WO1995032736A1 - Immobilisation de substances et d'agents de diagnostics biologiquement actifs au sein de poly(organophosphazene) reticules - Google Patents

Immobilisation de substances et d'agents de diagnostics biologiquement actifs au sein de poly(organophosphazene) reticules Download PDF

Info

Publication number
WO1995032736A1
WO1995032736A1 PCT/US1995/006854 US9506854W WO9532736A1 WO 1995032736 A1 WO1995032736 A1 WO 1995032736A1 US 9506854 W US9506854 W US 9506854W WO 9532736 A1 WO9532736 A1 WO 9532736A1
Authority
WO
WIPO (PCT)
Prior art keywords
type
microparticle
polymer
poly
group
Prior art date
Application number
PCT/US1995/006854
Other languages
English (en)
Inventor
Harry R. Allcock
Shawn R. Pucher
Karyn B. Visscher
Original Assignee
The Penn State Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Penn State Research Foundation filed Critical The Penn State Research Foundation
Priority to AU26581/95A priority Critical patent/AU2658195A/en
Publication of WO1995032736A1 publication Critical patent/WO1995032736A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G79/00—Macromolecular compounds obtained by reactions forming a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbon with or without the latter elements in the main chain of the macromolecule
    • C08G79/02—Macromolecular compounds obtained by reactions forming a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbon with or without the latter elements in the main chain of the macromolecule a linkage containing phosphorus
    • C08G79/025—Polyphosphazenes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L85/00—Compositions of macromolecular compounds obtained by reactions forming a linkage in the main chain of the macromolecule containing atoms other than silicon, sulfur, nitrogen, oxygen and carbon; Compositions of derivatives of such polymers
    • C08L85/02—Compositions of macromolecular compounds obtained by reactions forming a linkage in the main chain of the macromolecule containing atoms other than silicon, sulfur, nitrogen, oxygen and carbon; Compositions of derivatives of such polymers containing phosphorus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne une substance polymère comprenant un poly(organophosphazène) contenant au moins (i) un groupe de substitution réticulable par radiation; et (ii) un groupe de substitution hydrolysable dans les conditions d'utilisation. Ce procédé rend biodégradable le polymère lorsqu'il est combiné à une substance à administrer.
PCT/US1995/006854 1994-05-31 1995-05-31 Immobilisation de substances et d'agents de diagnostics biologiquement actifs au sein de poly(organophosphazene) reticules WO1995032736A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU26581/95A AU2658195A (en) 1994-05-31 1995-05-31 Immobilization of biologically active materials and diagnostic agents in cross-linked poly(organophosphazenes)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25151094A 1994-05-31 1994-05-31
US08/251,510 1994-05-31

Publications (1)

Publication Number Publication Date
WO1995032736A1 true WO1995032736A1 (fr) 1995-12-07

Family

ID=22952279

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/006854 WO1995032736A1 (fr) 1994-05-31 1995-05-31 Immobilisation de substances et d'agents de diagnostics biologiquement actifs au sein de poly(organophosphazene) reticules

Country Status (2)

Country Link
AU (1) AU2658195A (fr)
WO (1) WO1995032736A1 (fr)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997007226A1 (fr) * 1995-08-17 1997-02-27 Introgene B.V. Poly(organo)phosphazenes utilisables dans des systemes de transfection de synthese
WO2007114549A1 (fr) * 2006-04-04 2007-10-11 Korea Institute Of Science And Technology Conjugués de polyphosphazène thermosensible et de molécules bioactives, méthode de préparation et d'utilisation desdits conjugués
WO2007121118A2 (fr) * 2006-04-12 2007-10-25 Battelle Energy Alliance, Llc Matieres de decontamination, procedes permettant de retirer une matiere contaminante d'un materiau poreux et systemes et revetements pelables permettant de decontaminer des structures comprenant un materiau poreux
WO2008153278A1 (fr) 2007-06-14 2008-12-18 Korea Institute Of Science And Technology Hydrogels de phosphazène présentant une réticulation chimique, leur procédé de préparation et leur utilisation
US7658994B2 (en) 2003-12-30 2010-02-09 3M Innovative Properties Company Substrates and compounds bonded thereto
US8012118B2 (en) 2006-03-08 2011-09-06 Fresenius Medical Care Holdings, Inc. Artificial kidney dialysis system
US8241239B2 (en) 2006-08-24 2012-08-14 Fresenius Medical Care Holdings, Inc. Device for removing fluid from blood in a patient
US8715221B2 (en) 2006-03-08 2014-05-06 Fresenius Medical Care Holdings, Inc. Wearable kidney
US8777892B2 (en) 2008-11-03 2014-07-15 Fresenius Medical Care Holdings, Inc. Portable peritoneal dialysis system
EP2540764A3 (fr) * 2011-06-30 2015-12-02 Korea Institute of Science and Technology Composition de poly(organophosphazène) pour biomatériaux
AT515955A1 (de) * 2014-06-16 2016-01-15 Universität Linz Polymerstruktur und dreidimensionales Gerüst für die Gewebezüchtung
CN107129579A (zh) * 2016-02-26 2017-09-05 北京化工大学 一种光致荧光生物可降解聚膦腈及其制备方法
EP3368609A4 (fr) * 2015-10-28 2019-07-24 University of Maryland, College Park Transporteurs multifonctionnels biodégradables pour l'administration de médicaments

