WO1997045164A1 - Method for inhibiting of growth and preventing the formation of pigmental nevi on the skin - Google Patents
Method for inhibiting of growth and preventing the formation of pigmental nevi on the skin Download PDFInfo
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- WO1997045164A1 WO1997045164A1 PCT/RU1996/000133 RU9600133W WO9745164A1 WO 1997045164 A1 WO1997045164 A1 WO 1997045164A1 RU 9600133 W RU9600133 W RU 9600133W WO 9745164 A1 WO9745164 A1 WO 9745164A1
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- nevi
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- preventing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0616—Skin treatment other than tanning
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
- A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
- A61N2005/0644—Handheld applicators
Definitions
- the invention relates to medicine, in particular to dermatology and oncology, and is intended to inhibit the growth of congenital and acquired pigmented skin nevi and prevent the formation of new nevi.
- One option is a method for the surgical treatment of skin diseases (RF patent No. 2044552, class C. No. 61/06, 1995), in which the effect of CCB- is used to treat, in particular, moles (i.e., pigmented nevi) laser in modes sufficient for ablation.
- RF patent No. 2044552, class C. No. 61/06, 1995 in which the effect of CCB- is used to treat, in particular, moles (i.e., pigmented nevi) laser in modes sufficient for ablation.
- the purpose of the invention is to provide an effective method of inhibiting the growth of congenital and acquired skin nevi and preventing the occurrence of new acquired nevi.
- This goal is achieved by the fact that the patient’s retina is exposed to a luminous flux passing through a microscopic section of the tissue of the pigment nevus with the presence of melanocytes in it.
- the method is based on the phenomenon of transmitting information about the state of cells through the structure of the visual analyzer, which is as follows.
- Luminous flux from an artificial light source passing through a layer of cells at a certain stage of destruction and reaching the retina of the eye is capable of causing similar changes in cells of the same type in the organs of the whole organism (RF patent No. 2049998, class C. No. 01, 33/48, 1995).
- BEST MODE FOR CARRYING OUT THE INVENTION The method is carried out using the device shown in FIG. 1.
- the device comprises a housing 1, in which a light source 2 is placed — an incandescent lamp with a power of 40 watts. In front of the light source is placed a focusing lens 3, a green filter 4 and glass 5 with a cut of nevus tissue glued on it. On the line of the optical system in the wall of the housing has a hole 6.
- the method is as follows.
- the patient is located at a certain distance from the device (0.5 - 1.5 m), the hole 6 in the wall of which is at the level of his eyes.
- the incandescent lamp in the housing 1 of the device the light passes through the lens 3, the green filter 4, the glass with a microscopic section of tissue 5 glued on it and through the hole 6 it enters the patient’s retina.
- the slice is made from fixed for one day in a 10% formalin solution and histologically paraffin-guided biopsy of the pigmented nevus.
- the thickness of the slice is 10-20 microns, it is glued to a glass slide, consists of a balm and covered with a coverslip.
- the presence of a green filter in the device is optional. It is used to ensure the convenience of the patient. In its absence, the effect of suppressing the growth of nevus is observed in full.
- the exposure time is 10 minutes, for a course of 12-15 procedures daily or every other day.
- EXAMPLE 1 Patient M., 38 years old, complained of the presence and increase in the size of a pigmented formation on the right lower leg. From the anamnesis it was found that the pigmented nevus appeared about 5 years ago, over the past few months its slow growth has been noted. Over the past few years, there has been a tendency towards the appearance of acquired nevi. On examination: on the front surface of the right tibia in its middle third, a rounded formation with a diameter of up to 1 cm, a height of 0.4 cm, brown in color, with a smooth surface, and on the periphery - hyperemia of the skin. On the skin of the patient in various areas, multiple pigmented nevi from 0.1 to 0.5 cm in diameter.
- the patient’s retina was exposed to the light stream using the device described above for 10 minutes. daily, for a course of 15 procedures. After a full course of hyperemia along the periphery of the nevus was not observed, observation over the next two years showed that the growth of the pigmented nevus stopped and did not resume. Observation also confirmed the absence of the appearance of new pigmented nevi.
- EXAMPLE 2 Patient L., 48 years old, complained of the growth of pigmentation on the skin of the face. From the anamnesis it was found that the pigmented nevus is congenital, its slow growth was noted over the past 3-5 months. On examination: in the left infraorbital region, a pigmented formation of round shape up to 0.8 cm in diameter, up to 0.4 cm high, dark brown in color, with a fine tuberous surface.
- the patient’s retina was exposed to the light flux using the device described above for 10 minutes every other day, for a course of 12 procedures. After the course, there was a slight decrease in the size of the pigmented nevus (up to 0.6 cm in diameter).
