WO1996023537A1 - Prolongateur de piston pour machines d'injection automatique - Google Patents

Prolongateur de piston pour machines d'injection automatique Download PDF

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Publication number
WO1996023537A1
WO1996023537A1 PCT/US1996/000674 US9600674W WO9623537A1 WO 1996023537 A1 WO1996023537 A1 WO 1996023537A1 US 9600674 W US9600674 W US 9600674W WO 9623537 A1 WO9623537 A1 WO 9623537A1
Authority
WO
WIPO (PCT)
Prior art keywords
piston
syringe
holder
extender
injection machine
Prior art date
Application number
PCT/US1996/000674
Other languages
English (en)
Other versions
WO1996023537A9 (fr
Inventor
Reinhard Muller-Spath
Original Assignee
Mallinckrodt Medical, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Medical, Inc. filed Critical Mallinckrodt Medical, Inc.
Publication of WO1996023537A1 publication Critical patent/WO1996023537A1/fr
Publication of WO1996023537A9 publication Critical patent/WO1996023537A9/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14546—Front-loading type injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14566—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir for receiving a piston rod of the pump

Definitions

  • the present invention relates to piston extenders to be used in conjunction with machines for automatic injection of solutions, such as parenteral solutions, e.g. X-ray contrast media.
  • Automatic injection machines are used for intravascular injection of parenteral solutions, such as X-ray contrast media, in several procedures, including phlebography, i.e. X-ray photography of leg veins for diagnosing thrombosis, and computer tomography. Normally, these procedures require the injection of relatively large volumes of contrast media, e.g. in the range of about 100 to 200 ml.
  • the delivery of the contrast media may be controlled by machine settings so that a wide variety of desired injection profiles can be obtained with a high degree of accuracy, and in a simple manner, while meeting the particular medical requirements.
  • the various injection profiles can be stored and are therefore always available for further inspection and for future investigations.
  • injection machines can generally deliver parenteral solution at rates from 0.1 to 9.9 ml/s, selectable in 0.1 ml/s steps, and total injected volume of about 100 to 200 ml, selectable in 1 ml steps.
  • the injection of these large volumes is carried out at relatively high pressure, in the range of several bars to several tens of bars, the pressure being electronically controlled and limited for safety reasons.
  • Syringes which contain large volumes between 100 and 200 ml are generally known in clinical terminology as "high-pressure syringes" because of the relatively high pressure used for injection.
  • SUBSTITUTESHEET(RI/LE26) solutions for various procedures.
  • conventional manual syringes having normal volume capacities in the range from 1 to 100 ml may be used in conjunction with a conversion kit which allows manual syringes to be used with an injection machine designed for high pressure syringes.
  • a conversion kit is described in co-pending European Patent Application 94101290.8, hereby incorporated by reference, and further described below.
  • the conversion kit enables automatic injection machines designed for high-pressure syringes to be used for injection from manual syringes, and includes at least one conversion vessel, having a receiving head with a radial recess including a first region for substantially non-rotary reception of the peripheral edge projecting from the distal end of a high-pressure syringe and also including a second region for receiving the radial end regions of the wings of a manual injection syringe of predetermined size.
  • the conversion kit also includes at least one reducing sleeve for reducing the effective inner diameter of the cylindrical guide of the conversion vessel, comprising a substantially cylindrical sleeve member, having an outer diameter which will fit snugly within the inner diameter of the cylindrical guide and having an inner diameter which will snugly receive the outer diameter of the manual syringe, and a peripheral edge projecting radially from the distal end of the reducing sleeve and adapted to be received in the first region of the radial recess in the receiving head, and in which the peripheral edge of the distal end of the manual syringe can be received.
  • the conversion kit includes at least one conversion piston holder, having a radial maximum diameter equal to or less than the diameter of the piston of the manual syringe, and equipped with a means for releasably securing the piston holder to the free end of the spindle of the injection machine and equipped with a head for coupling the piston holder to the piston of a high-pressure syringe and for applying pressure to the piston of the manual syringe.
  • injection machines are used to both fill and dispense solutions to and from syringes.
  • syringes may be filled in accordance with the following general procedure. First, an empty syringe is installed within the injection machine.
  • the spindle of the injection machine is then attached to the piston of the syringe via a piston holder which is also attached to the spindle.
  • the spindle is then extended to push the piston to the distal end of the syringe.
  • the tip of the syringe is then contacted with a desired solution, either directly or through a filling means, such as a fill tube.
  • the spindle is then retracted, thus pulling the piston toward the proximal end of the syringe and filling the syringe with the solution by the suction created. Once filled, the solution source is removed from the tip of the syringe.
  • the spindle Prior to connecting the syringe to the delivery means needed for injection, the spindle may be extended a short distance to assure the elimination of air bubbles from the syringe chamber.
  • Fig. 1A is a cross-section view of a piston, generally designated by reference numeral 10, and a piston holder, generally designated by reference numeral 20, for a standard high-pressure syringe as known in the prior art.
  • piston 10 includes a main body 12, adapted to fit snugly within the chamber of a syringe, and a connection peg 14, connected to the main body 12, by a stem 16.
  • the piston holder 20, includes a main body 22, and a peg slot 24, in open connection with a stem slot 26.
  • the piston holder 20, also includes suitable means (not shown) for connection to the spindle of the injection machine.
