WO1997019337A1 - Boitier de fixation et de support d'echantillon biologique - Google Patents

Boitier de fixation et de support d'echantillon biologique Download PDF

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Publication number
WO1997019337A1
WO1997019337A1 PCT/JP1996/003301 JP9603301W WO9719337A1 WO 1997019337 A1 WO1997019337 A1 WO 1997019337A1 JP 9603301 W JP9603301 W JP 9603301W WO 9719337 A1 WO9719337 A1 WO 9719337A1
Authority
WO
WIPO (PCT)
Prior art keywords
biological sample
support
fixing
case
piece
Prior art date
Application number
PCT/JP1996/003301
Other languages
English (en)
Japanese (ja)
Inventor
Teiji Takezaki
Original Assignee
Teiji Takezaki
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP7300291A external-priority patent/JP3008078B2/ja
Priority claimed from JP30029095A external-priority patent/JPH09145565A/ja
Application filed by Teiji Takezaki filed Critical Teiji Takezaki
Priority to AU75072/96A priority Critical patent/AU7507296A/en
Publication of WO1997019337A1 publication Critical patent/WO1997019337A1/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G01N2001/315—Basket-type carriers for tissues

Definitions

  • the present invention provides a clinician to transfer a biological sample collected from a human body to a pathological examination room or the like, where the specimen is prepared into a sliced sample (preparation) ready for microscopic examination.
  • the clinician establishes the biological sample so that it does not deteriorate due to self-thawing or decay. That is, the biological sample is fixed and supported biologically and transferred to a pathological laboratory, etc., or dehydration, degreasing, or clearing is performed.
  • Background Art Conventionally, it is related to a case for inserting a biological sample necessary for processing and then embedding.
  • the biological sample is returned to the embedding cassette 42 again, and placed in each container containing alcohol or xylene as it is.
  • the biological sample is sequentially subjected to dehydration, degreasing, clearing, and embedding of paraffin or resin, etc. for each treatment:
  • the above-mentioned empty embedding case is left with a slight gap.
  • a bottom surface of the cutout 42 is arranged, and an embedding agent made of molten paraffin or resin is poured into the bottom surface of the cutout, and cooled and solidified by cooling, and fixed in the embedding agent.
  • the biological sample is embedded together with the support, together with the bottom of the embedded cassette 42:
  • the above-mentioned embedding cassette has a certain strength such as rigidity in order to take out a biological sample from the embedding cassette and fix the biological sample with paraffin based on the embedding cassette. Therefore, it is made of a hard synthetic resin or plastic, etc., and the wear of the cassette cannot be reduced below a certain limit. Therefore, if the embedded cassette becomes enormous, secure a storage place for it. , And movement becomes extremely difficult.
  • An object of the present invention is to provide a clinician with a biological sample contained therein, such as a conventional embedding cassette, which is moved to a laboratory or the like, as in a large hospital or a large laboratory. Even if the volume becomes enormous, it is necessary to ensure that there is no difficulty in securing a large space for storing the embedding cassettes and a space for dehydration, degreasing, and transparent treatment. It is to reduce the cost of stocking the embedded cassette:
  • Another purpose is to simplify the description of information on biological samples and prevent so-called contamination phenomena, such as making it difficult to confirm the contents of cassettes and confusing them with other biological samples. It is to stop.
  • a fixing support case for a biological sample is a fixing support case for fixing a biological sample in a state in which the biological sample is embedded in a fixing support, wherein the support forming a part of the fixing support case is provided.
  • a lid piece is provided on the piece so as to be openable and closable, and a perforated dish is fitted into a support hole formed in the center of one of the support piece and the lid piece. The overhanging flange is sandwiched between the support piece and the lid piece.
  • the case for fixing and supporting a biological sample is a fixing support case for fixing a biological sample in a state where the biological sample is embedded in a fixing support agent, wherein the support piece constituting a part of the fixing and supporting case is provided.
  • the support piece and the cover piece are formed by folding a hard sheet so that it can be opened and closed from the middle, and a support hole is formed in the center of the support piece.
  • a flange protruding from the outer periphery of the opening of the perforated dish made of a hard liquid-permeable sheet is hooked so that it can be freely attached and detached.
  • a predetermined quantity is accommodated in a desired arrangement state inside the bottom of a perforated dish formed of a sexual sheet, and fixed above and around the biological sample with a sample preserving and preservative stable solution such as glucomannan and formalin. Filling the support with the biological sample As well as fixing so as not to quality and by Uni support does not move within the porous dish liquid permeability.
