WO1997018323A2 - Materiaux de kinase relatifs a la phosphatidylinositol kinase du point de controle du cycle cellulaire, et procedes - Google Patents

Materiaux de kinase relatifs a la phosphatidylinositol kinase du point de controle du cycle cellulaire, et procedes Download PDF

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Publication number
WO1997018323A2
WO1997018323A2 PCT/US1996/019337 US9619337W WO9718323A2 WO 1997018323 A2 WO1997018323 A2 WO 1997018323A2 US 9619337 W US9619337 W US 9619337W WO 9718323 A2 WO9718323 A2 WO 9718323A2
Authority
WO
WIPO (PCT)
Prior art keywords
dna
mccs1
kinase
cell
seq
Prior art date
Application number
PCT/US1996/019337
Other languages
English (en)
Other versions
WO1997018323A3 (fr
Inventor
Merl F. Hoekstra
Doug A. Holtzman
Kathleen S. Keegan
Original Assignee
Icos Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icos Corporation filed Critical Icos Corporation
Priority to EP96945181A priority Critical patent/EP0807169A3/fr
Priority to IL12130696A priority patent/IL121306A0/xx
Priority to JP51918097A priority patent/JP2002515732A/ja
Priority to MX9705466A priority patent/MX9705466A/es
Priority to HU0002207A priority patent/HUP0002207A2/hu
Priority to SK1115-97A priority patent/SK111597A3/sk
Priority to AU14611/97A priority patent/AU1461197A/en
Publication of WO1997018323A2 publication Critical patent/WO1997018323A2/fr
Priority to NO973279A priority patent/NO973279L/no
Priority to FI973005A priority patent/FI973005A/fi
Publication of WO1997018323A3 publication Critical patent/WO1997018323A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases

Abstract

L'invention concerne d'une manière générale des gènes codant des protéines relatives à la phosphatidylinositol kinase (PIK) du point de contrôle du cycle cellulaire, ces protéines étant essentielles aux réponses de dommages de l'ADN dans les cellules. Ces kinases relatives à PIK sont nécessaires dans les chemins régulateurs qui arrêtent le cycle cellulaire suite à des dommages de l'ADN afin de permettre la réparation de l'ADN avant une mitose ou un début de réplication de l'ADN. Plus particulièrement, l'invention concerne une nouvelle kinase relative à PIK du point de contrôle du cycle des cellules humaines, MCCS1, et des séquences polynucléotidiques codant MCSS1. Des dosages permettant d'identifier des modulateurs de MCCS1 utiles par exemple en chimiothérapie et comme adjuvant de radiation sont également décrits dans l'invention. Celle-ci décrit également des dosages permettant d'identifier des modulateurs de la protéine relative à phosphatidylinositol kinase du point de contrôle du cycle cellulaire, lesquels ont reçu l'identification ATM.
PCT/US1996/019337 1995-11-16 1996-11-18 Materiaux de kinase relatifs a la phosphatidylinositol kinase du point de controle du cycle cellulaire, et procedes WO1997018323A2 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
EP96945181A EP0807169A3 (fr) 1995-11-16 1996-11-18 Materiaux de kinase relatifs a la phosphatidylinositol kinase du point de controle du cycle cellulaire, et procedes
IL12130696A IL121306A0 (en) 1995-11-16 1996-11-18 Cell cycle checkpoint pik-related kinase materials and methods
JP51918097A JP2002515732A (ja) 1995-11-16 1996-11-18 細胞周期チェックポイントｐｉｋ関連キナーゼ物質及び方法
MX9705466A MX9705466A (es) 1995-11-16 1996-11-18 Materiales y metodos de quinasa relacionada con fosfatidilinositolquinasa de punto de control del ciclo celular.
HU0002207A HUP0002207A2 (hu) 1996-10-21 1996-11-18 A sejtciklus szabályozási pont PIK-kel rokon kínázai és eljárás előállításukra
SK1115-97A SK111597A3 (en) 1995-11-16 1996-11-18 Cell-cycle checkpoint phosphatidylinositol- (pik-) related kinases, genes coding therefor and methods for assaying and modulating enzymatic activity
AU14611/97A AU1461197A (en) 1995-11-16 1996-11-18 Cell cycle checkpoint pik-related kinase materials and methods
NO973279A NO973279L (no) 1995-11-16 1997-07-15 PIK-beslektede kinasematerialer og fremgangsmåter for cellesykluskontrollpunkt
FI973005A FI973005A (fi) 1995-11-16 1997-07-15 Solusyklin kontrollikohdan PIK-sukuisia kinaasimateriaaleja ja menetelmiä

