WO1996032062A1 - Dispositif pour detecter des composants dans l'air expire - Google Patents

Dispositif pour detecter des composants dans l'air expire Download PDF

Info

Publication number
WO1996032062A1
WO1996032062A1 PCT/SE1996/000474 SE9600474W WO9632062A1 WO 1996032062 A1 WO1996032062 A1 WO 1996032062A1 SE 9600474 W SE9600474 W SE 9600474W WO 9632062 A1 WO9632062 A1 WO 9632062A1
Authority
WO
WIPO (PCT)
Prior art keywords
plate
air
exhalation air
component
carbon dioxide
Prior art date
Application number
PCT/SE1996/000474
Other languages
English (en)
Inventor
Stefan Nilsson
Original Assignee
Noster System Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Noster System Ab filed Critical Noster System Ab
Priority to JP8530960A priority Critical patent/JPH11503527A/ja
Priority to EP96910283A priority patent/EP0959764A1/fr
Priority to CA002217883A priority patent/CA2217883C/fr
Priority to HU9802039A priority patent/HU219755B/hu
Priority to AU53523/96A priority patent/AU693344B2/en
Priority to RU97118330/14A priority patent/RU2143844C1/ru
Publication of WO1996032062A1 publication Critical patent/WO1996032062A1/fr
Priority to PL96322738A priority patent/PL185366B1/pl
Priority to NO974692A priority patent/NO974692L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/097—Devices for facilitating collection of breath or for directing breath into or through measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/083—Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
    • A61B5/0836—Measuring rate of CO2 production
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath

Definitions

  • the present invention relates to a device for detecting one or more components in exhaled air, and particularly for detecting the presence of pathogenic bacteria Helicobacter pylori in stomach and intestinal tracts of human beings.
  • Gaseous components can be analyzed in various ways, such as by gas chromatography, flame photometry and spectrophotome- try, for instance. These methods, however, require the use of expensive equipment and are much too advanced in many cases. Simpler, alternative methods are those in which the gas is absorbed by a material and the presence or absence of a gaseous component indicated with the aid of a colour indicator. Examples in this respect are the blow tubes used to indicate the presence of alcohol in exhalation air. These devices have the drawback of not being constructed for separate measurements on the absorbent material.
  • stomach ulcers are caused mainly by the pathogenic bacteria Helicobacter pylori.
  • a method has been described for indicating the presence of this bacteria and has been applied in clinical research for a number of years. According to this method, patients are to swallow an isotope-labelled, preferably radioactive, urea preparation.
  • Helicobacter pylori present in the gastric and intestinal tract will break the urea down to carbon dioxide, among other materials. This carbon dioxide is then transported to the lungs through the normal physiology of the body, where it is exhaled together with the carbon dioxide that has been formed in remaining body organs.
  • the amount of carbon dioxide exhaled can be measured by causing the patient to blow the exhalation air through a tube and down into a liquid which absorbs carbon dioxide. This liquid is then examined with the aid of appropriate measuring instruments, for instance a scintillator counter, to indicate isotope labelled components in the exhaled carbon dioxide as a sign of the presence of Helicobacter pylori.
  • the object of the present invention is to provide apparatus for use in detecting one or more components in exhalation air.
  • the apparatus shall be producible at low costs and shall also satisfy requirements of long-term storability and reproducibility of test results.
  • Another object is also to obviate the complex handling of liquids and the use of space- consuming analysis instruments.
  • a device which consists of a tubular element, which may be rigid or soft as a plastic bag and through which air is conducted.
  • a nozzle is formed on one end of the tube.
  • the opposite end of the tube is fitted with a plate, which may either be an airtight plate or a porous membrane.
  • the plate is attached to the tube in a manner which will enable it to be readily removed therefrom.
  • the plate fitting may either have the form of a screw device or snap-coupling, or may simply comprise adhesive tape.
  • a dry, absorbent material has been mounted on or incorporated in the plate. This absorbent material is adapted solely to absorb a specific amount of desired gaseous component.
  • a colour indicator in the absorbent substance indicates when the maximum amount of gaseous component has been absorbed.
  • the patient blows exhalation air through the nozzle and causes said air to flow across or through the plate.
  • the plate can be separated from the tube when the plate becomes saturated.
  • the plate is then analyzed in an appropriate measuring instrument, to indicate the presence or absence of components in question.
  • the present invention is used to indicate the presence of isotope labelled carbon dioxide in exhalation air, and in particular to indicate the presence of radioactive carbon dioxide formed as a conversion product of the bacteria Helicobacter pylori.
  • the plate has mounted thereon or incorporates a carbon dioxide absorb ⁇ ing material. A patient administered with radioactive labelled urea is asked to blow through the inventive device. Carbon dioxide, including radioactively labelled carbon dioxide, is absorbed on the plate. The plate is then removed from the device and analyzed with regard to radioactivity in an appropriate measuring device, to indicate the presence of the bacterium Helicobacter pylori.
  • the present invention thus provides a simple device for use in indicating the presence or absence of components in exhalation air.
  • Figure 1 is a perspective view of an inventive device.
  • Figure 2a is a view from above of a further embodiment of the inventive device.
  • Figure 2b is a side view of the embodiment shown in Figure 2a.
  • Figure 1 illustrates primarily the embodiment in which a porous membrane is used and the air shall be caused to flow through the plate.
  • the device is comprised of a tubular element 1 provided with a nozzle 2 at one end.
  • An absorbent plate 3 is fitted detachably to the opposite end.
  • the outer edge of the plate will be perforated with holes 4, so as to enable air to flow through the device. These perforations are excluded when a porous membrane is used.
  • FIGS 2a and 2b show two views of one embodiment of the device suitable when an airtight plate is used.
  • the reference signs used in the Figures correspond to those used in Figure
  • the exhalation air then passes through the tubular element 1, and flows through the plate 3, or across the plate 3, and out through the holes 4.
  • the tube is constructed to ensure maximum contact between the air flow and the absorbent plate.
  • the plate is detached from the tubular element and introduced in a measuring instrument for indication of a desired component.
  • the whole of the upper part, including the plate is detached from the remainder of the device and introduced into the measuring instrument.
  • the device may be made from any suitable material, preferably cardboard, paperboard or plastic of different kinds.
  • plastics that can be used are polyethylene, polystyrene or PVC. It is appropriate that the device can be sterilized by radiation or heat.
  • the absorbent material will vary in dependence on the component to be indicated. Examples of carbon dioxide absorbent materials are sodium hydroxide and soda lime.
  • the colour reaction on the plate that signals when the plate is saturated can be achieved with the use of commercially available soda lime as a colour indicator.
  • Part of the device beneath or above the absorbent material will preferably be transparent, so that the colour reaction can be observed.
  • Components that are to be detected may, for instance, be labelled or marked by means of isotopes.
  • the measuring instrument used to detect labelled components will vary in accordance with labelling.
  • radioactively labelled components can be indicated with a Geiger ⁇ ller tube.
  • the device will preferably be packed in an airtight bag in a durable environment, for instance in a nitrogen gas environment when a carbon dioxide absorbent material is used.
  • the device may conveniently be adapted for one-time use only, for hygienic reasons.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • Physiology (AREA)
  • Medical Informatics (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analyzing Materials By The Use Of Fluid Adsorption Or Reactions (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