- the growth of congenital and acquired nevuses was suppressed in a group of patients.
- an additional similar course was required 2-3 months after the end of the main course. Further observation over 2 years showed a lack of growth of acquired and congenital nevus, as well as the elimination of the tendency to the occurrence of acquired nevi.
- the practical significance of the invention is to enable effective inhibition of the growth of pigmented nevi, as well as preventing the occurrence of acquired nevi, which reduces the need for surgical treatment and can indirectly contribute to the prevention of melanoblast.
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- Life Sciences & Earth Sciences (AREA)
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Abstract
The present invention relates to the field of medicine, more precisely to dermatology and oncology, and may be used for inhibiting the growth of congenital or acquired pigmental nevi on the skin as well as for preventing the formation of new nevi. This method is characterised by the fact that the retina of a patient's eye is submitted to the action of a light flow passing through a microscopic cut in the tissues of a pigmental nevi containing melanocytes. This method is applied for 10 minutes on a daily basis or every other day and in 12 to 15 sessions.
Description
СПОСОБ ТОРМОЖЕНИЯ РОСТА И ПРЕДУПРЕЖДЕНИЯ ВОЗН ИКНОВЕН ИЯ ПИ ГМЕНТНЫХ НЕВУСОВ КОЖИ METHOD OF GROWING BRAKING AND PREVENTING THE IDENTIFICATION OF THE PIENMENT OF INSTANT SKIN SKINS
ОБЛАСТЬ ТЕХНИКИ Изобретение относится к медицине, в частности к дерматологии и онкологии, и предназначено для торможения роста врожденных и приобретенных пигментных невусов кожи и предупреждения образования новых невусов.FIELD OF THE INVENTION The invention relates to medicine, in particular to dermatology and oncology, and is intended to inhibit the growth of congenital and acquired pigmented skin nevi and prevent the formation of new nevi.
ПРЕДШЕСТВУЮЩИЙ УРОВЕНЬ ТЕХНИКИ Для лечения пигментных невусов кожи предложены различные способы. Ведущим является хирургическое удаление невуса при его росте в случае подозрения на возможную малипшзацию, а также в косметических целях. Все эти способы травматичны для пациентов, в ряде случаев возникают рубцы на месте оперативного вмешательства. Кроме того, хирургическое удаление одного или нескольких пигментных невусов не приводит к остановке роста других невусов и не предотвращает их возникновения.BACKGROUND OF THE INVENTION Various methods have been proposed for the treatment of pigmented skin nevi. The leading is the surgical removal of the nevus during its growth in case of suspicion of a possible malipshy, as well as for cosmetic purposes. All these methods are traumatic for patients; in some cases, scars occur at the site of surgery. In addition, the surgical removal of one or more pigmented nevuses does not stop the growth of other nevuses and does not prevent their occurrence.
Одним из вариантов является способ хирургического лечения кожных заболеваний (патент РФ Ν 2044552, м. кл. Α61Ν 5/06, 1995 г.), при котором для лечения, в частности, родинок (т.е. пигментных невусов) применяется воздействие ССЬ-лазером в режимах, достаточных для абляции.One option is a method for the surgical treatment of skin diseases (RF patent No. 2044552, class C. No. 61/06, 1995), in which the effect of CCB- is used to treat, in particular, moles (i.e., pigmented nevi) laser in modes sufficient for ablation.
Недостатками этого способа являются его травматичность для больных, а также невозможность влиять на развитие не подвергнутых воздействию лазера пигментных невусов. Данный способ не может также применяться для профилактики возникновения новых невусов.The disadvantages of this method are its morbidity for patients, as well as the inability to influence the development of non-laser pigmented nevi. This method cannot also be used to prevent the occurrence of new nevi.
РАСКРЫТИЕ ИЗОБРЕТЕНИЯ Цель изобретения - создание эффективного способа торможения роста врожденных и приобретенных невусов кожи и предупреждения возникновения новых приобретенных невусов.SUMMARY OF THE INVENTION The purpose of the invention is to provide an effective method of inhibiting the growth of congenital and acquired skin nevi and preventing the occurrence of new acquired nevi.
Указанная цель достигается тем, что на сетчатку глаз пациента воздействуют световым потоком, проходящим через микроскопический срез ткани пигментного невуса с наличем в нем меланоцитов.This goal is achieved by the fact that the patient’s retina is exposed to a luminous flux passing through a microscopic section of the tissue of the pigment nevus with the presence of melanocytes in it.
Способ основан на явлении передачи информации о состоянии клеток через структуры зрительного анализатора, которое заключается в следующем.The method is based on the phenomenon of transmitting information about the state of cells through the structure of the visual analyzer, which is as follows.
