WO1994028722A1 - Sodium hypochlorite based disinfectant and sterilizer for medical-surgical instruments - Google Patents
Sodium hypochlorite based disinfectant and sterilizer for medical-surgical instrumentsInfo
- Publication number
- WO1994028722A1 WO1994028722A1 PCT/US1993/005091 US9305091W WO9428722A1 WO 1994028722 A1 WO1994028722 A1 WO 1994028722A1 US 9305091 W US9305091 W US 9305091W WO 9428722 A1 WO9428722 A1 WO 9428722A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- disinfectant solution
- milliliters
- aqueous disinfectant
- sodium
- hypochlorite
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/08—Alkali metal chlorides; Alkaline earth metal chlorides
Definitions
- the present invention relates to a composition containing an alkali metal or alkaline earth metal hypochlorite as the active ingredient for the disinfection and sterilization of hard surfaces and plastic, metal and glass instruments for surgery and dentistry.
- the present invention also relates to a method of disinfecting or sterilizing hard surfaces or surgical and dental instruments with solutions of alkali metal or alkaline earth metal hypochlorites.
- alkali metal and alkaline earth metal hypochlorites are useful for their disinfecting and bleaching properties. See, e.g.. U.S. Patent No. 3,717,580 to Echols et al.
- chlorine-based disinfectants Despite the long history of efficacious use of chlorine-based disinfectants, few chlorine compounds are used today as sterilants in medical and dental practice. The many problems associated with chlorine-based disinfectants limit their usefulness for disinfecting or sterilizing instruments or hard surfaces. For example, the instability of the active ingredient causes the effectiveness of some hypochlorite disinfectant solutions to deteriorate significantly within a few hours of preparation. An even more significant problem associated with use of chlorine-based disinfectants, however, is the highly corrosive nature of these solutions due to high oxidation potential. For example, concentrations of hypochlorous acid sufficient to sterilize standard bacteriological challenges also quickly attack metals, even stainless steel, causing discoloration and pitting. Metal instruments soaked in chlorine solutions tend to be irreversibly damaged; sharp edges are destroyed and metal surfaces are pitted and darkened.
- a first embodiment of the present invention is directed to an aqueous disinfectant solution comprising an alkali metal or alkaline earth metal hypochlorite, an amount of base sufficient to raise the pH of the solution to at least .12, and water.
- a second embodiment of the present invention is directed to a method for sterilizing medical and dental instruments and hard surfaces which comprises contacting the medical or dental instruments or hard surface with an aqueous disinfecting solution comprising an alkali metal or alkaline earth metal hypochlorite, an amount of a base sufficient to raise the pH of the solution to at least 12, and water, for a time sufficient to disinfect the medical or dental instruments or hard surface.
- an aqueous disinfecting solution comprising an alkali metal or alkaline earth metal hypochlorite, an amount of a base sufficient to raise the pH of the solution to at least 12, and water, for a time sufficient to disinfect the medical or dental instruments or hard surface.
- the present invention is directed to an aqueous disinfectant solution which comprises an alkali metal or alkaline earth metal hypochlorite, an amount of base sufficient to raise the pH of the solution to at least 12, and water.
- the disinfectant solution according to the present invention allows for the rapid and effective sterilization of medical and dental instruments and hard surfaces, without corrosion of metal or damage to plastic, optical fibers or glass.
- the active ingredient in the aqueous disinfectant solution is an alkali metal or alkaline earth metal hypochlorite.
- the active ingredient is an alkali metal hypochlorite. More preferably, the alkali metal hypochlorite is sodium hypochlorite.
- Sodium hypochlorite is commercially available from sources such as Sigma®.
- a particularly preferred sodium hypochlorite is commercially available from A uchina, Inc. under the name AmuchinaTM.
- AmuchinaTM is an electrolytic chloroxidizer which provides 11 grams of chlorine per liter.
- the use of AmuchinaTM in the present invention is particularly preferred on account of the high purity with respect to metal content and increased stability of the active agent in AmuchinaTM as compared to other commercially available sodium hypochlorites.
- the amount of alkali metal or alkaline earth metal hypochlorite employed in the aqueous disinfectant solution according to the present invention can be the minimum amount needed to show a positive disinfecting effect in any of the known methods for determining disinfecting capacity, such as standard bacteriological challenges, or such higher concentrations as may be appropriate. In general, any amount which elicits disinfecting effects is appropriate.
