WO1998001107A1 - Compositions cosmetiques hydratantes et protectrices pour la peau - Google Patents

Compositions cosmetiques hydratantes et protectrices pour la peau Download PDF

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Publication number
WO1998001107A1
WO1998001107A1 PCT/BR1997/000025 BR9700025W WO9801107A1 WO 1998001107 A1 WO1998001107 A1 WO 1998001107A1 BR 9700025 W BR9700025 W BR 9700025W WO 9801107 A1 WO9801107 A1 WO 9801107A1
Authority
WO
WIPO (PCT)
Prior art keywords
weight
usual
titanium dioxide
moisturizing
agent
Prior art date
Application number
PCT/BR1997/000025
Other languages
English (en)
Inventor
Almir Stork Nunes
Simoni Chitarra Souza
Luiz Gustavo Martins Matheus
Original Assignee
Indústria e Comércio de Cosméticos Natura Ltda.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indústria e Comércio de Cosméticos Natura Ltda. filed Critical Indústria e Comércio de Cosméticos Natura Ltda.
Priority to EP97935379A priority Critical patent/EP0859589A1/fr
Publication of WO1998001107A1 publication Critical patent/WO1998001107A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/29—Titanium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations

Definitions

  • the present invention refers to skin moisturizing and protective cosmetic compositions against ultraviolet and infrared radiation, which contain natural origin melanin pigment as free radicals capturer.
  • UV ultraviolet radiation
  • UV rays are responsible for collagen fibers destruction and for abnormal elastic fibers production, besides promoting alterations on the dermal microvascularization.
  • the skin suffers degeneration in its structure and abnormalities in its normal pigmentation process.
  • the free radicals formation has an important role in the so called photoaging, due to the attack upon the cutaneous tissue structural molecules as much as due to their self-defense implication, the antioxidant mechanisms.
  • the new solar protection compositions comprise filters with a much wider protection spectrum, considering also infrared (IR) radiation, whose main biological manifestation is felt in form of heat. Recent studies showed the high damaging potential that this solar spectrum range can cause in synergy with UV radiation.
  • IR infrared
  • the natural origin melanin is also included in the photoprotectives. This compound, skin's normal defense essential substance, is responsible for sunlight absorption and reflection mechanisms, and is capable of promoting free radicals stabilization, which are generated by the incident radiation.
  • the flavonoids contained in a vegetable extract of considerable anti- inflammatory and antiradicals actions.
  • the solar spectrum reaching earth's surface is formed by visible light (400 to 700 nm), infrared radiation (700 to 3000 nm) and, in last instance, microwaves and radio waves
  • visible light 400 to 700 nm
  • infrared radiation 700 to 3000 nm
  • microwaves and radio waves The radiations exhibiting the longer wave lengths are the ones with deeper cutis penetration, being almost able of crossing it
  • the biological response against IR radiation (which promotes a molecules vibration) is specifically given as a temperature increase For wave lengths longer than 800 nm, occurs also a photochemical reaction similar to UV
  • IR rays increase the damages that would be caused only by UV rays formation of elastic fibers much different from those resulting in actinic elastosis (they are thinner, being similar to feathers), influence over the dermal collagen quantity with a mucopolysacchandes concentration increase (proportional to irradiation period) and damages in the cellular DNA structure and its restoring mechanism (IR exclusive action), what contributes to an oncogenic action
  • the acute IR radiation exposition promotes epidermis pidic bilayer thickness reduction, erythema with blood vessels dilatation, mastocytes granulation (cells of the organism defense system) and free arachidonic acid and prostaglandines concentration increase, these are mediator agents of the radiation induced inflammatory response
