WO1997008934A3 - Derives d'acide aryl-acrylique convenant comme inhibiteurs de proteine-tyrosine-phosphatase - Google Patents

Derives d'acide aryl-acrylique convenant comme inhibiteurs de proteine-tyrosine-phosphatase Download PDF

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Publication number
WO1997008934A3
WO1997008934A3 PCT/US1996/018401 US9618401W WO9708934A3 WO 1997008934 A3 WO1997008934 A3 WO 1997008934A3 US 9618401 W US9618401 W US 9618401W WO 9708934 A3 WO9708934 A3 WO 9708934A3
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WIPO (PCT)
Prior art keywords
acrylic acid
protein tyrosine
tyrosine phosphatase
acid derivatives
derivatives useful
Prior art date
Application number
PCT/US1996/018401
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English (en)
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WO1997008934A2 (fr
Inventor
Adnan M M Mjalli
Xiaodong Cao
Edmund J Moran
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Ontogen Corp
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Filing date
Publication date
Priority claimed from US08/543,630 external-priority patent/US5770620A/en
Application filed by Ontogen Corp filed Critical Ontogen Corp
Priority to EP96940489A priority Critical patent/EP0833629A4/fr
Priority to AU77358/96A priority patent/AU713863B2/en
Priority to JP9511473A priority patent/JPH11508919A/ja
Publication of WO1997008934A2 publication Critical patent/WO1997008934A2/fr
Publication of WO1997008934A3 publication Critical patent/WO1997008934A3/fr

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    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
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    • C07D209/04—Indoles; Hydrogenated indoles
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    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07K5/06—Dipeptides
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Abstract

La présente invention concerne de nouveaux composés modulant la protéine-tyrosine-phosphatase, lesquels composés présentent une structure d'acide aryl-acrylique. L'invention concerne également des compositions comprenant ces composés, ainsi que des procédés de fabrication et d'utilisation de ces composés.
PCT/US1996/018401 1995-06-19 1996-06-19 Derives d'acide aryl-acrylique convenant comme inhibiteurs de proteine-tyrosine-phosphatase WO1997008934A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP96940489A EP0833629A4 (fr) 1995-06-19 1996-06-19 Derives d'acide aryl-acrylique convenant comme inhibiteurs de proteine-tyrosine-phosphatase
AU77358/96A AU713863B2 (en) 1995-06-19 1996-06-19 Aryl acrylic acid derivatives useful as protein tyrosine phosphatase inhibitors
JP9511473A JPH11508919A (ja) 1995-06-19 1996-06-19 蛋白質チロシンホスファターゼ阻害剤として有用なアリールアクリル酸誘導体

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US49226495A 1995-06-19 1995-06-19
US08/543,630 US5770620A (en) 1995-06-19 1995-10-16 Aryl acrylic acid derivatives useful as protein tyrosine phosphatase inhibitors
US08/543,630 1995-10-16
US08/492,264 1995-10-16

Publications (2)

Publication Number Publication Date
WO1997008934A2 WO1997008934A2 (fr) 1997-03-13
WO1997008934A3 true WO1997008934A3 (fr) 1997-04-24

