WO1997006773A1 - New chemical mixtures for mouth care, gum care and dental care, processes for their preparation and use thereof - Google Patents

New chemical mixtures for mouth care, gum care and dental care, processes for their preparation and use thereof Download PDF

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Publication number
WO1997006773A1
WO1997006773A1 PCT/SI1996/000021 SI9600021W WO9706773A1 WO 1997006773 A1 WO1997006773 A1 WO 1997006773A1 SI 9600021 W SI9600021 W SI 9600021W WO 9706773 A1 WO9706773 A1 WO 9706773A1
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WO
WIPO (PCT)
Prior art keywords
aluminium
ammonium sulphate
dodecahydrate
mixture
sulphate dodecahydrate
Prior art date
Application number
PCT/SI1996/000021
Other languages
French (fr)
Inventor
Slavko Dokmann
Original Assignee
Slavko Dokmann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Slavko Dokmann filed Critical Slavko Dokmann
Priority to AU66735/96A priority Critical patent/AU6673596A/en
Publication of WO1997006773A1 publication Critical patent/WO1997006773A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/26—Aluminium; Compounds thereof

Definitions

  • the invention relates to novel chemical mixtures for mouth care, gum care and den ⁇ tal care containing aluminium and ferric salts, to processes for their preparation and their use.
  • the invention particularly relates to novel chemical mixtures characterized in that they contain aluminium ammonium sulphate or aluminium potassium sulphate or a mixture of aluminium ammonium sulphate and aluminium potassium sulphate or a mixture of aluminium ammonium sulphate, aluminium potassium sulphate and ferric ammonium sulphate or a mixture of aluminium ammonium sulphate and ferric am ⁇ monium sulphate or a mixture of aluminium potassium sulphate and ferric am ⁇ monium sulphate and/or boric acid and appropriate humectants, ethanol, sodium fluoride, a flavouring component, a non-ionic tenside and water.
  • Solutions for oral care and gum care and pastes for dental care described in the in ⁇ vention have pronounced deodorant, astringent and disinfectant properties.
  • a particular advantage of the products described in the invention is that due to the excellent choice of the flavour as breath freshener bad breath is removed effectively and for a longer period of time.
  • a further effect of the chemical mixtures described in this invention is their astrin ⁇ gent action on the mouth mucosa and thus by rinsing the mouth all waste plaque sub ⁇ stances are eliminated. At the same time direct causes of dental and gum diseases are diminished.
  • An important advantage of the solutions of the present invention is their potent dis ⁇ infectant action. It is shown in their bactericidal activity since they reduce bacterial flora in the mouth and inhibit bacterial enzymes converting sugars into acids.
  • aluminium salts and various sulphates have excellent deodorant, astringent and pronounced bactericidal and fungicidal properties.
  • Gargle solutions had the following compositions: Solution I contained: alum 1.5 g menthol solution 25.0 g water 500 ml
  • Solution II contained: hydrogen peroxide 0.12 %
  • Solution III contained: sodium chloride 5.0 g sodium hydrogen carbonate 50.0 g water 500 ml
  • Solution IV contained: boric acid 2 %
  • Solution V contained: sodium peroxyborate 0.54 %
  • the activity of the solutions decreased in the following order: I> V> VI > III > II > IV. Their inhibitory activity against Bacillus subtilis and Saccharomyces albicans was tested. The activity of the gargle solution was tested in the following order:
  • the present invention relates to novel refreshing and antiseptic chemical mixtures for mouth care, gum care and dental care containing as active components aluminium ammonium sulphate, aluminium potassium sulphate and ferric am ⁇ monium sulphate and/or boric acid and ethanol, glycerin, sodium fluoride, a flavour ⁇ ing component, an appropriate tenside, a colour and water.
  • An advantage of the solutions and pastes for oral hygiene, dental hygiene and gum treatment described in the present invention is that by their use bad breath is removed for a longer period of time.
  • oral hygiene preparations of the invention By the use of oral hygiene preparations of the invention the formation of plaque and tartar and the deposition thereof on tooth necks and gums are prevented, whereby the possibility of gingivitis is reduced.
  • the plaque mainly consists of organic disintegration products which are a good culture medium for bacteria, which by enzymatic disintegration of calcareous substances from saliva produce tartar. In this process also microorganisms belonging to lactobacteria as well as some other bacteria take part.
  • Tartar is deposited on tooth necks and can cause gum inflammation or gingivitis.
  • tartar is one of the causes for periodontosis since by the deposition thereof the gum tissue becomes unprotected, more sensitive and easily inflammable.
  • Beside dental caries periodontosis is the most frequent dental disease.
  • Dental caries is caused by pathomorphologic decay of tooth enamel and dentin. Biochemically, this is an enzymatic dissolution of hard tooth parts caused by phosphatases, oxidases and proteases of bacteria in the mouth and by the influence of saliva. The reasons there- for are the diet, hormonal-vegetative anomalies, genetic factors and consequences of various diseases. Lack of vitamins in the diet and disturbances in the organism also increase periodontosis.
  • the object of the present invention are novel chemical mixtures for mouth care, gum care and dental care and solutions and pastes intended for general oral hygiene after cleaning one's teeth.
  • the described preparations also diminish direct causes of dental and gum diseases and satisfy the following basic conditions:
  • the mixtures of the present invention for mouth care, gum care and dental care com ⁇ prise aluminium ammonium sulphate dodecahydrate and/or aluminium potassium sulphate dodecahydrate and/or ferric ammonium sulphate dodecahydrate and/or boric acid and sodium fluoride, Tween ® 20, an edible flavour, glycerin, ethanol, a colour and purified water.
  • the described invention particularly relates to novel mixtures, characterized in that they contain 0.5 to 10.0% of aluminium ammonium sulphate dodecahydrate or 0.2 to 8.0% of aluminium potassium sulphate dodecahydrate or a mixture of 0.5 to 4.0% of aluminium ammonium sulphate dodecahydrate and 1.0 to 3.0% of aluminium potas ⁇ sium sulphate dodecahydrate, or a mixture of 2.0 to 3.5% of aluminium ammonium sulphate dodecahydrate, 0.5 to 1.0% of aluminium potassium sulphate dodeca ⁇ hydrate and 0.1 to 0.3% of ferric ammonium sulphate dodecahydrate, or a mixture of 1.5 to 4.0% of aluminium ammonium sulphate dodecahydrate and 0.1 to 0.3% of fer ⁇ ric ammonium sulphate dodecahydrate or a mixture of 1.5 to 3.0% of aluminium potassium sulphate dodecahydrate and 0.15 to 0.3% of ferric ammonium sulphate dodecahydrate.
  • the described mixtures for rinsing the oral cavity are characterized in that they con ⁇ tain 0.15 to 0.3% of sodium fluoride and/or 0.1 to 1.5% of boric acid and 1.0 to 5.0% of glycerin, 0.2 to 1.5% of Tween ® 20, 5 to 10% of ethanol, 0.1 to 0.5% of flavour, an appropriate amount of an edible colour and purified water.
  • the described mixtures for cleaning one's teeth are characterized in that they contain 0.5 to 0.8% of sodium monofluoro phosphate, 0.04 to 0.08% of saccharin, 0.5 to 1.0% of Deydrazol A 400 P, 15.0 to 25.0% of glycerin, 30.0 to 35.0% of phosphate salts, 2.0 to 2.4% of silicates, 0.5 to 1.5% of paraffin oil, 1.0 to 2.0% of Texapon K 12 and ap ⁇ intestinalte ammounts of an edible flavour, a colour and purified water.
  • the invention also refers to an application/use of the described solutions for mouth care, gum care and dental care, characterized in that the mouth cavity is rinsed with the preparations after the cleaning of teeth or the teeth are cleaned with the preparations of the invention.
  • the invention is illustrated by the following examples.
  • the process comprised the mixing and slow heating to 25 to 30°C of the following substances:
  • the cold solution was tinted by admixing 3 mg of Indigotin colour (CI.73015).
  • the prepared solution was filled into suitable polyethylene or glass bottles.
  • the process comprised the mixing and slow heating to 25 to 30°C of the following substances:
  • the process comprised the mixing and slow heating to 25 to 30°C of the following substances:
  • the cold solution was tinted by admixing 3 mg of Indigotin colour (CI.73015).
  • the prepared solution was filled into suitable polyethylene or glass bottles.
  • the process comprised the mixing and slow heating to 25 to 30°C of the following substances:
  • Example 5 The cold solution was tinted by admixing 3 mg of Indigotin colour (CI.73015). The prepared solution was filled into suitable polyethylene or glass bottles.
  • Example 5 The cold solution was tinted by admixing 3 mg of Indigotin colour (CI.73015). The prepared solution was filled into suitable polyethylene or glass bottles.
  • the process comprised the mixing and slow heating to 25 to 30°C of the following substances:
  • the cold solution was tinted by admixing 3 mg of Indigotin colour (CI. 73015).
  • the prepared solution was filled into suitable polyethylene or glass bottles.
  • the process comprised the mixing and slow heating to 25 to 35°C of the following components:
  • aluminium ammonium sulphate dodecahydrate 0.5 - 10.0 % sodium monofluoro phosphate 0.5 - 0.7 % saccharin 0.05 - 0.06 %
  • the process comprised the mixing and slow heating to 25 to 35°C of the following components:
  • Dehydazol A 400 P 0.5 - 1.0 % glycerin 20.0 - 25.0 % phosphates (Dentphos K) 30.0 - 32.0 % silicates (Aerosil 200) 2.0 - 2.5 % paraffin oil 0.5 - 0.8 %
  • the prepared mixture was aromatized with the desired flavour, coloured with an edible colour and filled into polyethylene or aluminium tubes.
  • the process comprised the mixing and slow heating to 25 to 35°C of the following components:
  • Texapon K 12 1.0 - 1.5 % purified water 33.54 - 45.46 %
  • the prepared mixture was aromatized with the desired flavour, coloured with an edible colour and filled into polyethylene or aluminium tubes.
  • the process comprised the mixing and slow heating to 25 to 35°C of the following components:
  • Dehydazol A 400 P 0.5 - 1.0 % glycerin 20.0 - 25.0 % phosphates (Dentphos K) 30.0 - 32.0 % silicates (Aerosil 200) 2.0 - 2.5 % paraffin oil 0.5 - 1.0 %
  • the prepared mixture was aromatized with the desired flavour, coloured with an edible colour and filled into polyethylene or aluminium tubes.
  • the process comprised the mixing and slow heating to 25 to 35°C of the following components:
  • Dehydazol A 400 P 0.5 - 1.0 % glycerin 20.0 - 25.0 % phosphates (Dentphos K) 30.0 - 32.0 % silicates (Aerosil 200) 2.0 - 2.5 % paraffin oil 1.0 - 1.5 % Texapon K 12 1.5 - 2.0 % purified water 32.02 - 42.80 %
  • the prepared mixture was aromatized with the desired flavour, coloured with an edible colour and filled into polyethylene or aluminium tubes.
  • the process comprised the mixing and slow heating to 25 to 35°C of the following components:
  • Dehydazol A 400 P 0.5 - 1.0 % glycerin 20.0 - 22.0 % phosphates (Dentphos K) 30.0 - 32.0 % silicates (Aerosil 200) 2.0 - 2.5 % paraffin oil 0.5 - 0.8 %
  • Texapon K 12 1.0 - 2.0 % purified water 30.84 - 45.26 %
  • the prepared mixture was aromatized with the desired flavour, coloured with an edible colour and filled into polyethylene or aluminium tubes.

