WO1996012737A3 - Compositions and treatment for multiple sclerosis - Google Patents

Compositions and treatment for multiple sclerosis Download PDF

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Publication number
WO1996012737A3
WO1996012737A3 PCT/US1995/013682 US9513682W WO9612737A3 WO 1996012737 A3 WO1996012737 A3 WO 1996012737A3 US 9513682 W US9513682 W US 9513682W WO 9612737 A3 WO9612737 A3 WO 9612737A3
Authority
WO
WIPO (PCT)
Prior art keywords
disease
multiple sclerosis
compositions
autoantigen
myelin
Prior art date
Application number
PCT/US1995/013682
Other languages
French (fr)
Other versions
WO1996012737A9 (en
WO1996012737A2 (en
Inventor
Dawn Smilek
Michael Samson
Malcolm Gefter
Di-Hwei Hsu
Jia-Dong Shi
Xavier Paliard
Brigitte Devaux
Jonathan Rothbard
Henry Franzen
Original Assignee
Immulogic Pharma Corp
Dawn Smilek
Michael Samson
Malcolm Gefter
Hsu Di Hwei
Shi Jia Dong
Xavier Paliard
Brigitte Devaux
Jonathan Rothbard
Henry Franzen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to SK512-97A priority Critical patent/SK51297A3/en
Application filed by Immulogic Pharma Corp, Dawn Smilek, Michael Samson, Malcolm Gefter, Hsu Di Hwei, Shi Jia Dong, Xavier Paliard, Brigitte Devaux, Jonathan Rothbard, Henry Franzen filed Critical Immulogic Pharma Corp
Priority to BR9509438A priority patent/BR9509438A/en
Priority to EP95941330A priority patent/EP0787147A1/en
Priority to AU42782/96A priority patent/AU4278296A/en
Priority to CZ971226A priority patent/CZ122697A3/en
Priority to SI9520118A priority patent/SI9520118A/en
Priority to JP8514109A priority patent/JPH10504039A/en
Publication of WO1996012737A2 publication Critical patent/WO1996012737A2/en
Publication of WO1996012737A9 publication Critical patent/WO1996012737A9/en
Publication of WO1996012737A3 publication Critical patent/WO1996012737A3/en
Priority to IS4466A priority patent/IS4466A/en
Priority to NO971900A priority patent/NO971900L/en
Priority to FI971750A priority patent/FI971750A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/215—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Rehabilitation Therapy (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The present invention provides isolated peptides and combinations of peptides derived form myelin autoantigens such as MBP, MOG, PLP, and MAG suitable for treating multiple sclerosis, including prophylactic and therapeutic compositions and methods for preventing or treating multiple sclerosis. Preferred compositions of the invention comprise at least one isolated, purified peptide, free from all other polypeptides or contaminants, the peptide comprising an amino acid sequence, the myelin autoantigen which has T cell activity. A therapeutic composition of the invention is capable of down regulating the autoantigen specific immune response to the myelin autoantigen in a population of humans suffering from, or susceptible to multiple sclerosis, such that disease symptoms are reduced, eliminated, or reversed and/or the onset or progression of disease symptoms is prevented or slowed. Additionally, compositions and methods of the instant invention when administered in an advanced stage of disease, reverse ongoing paralysis or other signs of disease when administered during the acute phase of disease or prevents relapse when administered during remission.
PCT/US1995/013682 1994-10-25 1995-10-25 Compositions and treatment for multiple sclerosis WO1996012737A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
SI9520118A SI9520118A (en) 1994-10-25 1995-10-25 Compositions and treatment for multiple sclerosis
BR9509438A BR9509438A (en) 1994-10-25 1995-10-25 Compositions and treatment for multiple sclerosis
EP95941330A EP0787147A1 (en) 1994-10-25 1995-10-25 Compositions and treatment for multiple sclerosis
AU42782/96A AU4278296A (en) 1994-10-25 1995-10-25 Compositions and treatment for multiple sclerosis
CZ971226A CZ122697A3 (en) 1994-10-25 1995-10-25 Preparations and methods of treating disseminated sclerosis
SK512-97A SK51297A3 (en) 1994-10-25 1995-10-25 Compositions and treatment for multiple sclerosis
JP8514109A JPH10504039A (en) 1994-10-25 1995-10-25 Compositions and treatments for multiple sclerosis
IS4466A IS4466A (en) 1994-10-25 1997-04-17 Composition and treatment for multiple sclerosis
FI971750A FI971750A (en) 1994-10-25 1997-04-24 Compositions and treatment for multiple sclerosis
NO971900A NO971900L (en) 1994-10-25 1997-04-24 Mixtures and treatment of multiple sclerosis

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US32822494A 1994-10-25 1994-10-25
US40422895A 1995-03-15 1995-03-15
US08/328,224 1995-03-15
US08/404,228 1995-03-15

Publications (3)

Publication Number Publication Date
WO1996012737A2 WO1996012737A2 (en) 1996-05-02
WO1996012737A9 WO1996012737A9 (en) 1996-07-18
WO1996012737A3 true WO1996012737A3 (en) 1996-10-10

Family

ID=26986277

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/013682 WO1996012737A2 (en) 1994-10-25 1995-10-25 Compositions and treatment for multiple sclerosis

Country Status (15)

