WO1997001304A1 - Particules d'apatite radiomarquees contenant un ion paramagnetique - Google Patents

Particules d'apatite radiomarquees contenant un ion paramagnetique Download PDF

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Publication number
WO1997001304A1
WO1997001304A1 PCT/US1996/010808 US9610808W WO9701304A1 WO 1997001304 A1 WO1997001304 A1 WO 1997001304A1 US 9610808 W US9610808 W US 9610808W WO 9701304 A1 WO9701304 A1 WO 9701304A1
Authority
WO
WIPO (PCT)
Prior art keywords
particles
composition
apatite
group
hydroxyapatite
Prior art date
Application number
PCT/US1996/010808
Other languages
English (en)
Inventor
James W. Brodack
Edward A. Deutsch
Karen E. Deutsch
Original Assignee
Mallinckrodt Medical, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Medical, Inc. filed Critical Mallinckrodt Medical, Inc.
Publication of WO1997001304A1 publication Critical patent/WO1997001304A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A61K49/183—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an inorganic material or being composed of an inorganic material entrapping the MRI-active nucleus, e.g. silica core doped with a MRI-active nucleus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Nanotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La présente invention se rapporte à des procédés et à des compositions pour améliorer l'imagerie de diagnostic médical et la thérapie pour le traitement de l'arthrite rhumatoïde. Les compositions sont dérivées de particules d'apatite comprenant, sans caractère limitatif, l'hydroxyapatite, la fluoroapatite, l'idioapatite, le carbone-apatite et leurs mélanges et dérivés. Lesdites compositions contiennent une espèce paramagnétique incorporée dans les particules d'apatite afin d'améliorer le contraste de la résonance magnétique et un radionuclide capable de fournir une dose thérapeutique de radioactivité. L'invention se rapporte aussi à une composition de combinaison diagnostique/thérapeutique et à des procédés pour établir un diagnostic médical et appliquer des procédures thérapeutiques, impliquant l'administration à un mammifère à sang chaud d'une quantité suffisante pour un diagnostic de l'ion paramagnétique et une quantité efficace thérapeutiquement du radionuclide et ensuite pour effectuer le traitement médical et les procédures de diagnostic.
PCT/US1996/010808 1995-06-29 1996-06-25 Particules d'apatite radiomarquees contenant un ion paramagnetique WO1997001304A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49664595A 1995-06-29 1995-06-29
US08/496,645 1995-06-29

Publications (1)

Publication Number Publication Date
WO1997001304A1 true WO1997001304A1 (fr) 1997-01-16

Family

ID=23973545

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/010808 WO1997001304A1 (fr) 1995-06-29 1996-06-25 Particules d'apatite radiomarquees contenant un ion paramagnetique

Country Status (1)