  • the peg slot 24, and stem slot 26, are constructed so as to loosely receive the peg 14, and stem 16, of the piston 10, when connected together as shown in Fig. IB.
  • Fig. 1C is bottom view of the piston holder 20 showing the stem slot 26, having a key shaped opening.
  • a first portion 27, of stem slot 26, is dimensioned to allow the peg 14, of the piston 10, to fit through and be received in the peg slot 24.
  • piston holder 20 coacts positively with the piston 10, so that when the piston holder 20, is retracted or extended, by action of the spindle, the piston
  • Fig. 2A is a cross-section view of a piston, generally designated by reference numeral 30, and a piston holder, generally designated by reference numeral 40, for a standard manual syringe as known in the prior art.
  • piston 30, includes a main body 32, adapted to fit snugly within the c ⁇ iamber of a syringe, and a screw threaded cavity 34, formed within the main body 32.
  • the piston holder 40 includes a main body 42, and a screw threaded extension 44.
  • the piston holder 40 also includes suitable means (not shown) for connection to the spindle of the injection machine.
  • the screw threaded extension 44, and screw threaded cavity 34 are constructed so as to positively coact when the piston 30, and piston holder 40, are connected together as shown in Fig. 2B.
  • the piston holder 40 coacts positively with the piston 30, so that when the piston holder 40, is retracted or extended, by action of the spindle, the piston 30, is moved in the same manner.
  • pre-filled syringes have helped to avoid the need to fill syringes using the injection machine.
  • pre-filled syringes usually have the same piston configurations as those shown in Figs. 1 and 2. Therefore, the disadvantages noted above still exist.
  • the exposed portion of the interior of the chamber of the pre-filled syringe may not be sterile, especially upon exposure to the ambient conditions upon connection of the syringe to the injection machine.
  • the above objects and others can be accomplished according to the present invention by providing a piston extender or piston holder which does not positively connect with the piston of the syringe.
  • the piston extender or piston holder of the present invention can have several configurations as will be explained in greater detail below.
  • Fig. 1A is a cross-section view of a piston and a piston holder for a standard high-pressure syringe as known in the prior art.
  • Fig. IB is a cross-section view of the piston and the piston holder shown in Fig. 1A shown connected together.
  • Fig. 1C is a bottom view of the piston holder shown in Fig. 1A.
  • Fig. 2A is a cross-section view of a piston and a piston holder for a standard manual syringe as known in the prior art.
  • Fig. 2B is a cross-section view of the piston and the piston holder shown in Fig. 2A shown connected together.
  • Fig. 3 is a cross-section view of a piston extender for a manual syringe according to one embodiment of the present invention.
  • Fig. 4 is a cross-section view of a piston extender for a high-pressure syringe according to another embodiment of the present invention.
  • Fig. 3 is a cross-section view of a piston extender, generally designated by reference numeral 50, for a manual syringe according to one embodiment of the present invention.
  • piston extender 50 includes a main body 52, and a peg extension 54.
  • the peg 54 has a smooth exterior surface and is sized to fit loosely within the screw threaded cavity of a manual syringe piston. Therefore, the piston extender 50, can be used to push the piston, but does not positively connect to the piston, making retraction of the piston impossible.
  • the piston extender 50 can be made in several different configurations.
  • the piston extender 50 can be adapted to connect with the piston holder of the injection machine. This connection can be of any suitable means such as the connections shown between the pistons andpiston holders in Figs. 1 or 2.
  • the piston extender 50 can include means for direct connection to the spindle of the injection machine and thereby take the place of the original piston holder.
  • the piston holder 50 can be made in several different lengths to acc ⁇ r ⁇ rodate different sized syringes. A longer piston holder 50, can be particularly useful when being used with an under filled syringe, as the piston holder 50, can fill the exposed interior portion of the syringe chamber.
  • the piston holder 50 may also be made is a wide variety of diameters for use with any number of different sized syringes.
  • Fig. 4 is a cross-section view of a piston extender, generally designated by reference numeral 60, for a high-pressure syringe according to further embodiment of the present invention.
  • piston extender 60 includes a main body 62, and a hollow portion 64.
  • the hollow portion 64 has a smooth interior and is sized to fit loosely around the peg and stem of a high-pressure syringe piston. Therefore, the piston extender 60, can be used to push the piston, but does not positively connect to the piston, making retraction of the piston impossible.
  • the piston extender 60 can also be made in several different configuration.
  • the piston extender 60 can be adapted to connect with the piston holder of the injection machine. This connection can be of any suitable means such as the connections shownbetween the pistons andpiston holders in Figs. 1 or 2.
  • the piston extender 60 can include means for direct connection to the spindle of the injection machine and thereby take the place of the original piston holder.
  • the piston holder 60 may also be made is a wide variety of diameters for use with any number of different sized syringes.
  • the piston holder 60 can be made in several different lengths to accommodate different sized syringes. A longer piston holder 60, can be particularly useful when being used with an under filled syringe, as the piston holder 60, can fill the exposed interior portion of the syringe chamber.
  • the piston extenders according to the present invention overcome all of the disadvantages of having a piston holder which positively connects with the piston of a syringe.
  • the piston extenders of the present invention enable injection to be carried out by pushing of the piston, but make retraction of the syringe impossible. Therefore, air can not be drawn into the chamber of the syringe by mistakenly retracting the piston.