  • the biological sample in the inferior state accommodated in the fixing support case is put as it is in another capsule containing a gelling agent mixed with a deterioration preventing agent of the biological sample together with the fixing support case.
  • the fixing support case accommodated in the capsule is taken out, and then put directly into each container containing alcohol or xylene, etc., and the biological sample is sequentially dehydrated, degreased, transparent, and removed from paraffin or resin or the like. Immersed in an embedding medium.
  • the biological sample in the fixing support case in this manner is immersed in alcohol as it is, dehydrated and degreased, immersed in xylol to remove alcohol (penetration), and further purified with paraffin or paraffin.
  • Replace with the embedding agent by immersing it in an embedding agent made of resin, etc., and then take it out of the fixed support case in the form of a gel block embedded in the fixing support, and place it on the embedding dish as it is Place on:
  • An embedding support base such as an embedding cassette which is separately prepared is arranged above the gel-like block with a slight gap, and from above, a molten paraffin or resin or the like is placed from above. Injecting an embedding agent consisting of, followed by cooling to solidify by cooling and embedding a biological sample in the embedding agent together with the fixing support together with the bottom surface of the embedding support base It is.
  • the case for supporting fixation of a biological sample is a fixing support case for fixing a biological sample in a state where the biological sample is embedded in a fixing support, wherein the flat case is formed by a perforated plate constituting the case for fixing support.
  • a container and a cover plate are fitted openably and closably, and a window hole for installing a liquid-permeable perforated dish is formed in one of the flat container and the cover plate.
  • a support frame protrudes inward, and a flange at the periphery of the opening of the perforated dish is sandwiched between the support frame and the inner surface of the lid plate or between the support frame and the bottom of the flat container.
  • a biological sample collected by a clinician from a human body is stored in the bottom of a perforated dish, which is locked in a window formed in either the lid plate or the bottom of the flat container, and these are separately placed in a prone state.
  • Put in a prepared capsule soak in the alteration preventive agent in it, fix it so that the biological sample does not deteriorate in the embedding cassette, and hold it.
  • Into a closed embedding cassette that is fitted to a flat container and the embedding cassette is transferred to a predetermined treatment plant, where the cassettes are sequentially dehydrated, degreased, transparent, and embedded.
  • FIG. 1 is a plan view of an embodiment of a biological sample anchoring support case according to the present invention.
  • FIG. 2 is a sectional view taken along the line II-II in FIG.
  • FIG. 3 is a perspective view of a part of FIG. 1 and FIG.
  • FIG. 4 is a perspective view of another part of FIGS. 1 and 2
  • FIG. 5 is a perspective view of another embodiment of FIG.
  • FIG. 6 is a perspective view of still another embodiment of FIG.
  • FIG. 7 is a cross-sectional view of another embodiment of the biological sample fixing support case of the present invention.
  • FIG. 8 is a plan view of a part of FIG.
  • FIG. 9 is a cross-sectional view taken along the line IX—IL of FIG.
  • FIG. 10 is a plan view of still another embodiment of the biological sample fixing support case of the present invention.
  • FIG. 11 is a plan view of still another embodiment of the biological sample fixing support case of the present invention.
  • FIG. 12 is a plan view of still another embodiment of the biological sample fixing support case of the present invention.
  • FIG. 13 is a cross-sectional view taken along the line XIII-XIII of FIG.
  • FIG. 14 is a perspective view of an embodiment of the cassette for embedding a biological sample of the present invention, which is different from FIGS. 1 to 13.
  • FIG. 15 is a cross-sectional view taken along line II-II of the embedding cassette of FIG.
  • FIG. 16 is a perspective view of a part of FIG.
  • FIG. 17 is a perspective view of another embodiment of the present invention.
  • FIG. 18 is a vertical cross-sectional view taken along the line VV of the embodiment of FIG. 17 in use.
  • FIG. 19 is a perspective view of yet another embodiment of the present invention:
  • FIG. 20 is a vertical cross-sectional view of the VII-VII line portion showing the use state of FIG. 19.
  • FIG. 21 is a perspective view of an embodiment in which a part of the embodiment shown in Fig. 19 is modified:
  • Fig. 22 is a sectional view taken along line IX-IX of the embodiment shown in Fig. 19 in use.
  • FIG. 23 is a perspective view of an embodiment in which the embodiment of FIG. 19 is partially modified:
  • FIG. 24 is a cross-sectional view taken along line XI-XI of the embodiment of FIG. 2 in use:
  • FIG. 25 is a perspective view of the embodiment of FIG. 23 with a partially modified embodiment. .