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  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
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Abstract

The invention relates to novel chemical mixtures, characterized in that they contain 0.5 to 10.0 % of aluminium ammonium sulphate dodecahydrate or 0.2 to 8.0 % of aluminium potassium sulphate dodecahydrate or a mixture of 0.5 to 4.0 % of aluminium ammonium sulphate dodecahydrate and 1.0 to 3.0 % of aluminium potassium sulphate dodecahydrate, or a mixture of 2.0 to 3.5 % of aluminium ammonium sulphate dodecahydrate, 0.5 to 1.0 % of aluminium potassium sulphate dodecahydrate and 0.1 to 0.3 % of ferric ammonium sulphate dodecahydrate, or a mixture of 1.5 to 4.0 % of aluminium ammonium sulphate dodecahydrate and 0.1 to 0.3 % of ferric ammonium sulphate dodecahydrate or a mixture of 1.5 to 3.0 % of aluminium potassium sulphate dodecahydrate and 0.15 to 0.3 % of ferric ammonium sulphate dodecahydrate. The described mixtures are characterized in that they contain 0.15 to 0.3 % of sodium fluoride and/or 0.1 to 1.5 % of boric acid and 1.0 to 5.0 % of glycerin, 0.2 to 1.5 % of Tween® 20, 5 to 10 % of ethanol, 0.1 to 0.5 % of a flavour, an appropriate amount of an edible colour and purified water. The described mixtures are characterized in that they contain 0.5 to 0.8 % of sodium monofluoro phosphate, 0.04 to 0.08 % of saccharin, 0.5 to 1.0 % of Dehydazol A, 15.0 to 25.0 % of glycerin, 30.0 to 35.0 % of phosphate salts, 2.0 to 2.4 % of silicates, 0.5 to 1.5 % of paraffin oil, 1.0 to 2.0 % of Texapon K 12, edible flavours, edible colours and purified water. The invention particularly relates to processes for the preparation of solutions for mouth care, gum care and dental care and to the use thereof.