Un dispositif pour détecter un ou plusieurs composants dans l'air expiré comprend un élément tubulaire. L'air expiré est introduit par une extrémité de cet élément. Une plaque absorbant un ou des composants est fixée à l'autre extrémité. La plaque peut être détachée pour doser les composants dans un appareil de mesure.
PCT/SE1996/000474 1995-04-11 1996-04-11 Dispositif pour detecter des composants dans l'air expire WO1996032062A1 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP8530960A JPH11503527A (ja) 1995-04-11 1996-04-11 吐き出した息中の成分を検出する装置
EP96910283A EP0959764A1 (fr) 1995-04-11 1996-04-11 Dispositif pour detecter des composants dans l'air expire
CA002217883A CA2217883C (fr) 1995-04-11 1996-04-11 Dispositif pour detecter des composants dans l'air expire
HU9802039A HU219755B (hu) 1995-04-11 1996-04-11 Eszköz kilélegzett levegőben lévő egy vagy több komponens kimutatásához való alkalmazásra
AU53523/96A AU693344B2 (en) 1995-04-11 1996-04-11 A device for detecting components in exhaled air
RU97118330/14A RU2143844C1 (ru) 1995-04-11 1996-04-11 Устройство для обнаружения компонентов в выдыхаемом воздухе
PL96322738A PL185366B1 (pl) 1995-04-11 1997-10-09 Urządzenie do wykrywania składników wydychanego powietrza
NO974692A NO974692L (no) 1995-04-11 1997-10-10 Anordning for påvisning av komponenter i ekshalasjonsluft

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9501351A SE505335C2 (sv) 1995-04-11 1995-04-11 Anordning för påvisande av komponenter i utandningsluft
SE9501351-2 1995-04-11

Publications (1)

Publication Number Publication Date
WO1996032062A1 true WO1996032062A1 (fr) 1996-10-17

Family

ID=20397933

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE1996/000474 WO1996032062A1 (fr) 1995-04-11 1996-04-11 Dispositif pour detecter des composants dans l'air expire

Country Status (13)