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US55866695A 1995-11-16 1995-11-16
US08/558,666 1995-11-16
US73129696A 1996-02-27 1996-02-27
US08/007,312 1996-02-27
US72530496A 1996-10-21 1996-10-21
US08/725,304 1996-10-21

Publications (2)

Publication Number Publication Date
WO1997018323A2 true WO1997018323A2 (fr) 1997-05-22
WO1997018323A3 WO1997018323A3 (fr) 1997-10-09

Family

ID=27415779

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/019337 WO1997018323A2 (fr) 1995-11-16 1996-11-18 Materiaux de kinase relatifs a la phosphatidylinositol kinase du point de controle du cycle cellulaire, et procedes

Country Status (6)

Country Link
CN (1) CN1199420A (fr)
AU (1) AU1461197A (fr)
IL (1) IL121306A0 (fr)
NO (1) NO973279L (fr)
PL (1) PL322876A1 (fr)
WO (1) WO1997018323A2 (fr)

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0826031A1 (fr) * 1995-05-16 1998-03-04 RAMOT UNIVERSITY AUTHORITY FOR APPLIED RESEARCH & INDUSTRIAL DEVELOPMENT LTD. Gene de l'ataxia-telangiectasie et son organisation genomique
EP0826033A1 (fr) * 1995-05-16 1998-03-04 RAMOT UNIVERSITY AUTHORITY FOR APPLIED RESEARCH & INDUSTRIAL DEVELOPMENT LTD. Gene de l'ataxie-telangiectasie
WO1999002653A1 (fr) * 1997-07-11 1999-01-21 Trustees Of The University Of Pennsylvania Acide nucleique codant une nouvelle proteine induite par chimiotherapie, et ses procedes d'utilisation
WO1999004266A2 (fr) * 1997-07-16 1999-01-28 Kudos Pharmaceuticals Limited Techniques, methodes et procedes therapeutiques
WO1999011795A1 (fr) * 1997-09-05 1999-03-11 Icos Corporation Materiels de proteine-kinase point de controle du cycle cellulaire, effecteur de chk1 mammalien et methodes
WO1999015157A2 (fr) * 1997-09-25 1999-04-01 The University Of British Columbia Inhibiteurs des points de controle g2 et dosage
WO1999025843A2 (fr) * 1997-10-22 1999-05-27 The Scripps Research Institute Kinase humaine de controle, hcds1, compositions et procedes
US6071691A (en) * 1998-04-27 2000-06-06 Oregon Health Science University Materials and methods for modulating differentiation
WO2000047760A2 (fr) * 1999-02-10 2000-08-17 St. Jude Children's Research Hospital Modulation d'atm kinase utile a des fins de criblage et therapeutiques
US6387640B1 (en) 1999-02-10 2002-05-14 St. Jude Children's Research Hospital ATM kinase modulation for screening and therapies
US6670167B1 (en) 1999-11-01 2003-12-30 Agouron Pharmaceuticals, Inc. Catalytic domain of the human effector cell cycle checkpoint protein kinase materials and methods for identification of inhibitors thereof
WO2004038008A2 (fr) * 2002-10-25 2004-05-06 University Of Massachusetts Modulation de la proliferation cellulaire
US7049313B2 (en) 2002-02-25 2006-05-23 Kudos Pharmaceuticals Ltd. ATM inhibitors
EP0856058B1 (fr) * 1995-09-06 2006-07-26 ICOS Corporation Genes de point de controle a cycle cellulaire
US7105518B2 (en) 2001-08-14 2006-09-12 Cancer Research Technology Limited Thiopyrane-4-ones as DNA protein kinase inhibitors
US7226918B2 (en) 2001-08-14 2007-06-05 Cancer Research Technology Limited DNA-PK inhibitors
US7402607B2 (en) 2004-09-20 2008-07-22 Kudos Pharmaceuticals Limited DNA-PK inhibitors
US7429660B2 (en) 2003-08-13 2008-09-30 Kudos Pharmaceuticals Limited ATM inhibitors
US7642254B2 (en) 2005-02-09 2010-01-05 Kudos Pharmaceuticals Limited ATM inhibitors
US7696203B2 (en) 2005-04-15 2010-04-13 Kudos Pharmaceuticals Limited DNA-PK inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997009433A1 (fr) * 1995-09-06 1997-03-13 Icos Corporation Genes de point de controle a cycle cellulaire

