WO1997023612A3 - Zielgerichtete verbindungen mit knorpel- und/oder knocheninduzierender aktivität - Google Patents

Zielgerichtete verbindungen mit knorpel- und/oder knocheninduzierender aktivität Download PDF

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Publication number
WO1997023612A3
WO1997023612A3 PCT/EP1996/005768 EP9605768W WO9723612A3 WO 1997023612 A3 WO1997023612 A3 WO 1997023612A3 EP 9605768 W EP9605768 W EP 9605768W WO 9723612 A3 WO9723612 A3 WO 9723612A3
Authority
WO
WIPO (PCT)
Prior art keywords
bone
inducing
cartilage
compounds
formation
Prior art date
Application number
PCT/EP1996/005768
Other languages
English (en)
French (fr)
Other versions
WO1997023612A2 (de
Inventor
Gertrud Hoetten
Rolf Bechtold
Jens Pohl
Michael Paulista
Original Assignee
Bioph Biotech Entw Pharm Gmbh
Gertrud Hoetten
Rolf Bechtold
Jens Pohl
Michael Paulista
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioph Biotech Entw Pharm Gmbh, Gertrud Hoetten, Rolf Bechtold, Jens Pohl, Michael Paulista filed Critical Bioph Biotech Entw Pharm Gmbh
Priority to AU13037/97A priority Critical patent/AU1303797A/en
Publication of WO1997023612A2 publication Critical patent/WO1997023612A2/de
Publication of WO1997023612A3 publication Critical patent/WO1997023612A3/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Die vorliegende Erfindung betrifft neue Verbindungen mit knorpel- und/oder knocheninduzierender Aktivität, die eine hohe Affinität zur extrazellulären Matrix und/oder zu zellulären Bestandteilen von Knorpel und/oder Knochen von Wirbeltieren und/oder zu einer biokompatiblen Trägermatrix für Gelenk- oder Knochenimplantate, oder Knochenklebstoffe, aufweisen. Die neuen Verbindungen könnnen, abhängig von der Indikation, durch gleichzeitige Hemmung der Knochenresorption in ihrer Wirkung verstärkt werden. Die Erfindung betrifft weiterhin die Herstellung dieser Verbindungen und diese Verbindungen enthaltende pharmakologische Zusammensetzungen, die zur Behandlung und Prävention von Erkrankungen, die den Knorpel und/oder Knochen betreffen, wie z.B. Osteoporose, sowie zur Behandlung und Prävention von Schädigungen des Knorpel- und/oder Knochengewebes verwendet werden können.
PCT/EP1996/005768 1995-12-22 1996-12-20 Zielgerichtete verbindungen mit knorpel- und/oder knocheninduzierender aktivität WO1997023612A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU13037/97A AU1303797A (en) 1995-12-22 1996-12-20 Targeted compounds with cartilage formation-inducing and/or bone formation-inducing activity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19548476A DE19548476A1 (de) 1995-12-22 1995-12-22 Zielgerichtete Verbindungen mit knorpel- und/oder knocheninduzierender Aktivität
DE19548476.2 1995-12-22

Publications (2)

Publication Number Publication Date
WO1997023612A2 WO1997023612A2 (de) 1997-07-03
WO1997023612A3 true WO1997023612A3 (de) 1997-08-28

Family

ID=7781240

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1996/005768 WO1997023612A2 (de) 1995-12-22 1996-12-20 Zielgerichtete verbindungen mit knorpel- und/oder knocheninduzierender aktivität

Country Status (3)

Country Link
AU (1) AU1303797A (de)
DE (1) DE19548476A1 (de)
WO (1) WO1997023612A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19906096A1 (de) * 1999-02-13 2000-08-17 Walter Sebald Protein mit einem Heparin-bindenden Epitop
DE10037850A1 (de) * 2000-08-01 2002-02-21 Herbert P Jennissen Verfahren zur Herstellung bioaktiver Implantatoberflächen
KR101421719B1 (ko) * 2007-09-18 2014-07-30 삼성전자주식회사 금속 하이드록시 탄산염을 이용한 나노 형광체의 제조방법및 그로부터 제조된 나노 형광체

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992019262A1 (en) * 1991-05-03 1992-11-12 Celtrix Pharmaceuticals, Inc. Bone growth factors and inhibitors of bone resorption for promoting bone formation
WO1993006872A1 (en) * 1991-10-11 1993-04-15 Genetics Institute, Inc. Formulations of blood clot-polymer matrix for delivery of osteogenic proteins
WO1995016035A2 (en) * 1993-12-07 1995-06-15 Genetics Institute, Inc. Bmp-12, bmp-13 and tendon-inducing compositions thereof
EP0691349A2 (de) * 1994-07-04 1996-01-10 Hoechst Japan Limited Dimere Knochenmorphogeneseproteine und ihre Fragmente und Analoge und sie enthaltende pharmazeutische Zubereitungen
EP0704532A2 (de) * 1994-06-10 1996-04-03 United States Surgical Corporation Rekombinante Chimäre Proteine und Verfahren zur deren Verwendung
WO1996039430A1 (en) * 1995-06-06 1996-12-12 Hall Frederick L TGF-β FUSION PROTEINS AND THEIR USE IN WOUND HEALING
WO1997003188A2 (de) * 1995-07-12 1997-01-30 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Verwendung von mp52 oder mp121 zur behandlung und prävention von erkrankungen des nervensystems

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992019262A1 (en) * 1991-05-03 1992-11-12 Celtrix Pharmaceuticals, Inc. Bone growth factors and inhibitors of bone resorption for promoting bone formation
WO1993006872A1 (en) * 1991-10-11 1993-04-15 Genetics Institute, Inc. Formulations of blood clot-polymer matrix for delivery of osteogenic proteins
WO1995016035A2 (en) * 1993-12-07 1995-06-15 Genetics Institute, Inc. Bmp-12, bmp-13 and tendon-inducing compositions thereof
EP0704532A2 (de) * 1994-06-10 1996-04-03 United States Surgical Corporation Rekombinante Chimäre Proteine und Verfahren zur deren Verwendung
EP0691349A2 (de) * 1994-07-04 1996-01-10 Hoechst Japan Limited Dimere Knochenmorphogeneseproteine und ihre Fragmente und Analoge und sie enthaltende pharmazeutische Zubereitungen
WO1996039430A1 (en) * 1995-06-06 1996-12-12 Hall Frederick L TGF-β FUSION PROTEINS AND THEIR USE IN WOUND HEALING
WO1997003188A2 (de) * 1995-07-12 1997-01-30 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Verwendung von mp52 oder mp121 zur behandlung und prävention von erkrankungen des nervensystems

Also Published As

Publication number Publication date
DE19548476A1 (de) 1997-06-26
AU1303797A (en) 1997-07-17
WO1997023612A2 (de) 1997-07-03

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