- the amount of hypochlorite employed is preferably sufficient to provide a concentration of available chlorine within the range of 225.0 to 287.5 parts per million. When sodium hypochlorite is employed in the aqueous disinfectant solution, 0.0225 to 0.0288 grams of sodium hypochlorite (as available chlorine) are preferably used per 100 milliliters of solution.
- the aqueous disinfectant solution also contains a base.
- the base may be any of the known compounds which cause an aqueous solution to have an alkaline pH, i.e., a pH greater than 7. Suitable bases are readily available from commercial sources, such as Sigma®.
- the base employed in the aqueous disinfectant solution is an alkali metal or alkaline earth metal base. Particularly preferred are the alkali metal and alkaline earth metal hydroxides. Most preferred is sodium hydroxide.
- the amount of base employed in the aqueous disinfectant solution is at least the minimum amount of base sufficient to raise the pH of the solution to at least 12.
- the amount of base employed is sufficient to raise the pH of the aqueous disinfectant solution to within the range of 12 to 13.
- sodium hydroxide employed as the base, 3.6 to 4.4 grams of sodium hydroxide are preferably used per 100 milliliters of solution.
- a preferred embodiment of the present invention comprises: 0.0225 to 0.0288 grams of sodium hypochlorite (as available chlorine), 3.6 to 4.4 grams of sodium hydroxide, and purified water sufficient to make 100 milliliters.
- a particularly preferred embodiment comprises: 0.025 grams of sodium hypochlorite (as available chlorine), 4.0 grams of sodium hydroxide, and purified water sufficient to make 100 milliliters.
- the aqueous disinfectant solution may also contain conventional pharmaceutical additives and excipients.
- the aqueous disinfectant solution also contains sodium chloride.
- 100 milliliters of the aqueous disinfectant solution according to the present invention preferably also contains 0.35 to 0.45 grams of sodium chloride.
- a preferred embodiment of the present invention comprises: 0.0225 to 0.0288 grams of sodium hypochlorite (as available chlorine), 3.6 to 4.4 grams of sodium hydroxide, 0.35 to 0.45 grams of sodium chloride, and purified water sufficient to make 100 milliliters.
- a particularly preferred embodiment comprises: 0.025 grams of sodium hypochlorite (as available chlorine), 4.0 grams of sodium hydroxide, 0.39 grams of sodium chloride, and purified water sufficient to make 100 milliliters.
- the aqueous disinfectant solution according to the present invention may be prepared by any of the methods known to those skilled in the art.
- the alkali metal or alkaline earth metal hypochlorite, the base, and water are added to a mixer and mixed at low speed for a time sufficient to prepare the aqueous disinfectant solution.
- the solution can be sampled and tested for available chlorine, pH, and concentration of base.
- the amount of available chlorine is within the range of 225.0 to 287.5 parts per million and the pH is within the range of 12 to 13.
- the concentration of sodium hydroxide is preferably within the range of 3.6 to 4.4%.
- the aqueous disinfectant solution according to the present invention may be used to sterilize and disinfect rapidly and effectively medical and dental instruments and hard surfaces.
- the aqueous disinfectant solution may be used to disinfect and sterilize metal surgical instruments, such as scalpels, plastic instruments, such as face masks, catheters, couplings, pipes for connections, collectors, and tubes for respiration, instruments with lenses, such as endoscopes, and instruments and devices used in dentistry.
- the aqueous disinfectant solution may also be used to disinfect hard surfaces, such as tables and floors.
- the aqueous disinfectant solution according to this invention may be used as a concentrate or diluted 1:5 or 1:10 with water. It is within the skill of the worker in the art to determine the appropriate concentration of the aqueous disinfectant solution based upon the intended application and the desired result.
- the aqueous disinfectant solution according to the present invention be poured into a suitable receptacle, such as a basin, and the instruments to be sterilized and disinfected be soaked in the solution for a time sufficient to disinfect and sterilize the instruments.
- a suitable receptacle such as a basin
- the instruments to be sterilized and disinfected be soaked in the solution for a time sufficient to disinfect and sterilize the instruments.
- the instruments are soaked in the aqueous disinfectant solution for about 15 minutes at room temperature and then washed with sterile physiological solution or sterile distilled water prior to use.
- the mixer was turned on at low speed for 1 hour. Samples were taken at intervals to test for available chlorine (225, - 287.5 ppm), pH (12.0 - 13.0), and sodium hydroxide (3.6 - 4.4%).
