WO1995001788A1 - Procedes et articles d'administration de medicament dans la cavite buccale - Google Patents

Procedes et articles d'administration de medicament dans la cavite buccale Download PDF

Info

Publication number
WO1995001788A1
WO1995001788A1 PCT/US1994/007705 US9407705W WO9501788A1 WO 1995001788 A1 WO1995001788 A1 WO 1995001788A1 US 9407705 W US9407705 W US 9407705W WO 9501788 A1 WO9501788 A1 WO 9501788A1
Authority
WO
WIPO (PCT)
Prior art keywords
drug
fiber
article
polyvinyl alcohol
matrix
Prior art date
Application number
PCT/US1994/007705
Other languages
English (en)
Inventor
Robert J. Chapman
Charles M. Habib
Daniel Graiver
H. Franklin Stewart
Original Assignee
Trustees Of Tufts College
Mizu Systems Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trustees Of Tufts College, Mizu Systems Corporation filed Critical Trustees Of Tufts College
Priority to AU73272/94A priority Critical patent/AU7327294A/en
Publication of WO1995001788A1 publication Critical patent/WO1995001788A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8129—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers or esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers, e.g. polyvinylmethylether
    • A—HUMAN NECESSITIES
    • A46—BRUSHWARE
    • A46B—BRUSHES
    • A46B11/00—Brushes with reservoir or other means for applying substances, e.g. paints, pastes, water
    • A—HUMAN NECESSITIES
    • A46—BRUSHWARE
    • A46D—MANUFACTURE OF BRUSHES
    • A46D1/00—Bristles; Selection of materials for bristles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms

Definitions

  • the fiber can be woven or spun with similar fibers or with other fibers with different mechanical properties, for use as line, floss, sutures, or the like.
  • One embodiment of the present article features a drug comprising fluoride,
  • the floss or line can be used to apply fluoride to the teeth as the teeth are flossed in a conventional manner.
  • One embodiment of the present article features drug held in a polyvinyl alcohol matrix in the form of a bead.
  • the bead can be made in the form of a troche, lozenge and the like. The bead releases drug in effective concentrations over a prolonged period of time.
  • a further embodiment of the present invention features a method of delivering and releasing an effective dose of drug to the oral cavity.
  • the delivery of drug to the oral cavity can be for a local treatment of a disease of the oral cavity, or a nonlocal or systemic treatment of a disease.
  • One method comprises the step of administering to the oral cavity of a subject, a drug held in a polyvinyl alcohol matrix.
  • the polyvinyl alcohol matrix releases the drug in a consistent, sustained manner in the presence of oral secretions.
  • Figure 1 is a view of a bead in partial cutaway embodying features of the present invention
  • FIG. 9-12 depict graphically the release of NaF from brushes made in accordance with the present invention. Detailed Description

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des procédés et des articles fabriqués permettant de libérer un médicament dans la cavité buccale. Dans lesdits procédés et articles, le médicament est contenu dans une matrice à l'alcool de polyvinyle libèrant le médicament de manière constante.
PCT/US1994/007705 1993-07-09 1994-07-11 Procedes et articles d'administration de medicament dans la cavite buccale WO1995001788A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU73272/94A AU7327294A (en) 1993-07-09 1994-07-11 Methods and articles for administering drug to the oral cavity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/089,706 1993-07-09
US08/089,706 US5520924A (en) 1993-07-09 1993-07-09 Methods and articles for administering drug to the oral cavity

Publications (1)

Publication Number Publication Date
WO1995001788A1 true WO1995001788A1 (fr) 1995-01-19

Family

ID=22219176

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1994/007705 WO1995001788A1 (fr) 1993-07-09 1994-07-11 Procedes et articles d'administration de medicament dans la cavite buccale

Country Status (3)

Country Link
US (1) US5520924A (fr)
AU (1) AU7327294A (fr)
WO (1) WO1995001788A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998029006A1 (fr) * 1996-12-30 1998-07-09 Jungang Zhang Brosse a dents a fonction prophylactique
DE19913732A1 (de) * 1999-03-26 2000-09-28 Lohmann Therapie Syst Lts Nikotin-TTS mit einem Zusatz von Monoterpenketonen
WO2002053115A1 (fr) * 2001-01-04 2002-07-11 Muehleisen Michael Composition utilisee dans le cadre de la desaccoutumance au tabac
EP1604652A2 (fr) * 2004-06-07 2005-12-14 Nitto Denko Corporation Préparation topique anésthésique pour le prétraitement en endoscopie gastrointestinale supérieure
US10098376B2 (en) 2003-11-07 2018-10-16 U.S. Smokeless Tobacco Company Llc Tobacco compositions
US10945454B2 (en) 2003-11-07 2021-03-16 U.S. Smokeless Tobacco Company Llc Tobacco compositions