  • the chronic exposition can cause solar elastosis and lead to cutaneous aging due to actinic action
  • IR and UV radiations effects are difficult of being separately considered they exhibit synergetic actuation on photoagmg and photocarcinogenesis
  • the knowledge of the damaging effects caused by this non-ionizing radiation obliges technological development in direction to the manufacturing of products also conside ⁇ ng this IR radiation
  • the active component selected to exert IR protective function is a mineral pigment, capable of reflecting this radiation Basically, it is a titanium dioxide micronized particle, coated with mica (10 to 60 ⁇ m diameter), commercially known as Timiron Super Red ® (Merck).
  • the reflective agent is capable of producing a 5 to 7°C temperature reduction on the cutaneous surface.
  • the melanins are organic polymers exhibiting several conjugated double bindings, so that they perform light absorption in the UV, visible light and IR ranges. Specifically, these wide spectrum pigments perform an uniform UVA radiation absorption, exerting an important role in the direct photoprotection related to this spectrum range.
  • the melanin added to the photoprotectives contained in the new solar composition is a natural product obtained through the refinement of cephalopods tincture: Sepia Melanilna ® (Melco). It is a non-toxic and hypoallergenic product. It is a photoprotector agent and free radicals capturer, produced by sunlight. Its main actions are:
  • Antioxidant protects the cells against oxygen metabolites, inhibiting the lipidic peroxidation and exerting an important protective role against oxidative protean damage. In a 0,25% concentration, is capable of inhibiting 71% of the substrate oxidation process. For a brief comparison, 0,10% of vitamin E acetate (considered one of the best antioxidizing agents) reduces the oxidation process in 89%.
  • Free radicals capturer melanin is considered a stable free radical; consequently exhibits an electrons exchange ability. This property enables it to "neutralize" free radicals which can cause cell damage.
  • Photoprotection actuates against erythema, actinic aging and skin cancer. Acts together with other filters, helping in the SPF value increase.
  • UVB filters + melanin are excellent protectives against UVA and UVB radiation and lipidic peroxidation, promoting a 15% reduction in the damages caused by UVA rays and a 96,58% reduction in the damages caused by UVB rays.
  • the bioflavonoids (rutin, quercitol, rhamnetol, esculin) are protection factors derived from vitamin P, which are concerned in the capillary permeability process. They exhibit properties against skin aging, inhibiting the action of enzymes responsible for conjunctive tissue degradation (collagenase, elastosis, hyaluronidase). They stimulate the cells mitotic potential and exhibit antiradicals, scaring, repairing and re-balancing properties for the skin damaged by the sun.
  • the solar exposition promotes a skin tissue temperature increase, resulting in perspiration, leading to water and mineral loss.
  • seaweeds extract As hydrophilic agents for the reposition of the lost hydration, minerals contained in seaweeds extract were chosen: selenium, zinc, chrome, calcium, magnesium, silicon, fluorine, nickel and cobalt. These elements, also known as oligoelements, participate in the cells normal growth, in the synthesis of proteins precursors and codifiers (RNA and DNA), in the synthesis (zinc and silicon) and transformation (copper) of tropocollagen in collagen, in the transformation of keratin precursor in keratin in the corneal layer and in the electrons transportation in the respiratory chain.
