09077 1996-07-19

Publications (2)

Publication Number Publication Date
WO1998003653A2 WO1998003653A2 (fr) 1998-01-29
WO1998003653A3 true WO1998003653A3 (fr) 1998-03-26

Family

ID=9494242

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR1997/001340 WO1998003653A2 (fr) 1996-07-19 1997-07-18 Procede de preparation d'organes de mammiferes non humains transgeniques en vue de leur transplantation chez l'homme, et sequences nucleotidiques pour la mise en oeuvre de ce procede

Country Status (6)

Country Link
EP (1) EP0914434A2 (fr)
JP (1) JP2000516804A (fr)
AU (1) AU3852597A (fr)
CA (1) CA2258872A1 (fr)
FR (1) FR2751346A1 (fr)
WO (1) WO1998003653A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9825555D0 (en) * 1998-11-20 1999-01-13 Imp College Innovations Ltd Suppression of xenotransplant rejection
US6787638B1 (en) * 1998-12-02 2004-09-07 Applied Molecular Evolution, Inc. Tumor specific human monoclonal antibodies and methods of use
US6399578B1 (en) 1998-12-09 2002-06-04 La Jolla Pharmaceutical Company Conjugates comprising galactose α1,3 galactosyl epitopes and methods of using same
EP1539235A2 (fr) 2002-07-01 2005-06-15 Human Genome Sciences, Inc. Anticorps qui se lient specifiquement a reg iv
JP4738101B2 (ja) * 2005-08-29 2011-08-03 花王株式会社 吸収性シート

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0378188A1 (fr) * 1989-01-11 1990-07-18 Konica Corporation Galactosyltransférase humaine associée au cancer, son usage et moyens de diagnostic
WO1994021799A1 (fr) * 1993-03-16 1994-09-29 Austin Research Institute UTILISATION DE GALα (1,3) GALACTOSYL-TRANSFERASE PORCINE DANS LE TRAITEMENT DE XENOGREFFES
WO1994025586A1 (fr) * 1993-04-30 1994-11-10 The Scripps Research Institute Animaux transgeniques a reponse immunitaire obtenue par genie genetique
WO1995020661A1 (fr) * 1994-01-27 1995-08-03 Bresatec Ltd. Procedes et substances destines a la prise en charge du rejet hyperaigu suite a une heterogreffe chez l'homme
WO1995024495A1 (fr) * 1994-03-09 1995-09-14 Abbott Laboratories Production transgenique d'oligosaccharides et de glycoconjugues
WO1995033828A1 (fr) * 1994-06-03 1995-12-14 Diacrin, Inc. Modification cellulaire et procedes d'inhibition des reactions suraigues de rejet des xenogreffes

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0378188A1 (fr) * 1989-01-11 1990-07-18 Konica Corporation Galactosyltransférase humaine associée au cancer, son usage et moyens de diagnostic
WO1994021799A1 (fr) * 1993-03-16 1994-09-29 Austin Research Institute UTILISATION DE GALα (1,3) GALACTOSYL-TRANSFERASE PORCINE DANS LE TRAITEMENT DE XENOGREFFES
WO1994025586A1 (fr) * 1993-04-30 1994-11-10 The Scripps Research Institute Animaux transgeniques a reponse immunitaire obtenue par genie genetique
WO1995020661A1 (fr) * 1994-01-27 1995-08-03 Bresatec Ltd. Procedes et substances destines a la prise en charge du rejet hyperaigu suite a une heterogreffe chez l'homme
WO1995024495A1 (fr) * 1994-03-09 1995-09-14 Abbott Laboratories Production transgenique d'oligosaccharides et de glycoconjugues
WO1995033828A1 (fr) * 1994-06-03 1995-12-14 Diacrin, Inc. Modification cellulaire et procedes d'inhibition des reactions suraigues de rejet des xenogreffes

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
J. MARKS ET AL.: "By-passing immunization. Human antibodies from V-gene libraries displayed on phage.", JOURNAL OF MOLECULAR BIOLOGY, vol. 222, no. 3, 1991, LONDRES, GRANDE BRETAGNE, pages 581 - 597, XP000670314 *
K. MCCURRY ET AL.: "Human complement regulatory proteins expressed in transgenic swine protect swine xenografts from humoral injury.", TRANSPLANTATION PROCEEDINGS, vol. 28, no. 2, April 1996 (1996-04-01), NEW YORK, NY, ŸTATS-UNIS, pages 758, XP000644542 *
K. STRAHAN ET AL.: "cDNA sequence and chromosome localization of pig alpha1,3 galactosyltransferase.", IMMUNOGENETICS, vol. 41, no. 2/3, 1995, BERLIN, ALLEMAGNE, pages 101 - 105, XP000670235 *
M. SANDRIN ET AL.: "Anti-pig IgM antibodies in human serum react predominantly with Gal(alpha1,3)Gal epitopes.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE USA, vol. 90, no. 23, 1 December 1993 (1993-12-01), WASHINGTON, DC, ŸTATS-UNIS, pages 11391 - 11395, XP000561954 *

Also Published As

Publication number Publication date
CA2258872A1 (fr) 1998-01-29
FR2751346A1 (fr) 1998-01-23
EP0914434A2 (fr) 1999-05-12
AU3852597A (en) 1998-02-10
WO1998003653A2 (fr) 1998-01-29
JP2000516804A (ja) 2000-12-19

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