Description

New Chemical Mixtures for Mouth Care, Gum Care and Dental Care, Processes for Their Preparation and Use Thereof
Technical Field ofthe Invention
LPC: A 61K 7/16 A 61K 7/18 A 61K 31/20
The invention relates to novel chemical mixtures for mouth care, gum care and den¬ tal care containing aluminium and ferric salts, to processes for their preparation and their use.
The invention particularly relates to novel chemical mixtures characterized in that they contain aluminium ammonium sulphate or aluminium potassium sulphate or a mixture of aluminium ammonium sulphate and aluminium potassium sulphate or a mixture of aluminium ammonium sulphate, aluminium potassium sulphate and ferric ammonium sulphate or a mixture of aluminium ammonium sulphate and ferric am¬ monium sulphate or a mixture of aluminium potassium sulphate and ferric am¬ monium sulphate and/or boric acid and appropriate humectants, ethanol, sodium fluoride, a flavouring component, a non-ionic tenside and water.
Solutions for oral care and gum care and pastes for dental care described in the in¬ vention have pronounced deodorant, astringent and disinfectant properties.
A particular advantage of the products described in the invention is that due to the excellent choice of the flavour as breath freshener bad breath is removed effectively and for a longer period of time.
A further effect of the chemical mixtures described in this invention is their astrin¬ gent action on the mouth mucosa and thus by rinsing the mouth all waste plaque sub¬ stances are eliminated. At the same time direct causes of dental and gum diseases are diminished. An important advantage of the solutions of the present invention is their potent dis¬ infectant action. It is shown in their bactericidal activity since they reduce bacterial flora in the mouth and inhibit bacterial enzymes converting sugars into acids.
In the literature there have not been described the preparation and use of washes and pastes for mouth care, gum care and dental care with excellent refreshing and protective properties containing a mixture of aluminium ammonium sulphate or a mixture of aluminium ammonium sulphate with aluminium potassium sulphate and ferric ammonium sulphate in various combinations.
It is very well known that, due to their specific properties, various alums and sulphate salts are used in preparations for dental and oral hygiene.
It is known that aluminium salts and various sulphates have excellent deodorant, astringent and pronounced bactericidal and fungicidal properties.
In the literature there are described numerous preparations or washes for mouth care and dental care which contain alums or sulphate salts as an active ingredient. Thus in the literature there is described an anti-caries dental agent or emulsion for rinsing the mouth containing potassium aluminium sulphate dodecahydrate and cor¬ responding tensides and humectants (EP-A-270 977 of 15.06.1988, Chem. Abstr. 110 (1989) 198967 b).
In many patents also the use of sulphate salts as active components in mouthwashes is described. So there is described a mouthwash for removing bad breath containing a zinc salt (Zn-sulphate) and an appropriate emulsifying agent (EP-A-251 542 of 07.01.1988, Chem. Abstr. 108 (1988) 101135 b). In 1991 a chemical mixture for dental hygiene was described, which was used for the treatment of dental diseases and gin¬ givitis and contained 16% of calcium sulphate, ethanol, glycerin and water (WO 91/99168 of 08.08.1991, Chem. Abstr. 115 (1991) 142051 j). For prevention of periodontosis an oral composition prepared from ferric sulphate is described (JP 90/164,815 of 25.06.1990, Chem. Abstr. 113 (1990) 170854 k).
In the literature also the testing of different gargle solutions is described (Yakuziagaku 17, (1957) 134-6, Chem. Abst. 52 (1958) 11275 b). Gargle solutions had the following compositions: Solution I contained: alum 1.5 g menthol solution 25.0 g water 500 ml
Solution II contained: hydrogen peroxide 0.12 %
Solution III contained: sodium chloride 5.0 g sodium hydrogen carbonate 50.0 g water 500 ml
Solution IV contained: boric acid 2 %
Solution V contained: sodium peroxyborate 0.54 %
Solution VI contained:
Rivanole 0.25 g boric acid 20 g water 1000 ml
The activity of the solutions decreased in the following order: I> V> VI > III > II > IV. Their inhibitory activity against Bacillus subtilis and Saccharomyces albicans was tested. The activity of the gargle solution was tested in the following order:
1. B. subtilis
2. 2x dilution
3. 4x dilution
4. S. albicans
5. 2x dilution
6. 4x dilution
The results for the solution I were as follows: 1 2 3 4 5 6 + The present invention relates to novel refreshing and antiseptic chemical mixtures for mouth care, gum care and dental care containing as active components aluminium ammonium sulphate, aluminium potassium sulphate and ferric am¬ monium sulphate and/or boric acid and ethanol, glycerin, sodium fluoride, a flavour¬ ing component, an appropriate tenside, a colour and water.
An advantage of the solutions and pastes for oral hygiene, dental hygiene and gum treatment described in the present invention is that by their use bad breath is removed for a longer period of time.
By using the described mixtures consequences of microbicidal processes in the mouth cavity are prevented and removed. By their regular use the pathomorphologic decay of hard tooth substances and thereby the possibility of dental caries are reduced.
By the use of oral hygiene preparations of the invention the formation of plaque and tartar and the deposition thereof on tooth necks and gums are prevented, whereby the possibility of gingivitis is reduced.
There are different reasons for bad breath. It may be produced from tonsillitis and diseases of esophagus or stomach. However, most frequently bad breath is caused by food debris after a meal. Food debris disintegrated by saliva and bacteria cause bad breath since from proteins, carbohydrates and fats ammonia, amines, hydrogen sul¬ fide, mercaptans and various aldehydes and ketones are formed.