Abstract

La présente invention concerne des prolongateurs de pistons (60) à utiliser avec des machines d'injection automatique de solutions telles que les solutions parentérales, par exemple des agents de contraste pour rayons X. En particulier, l'invention concerne un prolongateur de piston (60) d'un porte-piston (50) qui n'est pas à proprement parler relié au piston (30) d'une seringue et, par conséquent, ne peut pas être utilisé pour faire revenir le piston (30) en arrière.
PCT/US1996/000674 1995-01-30 1996-01-22 Prolongateur de piston pour machines d'injection automatique WO1996023537A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38052695A 1995-01-30 1995-01-30
US08/380,526 1995-01-30

Publications (2)

Publication Number Publication Date
WO1996023537A1 true WO1996023537A1 (fr) 1996-08-08
WO1996023537A9 WO1996023537A9 (fr) 1996-10-24

Family

ID=23501513

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/000674 WO1996023537A1 (fr) 1995-01-30 1996-01-22 Prolongateur de piston pour machines d'injection automatique

Country Status (1)

Country Link
WO (1) WO1996023537A1 (fr)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1718600A (en) * 1927-12-17 1929-06-25 Arthur E Smith Syringe device
US4592745A (en) * 1984-02-29 1986-06-03 Novo Industri A/S Dispenser
US4677980A (en) * 1984-06-06 1987-07-07 Medrad, Inc. Angiographic injector and angiographic syringe for use therewith
US5059179A (en) * 1989-05-15 1991-10-22 David Quatrochi Non-reusable syringe assembly
US5215524A (en) * 1992-07-14 1993-06-01 Vallelunga Anthony J Plunger for non-reuseable syringe
US5478321A (en) * 1991-01-15 1995-12-26 Kimber; Michael B. Plastic syringe

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1718600A (en) * 1927-12-17 1929-06-25 Arthur E Smith Syringe device
US4592745A (en) * 1984-02-29 1986-06-03 Novo Industri A/S Dispenser
US4677980A (en) * 1984-06-06 1987-07-07 Medrad, Inc. Angiographic injector and angiographic syringe for use therewith
US5059179A (en) * 1989-05-15 1991-10-22 David Quatrochi Non-reusable syringe assembly
US5478321A (en) * 1991-01-15 1995-12-26 Kimber; Michael B. Plastic syringe
US5215524A (en) * 1992-07-14 1993-06-01 Vallelunga Anthony J Plunger for non-reuseable syringe

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