  • the seaweeds extract active components supply water and electrolytes to the conjunctive tissue, conferring skin turgidity and firmness, increasing skin tension and improving its elasticity. They also react with the corneal layer amino groups, forming protective pellicles and reducing the transepidermal water loss.
  • the present invention refers, in particular, to anti-solar emulsions, for skin protection against aggressions caused by UVB, UVA and IR radiation. They have moisturizing function and their differential is based on the antiradicals action.
  • the main active component is melanin, of natural origin. They are water-resistant products.
  • compositions are manufactured through usual processing techniques, exception made to the powders dispersion, which requires special attention to avoid posterior agglomeration.
  • the oily phase or, better, the non-aqueous phase shall be previously heated at 80°C and, together with titanium dioxide, be submitted to a high efficiency homogenizer, in order to guarantee total pigment dispersion.
  • the coated particle shall not be submitted to trituration.
  • the already dispersed oily phase should be added to the aqueous phase, so that it is possible to proceed to emulsification.
  • the product should be cooled down at 45°C for the IR filter and melanin incorporation, in order to guarantee these active components action.
  • the process termination is done through the addition of the remaining formulation ingredients.
  • the invention provides fluid emulsions, lightly pigmented (brownish), not oily, not fatty and of easy spreading, in order to guarantee the uniformity of the protective film applied onto the skin.
  • This photoprotectives line contains chemical filters, that protect the skin against the damages caused by UVB and UVA radiation (absorption).
  • the physical filters with a wider spectrum, are UVB, UVA and IR radiation reflectors.
  • the natural melanin in synergy with vitamin E, confers the product free radicals capturing action, neutralizing unstable molecules and avoiding the formation of new ones (chain reaction).
  • the moisturizing action occurs through oligoelements reposition (micronutrients), which are lost together with the transepidermal water loss (TEWL) when the skin is exposed to the sun (excessive drying).
  • oligoelements reposition micronutrients
  • TEWL transepidermal water loss
  • compositions contain, besides their active components, additional materials or additives. These are added to guarantee formulation physicochemical and microbiological stability, as also a pleasant sensorial when the product is applied to the skin.
  • the additional materials constituting the formulation vehicle include sequestering, antioxidant and preservative agents, emollients, thickeners/ neutralizers and emulgators, already known by themselves, that can be solid or liquid. Examples of each of these components, that can be used associated or separately, and their usage concentration, include:
  • Sequestering agent 0,05 to 0,50%
  • BHT butyl hydroxytoluene
  • BHA butyl hydroxyanisole
  • emollients we can name isopropyl isostearate, isobutyl palmitate, isocetyl stearate, octyl palmitate, isopropyl laurate, cetyl lactate, isopropyl linoleate, palmitic acid, oleic alcohol, octadecanol, behenyl alcohol, cetyl palmitate, octyl isostearate, isopropyl stearate, alkyl benzoate, mineral oil, lanolin alcohols and derivatives, waxes and vegetable oils, and silicone and their derivatives.
  • sorbitan As emulgators, we can name sorbitan, glycerol, waxes and phosphated fatty amines derivatives, acrylic polymers, polyoxiethylenes, polyethylene glycols derivatives, with or without neutralization.
  • thickeners we can name carboxyvinyl polymers, gums, starches, modified aluminium and magnesium silicates, alkylaryl ammonium, esmectitas, cellulose derivatives, hydrated aluminium silicates.
  • EDTA ethylenediamine tetraacetic acid
  • ethydronic acid ethydronic acid
  • deferrioxamine lactoferrine