  • FIG. 26 is a cross-sectional view taken along the line XIII-XIII of the embodiment of FIG. 25.
  • FIG. 27 is a perspective view of another part of FIG.
  • FIG. 28 is a perspective view of another embodiment of FIG.
  • FIG. 29 is a perspective view of still another embodiment of FIG. 27.
  • FIG. 30 shows a conventional case for supporting and fixing a biological sample. (Best Mode for Carrying Out the Invention) An embodiment of the present invention will be described with reference to FIGS. 1 to 3 of the accompanying drawings.
  • the fixing support case for the sample is made of a rectangular liquid-permeable sheet that has immersion properties over the entire surface, such as cardboard or thick Japanese paper, or a hard synthetic resin such as polypropylene or polyethylene terephthalate, cardboard, or paraffin paper. It consists of a rectangular liquid-permeable sheet 1 with a number of small holes 1a perforated in a predetermined part of the device, etc. And a support hole 5 is formed in the center of the support piece 3
  • a flange 9 projecting from the outer peripheral edge of the opening 8 of the perforated dish 7 formed of a liquid-permeable sheet made of a transparent hard synthetic resin is provided on the inner surface of the peripheral portion 6 of the support hole 5. , Hang it.
  • the clinician takes the required biological sample 12 from the human body and As shown in FIG. 2, a predetermined quantity is stored in the bottom part 13 of the perforated dish 7 formed of a liquid-permeable sheet in a predetermined state as shown in FIG. 2, and samples such as glucomannan and formalin are placed above and around the biological sample 12.
  • Fill fixing support 14 consisting of preservative and preservative stabilizer:
  • the biological sample is placed in a capsule (not shown) prepared in advance and immersed in a gelling agent for glucomannan (not shown) to gel the glucomannan.
  • 1 and 2 are fixed so that they do not deteriorate, and are supported integrally with the perforated dish 7 so that they do not move together.
  • the biological sample 12 housed in the fixing support case is transferred to a pathological examination room or the like while being placed in the capsule, where it is fixed in the capsule.
  • the support case is taken out and placed as it is in each container (not shown) containing alcohol or xylene, etc., and the biological sample 12 is sequentially dehydrated, degreased, passed through, and wrapped in paraffin or resin or the like as before.
  • the biological sample 12 is taken out of the fixing support case in the form of a gel-like block embedded in the fixing support 14, and the biological sample 12 is left as it is in an embedding dish (shown in the figure). No) Place on top.
  • the shape of the support piece 3 and the lid piece 4 is changed to a shape having only the tongue piece 15 without the concave notch 18 and the locking piece 17 shown in FIG.
  • the tongue piece 15 may be bent at the bending line 15a, inserted into the fine hole 16 formed in the support piece 3, and rolled up in the state shown in FIG.
  • the shape of the support piece 3 and the lid piece 4 is changed by simply folding the wire without providing the concave notch 18, the locking piece 17, and the tongue piece 15 shown in FIG. It may be a shape that only folds at 2.
  • the supporting piece 3 and the lid piece 4 are folded, then the appropriate places that do not affect the perforated dish 7 are fastened with a stapler or a clip or a pin (not shown) and folded.
  • the support piece 3 and the cover piece 4 are held flat by a stapler, a clip, a pin, or the like, as described above. It goes without saying that it can be applied in the example.
  • the perforated dish 7 is made of a translucent or opaque hard synthetic resin.
  • the perforated dish 7 may be formed of a liquid-permeable sheet made of a transparent hard synthetic resin.
  • a window hole 20 is formed in the center of the perforated dish 7a, and a liquid-permeable sheet-like flake 21 with a frame 19 is placed inside the window hole 20.
  • the sheet-like flakes 21 are preferably made of a material to which the fixing support agent 14 does not easily adhere, such as a cloth made of synthetic resin fibers.
  • a support hole 5 is formed in the center of the support piece 3, and a hard synthetic resin is formed on the inner surface of the peripheral portion 6 of the support hole 5.
  • a perforated dish 7b may be formed integrally with the support piece 3 at the center thereof.
  • the hydrophilic sheet 10 is made of a material which is hydrophilic and easily adheres to the surface of the fixing supporter 14, and is made of alcohol. Use materials that have properties incompatible with ruxylene, such as Japanese paper, sponge slices, and cloth.
  • a reference marker 11 may be displayed at least on one side edge of the hydrophilic sheet 10 .
  • the reference marker 11 may be used when a plurality of biological samples 12 are put. This is useful when it is necessary to indicate the order in which the biological samples 12 were collected, and the positional relationship such as from which part of the organ to be collected, etc.For example, multiple biological samples starting from the reference marker 11 It is decided in advance that 1 and 2 should be arranged according to a certain standard, so that confusion does not occur when embedding.
