WO1995027051A1 - Decarboxylase d'acide glutamatique (gad), procede de preparation de gad modifiee, procede d'administration de gad modifiee et d'un peptide - Google Patents

Decarboxylase d'acide glutamatique (gad), procede de preparation de gad modifiee, procede d'administration de gad modifiee et d'un peptide Download PDF

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Publication number
WO1995027051A1
WO1995027051A1 PCT/SE1995/000354 SE9500354W WO9527051A1 WO 1995027051 A1 WO1995027051 A1 WO 1995027051A1 SE 9500354 W SE9500354 W SE 9500354W WO 9527051 A1 WO9527051 A1 WO 9527051A1
Authority
WO
WIPO (PCT)
Prior art keywords
gad
modified
antigen
binding site
molecule
Prior art date
Application number
PCT/SE1995/000354
Other languages
English (en)
Inventor
Anders Essen-Möller
Original Assignee
Synectics Biotechnology Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synectics Biotechnology Ab filed Critical Synectics Biotechnology Ab
Priority to AU22261/95A priority Critical patent/AU2226195A/en
Publication of WO1995027051A1 publication Critical patent/WO1995027051A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Décarboxylase d'acide glutamatique (GAD) caractérisée par une immunogénicité sensiblement préservée relativement au diabète par rapport à une GAD non modifiée et par une efficacité réduite ou inexistante relativement à une synthèse de GABA. L'invention concerne également un procédé de préparation d'une GAD modifiée, ainsi qu'un procédé d'administration d'une GAD modifiée et d'un peptide.
PCT/SE1995/000354 1994-03-31 1995-03-31 Decarboxylase d'acide glutamatique (gad), procede de preparation de gad modifiee, procede d'administration de gad modifiee et d'un peptide WO1995027051A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU22261/95A AU2226195A (en) 1994-03-31 1995-03-31 Modified gad, a method for manufacturing of modified gad and a method to supply modified gad and peptide

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9401118A SE9401118L (sv) 1994-03-31 1994-03-31 GAD, en metod för framställning av modifierat GAD samt en metod för att tillföra modifierat GAD samt peptid
SE9401118-6 1994-03-31

Publications (1)

Publication Number Publication Date
WO1995027051A1 true WO1995027051A1 (fr) 1995-10-12

Family

ID=20393518

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE1995/000354 WO1995027051A1 (fr) 1994-03-31 1995-03-31 Decarboxylase d'acide glutamatique (gad), procede de preparation de gad modifiee, procede d'administration de gad modifiee et d'un peptide

Country Status (3)

Country Link
AU (1) AU2226195A (fr)
SE (1) SE9401118L (fr)
WO (1) WO1995027051A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997012034A1 (fr) * 1995-09-29 1997-04-03 Diamyd Therapeutics Ab Decarboxylase d'acide glutamique (dag) modifiee
EP0973934A1 (fr) * 1997-02-25 2000-01-26 Genzyme Transgenics Corporation Proteines non secretees produites de maniere transgenique
US6093396A (en) * 1996-09-27 2000-07-25 Diamyd Therapeutics Ab Modified glutamic acid decarboxylase (GAD)
EP1793000A1 (fr) * 1997-02-25 2007-06-06 GTC Biotherapeutics, Inc. Protéines non sécrétées produites de manière transgénique

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992005446A1 (fr) * 1990-09-21 1992-04-02 Regents Of The University Of California Decarboxylase de l'acide glutamique clone
WO1992020811A2 (fr) * 1991-05-15 1992-11-26 Zymogenetics, Inc. Clonage et expression de l'autoantigene decarboxylase de l'acide glutamique d'ilots humains

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992005446A1 (fr) * 1990-09-21 1992-04-02 Regents Of The University Of California Decarboxylase de l'acide glutamique clone
WO1992020811A2 (fr) * 1991-05-15 1992-11-26 Zymogenetics, Inc. Clonage et expression de l'autoantigene decarboxylase de l'acide glutamique d'ilots humains

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997012034A1 (fr) * 1995-09-29 1997-04-03 Diamyd Therapeutics Ab Decarboxylase d'acide glutamique (dag) modifiee
US6093396A (en) * 1996-09-27 2000-07-25 Diamyd Therapeutics Ab Modified glutamic acid decarboxylase (GAD)
EP0973934A1 (fr) * 1997-02-25 2000-01-26 Genzyme Transgenics Corporation Proteines non secretees produites de maniere transgenique
EP0973934A4 (fr) * 1997-02-25 2003-02-05 Genzyme Transgenics Corp Proteines non secretees produites de maniere transgenique
EP1793000A1 (fr) * 1997-02-25 2007-06-06 GTC Biotherapeutics, Inc. Protéines non sécrétées produites de manière transgénique

Also Published As

Publication number Publication date
SE9401118L (sv) 1995-10-01
AU2226195A (en) 1995-10-23
SE9401118D0 (sv) 1994-03-31

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