Country Link
EP (1) EP0959764A1 (fr)
JP (1) JPH11503527A (fr)
KR (1) KR19980703695A (fr)
CN (1) CN1180997A (fr)
AU (1) AU693344B2 (fr)
CA (1) CA2217883C (fr)
CZ (1) CZ289458B6 (fr)
HU (1) HU219755B (fr)
NO (1) NO974692L (fr)
PL (1) PL185366B1 (fr)
RU (1) RU2143844C1 (fr)
SE (1) SE505335C2 (fr)
WO (1) WO1996032062A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6265221B1 (en) 1996-12-09 2001-07-24 Noster System Ab Device for trapping and assaying C14 labelled carbon dioxide and method of use
GB2381580A (en) * 2001-10-30 2003-05-07 Sentec Ltd Sample collection
US6703616B1 (en) 1997-11-20 2004-03-09 Wedholm Medical Ab Apparatus and a method for measuring radiation
GB2427687A (en) * 2005-06-25 2007-01-03 Sensam Ltd Breath sampling device

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102338757A (zh) * 2010-07-26 2012-02-01 深圳市中核海得威生物科技有限公司 幽门螺杆菌14c检测装置和方法
US9931054B2 (en) 2012-09-20 2018-04-03 Koninklijke Philips N.V. Low dead space liquid trap
KR20160067582A (ko) 2014-12-04 2016-06-14 동아대학교 산학협력단 유량 조절 가능한 튜브 밸브
CN105547969A (zh) * 2015-12-23 2016-05-04 深圳职业技术学院 幽门螺旋杆菌测试仪
CN106053387B (zh) * 2016-06-29 2019-04-23 南京青辰光电科技有限公司 一种呼出气体检测方法及装置
JP6419999B1 (ja) * 2018-02-01 2018-11-07 靖 高島 吸気装置
CN110243811B (zh) * 2019-04-30 2023-05-16 广州超威生物科技有限公司 一种评测二氧化氯释放速率的方法
CN112345635A (zh) * 2020-10-28 2021-02-09 上海交通大学 一种基于呼出气体挥发性有机物分析的胃病诊断系统
CN114137039B (zh) * 2021-11-25 2024-01-09 西安交通大学 一种集成无线无源氨气传感器标签的储气袋及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4564021A (en) * 1982-09-09 1986-01-14 Dragerwerk Ag Mouthpiece for a breath-alcohol measuring device
US4947861A (en) * 1989-05-01 1990-08-14 Hamilton Lyle H Noninvasive diagnosis of gastritis and duodenitis
EP0480177A2 (fr) * 1990-10-12 1992-04-15 Wayne Lamont Appareil à alcotest

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1720002A1 (ru) * 1989-01-18 1992-03-15 Медико-Инженерный Центр Профилактики Заболеваний Органов Дыхания "Аэрозоль" Способ исследовани состо ни больных при нарушении жирового или углеводного обмена и устройство дл контрол состава выдыхаемого воздуха

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4564021A (en) * 1982-09-09 1986-01-14 Dragerwerk Ag Mouthpiece for a breath-alcohol measuring device
US4947861A (en) * 1989-05-01 1990-08-14 Hamilton Lyle H Noninvasive diagnosis of gastritis and duodenitis
EP0480177A2 (fr) * 1990-10-12 1992-04-15 Wayne Lamont Appareil à alcotest

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6265221B1 (en) 1996-12-09 2001-07-24 Noster System Ab Device for trapping and assaying C14 labelled carbon dioxide and method of use
EP0943093B1 (fr) * 1996-12-09 2003-11-12 Noster System AB Dispositif pour capturer et doser le dioxide de carbone et procede d'utilisation
US6703616B1 (en) 1997-11-20 2004-03-09 Wedholm Medical Ab Apparatus and a method for measuring radiation
GB2381580A (en) * 2001-10-30 2003-05-07 Sentec Ltd Sample collection
GB2427687A (en) * 2005-06-25 2007-01-03 Sensam Ltd Breath sampling device
GB2427687B (en) * 2005-06-25 2009-12-09 Sensam Ltd Breath sampling device
US7856863B2 (en) 2005-06-25 2010-12-28 Sensam Limited Breath sampling device
AU2006263759B2 (en) * 2005-06-25 2012-02-16 Sensam Limited Breath sampling device

Also Published As

Publication number Publication date
HUP9802039A3 (en) 1999-04-28
KR19980703695A (ko) 1998-12-05
PL185366B1 (pl) 2003-04-30
SE9501351L (sv) 1996-10-12
NO974692D0 (no) 1997-10-10
AU693344B2 (en) 1998-06-25
CN1180997A (zh) 1998-05-06
HUP9802039A2 (hu) 1998-12-28
EP0959764A1 (fr) 1999-12-01
CA2217883A1 (fr) 1996-10-17
SE9501351D0 (sv) 1995-04-11
PL322738A1 (en) 1998-02-16
CZ289458B6 (cs) 2002-01-16
JPH11503527A (ja) 1999-03-26
NO974692L (no) 1997-10-10
HU219755B (hu) 2001-07-30
MX9707786A (es) 1998-06-28
RU2143844C1 (ru) 2000-01-10
CA2217883C (fr) 2001-08-07
AU5352396A (en) 1996-10-30
SE505335C2 (sv) 1997-08-11
CZ322897A3 (cs) 1998-03-18

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