  • SPF 4 chemical filter: octyl metoxycinnamate2, 000-4, 000% chemical filter: butyl metoxy dibenzoyl methane0,200-1,000% chemical filter: benzophenone 30,500-1 ,000% physical filter: coated titanium dioxide 0,000-1 ,000% physical filter IV: titanium dioxide and mica 0,500-1,000% antiradicals agent: natural melanin0,005-1 ,000% antiradicals/moisturizing agent:0, 100-2,000% moisturizing agent: oligoelementsO, 500-5, 000% SPF 8: chemical filter: octyl metoxycinnamate3, 000-6,000% chemical filter: butyl metoxy dibenzoyl methanel , 000-2,000% chemical filter: benzophenone 31,000-3,000% physical filter: coated titanium dioxide 1 ,000
  • antiradicals agent natural melanin0,005-1,000%
  • moisturizing agent oligoelements0,500-5,000% Summing up the referred active components, we obtain the following minimal and maximal values for the four above mentioned types, being: 3,805 to 16,000% for SPF 4 7,105 to 22,000% for SPF 8 11 ,605 to 28,000% for SPF 15 14,605 to 34,000% for SPF 30
  • the SPF 4 type will be completed with these usual additives, whose conjoint ratio will vary between 96,195% to 84,000%, by weight, in order to complete global composition's 100%.
  • the SPF 8 type will be completed with 92,895% to 78,000%, by weight, of these additives.
  • SPF 15 type composition 88,395% to 72,000%, by weight, of the referred formulation additives will be added.
  • SPF 30 type composition 85,395% to 66,000%, by weight, will be added.
  • the first step is the preparation of two phases: an oily phase, in other words, not exactly aqueous, and an aqueous phase.
  • the oily phase non-aqueous, is prepared first, with the addition of surfactant agent, if suitable, and titanium dioxide pigment (without coating), including heating and mechanical homogenization.
  • the aqueous phase also heated at 80°C, and containing the completing ingredients, specially the emulsifying agent, is added to this first prepared oily phase.
  • the solar protection compositions were submitted to usual dermatological tests, which include primary and accumulated dermal irritability, sensitization, phototoxicity and photoallergy. These tests, when exhibiting favorable results as in this present case, guarantee the products innocuousness and confer them the condition of "dermatologist tested”. The products were also submitted to the comedogenicity test, what confers the products the status of "not comedogenic”.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention a trait à des compositions cosmétiques hydratantes et protectrices pour la peau contre les rayonnements ultraviolet et infrarouge, comprenant une nouvelle association de composants actifs, préparés avec des excipients et des additifs déjà connus. Spécifiquement, lesdites compositions contiennent un ensemble de composants actifs comprenant: (a) un filtre physique constitué de dioxyde de titane enrobé et/ou de dioxyde de titane et de mica, généralement dans des proportions variant entre 0,5 % et 6 % en poids; (b) un filtre chimique, constitué d'au moins un composant d'un groupe constitué d'octylméthoxycinnamate, de méthoxy-dibenzoylméthane de butyle, de benzophénone 3, généralement dans des proportions variant entre 2,7 % et 20 % en poids; (c) un agent anti-radicaux, comme la mélanine naturelle, généralement dans des proportions variant entre 0,005 % et 1 % en poids; (d) un agent hydratant usuel, pouvant être associé à un agent anti-radicaux complémentaire, généralement dans des proportions variant entre 0,1 % et 2 % en poids; (e) des oligo-éléments présentant une action hydratante, généralement dans des proportions variant entre 0,5 % et 5 % en poids. A ces composants actifs s'ajoutent des excipients et des additifs usuels complétant la composition cosmétique à hauteur de 100 %.
PCT/BR1997/000025 1996-07-05 1997-07-04 Compositions cosmetiques hydratantes et protectrices pour la peau WO1998001107A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP97935379A EP0859589A1 (fr) 1996-07-05 1997-07-04 Compositions cosmetiques hydratantes et protectrices pour la peau