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EP (1) EP0833629A4 (fr)
JP (1) JPH11508919A (fr)
AU (1) AU713863B2 (fr)
CA (1) CA2224874A1 (fr)
WO (1) WO1997008934A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2381497A (en) * 1996-04-19 1997-11-12 Novo Nordisk A/S Modulators of molecules with phosphotyrosine recognition units
US6043247A (en) * 1996-04-19 2000-03-28 Novo Nordisk A/S Modulators of molecules with phosphotyrosine recognition units
US6242493B1 (en) 1998-03-13 2001-06-05 Merck Frosst Canada & Co. Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment
WO1999047497A2 (fr) * 1998-03-13 1999-09-23 Merck Frosst Canada & Co. Acides carboxyliques et acylsulfonamides, compositions contenant ces composes et methodes de traitement
US6451827B2 (en) 1998-05-12 2002-09-17 Wyeth 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia
WO1999061410A1 (fr) * 1998-05-12 1999-12-02 American Home Products Corporation Diphenyles 2,3,5-substitues utiles pour le traitement de la resistance insulinique et de l'hyperglycemie
US6613903B2 (en) 2000-07-07 2003-09-02 Novo Nordisk A/S Modulators of protein tyrosine phosphatases (PTPases)
US6498182B2 (en) 2000-09-26 2002-12-24 Biovitrum Ab Compounds
CA2469228A1 (fr) 2001-12-03 2003-06-12 Japan Tobacco Inc. Compose azole et utilisation medicinale de celui-ci
US7230133B2 (en) 2003-05-01 2007-06-12 Bristol-Myers Squibb Company Malonamides and malonamide derivatives as modulators of chemokine receptor activity
JP4822312B2 (ja) * 2005-05-13 2011-11-24 学校法人慶應義塾 ナフトキノン誘導体化合物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206392A (en) * 1992-04-27 1993-04-27 American Cyanamid Company Facile synthesis of arylmaleic acids and anhydrides

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5216024A (en) * 1987-07-28 1993-06-01 Baylor College Of Medicine Cell growth inhibitors and methods of treating cancer and cell proliferative diseases
GB8913708D0 (en) * 1989-06-14 1989-08-02 Unilever Plc Cosmetic composition
WO1991016305A1 (fr) * 1990-04-16 1991-10-31 Rhone-Poulenc Rorer International (Holdings), Inc. Composes d'ethenediyle heterocyclique qui inhibent la kinase de tyrosine de recepteur egf
WO1994008600A1 (fr) * 1992-10-09 1994-04-28 Joslin Diabetes Center Inhibition de molecules transductrices de signaux
GB9306473D0 (en) * 1993-03-29 1993-05-19 Bioglan Lab Ltd Pharmaceutically useful compounds
AU691820B2 (en) * 1993-07-15 1998-05-28 Cancer Research Campaign Technology Limited Prodrugs of protein tyrosine kinase inhibitors
IL112205A0 (en) * 1994-01-06 1995-03-15 Res Dev Foundation Curcumin, analogues of curcumin and novel uses thereof
AU4972096A (en) * 1995-02-01 1996-08-21 Affymax Technologies N.V. Peptides and compounds that bind to sh2 domains
AU2381497A (en) * 1996-04-19 1997-11-12 Novo Nordisk A/S Modulators of molecules with phosphotyrosine recognition units

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206392A (en) * 1992-04-27 1993-04-27 American Cyanamid Company Facile synthesis of arylmaleic acids and anhydrides

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, 1995, Vol. 5, No. 24, CAO et al., "Synthesis of NH-Acyl-alpha-Aminoamides on Rink Resin: Inhibitors of the Hematopoietic Protein Tyrosine Phosphatase (HePTP)", pages 2953-2958. *
J. CHEM. SOC. PERKIN. 2 May 1993, ARENA et al., "Thermodynamics of Protonation of Some Five-membered Heteroarylcarboxylates, -alkanoates and -trans-propenoates", pages 1941-1945. *
J. CHEM. SOC. PERKIN. TRANS., 1 December 1992, Vol. 24, CRUMP et al., "Diastereoselectivity of Electrophilic Attack on Trigonal Carbon Adjacent to a Stereogenic Centre: Diastereoselective Alkylation and Protonation of Open-chain Enolates Having a Stereogenic Centre Carrying a Silyl Group at the beta *
See also references of EP0833629A4 *

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AU7735896A (en) 1997-03-27
CA2224874A1 (fr) 1997-03-13
EP0833629A2 (fr) 1998-04-08
EP0833629A4 (fr) 1998-09-16
AU713863B2 (en) 1999-12-09
WO1997008934A2 (fr) 1997-03-13
JPH11508919A (ja) 1999-08-03

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