Световой поток от искусственного источника освещения, проходящий через
слой клеток в определенной стадии деструкции и попадающий на сетчатку глаз, способен вызывать аналогичные изменения в клетках такого же типа в органах целостного организма (патент РФ Ν 2049998, м. кл. Ο01Ν, 33/48, 1995 г.). ЛУЧШИЙ ВАРИАНТ ОСУЩЕСТВЛЕНИЯ ИЗОБРЕТЕНИЯ Способ осуществляется с помощью устройства, изображенного ла фиг. 1.Luminous flux from an artificial light source passing through a layer of cells at a certain stage of destruction and reaching the retina of the eye is capable of causing similar changes in cells of the same type in the organs of the whole organism (RF patent No. 2049998, class C. No. 01, 33/48, 1995). BEST MODE FOR CARRYING OUT THE INVENTION The method is carried out using the device shown in FIG. 1.
Устройство содержит корпус 1 , в котором помещен источник света 2 - лампа накаливания мощностью 40 вт. Перед источником света помещена фокусирующая линза 3, зеленый светофильтр 4 и стекло 5 с наклеенным на нем срезом ткани невуса. На линии оптической системы в стенке корпуса имеется отверстие 6.The device comprises a housing 1, in which a light source 2 is placed — an incandescent lamp with a power of 40 watts. In front of the light source is placed a focusing lens 3, a green filter 4 and glass 5 with a cut of nevus tissue glued on it. On the line of the optical system in the wall of the housing has a hole 6.
Способ осуществляется следующим образом. Пациент располагается на некотором расстоянии от устройства (0,5 - 1 ,5 м), отверстие 6 в стенке которого находится на уровне его глаз. При включении лампы накаливания в корпусе 1 устройства свет проходит через линзу 3, зеленый светофильтр 4, стекло с наклеенным на нем микроскопическим срезом ткани 5 и через отверстие 6 попадает на сетчатку глаз пациента.The method is as follows. The patient is located at a certain distance from the device (0.5 - 1.5 m), the hole 6 in the wall of which is at the level of his eyes. When you turn on the incandescent lamp in the housing 1 of the device, the light passes through the lens 3, the green filter 4, the glass with a microscopic section of tissue 5 glued on it and through the hole 6 it enters the patient’s retina.
Срез изготавливают из фиксированного в течение одних суток в 10- процентном растворе формалина и прошедшего гистологическую парафиновую проводку биопсийного материала пигментного невуса. Толщина среза 10-20 мкм, он наклеивается на предметное стекло, заключается в бальзам и накрывается покровным стеклом.The slice is made from fixed for one day in a 10% formalin solution and histologically paraffin-guided biopsy of the pigmented nevus. The thickness of the slice is 10-20 microns, it is glued to a glass slide, consists of a balm and covered with a coverslip.
Наличие зеленого светофильтра в устройстве не является обязательным. Он используется для обеспечения удобства пациента. При его отсутствии эффект подавления роста невуса наблюдается в полном объеме. Время экспозиции составляет 10 минут, на курс 12-15 процедур ежедневно или через день.The presence of a green filter in the device is optional. It is used to ensure the convenience of the patient. In its absence, the effect of suppressing the growth of nevus is observed in full. The exposure time is 10 minutes, for a course of 12-15 procedures daily or every other day.
ПРИМЕР 1. Пациент ка М., 38 лет, предъявляла жалобы на наличие и увеличение в размерах пигментного образования на правой голени. Из анамнеза выяснено, что пигментный невус появился около 5 лет назад, в течение последних нескольких месяцев от мечался его медленный рост. В течение последних нескольких лет имеется тенденция к возникновению приобретенных невусов. При осмотре: на передней поверхности правой голени в средней ее трети округлое образование диаметром до 1 см, высотой 0,4 см, коричневого цвета, с гладкой новерхносι ыо, по периферии - гиперемия кожи. На коже пациентки в различных участках множественные пигментные невусы от 0.1 до 0,5 см. в диаметре.
Проведено воздействие на сетчатку глаз пациентки световым потоком с помощью описанного выше устройства в течение 10 мин. ежедневно, на курс 15 процедур. После проведения полного курса гиперемии по периферии невуса не отмечалось, наблюдение в течение последующих двух лет показало, что рост пигментного невуса прекратился и не возобновлялся. Наблюдение также подтвердило отсутствие возникновения новых пигментных невусов.EXAMPLE 1. Patient M., 38 years old, complained of the presence and increase in the size of a pigmented formation on the right lower leg. From the anamnesis it was found that the pigmented nevus appeared about 5 years ago, over the past few months its slow growth has been noted. Over the past few years, there has been a tendency towards the appearance of acquired nevi. On examination: on the front surface of the right tibia in its middle third, a rounded formation with a diameter of up to 1 cm, a height of 0.4 cm, brown in color, with a smooth surface, and on the periphery - hyperemia of the skin. On the skin of the patient in various areas, multiple pigmented nevi from 0.1 to 0.5 cm in diameter. The patient’s retina was exposed to the light stream using the device described above for 10 minutes. daily, for a course of 15 procedures. After a full course of hyperemia along the periphery of the nevus was not observed, observation over the next two years showed that the growth of the pigmented nevus stopped and did not resume. Observation also confirmed the absence of the appearance of new pigmented nevi.