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BR9602991A BR9602991A (pt) 1996-07-05 1996-07-05 Composições cosméticas hidratantes e protetoras da pele contra as radiações ultravioleta e infravermelha
BRPI9602991-9 1996-07-05

Publications (1)

Publication Number Publication Date
WO1998001107A1 true WO1998001107A1 (fr) 1998-01-15

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PCT/BR1997/000025 WO1998001107A1 (fr) 1996-07-05 1997-07-04 Compositions cosmetiques hydratantes et protectrices pour la peau

Country Status (7)

Country Link
EP (1) EP0859589A1 (fr)
AR (1) AR007721A1 (fr)
BR (1) BR9602991A (fr)
CA (1) CA2231275A1 (fr)
CO (1) CO5280067A1 (fr)
MX (1) MX9801733A (fr)
WO (1) WO1998001107A1 (fr)

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0898955A2 (fr) * 1997-08-09 1999-03-03 MERCK PATENT GmbH Moyen de protection solaire avec une protection ultra-spectrale
WO1999024000A2 (fr) * 1997-11-12 1999-05-20 Merck Patent Gmbh Formulation cosmetique photostable contenant du butylmethoxydibenzoylmethane
WO1999062476A1 (fr) * 1998-06-04 1999-12-09 Unilever Plc Composition cosmetique antisolaire
GB2352174A (en) * 1999-07-22 2001-01-24 Secr Defence Barrier creams for the mitigation of heat burns
WO2001037847A2 (fr) * 1999-11-22 2001-05-31 Children's Hospital Medical Center Compositions de vernix non toxiques et leur procede de production
DE10050155A1 (de) * 2000-10-11 2002-04-18 Beiersdorf Ag Kosemtische und dermatologische Zubereitungen mit einem Gehalt an Desferrioxamin
US6562358B2 (en) 1998-03-02 2003-05-13 Children's Hospital Medical Center Nontoxic vernix compositions and method of producing
WO2003075876A1 (fr) * 2002-03-12 2003-09-18 Ove Karlsson Konsult Nouvelle composition contenant un ensemble pigmentaire presentant un noyau en mica
US7897144B2 (en) 2001-02-28 2011-03-01 Johnson & Johnson Comsumer Companies, Inc. Compositions containing legume products
US7959935B2 (en) 2002-05-03 2011-06-14 Children's Hospital Medical Center Simulated vernix compositions for skin cleansing and other applications
US7985404B1 (en) 1999-07-27 2011-07-26 Johnson & Johnson Consumer Companies, Inc. Reducing hair growth, hair follicle and hair shaft size and hair pigmentation
US8001926B2 (en) 2002-11-07 2011-08-23 Abbott Laboratories System and method of loading and detecting beneficial agent on a prosthesis
US8039026B1 (en) 1997-07-28 2011-10-18 Johnson & Johnson Consumer Companies, Inc Methods for treating skin pigmentation
US8093293B2 (en) 1998-07-06 2012-01-10 Johnson & Johnson Consumer Companies, Inc. Methods for treating skin conditions
US8106094B2 (en) 1998-07-06 2012-01-31 Johnson & Johnson Consumer Companies, Inc. Compositions and methods for treating skin conditions
WO2012107550A2 (fr) 2011-02-11 2012-08-16 Laboratorios Cinfa, S.A. Principe actif dérivé de la biotechnologie, dans des compositions cosmétiques pour protéger la peau de lésions induites ou produites par des rayonnements infrarouges
US8431550B2 (en) 2000-10-27 2013-04-30 Johnson & Johnson Consumer Companies, Inc. Topical anti-cancer compositions and methods of use thereof
KR101511021B1 (ko) 2012-06-28 2015-04-10 동국대학교 산학협력단 멜라닌세포의 세포 독성 진단용 조성물
EP2600824A4 (fr) * 2010-06-29 2016-03-09 Amorepacific Corp Composition cosmétique pour prévenir le vieillissement cutané
EP2233127B1 (fr) 2004-03-17 2020-05-27 Stada Arzneimittel Ag Utilisation d'antioxydants pour préparer des compositions pharmaceutiques ou cosmétiques pour protéger la peau contre les dommages provoqués par les rayonnements infra-rouges

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2206282A (en) * 1987-06-23 1989-01-05 Neutrogena Corp Topical composition for protecting against solar radiation
EP0518773A1 (fr) * 1991-06-14 1992-12-16 L'oreal Composition cosmétique contenant un mélange de nanopigments d'oxydes métalliques et de pigments mélaniques
US5571503A (en) * 1995-08-01 1996-11-05 Mausner; Jack Anti-pollution cosmetic composition

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2206282A (en) * 1987-06-23 1989-01-05 Neutrogena Corp Topical composition for protecting against solar radiation
EP0518773A1 (fr) * 1991-06-14 1992-12-16 L'oreal Composition cosmétique contenant un mélange de nanopigments d'oxydes métalliques et de pigments mélaniques
US5571503A (en) * 1995-08-01 1996-11-05 Mausner; Jack Anti-pollution cosmetic composition