  • one corner of the square hydrophilic sheet 10 is provided as shown in FIG.
  • a notch 11a is formed on the surface of the hydrophilic sheet 10 as a reference mark, or a protrusion 11b is formed at one corner of the hydrophilic sheet 10 as shown in FIG. It is also possible.
  • a liquid-permeable sheet is double-folded from the middle folding line, and a support plate is provided with a liquid-perforated dish made of a synthetic resin sheet. Therefore, the thickness of the entire anchoring support case is smaller than that of the conventional one, and when a clinician moves a biological sample in the anchoring support case to an examination room, etc. Even if the number of biological samples becomes enormous, such as in a place, there is no difficulty in securing a vast place to store them. In addition, since the number of treatments per unit of time for dehydration, degreasing, and clearing increases, the overall treatment speed increases and the cost decreases.
  • the supporting piece and the cover piece need only be made of an inexpensive material, such as cardboard or paraffin paper, as they only need to hold the perforated dish when transferring the biological sample and have hardness enough to withstand multiple bending. Can be.
  • the cost can be significantly reduced as compared with the case where a conventional embedding cassette is used.
  • the cost can be further reduced because the time and labor required for separately manufacturing the perforated dish can be reduced ( :
  • the processing time can be shortened and the number of cases processed per unit time can be shortened compared with the case where the locking piece is fitted or the tongue piece is rolled into the pore.
  • the overall shape in the folded state was almost It is flat and has a wide flat area around the multi-hole plate, making it easy to fill out the case directly: This eliminates the need to create a separate slip and prevents slips from being misplaced or lost thing
  • the perforated dish is made of transparent synthetic resin, the contents can be checked without opening the case, and the sample can be checked. You can also easily fill out the case
  • a window is formed in the center of the multi-hole dish, and a liquid-permeable sheet with a frame is provided inside the window.
  • a liquid-permeable sheet with a frame is provided inside the window.
  • the fixing support can be more securely fixed. However, dropping of biological samples can be prevented. Further, since the sheet increases the fixing strength, the concentration of the fixing support can be reduced, and the cost can be further reduced.
  • a flat plate 22 formed of the same porous plate as a flat container 22 formed of a porous plate of a hard synthetic resin or the like is provided with a lid plate 23 formed of the same.
  • the embedding cassette which is openably and closably fitted with the engaging piece 24 and the locking piece 24a on the side and the engaging hole 25 and the locking portion 25a on the flat container 1, etc.
  • a window hole 27 is formed in the container 1 for hemorrhoids of the liquid-permeable perforated dish 26, and a support frame 28 is protruded from the periphery of the window hole 27 toward the inside of the flat container 22.
  • the perforated dish 26 is integrally formed of a transparent hard synthetic resin liquid-permeable sheet
  • the biological sample 31 collected from the human body for examination or treatment by the clinician is placed in the bottom of the perforated dish 26 as shown in FIG. In such a state, they are placed in a separately prepared capsule and immersed in a denaturation inhibitor to fix the biological sample so that it does not deteriorate in the embedding cassette. Depending on the type of biological sample, transfer and Some of them fall off during processing.In such a case, for example, the fixing method using a fixing support disclosed in Japanese Patent Application No. 7-169003 ensures that the inside of the perforated dish 26 is securely inserted.
  • a fixing support 32 composed of a sample storage and preservative stabilizer such as glucomannan and formalin is filled above and around the biological sample 31, and these are preliminarily prepared in this state.
  • the biological sample 31 is moved in an embedding cassette by putting in a separately prepared capsule (not shown) and immersing in a glucomannan gelling agent to gel the glucomannan.
  • the lid plate 23 is fitted into the flat container 22 to form a sealed embedded cassette, and the embedded cassette in that state is placed in a predetermined treatment plant.
  • the cassettes are sequentially treated with dehydrating, degreasing, clearing, and embedding agents, and then the cover plate 23 of the embedding cassette is opened and embedded in the perforated dish 26 into the fixing support 32.
  • the embedding support base used for embedding may be prepared separately, or a flat container 1 of an embedding cassette containing four or more biological samples may be used.
  • a window hole 27 is provided at the center of the flat container 22, and a support frame 28 is protruded from the inner peripheral edge of the window hole 27 toward the inside of the flat container 22.