ПРИМЕР 2. Пациента Л., 48 лет, предъявляла жалобы на рост пигментного образования на коже лица. Из анамнеза выяснено, что пигментный невус является врожденным, отмечался его медленный рост в течение последних 3-5 месяцев. При осмотре: в левой подглазничной области пигментное образование округлой формы до 0,8 см в диаметре, высотой до 0,4 см, темно- коричневого цвета, с мелкобугристой поверхностью.EXAMPLE 2. Patient L., 48 years old, complained of the growth of pigmentation on the skin of the face. From the anamnesis it was found that the pigmented nevus is congenital, its slow growth was noted over the past 3-5 months. On examination: in the left infraorbital region, a pigmented formation of round shape up to 0.8 cm in diameter, up to 0.4 cm high, dark brown in color, with a fine tuberous surface.
Проводилось воздействие на сетчатку глаз пациентки световым потоком с помощью описанного выше устройства по 10 минут через день, на курс 12 процедур. После проведения курса отмечалось некоторое уменьшение в размерах пигментного невуса (до 0,6 см в диаметре).The patient’s retina was exposed to the light flux using the device described above for 10 minutes every other day, for a course of 12 procedures. After the course, there was a slight decrease in the size of the pigmented nevus (up to 0.6 cm in diameter).
Дальнейшее наблюдение в течение 2 лет не выявило признаков роста пигментного невуса и возникновения приобретенных невусов.Further observation over 2 years showed no signs of growth of the pigmented nevus and the occurrence of acquired nevi.
По предложенному способу у группы пациентов проведено подавление роста врожденных и приобретенных невусов. В случае имеющейся тенденции к возникновению приобретенных невусов в ряде случаев требовалось проведение дополнительного аналогичного курса через 2-3 месяца после окончания основного курса. Дальнейшее наблюдение в течение 2 лет показало отсутствие роста приобретенных и врожденных невусов, а также устранение тенденции к возникновению приобретенных невусов.According to the proposed method, the growth of congenital and acquired nevuses was suppressed in a group of patients. In the case of the existing tendency to the occurrence of acquired nevus in some cases, an additional similar course was required 2-3 months after the end of the main course. Further observation over 2 years showed a lack of growth of acquired and congenital nevus, as well as the elimination of the tendency to the occurrence of acquired nevi.
ПРОМЫШЛЕННАЯ ПРИМЕНИМОСТЬINDUSTRIAL APPLICABILITY
Практическое значение изобретения состоит в обеспечении возможности эффективного торможения роста пигментных невусов, а также предотвращения возникновения приобретенных невусов, что снижает необходимость хирургического лечения и косвенно может способствовать профилактике меланобластом.
The practical significance of the invention is to enable effective inhibition of the growth of pigmented nevi, as well as preventing the occurrence of acquired nevi, which reduces the need for surgical treatment and can indirectly contribute to the prevention of melanoblast.
Claims
ФОРМУЛА ИЗОБРЕТЕНИЯ Способ торможения роста и предупреждения возникновения пигментных невусов кожи, отличающийся тем, что воздействие осуществляют на сетчатку глаз пациента световым потоком, проходящим через микроскопический срез ткани пигментного невуса, содержащий меланоциты, по 10 минут ежедневно или через день, на курс 12-15 процедур.
SUMMARY OF THE INVENTION A method for inhibiting the growth and preventing the appearance of pigmented nevus of the skin, characterized in that the effect is exerted on the patient's retina by a light stream passing through a microscopic section of the pigmented nevus tissue containing melanocytes, for 10 minutes daily or every other day, for a course of 12-15 procedures .
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/RU1996/000133 WO1997045164A1 (en) | 1996-05-28 | 1996-05-28 | Method for inhibiting of growth and preventing the formation of pigmental nevi on the skin |
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| Application Number | Priority Date | Filing Date | Title |
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| PCT/RU1996/000133 WO1997045164A1 (en) | 1996-05-28 | 1996-05-28 | Method for inhibiting of growth and preventing the formation of pigmental nevi on the skin |
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| WO1997045164A1 true WO1997045164A1 (en) | 1997-12-04 |
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