Cited By (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8039026B1 (en) 1997-07-28 2011-10-18 Johnson & Johnson Consumer Companies, Inc Methods for treating skin pigmentation
EP0898955A2 (fr) * 1997-08-09 1999-03-03 MERCK PATENT GmbH Moyen de protection solaire avec une protection ultra-spectrale
EP0898955A3 (fr) * 1997-08-09 2001-11-21 MERCK PATENT GmbH Moyen de protection solaire avec une protection ultra-spectrale
US6436374B1 (en) 1997-11-12 2002-08-20 Merck Patent Gesellschaft Mit Beschraenkter Haftung Light-stable cosmetic formulation containing butylmethoxydibenzoylmethane
WO1999024000A2 (fr) * 1997-11-12 1999-05-20 Merck Patent Gmbh Formulation cosmetique photostable contenant du butylmethoxydibenzoylmethane
WO1999024000A3 (fr) * 1997-11-12 1999-07-29 Merck Patent Gmbh Formulation cosmetique photostable contenant du butylmethoxydibenzoylmethane
US6846490B2 (en) 1998-03-02 2005-01-25 Children's Hospital Medical Center Nontoxic vernix compositions and method of producing
US6333041B1 (en) 1998-03-02 2001-12-25 Children's Hospital Medical Center Nontoxic vernix compositions and method of producing
US6562358B2 (en) 1998-03-02 2003-05-13 Children's Hospital Medical Center Nontoxic vernix compositions and method of producing
WO1999062476A1 (fr) * 1998-06-04 1999-12-09 Unilever Plc Composition cosmetique antisolaire
US8093293B2 (en) 1998-07-06 2012-01-10 Johnson & Johnson Consumer Companies, Inc. Methods for treating skin conditions
US8106094B2 (en) 1998-07-06 2012-01-31 Johnson & Johnson Consumer Companies, Inc. Compositions and methods for treating skin conditions
GB2352174B (en) * 1999-07-22 2004-06-23 Secr Defence Barrier cream
US6309631B1 (en) 1999-07-22 2001-10-30 Secretary Of State For Defence In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland Barrier cream
GB2352174A (en) * 1999-07-22 2001-01-24 Secr Defence Barrier creams for the mitigation of heat burns
US7985404B1 (en) 1999-07-27 2011-07-26 Johnson & Johnson Consumer Companies, Inc. Reducing hair growth, hair follicle and hair shaft size and hair pigmentation
WO2001037847A3 (fr) * 1999-11-22 2002-01-17 Childrens Hosp Medical Center Compositions de vernix non toxiques et leur procede de production
WO2001037847A2 (fr) * 1999-11-22 2001-05-31 Children's Hospital Medical Center Compositions de vernix non toxiques et leur procede de production
DE10050155A1 (de) * 2000-10-11 2002-04-18 Beiersdorf Ag Kosemtische und dermatologische Zubereitungen mit einem Gehalt an Desferrioxamin
US8431550B2 (en) 2000-10-27 2013-04-30 Johnson & Johnson Consumer Companies, Inc. Topical anti-cancer compositions and methods of use thereof
US7897144B2 (en) 2001-02-28 2011-03-01 Johnson & Johnson Comsumer Companies, Inc. Compositions containing legume products
WO2003075876A1 (fr) * 2002-03-12 2003-09-18 Ove Karlsson Konsult Nouvelle composition contenant un ensemble pigmentaire presentant un noyau en mica
US7959935B2 (en) 2002-05-03 2011-06-14 Children's Hospital Medical Center Simulated vernix compositions for skin cleansing and other applications
US8001926B2 (en) 2002-11-07 2011-08-23 Abbott Laboratories System and method of loading and detecting beneficial agent on a prosthesis
EP2233127B1 (fr) 2004-03-17 2020-05-27 Stada Arzneimittel Ag Utilisation d'antioxydants pour préparer des compositions pharmaceutiques ou cosmétiques pour protéger la peau contre les dommages provoqués par les rayonnements infra-rouges
EP1591105B1 (fr) 2004-03-17 2020-05-27 Stada Arzneimittel Ag Utilisation d'antioxydants pour préparer des compositions pharmaceutiques ou cosmétiques pour protéger la peau contre les dommages provoqués par les rayonnements infra-rouges
EP2600824A4 (fr) * 2010-06-29 2016-03-09 Amorepacific Corp Composition cosmétique pour prévenir le vieillissement cutané
WO2012107550A2 (fr) 2011-02-11 2012-08-16 Laboratorios Cinfa, S.A. Principe actif dérivé de la biotechnologie, dans des compositions cosmétiques pour protéger la peau de lésions induites ou produites par des rayonnements infrarouges
KR101511021B1 (ko) 2012-06-28 2015-04-10 동국대학교 산학협력단 멜라닌세포의 세포 독성 진단용 조성물

Also Published As

Publication number Publication date
CO5280067A1 (es) 2003-05-30
EP0859589A1 (fr) 1998-08-26
BR9602991A (pt) 1998-04-28
MX9801733A (es) 1998-11-29
AR007721A1 (es) 1999-11-10
CA2231275A1 (fr) 1998-01-15

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