Country Link
EP (1) EP0787147A1 (en)
JP (1) JPH10504039A (en)
AU (1) AU4278296A (en)
BR (1) BR9509438A (en)
CA (1) CA2203629A1 (en)
CZ (1) CZ122697A3 (en)
FI (1) FI971750A (en)
HU (1) HUT77047A (en)
IL (1) IL115766A0 (en)
IS (1) IS4466A (en)
NO (1) NO971900L (en)
PL (1) PL324091A1 (en)
SI (1) SI9520118A (en)
SK (1) SK51297A3 (en)
WO (1) WO1996012737A2 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6252040B1 (en) 1991-10-22 2001-06-26 The Governors Of The University Of Alberta Peptide specificity of anti-myelin basic protein and the administration of myelin basic protein peptides to multiple sclerosis patients
US6156535A (en) 1995-08-04 2000-12-05 University Of Ottawa Mammalian IAP gene family, primers, probes, and detection methods
ES2314515T3 (en) 1996-03-21 2009-03-16 Circassia Limited CRYPTIC PEPTIDES AND METHOD FOR IDENTIFICATION.
EP0939826A2 (en) * 1996-08-15 1999-09-08 Agrivax Incorporated Delivery of tolerogenic antigens via edible plants or plant-derived products
CA2494338C (en) * 1997-04-04 2007-07-17 The Governors Of The University Of Alberta Peptide specificity of anti-myelin basic protein and the administration of myelin basic protein peptides to multiple sclerosis patients
SE9703287D0 (en) * 1997-09-11 1997-09-11 Astra Ab Peptides
JP2002513558A (en) * 1998-05-05 2002-05-14 コリクサ コーポレイション Myelin basic protein peptide and use thereof
US20020072493A1 (en) 1998-05-19 2002-06-13 Yeda Research And Development Co. Ltd. Activated T cells, nervous system-specific antigens and their uses
WO1999060021A2 (en) * 1998-05-19 1999-11-25 Yeda Research And Development Co. Ltd. Use of activated t cells, nervous system-specific antigens for treating disorders of the nevrous system
EP1288226A1 (en) * 2001-09-03 2003-03-05 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Modification of the expression levels of Toll-like receptor familiy members for influencing neurodegeneration and neuroprotection in the human central nervous system
GB0202399D0 (en) * 2002-02-01 2002-03-20 Univ Bristol Peptide
CN1656222B (en) 2002-03-27 2011-11-30 艾格拉治疗公司 Antisense IAP nucleobase oligomers and uses thereof
DE10230381A1 (en) 2002-07-05 2004-01-22 Institut für Medizintechnologie Magdeburg GmbH, IMTM Use of inhibitors of alanyl aminopeptidases and pharmaceutical compositions comprising them
US8012944B2 (en) 2003-10-30 2011-09-06 Pharmascience Inc. Method for treating cancer using IAP antisense oligomer and chemotherapeutic agent
WO2008130382A2 (en) 2006-10-31 2008-10-30 East Carolina University Fusion proteins comprising an anti -inflammatory cytokine and an antigen for treatment of immune disorders
EP2328908A4 (en) * 2008-08-28 2012-11-28 Univ New York State Res Found Treatment of amyloidoses using myelin basic protein and fragments thereof
CA2757287C (en) * 2009-03-31 2019-09-10 East Carolina University Cytokines and neuroantigens for treatment of immune disorders
AU2009354040A1 (en) 2009-10-12 2012-05-31 Lifebio Laboratories Llc Composition for treatment of Multiple Sclerosis
RU2448685C2 (en) * 2009-11-30 2012-04-27 Российская Федерация в лице Министерства промышленности и торговли Российской Федерации Liposomes containing oligopeptides - fragments of myelin basic protein, pharmaceutical composition and method of treating multiple sclerosis
EP2688904B1 (en) 2011-03-21 2017-12-27 Atlantic Cancer Research Institute Polypeptides with affinity for heat shock proteins (hsps) and hsp associated complexes (hacs) and their use in diagnosis and therapy
US10188707B2 (en) 2014-01-13 2019-01-29 Berg, LLC Enolase 1 (Eno1) compositions and uses thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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TAN ET AL: "REGULATION OF THE EFFECTOR STAGES OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS VIA NEUROANTIGEN-SPECIFIC TOLERANCE INDUCTION.II.FINE SPECIFICITY OF EFFECTOR T CELL INHIBITION", J.IMMUNOL., vol. 148, 1992, pages 2748 - 2755, XP002009747 *
VALLI ET AL: "BINDING OF MYELIN BASIC PROTEIN PEPTIDES TO HUMAN HISTOCOMPATIBILITY LEUKOCYTE ANTIGEN CLASS II MOLECULES AND THEIR RECOGNITION BY T CELLS FROM MULTIPLE SCLEROSIS PATIENTS", J.CLIN.INVEST., vol. 91, 1993, pages 616 - 628, XP000567819 *

Also Published As

Publication number Publication date
FI971750A (en) 1997-06-24
NO971900D0 (en) 1997-04-24
SK51297A3 (en) 1998-03-04
NO971900L (en) 1997-06-25
AU4278296A (en) 1996-05-15
WO1996012737A2 (en) 1996-05-02
CA2203629A1 (en) 1996-05-02
EP0787147A1 (en) 1997-08-06
IL115766A0 (en) 1996-01-19
CZ122697A3 (en) 1997-09-17
HUT77047A (en) 1998-03-02
FI971750A0 (en) 1997-04-24
SI9520118A (en) 1998-08-31
IS4466A (en) 1997-04-17
BR9509438A (en) 1997-12-23
PL324091A1 (en) 1998-05-11
JPH10504039A (en) 1998-04-14

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