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4889622A (en) * 1988-07-18 1989-12-26 Graham Mervyn Elliott Swimming pool skimmer
US5001203A (en) * 1988-04-11 1991-03-19 Ethyl Corporation UV curable polyorganophosphazene composition
US5053451A (en) * 1990-01-19 1991-10-01 The Pennsylvania Research Corporation Ionically cross-linkable polyphosphazene: poly(bis(carboxylatophenoxy) phosphazene) and its hydrogels and membranes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5001203A (en) * 1988-04-11 1991-03-19 Ethyl Corporation UV curable polyorganophosphazene composition
US4889622A (en) * 1988-07-18 1989-12-26 Graham Mervyn Elliott Swimming pool skimmer
US5053451A (en) * 1990-01-19 1991-10-01 The Pennsylvania Research Corporation Ionically cross-linkable polyphosphazene: poly(bis(carboxylatophenoxy) phosphazene) and its hydrogels and membranes

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997007226A1 (fr) * 1995-08-17 1997-02-27 Introgene B.V. Poly(organo)phosphazenes utilisables dans des systemes de transfection de synthese
US7658994B2 (en) 2003-12-30 2010-02-09 3M Innovative Properties Company Substrates and compounds bonded thereto
US8715221B2 (en) 2006-03-08 2014-05-06 Fresenius Medical Care Holdings, Inc. Wearable kidney
US8012118B2 (en) 2006-03-08 2011-09-06 Fresenius Medical Care Holdings, Inc. Artificial kidney dialysis system
CN101460198B (zh) * 2006-04-04 2013-08-07 韩国科学技术研究院 热敏性聚磷腈-生物活性分子缀合物、其制备方法及其用途
WO2007114549A1 (fr) * 2006-04-04 2007-10-11 Korea Institute Of Science And Technology Conjugués de polyphosphazène thermosensible et de molécules bioactives, méthode de préparation et d'utilisation desdits conjugués
US8287888B2 (en) 2006-04-04 2012-10-16 Korea Institute Of Science And Technology Thermosensitive polyphosphazene-bioactive molecule conjugates, preparation method thereof and use thereof
WO2007121118A2 (fr) * 2006-04-12 2007-10-25 Battelle Energy Alliance, Llc Matieres de decontamination, procedes permettant de retirer une matiere contaminante d'un materiau poreux et systemes et revetements pelables permettant de decontaminer des structures comprenant un materiau poreux
WO2007121118A3 (fr) * 2006-04-12 2008-08-07 Battelle Energy Alliance Llc Matieres de decontamination, procedes permettant de retirer une matiere contaminante d'un materiau poreux et systemes et revetements pelables permettant de decontaminer des structures comprenant un materiau poreux
US7723463B2 (en) 2006-04-12 2010-05-25 Battelle Energy Alliance, Llc Polyphosphazine-based polymer materials
US7833357B2 (en) 2006-04-12 2010-11-16 Battelle Energy Alliance, Llc Methods for removing contaminant matter from a porous material
US8070881B2 (en) 2006-04-12 2011-12-06 Battelle Energy Alliance Systems and strippable coatings for decontaminating structures that include porous material
US8241239B2 (en) 2006-08-24 2012-08-14 Fresenius Medical Care Holdings, Inc. Device for removing fluid from blood in a patient
US9138521B2 (en) 2006-08-24 2015-09-22 Fresenius Medical Care Holdings, Inc. Device for removing fluid from blood in a patient
WO2008153278A1 (fr) 2007-06-14 2008-12-18 Korea Institute Of Science And Technology Hydrogels de phosphazène présentant une réticulation chimique, leur procédé de préparation et leur utilisation
EP2155806A4 (fr) * 2007-06-14 2015-12-02 Korea Inst Sci & Tech Hydrogels de phosphazène présentant une réticulation chimique, leur procédé de préparation et leur utilisation
US8777892B2 (en) 2008-11-03 2014-07-15 Fresenius Medical Care Holdings, Inc. Portable peritoneal dialysis system
EP2540764A3 (fr) * 2011-06-30 2015-12-02 Korea Institute of Science and Technology Composition de poly(organophosphazène) pour biomatériaux
AT515955A1 (de) * 2014-06-16 2016-01-15 Universität Linz Polymerstruktur und dreidimensionales Gerüst für die Gewebezüchtung
AT515955B1 (de) * 2014-06-16 2016-08-15 Universität Linz Polymerstruktur und dreidimensionales Gerüst für die Gewebezüchtung
EP3368609A4 (fr) * 2015-10-28 2019-07-24 University of Maryland, College Park Transporteurs multifonctionnels biodégradables pour l'administration de médicaments
CN107129579A (zh) * 2016-02-26 2017-09-05 北京化工大学 一种光致荧光生物可降解聚膦腈及其制备方法