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997009433A1 (fr) * 1995-09-06 1997-03-13 Icos Corporation Genes de point de controle a cycle cellulaire

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CURRENT OPINION GENET. DEV., vol. 7, no. 2, 1997, pages 170-175, XP002036687 HOEKSTRA, M.F.: "Responses to DNA damage and regulation of cell cycle checkpoints by the ATM protein kinase family" *
EMBO JOURNAL, vol. 15, no. 23, 1996, pages 6641-6651, XP002023634 BENTLEY, N.J. ET AL.: "The Schizosaccharomyces pombe rad3 checkpoint gene" *
GENE, vol. 119, 1992, pages 83-89, XP002023633 SEATON, B.L. ET AL.: "Isolation and characterization of the Schizosaccharomyces pombe rad3 gene, involved in the DNA damage and DNA synthesis checkpoints" cited in the application *
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 93, April 1996, pages 2850-2855, XP002023632 CIMPRICH, K.A. ET AL.: "cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein" *
SCIENCE, vol. 268, 23 June 1995, pages 1749-1753, XP002036686 SAVITSKY, K. ET AL.: "A single ataxia telangiectasia gene with a product similar to PI-3 kinase" *

Cited By (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0826031A4 (fr) * 1995-05-16 2000-09-06 Univ Ramot Gene de l'ataxia-telangiectasie et son organisation genomique
EP0826033A1 (fr) * 1995-05-16 1998-03-04 RAMOT UNIVERSITY AUTHORITY FOR APPLIED RESEARCH & INDUSTRIAL DEVELOPMENT LTD. Gene de l'ataxie-telangiectasie
EP0826031A1 (fr) * 1995-05-16 1998-03-04 RAMOT UNIVERSITY AUTHORITY FOR APPLIED RESEARCH & INDUSTRIAL DEVELOPMENT LTD. Gene de l'ataxia-telangiectasie et son organisation genomique
EP0826033A4 (fr) * 1995-05-16 2000-09-06 Univ Ramot Gene de l'ataxie-telangiectasie
EP0856058B1 (fr) * 1995-09-06 2006-07-26 ICOS Corporation Genes de point de controle a cycle cellulaire
WO1999002653A1 (fr) * 1997-07-11 1999-01-21 Trustees Of The University Of Pennsylvania Acide nucleique codant une nouvelle proteine induite par chimiotherapie, et ses procedes d'utilisation
WO1999004266A2 (fr) * 1997-07-16 1999-01-28 Kudos Pharmaceuticals Limited Techniques, methodes et procedes therapeutiques
US7138236B1 (en) 1997-07-16 2006-11-21 Kudos Pharmaceuticals Limited Interactions of ATM, ATR or DAN-PK with p53
WO1999004266A3 (fr) * 1997-07-16 1999-08-19 Kudos Pharm Ltd Techniques, methodes et procedes therapeutiques
WO1999011795A1 (fr) * 1997-09-05 1999-03-11 Icos Corporation Materiels de proteine-kinase point de controle du cycle cellulaire, effecteur de chk1 mammalien et methodes
WO1999015157A2 (fr) * 1997-09-25 1999-04-01 The University Of British Columbia Inhibiteurs des points de controle g2 et dosage