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5713852A (en) * 1995-06-07 1998-02-03 Alza Corporation Oral dosage and method for treating painful conditions of the oral cavity
US6103257A (en) * 1998-07-17 2000-08-15 Num-Pop, Inc. System for delivering pharmaceuticals to the buccal mucosa
US6287689B1 (en) 1999-12-28 2001-09-11 Solutia Inc. Low surface energy fibers
US6630087B1 (en) 2001-11-16 2003-10-07 Solutia Inc. Process of making low surface energy fibers
WO2006039459A1 (fr) * 2004-09-30 2006-04-13 Bausch & Lomb Incorporated Capsule pour envelopper des comprimes pour une insertion chirurgicale dans le corps humain
US20070161936A1 (en) * 2006-01-06 2007-07-12 Svetlik Harvey E Wound treatment-dressing and method of manufacture
BRPI0822655A2 (pt) 2008-06-04 2015-06-30 Colgate Palmolive Co Implemento e sistema para cuidado oral
WO2012003319A2 (fr) 2010-07-02 2012-01-05 The Procter & Gamble Company Filaments comprenant des bandes non tissées avec agent actif et procédés de fabrication associés
MX345026B (es) 2010-07-02 2017-01-12 Procter & Gamble Material de trama y método para su elaboración.
WO2012003365A1 (fr) 2010-07-02 2012-01-05 The Procter & Gamble Company Filaments comprenant un agent actif ingérable, des voiles non tissées, et procédés de fabrication de ces filaments
ES2792800T3 (es) 2010-07-02 2020-11-12 Procter & Gamble Métodos de suministro de una sustancia activa para el cuidado de la salud mediante la administración de artículos para el cuidado de la salud personal que comprenden un filamento
HUE030120T2 (en) 2010-07-02 2017-04-28 Procter & Gamble Procedure for forming a film from a non-woven web
RU2555042C2 (ru) 2010-07-02 2015-07-10 Дзе Проктер Энд Гэмбл Компани Способ доставки активнодействующего вещества
US8721331B2 (en) * 2011-10-11 2014-05-13 Puthalath Koroth Raghuprasad Oral transmucosal drug delivery device
CN111556891B (zh) 2018-01-26 2021-11-05 宝洁公司 包含酶的水溶性单位剂量制品
EP3743503A1 (fr) 2018-01-26 2020-12-02 The Procter & Gamble Company Articles solubles dans l'eau et procédés connexes
CN111542590A (zh) 2018-01-26 2020-08-14 宝洁公司 包含香料的水溶性单位剂量制品
WO2019147532A1 (fr) 2018-01-26 2019-08-01 The Procter & Gamble Company Articles en dose unitaire soluble dans l'eau comprenant un parfum
WO2019168829A1 (fr) 2018-02-27 2019-09-06 The Procter & Gamble Company Produit de consommation comprenant un conditionnement plat contenant des articles de dose unitaire
EP3806686A4 (fr) * 2018-06-12 2022-03-23 Buzzelet Development And Technologies Ltd Dispositif d'administration de cannabis pour soins dentaires et son utilisation
US10982176B2 (en) 2018-07-27 2021-04-20 The Procter & Gamble Company Process of laundering fabrics using a water-soluble unit dose article
US11859338B2 (en) 2019-01-28 2024-01-02 The Procter & Gamble Company Recyclable, renewable, or biodegradable package
EP3712237A1 (fr) 2019-03-19 2020-09-23 The Procter & Gamble Company Articles fibreux de dose unitaire soluble dans l'eau comprenant des structures fibreuses solubles dans l'eau
MX2021013141A (es) 2019-06-28 2021-12-10 Procter & Gamble Articulos fibrosos solidos disolubles que contienen surfactantes anionicos.
JP7506249B2 (ja) 2020-07-31 2024-06-25 ザ プロクター アンド ギャンブル カンパニー ヘアケア用プリル含有水溶性繊維パウチ

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5899411A (ja) * 1981-12-05 1983-06-13 Shoichiro Ozaki 制ガン剤
JPS59110613A (ja) * 1982-12-16 1984-06-26 Toyobo Co Ltd 口腔粘膜適用カリクレイン製剤
BE903540A (fr) * 1984-10-30 1986-02-17 Elan Corp Plc Formulations a liberation progressive, procede pour leur preparation et compositions les renfermant
JPS63220804A (ja) * 1987-03-10 1988-09-14 土居　達郎 歯ブラシ
US4831168A (en) * 1985-05-03 1989-05-16 Hoechst Aktiengesellschaft Process for preparing 2-hydroxydibenzofuran-3-carboxylic acid and alkali metal salts thereof
JPH0596597A (ja) * 1991-10-05 1993-04-20 Tsutsumi Seisakusho:Kk 軟線材の製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3076218A (en) * 1961-06-08 1963-02-05 Johnson & Johnson Fluorinated toothbrush bristle and method of making same
JPH0678460B2 (ja) * 1985-05-01 1994-10-05 株式会社バイオマテリアル・ユニバース 多孔質透明ポリビニルアルユールゲル
US5098711A (en) * 1988-11-14 1992-03-24 Ira Hill Method of treating the oral cavity with dental floss containing chemotherapeutic agents
US4851168A (en) * 1988-12-28 1989-07-25 Dow Corning Corporation Novel polyvinyl alcohol compositions and products prepared therefrom