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Inorganic Chemistry (AREA)
- Agronomy & Crop Science (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002164308A CA2164308C (en) | 1993-06-03 | 1993-06-03 | Sodium hypochlorite based disinfectant and sterilizer for medical-surgical instruments |
AU45246/93A AU4524693A (en) | 1993-06-03 | 1993-06-03 | Sodium hypochlorite based disinfectant and sterilizer for medical-surgical instruments |
PCT/US1993/005091 WO1994028722A1 (en) | 1993-06-03 | 1993-06-03 | Sodium hypochlorite based disinfectant and sterilizer for medical-surgical instruments |
EP93915151A EP0701400A1 (en) | 1993-06-03 | 1993-06-03 | Sodium hypochlorite based disinfectant and sterilizer for medical-surgical instruments |
US08/765,047 US6207201B1 (en) | 1993-06-03 | 1993-06-03 | Sodium hypochlorite based disinfectant and sterilizer for medical-surgical instruments |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1993/005091 WO1994028722A1 (en) | 1993-06-03 | 1993-06-03 | Sodium hypochlorite based disinfectant and sterilizer for medical-surgical instruments |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1994028722A1 true WO1994028722A1 (en) | 1994-12-22 |
Family
ID=22236636
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1993/005091 WO1994028722A1 (en) | 1993-06-03 | 1993-06-03 | Sodium hypochlorite based disinfectant and sterilizer for medical-surgical instruments |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0701400A1 (en) |
AU (1) | AU4524693A (en) |
CA (1) | CA2164308C (en) |
WO (1) | WO1994028722A1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997019597A1 (en) * | 1995-11-29 | 1997-06-05 | Marco Rotondi | A composition for odontostomatological use in cleaning and disinfecting the root canals and viable dentine |
WO2014036659A1 (en) | 2012-09-07 | 2014-03-13 | Martin Marcus E | Disinfectant formulation comprising calcium hydroxide and sodium hypochlorite |
WO2019133844A1 (en) * | 2017-12-29 | 2019-07-04 | Cms Technology, Inc. | Systems and methods for high-ph treatment of foodstuffs and other substrates |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1937229A (en) * | 1929-12-24 | 1933-11-28 | Kantorowicz Hermann | Process of cleaning and disinfecting metallic articles |
CH200962A (en) * | 1936-10-10 | 1938-11-15 | Ig Farbenindustrie Ag | Liquid detergent with disinfecting properties and process for its manufacture. |
US4167561A (en) * | 1973-12-28 | 1979-09-11 | Lever Brothers Company | Hypochlorite disinfecting compositions and use thereof |
GB2021947A (en) * | 1978-05-26 | 1979-12-12 | Dhp Corp | Hypochlorite-Containing Antiseptic and Disinfectant |
EP0030401A1 (en) * | 1979-12-05 | 1981-06-17 | Unilever N.V. | Liquid, thickened chlorine bleaching composition |
US4390448A (en) * | 1981-10-22 | 1983-06-28 | International Flavors & Fragrances Inc. | Perfumed stable aqueous hypochlorite bleach compositions containing 2-methyl-2-octanol and thickened variation thereof |
FR2572419A1 (en) * | 1984-10-31 | 1986-05-02 | Diversey France | Detergent and disinfecting composition and its use especially in the agricultural and food fields, in particular in that of the cleaning of grape-harvesting machines |
US4898681A (en) * | 1988-08-31 | 1990-02-06 | Burton Charles D | Hypochlorite distinfectant stabilized with calcium chelant |
-
1993
- 1993-06-03 WO PCT/US1993/005091 patent/WO1994028722A1/en not_active Application Discontinuation
- 1993-06-03 AU AU45246/93A patent/AU4524693A/en not_active Abandoned
- 1993-06-03 CA CA002164308A patent/CA2164308C/en not_active Expired - Fee Related
- 1993-06-03 EP EP93915151A patent/EP0701400A1/en not_active Withdrawn
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1937229A (en) * | 1929-12-24 | 1933-11-28 | Kantorowicz Hermann | Process of cleaning and disinfecting metallic articles |
CH200962A (en) * | 1936-10-10 | 1938-11-15 | Ig Farbenindustrie Ag | Liquid detergent with disinfecting properties and process for its manufacture. |
US4167561A (en) * | 1973-12-28 | 1979-09-11 | Lever Brothers Company | Hypochlorite disinfecting compositions and use thereof |
GB2021947A (en) * | 1978-05-26 | 1979-12-12 | Dhp Corp | Hypochlorite-Containing Antiseptic and Disinfectant |