Food debris after a meal also cause plaque to accumulate on teeth. The plaque mainly consists of organic disintegration products which are a good culture medium for bacteria, which by enzymatic disintegration of calcareous substances from saliva produce tartar. In this process also microorganisms belonging to lactobacteria as well as some other bacteria take part.
Tartar is deposited on tooth necks and can cause gum inflammation or gingivitis. At the same time tartar is one of the causes for periodontosis since by the deposition thereof the gum tissue becomes unprotected, more sensitive and easily inflammable. Beside dental caries periodontosis is the most frequent dental disease. Dental caries is caused by pathomorphologic decay of tooth enamel and dentin. Biochemically, this is an enzymatic dissolution of hard tooth parts caused by phosphatases, oxidases and proteases of bacteria in the mouth and by the influence of saliva. The reasons there- for are the diet, hormonal-vegetative anomalies, genetic factors and consequences of various diseases. Lack of vitamins in the diet and disturbances in the organism also increase periodontosis.
The object of the present invention are novel chemical mixtures for mouth care, gum care and dental care and solutions and pastes intended for general oral hygiene after cleaning one's teeth. The described preparations also diminish direct causes of dental and gum diseases and satisfy the following basic conditions:
they prevent the development of bacteria, reduce bacterial flora in the mouth and thereby the consequences of bacterial fermentation of food debris in the mouth, they prevent the coating of the teeth by dentobacterial plaque and the accumula¬ tion of organic disintegration products on the teeth, they prevent the calcification of the plaque into tartar and enzymatic disintegra¬ tion of calcareous substances from saliva and the formation of dental calculus (tartar), they prevent the deposition of tartar on tooth necks and thereby directly prevent the causes of periodontosis, they prevent the deposition of plaque on tooth necks and thereby directly prevent the hypersensibility of gum tissue and the causes of gingivitis, they prevent or immediately stop gum bleeding, they prevent or soothe all inflammatory processes of the gums, they prevent the enzymatic dissolution of hard tooth parts, demineralization of enamel and formation of dental caries; they are characterized in that they contain aluminium ammonium sulphate dodecahydrate acting in a bactericide and astringent manner, they are characterized in that that they contain aluminium potassium sulphate dodecahydrate acting in a microbicide and astringent manner, are characterized in that they contain ferric ammonium sulphate dodecahydrate acting in a fungicide and astringent manner, they are characterized in that they contain an appropriate humectant, glycerin and tenside, they are characterized in that they contain sodium fluoride and boris acid, they are characterized in that they contain sodium monofluoro phosphate, sac¬ charin, phosphates, silicates and paraffin oil, they are characterized in that they contain an appropriate breath freshener, they are characterized in that, in addition to an active component, they contain ethanol and purified water.
The mixtures of the present invention for mouth care, gum care and dental care com¬ prise aluminium ammonium sulphate dodecahydrate and/or aluminium potassium sulphate dodecahydrate and/or ferric ammonium sulphate dodecahydrate and/or boric acid and sodium fluoride, Tween® 20, an edible flavour, glycerin, ethanol, a colour and purified water.
The described invention particularly relates to novel mixtures, characterized in that they contain 0.5 to 10.0% of aluminium ammonium sulphate dodecahydrate or 0.2 to 8.0% of aluminium potassium sulphate dodecahydrate or a mixture of 0.5 to 4.0% of aluminium ammonium sulphate dodecahydrate and 1.0 to 3.0% of aluminium potas¬ sium sulphate dodecahydrate, or a mixture of 2.0 to 3.5% of aluminium ammonium sulphate dodecahydrate, 0.5 to 1.0% of aluminium potassium sulphate dodeca¬ hydrate and 0.1 to 0.3% of ferric ammonium sulphate dodecahydrate, or a mixture of 1.5 to 4.0% of aluminium ammonium sulphate dodecahydrate and 0.1 to 0.3% of fer¬ ric ammonium sulphate dodecahydrate or a mixture of 1.5 to 3.0% of aluminium potassium sulphate dodecahydrate and 0.15 to 0.3% of ferric ammonium sulphate dodecahydrate.
The described mixtures for rinsing the oral cavity are characterized in that they con¬ tain 0.15 to 0.3% of sodium fluoride and/or 0.1 to 1.5% of boric acid and 1.0 to 5.0% of glycerin, 0.2 to 1.5% of Tween® 20, 5 to 10% of ethanol, 0.1 to 0.5% of flavour, an appropriate amount of an edible colour and purified water.
The described mixtures for cleaning one's teeth are characterized in that they contain 0.5 to 0.8% of sodium monofluoro phosphate, 0.04 to 0.08% of saccharin, 0.5 to 1.0% of Deydrazol A 400 P, 15.0 to 25.0% of glycerin, 30.0 to 35.0% of phosphate salts, 2.0 to 2.4% of silicates, 0.5 to 1.5% of paraffin oil, 1.0 to 2.0% of Texapon K 12 and ap¬ propriate ammounts of an edible flavour, a colour and purified water.
The invention also refers to an application/use of the described solutions for mouth care, gum care and dental care, characterized in that the mouth cavity is rinsed with the preparations after the cleaning of teeth or the teeth are cleaned with the preparations of the invention. The invention is illustrated by the following examples.
Example 1
The process comprised the mixing and slow heating to 25 to 30°C of the following substances:
aluminium ammonium sulphate dodecahydrate 5-100 g sodium fluoride 1.5-3 g
Tween 20 2-15 g boric acid 1-15 g edible flavour 1-5 g glycerin 10-50 g ethanol 50 - 100 ml purified water • 700 - 930 ml