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5899411A (ja) * 1981-12-05 1983-06-13 Shoichiro Ozaki 制ガン剤
JPS59110613A (ja) * 1982-12-16 1984-06-26 Toyobo Co Ltd 口腔粘膜適用カリクレイン製剤
BE903540A (fr) * 1984-10-30 1986-02-17 Elan Corp Plc Formulations a liberation progressive, procede pour leur preparation et compositions les renfermant
US4831168A (en) * 1985-05-03 1989-05-16 Hoechst Aktiengesellschaft Process for preparing 2-hydroxydibenzofuran-3-carboxylic acid and alkali metal salts thereof
JPS63220804A (ja) * 1987-03-10 1988-09-14 土居　達郎 歯ブラシ
JPH0596597A (ja) * 1991-10-05 1993-04-20 Tsutsumi Seisakusho:Kk 軟線材の製造方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 8843, Derwent World Patents Index; AN 88-302559 *
DATABASE WPI Week 9320, Derwent World Patents Index; AN 93-163934 *
PATENT ABSTRACTS OF JAPAN vol. 7, no. 201 (C - 184) 6 September 1983 (1983-09-06) *
PATENT ABSTRACTS OF JAPAN vol. 8, no. 225 (C - 247) 16 October 1984 (1984-10-16) *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998029006A1 (fr) * 1996-12-30 1998-07-09 Jungang Zhang Brosse a dents a fonction prophylactique
DE19913732A1 (de) * 1999-03-26 2000-09-28 Lohmann Therapie Syst Lts Nikotin-TTS mit einem Zusatz von Monoterpenketonen
US7029692B1 (en) 1999-03-26 2006-04-18 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system with nicotine and addition of monoterpene ketones
WO2002053115A1 (fr) * 2001-01-04 2002-07-11 Muehleisen Michael Composition utilisee dans le cadre de la desaccoutumance au tabac
US10098376B2 (en) 2003-11-07 2018-10-16 U.S. Smokeless Tobacco Company Llc Tobacco compositions
US10765140B2 (en) 2003-11-07 2020-09-08 U.S. Smokeless Tobacco Company Llc Tobacco compositions
US10945454B2 (en) 2003-11-07 2021-03-16 U.S. Smokeless Tobacco Company Llc Tobacco compositions
EP1604652A2 (fr) * 2004-06-07 2005-12-14 Nitto Denko Corporation Préparation topique anésthésique pour le prétraitement en endoscopie gastrointestinale supérieure
EP1604652A3 (fr) * 2004-06-07 2007-03-07 Nitto Denko Corporation Préparation topique anésthésique pour le prétraitement en endoscopie gastrointestinale supérieure

Also Published As

Publication number Publication date
AU7327294A (en) 1995-02-06
US5520924A (en) 1996-05-28

Similar Documents

Publication Publication Date Title
US5520924A (en) Methods and articles for administering drug to the oral cavity
US5855870A (en) Method for treating sensitive teeth
CA2093282C (fr) Dispositif d'administration intra-buccale de medicaments
US6340027B1 (en) Extensible polishing mono-filament dental floss
US5842489A (en) Texturized dental floss and method of making
RU2519329C2 (ru) Композиции и устройства
US9468510B2 (en) Floss device, a method of forming the floss device and a method of using the floss device
BRPI0609903A2 (pt) composições de fio dental que compreendem mentol e carboxamidas
CN110505867A (zh) 用于牙齿清洁的包括研磨剂的片剂
WO1989010740A1 (fr) Anesthesiant local buccal
US11980675B2 (en) Temporary tooth repair/treatment composition and methods of use thereof
JP2001504366A (ja) 歯ブラシおよび歯ブラシの剛毛を製造するための方法
US11622834B1 (en) Temporary tooth repair/treatment composition and methods of use thereof
US20230126661A1 (en) Dental flosser
TW201219016A (en) Elastomeric dental floss
WO1992010147A1 (fr) Fil dentaire contenant de la nicotine
US20140234380A1 (en) Composition for management of periodontal disease
EP3600240B1 (fr) Particules de soin buccal et leur système d'administration
US20230248477A1 (en) Temporary tooth repair/treatment composition and methods of use thereof
US20020006415A1 (en) Chemically active fiber compositions as delivery system for chemotherpeutic agents, epecially for substances useful in dental hygiene
US20030104038A1 (en) Cough treatment
RU2089172C1 (ru) Средство для лечения периодонтитов и пародонтитов
US20130108677A1 (en) Abrasive confectionary products
CA3193355A1 (fr) Composition de reparation/traitement de dent temporaire et methodes d'utilisation
JPS62223114A (ja) 徐放性歯周病治療剤

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AT AU BB BG BR BY CA CH CN CZ DE DK ES FI GB GE HU JP KE KG KP KR KZ LK LU LV MD MG MN MW NL NO NZ PL PT RO RU SD SE SI SK TJ TT UA UZ VN

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: CA