  • a window hole 27 is provided in the cover plate 23, and a support frame 28 is protruded from the inner peripheral edge of the window hole 27, and a front edge 28a of the support frame 28 and the inner surface of the flat container 22 are formed. It is also possible to clamp the flange 30 of the perforated dish 26 with:
  • the perforated dish 26 is formed of a transparent hard synthetic resin liquid-permeable sheet, but may be translucent or opaque:
  • a grid 38 may be formed in the window hole 27. This strengthens the bottom of the perforated dish 26 and increases its strength when used as an embedded support base. Also, as compared with the case where only the window 27 is provided, the portion that comes into contact with the embedding agent is increased, so that the embedding can be performed more integrally.
  • the lid plate 23 of the above embodiment is described as being made of a hard synthetic resin, a stainless steel or other stainless steel is used as shown in FIGS. 19 and 20 in place of the synthetic resin.
  • the fitting of the engaging piece 34 to the engaging hole 35 is the same as that of the above-described embodiment, but the other of the engaging pieces is connected to the spring-like engaging element.
  • 36 which engages with the engaging projections 37 provided on the flat container 22: Further, the embodiment shown in FIGS. 21 and 22 is the same as the embodiment shown in FIG. The difference is that the edge 36a of the child 36 is facing outward, whereas the edge 36b is facing inward.
  • the support frame 28 in each of the above-described embodiments protrudes along the inner peripheral edge of the window hole 27, while the outside of the cover plate 23 is provided. They differ in that they protrude along the periphery.
  • This embodiment is different from the embodiments of FIGS. 19 to 22 in that the engagement element 36 is also used as the support frame 28, and the volume of the portion surrounded by the support frame 28 is increased. Therefore, a relatively large biological sample 31 can be accommodated.
  • FIGS. 25 and 26 is different from the embodiment shown in FIGS. 23 and 24 in that the joint 36 is constituted by two parts, but is constituted integrally. Different c
  • FIGS. 18, 20, 22, 24, and 26 described above show a state in which the opening 29 of the perforated dish 26 faces downward.
  • the flat container 22 and the It is performed with the prone and upside down prone shown in Fig. 8,
  • the opening 29 of the perforated dish is filled with a hydrophilic sheet 33 having an affinity for the fixing support 32. May be arranged. Since the hydrophilic sheet 33 adheres well to the fixing support 32, by arranging the hydrophilic sheet 33, the fixing support 32 can be fixed more reliably. It is possible to lower the concentration.
  • the hydrophilic sheet 33 is made of a material which is hydrophilic and easily adheres to the surface of the fixing support 32 and has a property of being insoluble in alcohol and xylene, for example, a thin section of Japanese paper or sponge. Use a cloth or the like.
  • a reference mark 39 may be displayed at least on one side edge of the hydrophilic sheet 33.
  • the reference mark 39 may include a plurality of biological samples 31 in particular. This is useful when it is necessary to indicate the order in which the biological samples 31 were collected, and from which part of the organ to be collected, etc. It is determined in advance that a plurality of biological samples 31 are to be arranged on a certain basis as a starting point, so that confusion does not occur when embedding.
  • a square hydrophilic sheet 33 as shown in FIG. A notch 33a is formed in one corner of the hydrophilic sheet 33 as a reference mark, or a protrusion 33b is formed in one corner of the hydrophilic sheet 33 as shown in FIG. It is also possible that
  • FIGS. 14 and 2 The embodiment of the present invention shown in FIGS. 14 and 2 is as shown in the upper trace.
  • a window hole is formed in either the flat container or the cover plate of the embedding cassette, and the periphery of the window hole is formed.
  • a support frame is protruded toward the inside of the embedding cassette, and a perforated dish containing a biological sample is placed and held between the flat container and the cover plate.
  • a biological specimen embedding cassette that can serve as an embedding support base when slicing by a microtome can be provided, and costs can be reduced.
  • the perforated dish containing the biological sample is held between the flat container and the cover plate, the biological sample does not move or fall off, which facilitates handling such as transportation. If the sample is fixed, it can be more reliably prevented from falling off
  • the fixing support can be more reliably fixed.
  • the sheet increases the fixing strength, and the concentration of the fixing supporting agent can be reduced, and the cost can be further reduced. is there
  • this invention uses a porous dish, which is a main part of a fixing support case for fixing a biological sample embedded in a fixing support agent in a prone state, as described above. Since the sheet is formed using a sheet, the perforated dish can be formed simply by pressing at a low cost. It is particularly suitable and facilitates the pathological examination of a large number of patients and can be used to improve the accuracy of the examination.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