The cold solution was tinted by admixing 3 mg of Indigotin colour (CI.73015). The prepared solution was filled into suitable polyethylene or glass bottles.
Example 2
The process comprised the mixing and slow heating to 25 to 30°C of the following substances:
aluminium ammonium sulphate dodecahydrate 5-40 g aluminium potassium sulphate dodecahydrate 10-30 g sodium fluoride 1.5-3 g
Tween 20 2-15 g edible flavour 1-5 g glycerin 10-50 g ethanol 50 - 100 ml purified water 700 - 960 ml
The cold solution was tinted by admixing 3 mg of Indigotin colour (CI.73015). The prepared solution was filled into suitable polyethylene or glass bottles. Example 3
The process comprised the mixing and slow heating to 25 to 30°C of the following substances:
aluminium ammonium sulphate dodecahydrate 20-35 g aluminium potassium sulphate dodecahydrate 5-10 g ferric ammonium sulphate dodecahydrate 1-3 g sodium fluoride 1.5-3 g
Tween 20 2-15 g boric acid 1-15 g edible flavour 1-5 g glycerin 10-50 g ethanol 50 - 100 ml purified water 760 - 900 ml
The cold solution was tinted by admixing 3 mg of Indigotin colour (CI.73015). The prepared solution was filled into suitable polyethylene or glass bottles.
Example 4
The process comprised the mixing and slow heating to 25 to 30°C of the following substances:
aluminium ammonium sulpl late dodecahydrai te 15 - 40 g ferric ammonium sulphate dodecahydrate 1-3 g sodium fluoride 1.5-3 g
Tween 20 2-15 g boric acid 1-15 g edible flavour 1-5 g glycerin 10-50 g ethanol 50 - 100 ml purified water 770 - 920 ml
The cold solution was tinted by admixing 3 mg of Indigotin colour (CI.73015). The prepared solution was filled into suitable polyethylene or glass bottles. Example 5
The process comprised the mixing and slow heating to 25 to 30°C of the following substances:
aluminium potassium sulphate dodecahydrate 15 - 30 g ferric ammonium sulphate dodecahydrate 1.5 - 3 g sodium fluoride 1.5 - 3 g
Tween 20 2 - 15 g boric acid 1 - 15 g edible flavour 1 - 5 g glycerin 10 - 50 g ethanol 50 - 100 ml purified water 780 - 920 ml
The cold solution was tinted by admixing 3 mg of Indigotin colour (CI. 73015). The prepared solution was filled into suitable polyethylene or glass bottles.
Example 6
The process comprised the mixing and slow heating to 25 to 35°C of the following components:
aluminium ammonium sulphate dodecahydrate 0.5 - 10.0 % sodium monofluoro phosphate 0.5 - 0.7 % saccharin 0.05 - 0.06 %
Dehydazol A 400 P 0.8 - 1.0 % glycerin 20.0 - 22.0 % phosphates (Dentphos K) 30.0 - 32.0 % silicates (Aerosil 200) 2.0 - 2.3 % paraffin oil 0.5 - 0.8 %
Texapon K 12 1.5 - 1.8 % purified water 29.34 - 44.15 %
The prepared mixture was aromatized with the desired flavour, coloured with an edible colour and filled into polyethylene or aluminium tubes. Example 7
The process comprised the mixing and slow heating to 25 to 35°C of the following components:
aluminium ammonium sulphate dodecahydrate 0.5 - 4.0 % aluminium potassium sulphate dodecahydrate 1.0 - 3.0 % sodium monofluoro phosphate 0.6 - 0.8 % saccharin 0.04 - 0.06 %
Dehydazol A 400 P 0.5 - 1.0 % glycerin 20.0 - 25.0 % phosphates (Dentphos K) 30.0 - 32.0 % silicates (Aerosil 200) 2.0 - 2.5 % paraffin oil 0.5 - 0.8 %
Texapon K 12 1.0 - 1.5 % purified water 29.84 - 43.96 %
The prepared mixture was aromatized with the desired flavour, coloured with an edible colour and filled into polyethylene or aluminium tubes.
Example 8
The process comprised the mixing and slow heating to 25 to 35°C of the following components:
aluminium ammonium sulphate dodecahydrate 2.0 - 3.5 % aluminium potassium sulphate dodecahydrate 0.5 - 1.0 % ferric ammonium sulphate dodecahydrate 0.1 - 0.3 % sodium monofluoro phosphate 0.5 - 0.8 % saccharin 0.04 - 0.06 %
Dehydazol A 400 P 0.8 - 1.0 % glycerin 15.0 - 20.0 % phosphates (Dentphos K) 32.0 - 35.0 % silicates (Aerosil 200) 2.0 - 2.5 % paraffin oil 0.5 - 0.8 %
Texapon K 12 1.0 - 1.5 % purified water 33.54 - 45.46 % The prepared mixture was aromatized with the desired flavour, coloured with an edible colour and filled into polyethylene or aluminium tubes.
Example 9
The process comprised the mixing and slow heating to 25 to 35°C of the following components:
aluminium ammonium sulphate dodecahydrate 1.5 - 4.0 % ferric ammonium sulphate dodecahydrate 0.1 - 0.3 % sodium monofluoro phosphate 0.5 - 0.8 % saccharin 0.05 - 0.08 %
Dehydazol A 400 P 0.5 - 1.0 % glycerin 20.0 - 25.0 % phosphates (Dentphos K) 30.0 - 32.0 % silicates (Aerosil 200) 2.0 - 2.5 % paraffin oil 0.5 - 1.0 %
Texapon K 12 1.0 - 1.5 % purified water 31.82 - 43.85 %
The prepared mixture was aromatized with the desired flavour, coloured with an edible colour and filled into polyethylene or aluminium tubes.
Example 10
The process comprised the mixing and slow heating to 25 to 35°C of the following components:
aluminium potassium sulphate dodecahydrate 1.5 - 4.0 % ferric ammonium sulphate dodecahydrate 0.15 - 0.3 % sodium monofluoro phosphate 0.5 - 0.6 % saccharin 0.05 - 0.08 %
Dehydazol A 400 P 0.5 - 1.0 % glycerin 20.0 - 25.0 % phosphates (Dentphos K) 30.0 - 32.0 % silicates (Aerosil 200) 2.0 - 2.5 % paraffin oil 1.0 - 1.5 % Texapon K 12 1.5 - 2.0 % purified water 32.02 - 42.80 %
The prepared mixture was aromatized with the desired flavour, coloured with an edible colour and filled into polyethylene or aluminium tubes.
Example 11
The process comprised the mixing and slow heating to 25 to 35°C of the following components:
aluminium potassium dodecahydrate 0.2 - 8.0 % sodium monofluoro phosphate 0.5 - 0.8 % saccharin 0.04 - 0.06 %
Dehydazol A 400 P 0.5 - 1.0 % glycerin 20.0 - 22.0 % phosphates (Dentphos K) 30.0 - 32.0 % silicates (Aerosil 200) 2.0 - 2.5 % paraffin oil 0.5 - 0.8 %
Texapon K 12 1.0 - 2.0 % purified water 30.84 - 45.26 %
The prepared mixture was aromatized with the desired flavour, coloured with an edible colour and filled into polyethylene or aluminium tubes.