WO1999015157A3 (fr) * 1997-09-25 1999-09-23 Univ British Columbia Inhibiteurs des points de controle g2 et dosage
WO1999025843A3 (fr) * 1997-10-22 1999-08-05 Scripps Research Inst Kinase humaine de controle, hcds1, compositions et procedes
WO1999025843A2 (fr) * 1997-10-22 1999-05-27 The Scripps Research Institute Kinase humaine de controle, hcds1, compositions et procedes
US6071691A (en) * 1998-04-27 2000-06-06 Oregon Health Science University Materials and methods for modulating differentiation
WO2000047760A3 (fr) * 1999-02-10 2000-11-30 St Jude Childrens Res Hospital Modulation d'atm kinase utile a des fins de criblage et therapeutiques
US6348311B1 (en) 1999-02-10 2002-02-19 St. Jude Childre's Research Hospital ATM kinase modulation for screening and therapies
US6387640B1 (en) 1999-02-10 2002-05-14 St. Jude Children's Research Hospital ATM kinase modulation for screening and therapies
WO2000047760A2 (fr) * 1999-02-10 2000-08-17 St. Jude Children's Research Hospital Modulation d'atm kinase utile a des fins de criblage et therapeutiques
US6670167B1 (en) 1999-11-01 2003-12-30 Agouron Pharmaceuticals, Inc. Catalytic domain of the human effector cell cycle checkpoint protein kinase materials and methods for identification of inhibitors thereof
US7105518B2 (en) 2001-08-14 2006-09-12 Cancer Research Technology Limited Thiopyrane-4-ones as DNA protein kinase inhibitors
US7226918B2 (en) 2001-08-14 2007-06-05 Cancer Research Technology Limited DNA-PK inhibitors
US7674823B2 (en) 2001-08-14 2010-03-09 Cancer Research Technology Limited DNA-PK inhibitors
US7049313B2 (en) 2002-02-25 2006-05-23 Kudos Pharmaceuticals Ltd. ATM inhibitors
WO2004038008A3 (fr) * 2002-10-25 2006-03-23 Univ Massachusetts Modulation de la proliferation cellulaire
WO2004038008A2 (fr) * 2002-10-25 2004-05-06 University Of Massachusetts Modulation de la proliferation cellulaire
US7429660B2 (en) 2003-08-13 2008-09-30 Kudos Pharmaceuticals Limited ATM inhibitors
US7402607B2 (en) 2004-09-20 2008-07-22 Kudos Pharmaceuticals Limited DNA-PK inhibitors
US7732483B2 (en) 2004-09-20 2010-06-08 Kudos Pharmaceuticals Limited DNA-PK inhibitors
US7642254B2 (en) 2005-02-09 2010-01-05 Kudos Pharmaceuticals Limited ATM inhibitors
US7696203B2 (en) 2005-04-15 2010-04-13 Kudos Pharmaceuticals Limited DNA-PK inhibitors

Also Published As

Publication number Publication date
CN1199420A (zh) 1998-11-18
NO973279L (no) 1997-09-16
NO973279D0 (no) 1997-07-15
IL121306A0 (en) 1998-01-04
AU1461197A (en) 1997-06-05
PL322876A1 (en) 1998-03-02
WO1997018323A3 (fr) 1997-10-09

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