Also Published As

Publication number Publication date
AU2658195A (en) 1995-12-21

Similar Documents

Publication Publication Date Title
Li et al. Programmable construction of peptide‐based materials in living subjects: from modular design and morphological control to theranostics
US5562099A (en) Polymeric microparticles containing agents for imaging
WO1995032736A1 (fr) Immobilisation de substances et d'agents de diagnostics biologiquement actifs au sein de poly(organophosphazene) reticules
US5487390A (en) Gas-filled polymeric microbubbles for ultrasound imaging
AU752747B2 (en) Delivery of poly(ethylene glycol)-conjugated molecules from degradable hydrogels
Baranwal et al. Chitosan: an undisputed bio-fabrication material for tissue engineering and bio-sensing applications
CA2060176C (fr) Compositions pharmaceutiques a petites particules
JP3786832B2 (ja) 分解性のヘテロ二官能性ポリ（エチレングリコール）アクリレート及びそれから誘導されるゲル及び複合体
Bratlie et al. Materials for diabetes therapeutics
JP2865866B2 (ja) 診断剤の製造
CN1072966C (zh) 中空微胶囊的制备
JPH10508004A (ja) 限定されたｚ電位を有するキトサンまたはその誘導体を含む薬剤移送組成物
JPH11315098A (ja) ポリエチレングリコ―ル―蛋白質付加物
WO1995028150A1 (fr) Polyphospazenes photoreticulables et utilisation comme matieres de microencapsulation
EP2191007B1 (fr) Compositions d'hydrogel
Veronese et al. Influence of PEGylation on the release of low and high molecular-weight proteins from PVA matrices
D'urso et al. Poly (ethylene glycol)-serum albumin hydrogel as matrix for enzyme immobilization: biomedical applications
JP4665131B2 (ja) 高分子電解質複合体およびその製造方法
Jyothi et al. Microsphere as a novel drug delivery–a review
Ingemann et al. Peptide and protein drug delivery systems for non-parenteral routes of administration
Salunke et al. Microspheres: a review
AU2001282575B8 (en) Preparations for diagnosing extrapancreatic secretory function
Alfei et al. Synthesis and Characterization of Amine and Aldehyde-Containing Copolymers for Enzymatic Crosslinking of Gelatine
CN109954128A (zh) 一种可干扰β-淀粉样蛋白聚集并协助清除的功能化纳米凝胶及制备方法
Gidde et al. Microsphere as drug delivery system: An overview

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AU CA JP KR NO

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
122 Ep: pct application non-entry in european phase