Claims

Claims
1. Novel chemical mixtures for mouth care, gum care and dental care, charac¬ terized in that they contain aluminium ammonium sulphate or alummium potas¬ sium sulphate or a mixture of aluminium ammonium sulphate and aluminium potassium sulphate or a mixture of aluminium ammonium sulphate, aluminium potassium sulphate and ferric ammonium sulphate or a mixture of aluminium ammonium sulphate and ferric ammonium sulphate or a mixture of aluminium potassium sulphate and ferric ammonium sulphate.
2. Chemical mixtures according to claim 1, characterized in that they contain 0.5 to 10.0% of aluminium ammonium sulphate dodecahydrate or 0.2 to 8.0% of aluminium potassium sulphate dodecahydrate or a mixture of 0.5 to 4.0% of alummium ammonium sulphate dodecahydrate and 1.0 to 3.0% of aluminium potassium sulphate dodecahydrate, or a mixture of 2.0 to 3.5% of aluminium ammonium sulphate dodecahydrate, 0.5 to 1.0% of aluminium potassium sul¬ phate dodecahydrate and 0.1 to 0.3% of ferric ammonium sulphate dodeca¬ hydrate, or a mixture of 1.5 to 4.0% of aluminium ammonium sulphate dodeca¬ hydrate and 0.1 to 0.3% of ferric ammonium sulphate dodecahydrate or a mix¬ ture of 1.5 to 3.0% of aluminium potassium sulphate dodecahydrate and 0.15 to 0.3% of ferric ammonium sulphate dodecahydrate.
3. Novel chemical mixtures according to claims 1 and 2, characterized in that they contain 0.15 to 0.3% of sodium fluoride, and/or 0.1 to 1.5% of boric acid and 1.0 to 5.0% of glycerin, 0.2 to 1.5% of Tween®20, 5 to 10% of ethanol, 0.1 to 0.5% of a flavour, an appropriate amount of an edible colour and purified water.
4. Novel chemical mixtures according to claims 1 and 2, characterized in that they contain 0.5 to 0.8% of sodium monofluoro phosphate, 0.04 to 0.08% of sac¬ charin, 0.5 to 1.0% of Dehydazol A 400 P, 15.0 to 25.0% of glycerin, 30.0 to 35.0% of phosphate salts, 2.0 to 2.4% of silicates, 0.5 to 1.5% of paraffin oil, 1.0 to 2.0% of Texapon K 12 and appropriate amounts of a flavour, edible colours and purified water.
5. A process for the preparation of a novel chemical mixture, characterized in that aluminium ammonium sulphate dodecahydrate, sodium fluoride, Tween 20, and/or boric acid, an edible flavour, glycerin, ethanol, Indigotin and purified water are mixed together.
6. A process for the preparation of a novel chemical mixture, characterized in that aluminium ammonium sulphate dodecahydrate, aluminium potassium sulphate dodecahydrate, sodium fluoride, Tween 20, and/or boric acid and an edible flavour, glycerin, ethanol, Indigotin and purified water are mixed together.
7. A process for the preparation of a novel chemical mixture, characterized in that aluminium ammonium sulphate dodecahydrate, aluminium potassium sulphate dodecahydrate, ferric ammonium sulphate dodecahydrate, sodium fluoride, Tween 20, boric acid, an edible flavour, glycerin, ethanol, Indigotin and purified water are mixed together.
8. A process for the preparation of a novel chemical mixture, characterized in that aluminium ammonium sulphate dodecahydrate, ferric ammonium sulphate dodecahydrate, sodium fluoride, Tween 20, boric acid, an edible flavour, glycerin, ethanol, Indigotin and purified water are mixed together.
9. A process for the preparation of a novel chemical mixture, characterized in thaj aluminium potassium sulphate dodecahydrate, ferric ammonium sulphate dodecahydrate, sodium fluoride, Tween 20, boric acid, an edible flavour, glycerin, ethanol, Indigotin and purified water are mixed together.
10. A process for the preparation of a novel chemical mixture, characterized in that aluminium ammonium sulphate dodecahydrate, sodium monofluoro phosphate, saccharin, Dehydazol A 400 P, glycerin, phosphates (Dentphos K), silicates (Aerosil 200), paraffin oil, Texapon K 12, a flavour, edible colours and purified water are mixed together.
11. A process for the preparation of a novel chemical mixture, characterized in that aluminium ammonium sulphate dodecahydrate, aluminium potassium sulphate dodecahydrate, sodium monofluoro phosphate, saccharin, Dehydazol A 400 P, glycerin, phosphates (Dentphos K), silicates (Aerosil 200), paraffin oil, Texapon K 12, a flavour, edible colours and purified water are mixed together.
12. A process for the preparation of a novel chemical mixture, characterized in that aluminium ammonium sulphate dodecahydrate, aluminium potassium sulphate dodecahydrate, ferric ammonium sulphate dodecahydrate, sodium monofluoro phosphate, saccharin, Dehydazol A 400 P, glycerin, phosphates (Dentphos K), silicates (Aerosil 200), paraffin oil, Texapon K 12, a flavour, edible colours and purified water are mixed together.
13. A process for the preparation of a novel chemical mixture, characterized in that aluminium ammonium sulphate dodecahydrate, ferric ammonium sulphate dodecahydrate, sodium monofluoro phosphate, saccharin, Dehydazol A 400 P, glycerin, phosphates (Dentphos K), silicates (Aerosil 200), paraffin oil, Texapon K 12, a flavour, edible colours and purified water are mixed together.
14. A process for the preparation of a novel chemical mixture, characterized in that aluminium potassium sulphate dodecahydrate, ferric ammonium sulphate dodecahydrate, sodium monofluoro phosphate, saccharin, Dehydazol A 400 P, glycerin, phosphates (Dentphos K), silicates (Aerosil 200), paraffin oil, Texapon K 12, a flavour, edible colours and purified water are mixed together.
15. A process for the preparation of a novel chemical mixture, characterized in that aluminium potassium sulphate dodecahydrate, sodium monofluoro phosphate, saccharin, Dehydazol A 400 P, glycerin, phosphates (Dentphos K), silicates (Aerosil 200), paraffin oil, Texapon K 12, a flavour, edible colours and purified water are mixed together.
16. Chemical mixtures according to claims 1 to 3 and prepared according to claims 5 to 9, characterized in that they are in the form of solutions.
17. Chemical mixtures according to claims 1 to 2 and 4 and prepared according to claims 10 to 15, characterized in that they are in the form of pastes.
18. Use of novel chemical mixtures according to claims 1 to 3 and prepared accord¬ ing to claims 5 to 9, characterized in that the mouth cavity is rinsed therewith after the cleaning of teeth.
19. Use of novel chemical mixtures according to claims 1 to 2 and 4 and prepared according to claims 10 to 15, characterized in that the teeth are cleaned there¬ with.
20. Use of novel chemical mixtures according to claims 1 to 4 and prepared accord¬ ing to claims 6 to 15, characterized in that they are used for mouth care, gum care and dental care.
PCT/SI1996/000021 1995-08-17 1996-08-16 New chemical mixtures for mouth care, gum care and dental care, processes for their preparation and use thereof WO1997006773A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU66735/96A AU6673596A (en) 1995-08-17 1996-08-16 New chemical mixtures for mouth care, gum care and dental cae, processes for their preparation and use thereof