EP0030401A1 (en) * | 1979-12-05 | 1981-06-17 | Unilever N.V. | Liquid, thickened chlorine bleaching composition |
US4390448A (en) * | 1981-10-22 | 1983-06-28 | International Flavors & Fragrances Inc. | Perfumed stable aqueous hypochlorite bleach compositions containing 2-methyl-2-octanol and thickened variation thereof |
FR2572419A1 (en) * | 1984-10-31 | 1986-05-02 | Diversey France | Detergent and disinfecting composition and its use especially in the agricultural and food fields, in particular in that of the cleaning of grape-harvesting machines |
US4898681A (en) * | 1988-08-31 | 1990-02-06 | Burton Charles D | Hypochlorite distinfectant stabilized with calcium chelant |
Non-Patent Citations (1)
Title |
---|
CHEMISCHES ZENTRALBLATT, vol. 113, no. 21, 25 November 1942 (1942-11-25), BERLIN,DE;, pages 2441 * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997019597A1 (en) * | 1995-11-29 | 1997-06-05 | Marco Rotondi | A composition for odontostomatological use in cleaning and disinfecting the root canals and viable dentine |
US5976509A (en) * | 1995-11-29 | 1999-11-02 | Abbondi; Thomas | Composition for odontostomatological use in cleaning and disinfecting the root canals and viable dentine |
WO2014036659A1 (en) | 2012-09-07 | 2014-03-13 | Martin Marcus E | Disinfectant formulation comprising calcium hydroxide and sodium hypochlorite |
EP2892348A4 (en) * | 2012-09-07 | 2016-05-11 | Marcus E Martin | Disinfectant formulation comprising calcium hydroxide and sodium hypochlorite |
US10492496B2 (en) | 2012-09-07 | 2019-12-03 | Biosenta, Inc. | Disinfectant formulation comprising calcium hydroxide and sodium hypochlorite |
WO2019133844A1 (en) * | 2017-12-29 | 2019-07-04 | Cms Technology, Inc. | Systems and methods for high-ph treatment of foodstuffs and other substrates |
Also Published As
Publication number | Publication date |
---|---|
AU4524693A (en) | 1995-01-03 |
EP0701400A1 (en) | 1996-03-20 |
CA2164308A1 (en) | 1994-12-22 |
CA2164308C (en) | 2004-01-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6207201B1 (en) | Sodium hypochlorite based disinfectant and sterilizer for medical-surgical instruments | |
US5827542A (en) | Quick acting chemical sterilant | |
US5840343A (en) | Room temperature sterilant for medical devices | |
EP0785719B1 (en) | Cold sterilant solution | |
IE59186B1 (en) | Sterilant compositions | |
CN104206413B (en) | A kind of thimerosal for haemodialysis control unit cleaning and sterilizing and preparation method thereof | |
JP3370571B2 (en) | Disinfectant cleaning agents for medical equipment and disinfecting cleaning methods | |
US6007772A (en) | Cold sterilant solution | |
ES2057163T3 (en) | PROCEDURE TO CLEAN AND / OR DISINFECT AND STERILIZE HEMODIALYSIS DEVICES. | |
JP2006206535A (en) | Washing disinfectant for medical equipment | |
WO2009098873A1 (en) | Sterilized water, and method and device for producing the water | |
CA2164308C (en) | Sodium hypochlorite based disinfectant and sterilizer for medical-surgical instruments | |
US6331514B1 (en) | Sterilizing and disinfecting compound | |
EP1027827A1 (en) | Disinfectant composition | |
US6441045B1 (en) | Disinfectant composition | |
US20070286907A1 (en) | Germicide composition | |
JPH04135559A (en) | Disinfecting detergent for medical treating equipment for artificial dialysis or the like | |
KR20020096999A (en) | A disinfectant composition and method for disinfecting and/or sterilising a dental unit | |
EP1091647A1 (en) | Stabilized disinfectant preparation containing peroxides | |
JP2003073208A (en) | Bactericidal agent | |
US20030004216A1 (en) | Disinfectant composition | |
BRPI0803914A2 (en) | composition for microbial inactivation in surgical instruments |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AT AU BB BG BR CA CH CZ DE DK ES FI GB HU JP KP KR KZ LK LU MG MN MW NL NO NZ PL PT RO RU SD SE SK UA US VN |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2164308 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1993915151 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 1993915151 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 08765047 Country of ref document: US |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 1993915151 Country of ref document: EP |