Country Link
WO (1) WO1997001304A1 (fr)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000029034A1 (fr) * 1998-11-12 2000-05-25 Nycomed Amersham Plc Produits et procedes
WO2001028587A2 (fr) * 1999-10-18 2001-04-26 Ferx Incorporated Porteurs magnetiques cibles composes de fer et de matieres poreuses pour l'administration ciblee d'agents biologiquement actifs
WO2001062895A2 (fr) * 2000-02-24 2001-08-30 Xcyte Therapies, Inc. Stimulation et concentration simultanees de cellules
US6797514B2 (en) 2000-02-24 2004-09-28 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
US6867041B2 (en) 2000-02-24 2005-03-15 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
EP1526171A1 (fr) * 2000-02-24 2005-04-27 Xcyte Therapies, Inc Stimulation et concentration simultanées de cellules
WO2005079867A2 (fr) * 2004-02-20 2005-09-01 Algeta As Particules d'hydroxyapatite emettrices de rayons alpha
JP2007528373A (ja) * 2004-02-20 2007-10-11 アルゲッタ エイエス α放射性ヒドロキシアパタイト粒子
WO2008017944A3 (fr) * 2006-08-11 2008-06-12 Mds Canada Inc Composition appareillage et méthode servant pour l'imagerie
KR100912343B1 (ko) 2002-05-21 2009-08-14 후지쯔 가부시끼가이샤 금속 수식 애퍼타이트 함유막의 형성 방법, 여기에사용되는 코팅액, 및 금속 수식 애퍼타이트 함유막으로피복된 부위를 갖는 전자 기기
EP2177232A3 (fr) * 2003-02-28 2010-04-28 The European Atomic Energy Community (EURATOM), represented by the European Commission Activation et production de particules radiomarquées
US7977095B2 (en) 2003-05-08 2011-07-12 Life Technologies Corporation Generation and isolation of antigen-specific T cells
FR2957913A1 (fr) * 2010-03-26 2011-09-30 Commissariat Energie Atomique Nouvelle iodoapatite, son procede de preparation et ses utilisations
US20140227177A1 (en) * 2002-07-02 2014-08-14 Universiteit Utrecht Holding B.V. Scanning Suspension Comprising a Particle with a Diameter of at least 1 Micrometer
WO2016001871A1 (fr) * 2014-07-02 2016-01-07 Universidade Católica Portuguesa Filtres uv, procédé de production de ceux-ci et leur utilisation dans des compositions, en particulier des écrans solaires
US9528088B2 (en) 2002-06-28 2016-12-27 Life Technologies Corporation Methods for eliminating at least a substantial portion of a clonal antigen-specific memory T cell subpopulation
IT201900004673A1 (it) * 2019-03-28 2020-09-28 Consiglio Nazionale Ricerche Filtro solare fisico comprendente idrossiapatite o idrossiapatite modificata ottenuto da rifiuti dell’industria ittica e acquacoltura, processo per la sua produzione e composizioni fotoprotettive che lo comprendono

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5320824A (en) * 1989-10-12 1994-06-14 Mallinckrodt Medical, Inc. Radionuclide labelled particles useful for radiation synovectomy
US5342609A (en) * 1991-10-22 1994-08-30 Mallinckrodt Medical, Inc. Microfluidization of calcium/oxyanion-containing particles
US5520904A (en) * 1995-01-27 1996-05-28 Mallinckrodt Medical, Inc. Calcium/oxyanion-containing particles with a polymerical alkoxy coating for use in medical diagnostic imaging

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5320824A (en) * 1989-10-12 1994-06-14 Mallinckrodt Medical, Inc. Radionuclide labelled particles useful for radiation synovectomy
US5342609A (en) * 1991-10-22 1994-08-30 Mallinckrodt Medical, Inc. Microfluidization of calcium/oxyanion-containing particles
US5520904A (en) * 1995-01-27 1996-05-28 Mallinckrodt Medical, Inc. Calcium/oxyanion-containing particles with a polymerical alkoxy coating for use in medical diagnostic imaging

Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000029034A1 (fr) * 1998-11-12 2000-05-25 Nycomed Amersham Plc Produits et procedes
JP2005200426A (ja) * 1999-10-18 2005-07-28 Ferx Inc 磁気標的化キャリア
AU772755B2 (en) * 1999-10-18 2004-05-06 Ferx Incorporated Magnetic targeted carrier composed of iron and porous materials for the targeted delivery of biologically active agents
WO2001028587A3 (fr) * 1999-10-18 2002-01-03 Ferx Inc Porteurs magnetiques cibles composes de fer et de matieres poreuses pour l'administration ciblee d'agents biologiquement actifs
WO2001028587A2 (fr) * 1999-10-18 2001-04-26 Ferx Incorporated Porteurs magnetiques cibles composes de fer et de matieres poreuses pour l'administration ciblee d'agents biologiquement actifs
US6797514B2 (en) 2000-02-24 2004-09-28 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
US6867041B2 (en) 2000-02-24 2005-03-15 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
US6905874B2 (en) 2000-02-24 2005-06-14 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
WO2001062895A2 (fr) * 2000-02-24 2001-08-30 Xcyte Therapies, Inc. Stimulation et concentration simultanees de cellules
EP1526171A1 (fr) * 2000-02-24 2005-04-27 Xcyte Therapies, Inc Stimulation et concentration simultanées de cellules
WO2001062895A3 (fr) * 2000-02-24 2002-02-28 Xcyte Therapies Inc Stimulation et concentration simultanees de cellules
KR100912343B1 (ko) 2002-05-21 2009-08-14 후지쯔 가부시끼가이샤 금속 수식 애퍼타이트 함유막의 형성 방법, 여기에사용되는 코팅액, 및 금속 수식 애퍼타이트 함유막으로피복된 부위를 갖는 전자 기기
US9528088B2 (en) 2002-06-28 2016-12-27 Life Technologies Corporation Methods for eliminating at least a substantial portion of a clonal antigen-specific memory T cell subpopulation
US20140227177A1 (en) * 2002-07-02 2014-08-14 Universiteit Utrecht Holding B.V. Scanning Suspension Comprising a Particle with a Diameter of at least 1 Micrometer
US9731037B2 (en) * 2002-07-02 2017-08-15 Universitair Medisch Centrum Utrecht Scanning suspension comprising a particle with a diameter of at least 1 micrometer
EP2177232A3 (fr) * 2003-02-28 2010-04-28 The European Atomic Energy Community (EURATOM), represented by the European Commission Activation et production de particules radiomarquées
US7977095B2 (en) 2003-05-08 2011-07-12 Life Technologies Corporation Generation and isolation of antigen-specific T cells
US8142758B2 (en) 2004-02-20 2012-03-27 Algeta As Alpha-emitting hydroxyapatite particles
JP2007528373A (ja) * 2004-02-20 2007-10-11 アルゲッタ エイエス α放射性ヒドロキシアパタイト粒子
WO2005079867A3 (fr) * 2004-02-20 2006-03-16 Algeta As Particules d'hydroxyapatite emettrices de rayons alpha
WO2005079867A2 (fr) * 2004-02-20 2005-09-01 Algeta As Particules d'hydroxyapatite emettrices de rayons alpha
WO2008017944A3 (fr) * 2006-08-11 2008-06-12 Mds Canada Inc Composition appareillage et méthode servant pour l'imagerie
EP2054894A4 (fr) * 2006-08-11 2012-11-21 Nordion Canada Inc Composition appareillage et méthode servant pour l'imagerie
EP2054894A2 (fr) * 2006-08-11 2009-05-06 MDS (Canada) Inc. Composition appareillage et méthode servant pour l'imagerie
EP3355314A1 (fr) * 2006-08-11 2018-08-01 Biocompatibles Uk Ltd. Appareil de composition et procédé à utiliser en imagerie p.e.t.
FR2957913A1 (fr) * 2010-03-26 2011-09-30 Commissariat Energie Atomique Nouvelle iodoapatite, son procede de preparation et ses utilisations
WO2016001871A1 (fr) * 2014-07-02 2016-01-07 Universidade Católica Portuguesa Filtres uv, procédé de production de ceux-ci et leur utilisation dans des compositions, en particulier des écrans solaires
US10314772B2 (en) 2014-07-02 2019-06-11 Universidade Catolica Portuguesa UV-filters, method of producing the same and their use in compositions, in particular sunscreens
IT201900004673A1 (it) * 2019-03-28 2020-09-28 Consiglio Nazionale Ricerche Filtro solare fisico comprendente idrossiapatite o idrossiapatite modificata ottenuto da rifiuti dell’industria ittica e acquacoltura, processo per la sua produzione e composizioni fotoprotettive che lo comprendono
WO2020193750A1 (fr) * 2019-03-28 2020-10-01 Consiglio Nazionale Delle Ricerche Écran solaire physique comprenant de l'hydroxyapatite ou de l'hydroxyapatite modifiée obtenue à partir de déchets de pêcheries et d'aquaculture, procédé pour sa production et compositions photoprotectrices le comprenant

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