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Application Number Priority Date Filing Date Title
HRP950454A 1995-08-17
HR950454 1995-08-17

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Cited By (1)

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Publication number Priority date Publication date Assignee Title
RU2537034C1 (en) * 2013-11-29 2014-12-27 Закрытое акционерное общество "ФИРН М" (ЗАО "ФИРН М") Therapeutic agent for oral cleaning in individuals suffering xerostomia, possessing antiseptic action as spray, gel and mouthwash

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US4108981A (en) * 1976-08-02 1978-08-22 Indiana University Foundation Alkaline oral compositions comprising aluminum and a carboxylic acid
GB1543029A (en) * 1978-01-04 1979-03-28 Cabardo A Peridontal powder
JPS5498316A (en) * 1978-01-13 1979-08-03 Emu Kabarudo Jiyunia Aruberuto Powder composition for treating tooth root membrane
CA1133831A (en) * 1981-08-20 1982-10-19 Gita Banik Dental powder with natural ingredients
GB2100126A (en) * 1981-06-11 1982-12-22 Colgate Palmolive Co A dentifrice
US4414203A (en) * 1977-11-07 1983-11-08 Cabardo Jr Alberto M Periodontal powder containing exsiccated potassium alum
EP0270977A1 (en) * 1986-12-02 1988-06-15 Purdue Research Foundation Anticariogenic compositions
US5188819A (en) * 1992-02-21 1993-02-23 Purdue Research Foundation Manufacture of aluminum-based anticariogenic compositions

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Publication number Priority date Publication date Assignee Title
US4108981A (en) * 1976-08-02 1978-08-22 Indiana University Foundation Alkaline oral compositions comprising aluminum and a carboxylic acid
US4414203A (en) * 1977-11-07 1983-11-08 Cabardo Jr Alberto M Periodontal powder containing exsiccated potassium alum
GB1543029A (en) * 1978-01-04 1979-03-28 Cabardo A Peridontal powder
JPS5498316A (en) * 1978-01-13 1979-08-03 Emu Kabarudo Jiyunia Aruberuto Powder composition for treating tooth root membrane
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CA1133831A (en) * 1981-08-20 1982-10-19 Gita Banik Dental powder with natural ingredients
EP0270977A1 (en) * 1986-12-02 1988-06-15 Purdue Research Foundation Anticariogenic compositions
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2537034C1 (en) * 2013-11-29 2014-12-27 Закрытое акционерное общество "ФИРН М" (ЗАО "ФИРН М") Therapeutic agent for oral cleaning in individuals suffering xerostomia, possessing antiseptic action as spray, gel and mouthwash

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