Cette invention concerne un boîtier de fixation et/ou de support destiné au stockage de mannane dans lequel sont placés des échantillons biologiques, ces derniers étant prélevés sur le corps humain par un médecin et transférés dans une chambre d'inspection pathologique en vue d'une étude microscopique. Une plaque de support et une plaque de couverture, formant le boîtier de fixation et/ou de support, sont disposées de manière à pouvoir être ouvertes ou fermées. Une plaque perforée, faite d'une feuille rigide comportant de nombreux trous, est montée dans un trou de support pratiqué au centre de la plaque de support, le bord de la plaque perforée étant maintenu pincé entre la plaque de support et la plaque de couverture.
PCT/JP1996/003301 1995-11-17 1996-11-11 Boitier de fixation et de support d'echantillon biologique WO1997019337A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU75072/96A AU7507296A (en) 1995-11-17 1996-11-11 Case for fixing and supporting biological sample

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP7300291A JP3008078B2 (ja) 1995-11-17 1995-11-17 生物試料の包埋カセット
JP7/300291 1995-11-17
JP7/300290 1995-11-17
JP30029095A JPH09145565A (ja) 1995-11-17 1995-11-17 生検試料の定着支持用ケース

Publications (1)

Publication Number Publication Date
WO1997019337A1 true WO1997019337A1 (fr) 1997-05-29

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PCT/JP1996/003301 WO1997019337A1 (fr) 1995-11-17 1996-11-11 Boitier de fixation et de support d'echantillon biologique

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WO (1) WO1997019337A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7435601B2 (en) 2003-02-19 2008-10-14 Fitzco Incorporated Biological specimen handling method
CN109916681A (zh) * 2019-03-10 2019-06-21 西安培华学院 一种数字病理切片的移动装置

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51118531A (en) * 1975-03-20 1976-10-18 Miles Lab Biological sample treating container
JPS61502560A (ja) * 1984-06-19 1986-11-06 マクレ−ン，ウイリアム 組織標本識別のための方法と器具
JPH08211047A (ja) * 1995-02-03 1996-08-20 Teiji Takezaki 生検試料の定着支持方法とその定着支持剤及び包埋カセット

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51118531A (en) * 1975-03-20 1976-10-18 Miles Lab Biological sample treating container
JPS61502560A (ja) * 1984-06-19 1986-11-06 マクレ−ン，ウイリアム 組織標本識別のための方法と器具
JPH08211047A (ja) * 1995-02-03 1996-08-20 Teiji Takezaki 生検試料の定着支持方法とその定着支持剤及び包埋カセット

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MICROFILM OF THE SPECIFICATION AND DRAWINGS ANNEXED TO THE WRITTEN APPLICATION OF JAPANESE UTILITY MODEL, Application No. 28007/1987 (Laid-open No. 135166/1988) (MURASUMI KOGYO K.K.), 5 September 1988. *
MICROFILM OF THE SPECIFICATION AND DRAWINGS ANNEXED TO THE WRITTEN APPLICATION OF JAPANESE UTILITY MODEL, Application No. 28534/1982 (Laid-open No. 132870/1983) (SAKURA SEIKI K.K.), 7 September 1983. *
MICROFILM OF THE SPECIFICATION AND DRAWINGS ANNEXED TO THE WRITTEN APPLICATION OF JAPANESE UTILITY MODEL, Application No. 58527/1990 (Laid-open No. 18342/1992) (MURASUMI KOGYO K.K.), 17 February 1992. *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7435601B2 (en) 2003-02-19 2008-10-14 Fitzco Incorporated Biological specimen handling method
CN109916681A (zh) * 2019-03-10 2019-06-21 西安培华学院 一种数字病理切片的移动装置

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