WO1994027569A1 - Procede de traitement cutane au moyen d'une composition et d'un tampon - Google Patents

Procede de traitement cutane au moyen d'une composition et d'un tampon Download PDF

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Publication number
WO1994027569A1
WO1994027569A1 PCT/US1994/006443 US9406443W WO9427569A1 WO 1994027569 A1 WO1994027569 A1 WO 1994027569A1 US 9406443 W US9406443 W US 9406443W WO 9427569 A1 WO9427569 A1 WO 9427569A1
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WO
WIPO (PCT)
Prior art keywords
skin
peeling
composition
exfoliating
treated
Prior art date
Application number
PCT/US1994/006443
Other languages
English (en)
Inventor
Burt Shaffer
Jeffrey Rapaport
Original Assignee
Dermatology Home Products, Inc.
Pharmagen, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/070,559 external-priority patent/US5505948A/en
Application filed by Dermatology Home Products, Inc., Pharmagen, Inc. filed Critical Dermatology Home Products, Inc.
Priority to AU70568/94A priority Critical patent/AU7056894A/en
Priority to EP94919412A priority patent/EP0703775A4/fr
Priority to CA002164229A priority patent/CA2164229C/fr
Publication of WO1994027569A1 publication Critical patent/WO1994027569A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/005—Preparations for sensitive skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0208—Tissues; Wipes; Patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q9/00—Preparations for removing hair or for aiding hair removal
    • A61Q9/04—Depilatories
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants

Definitions

  • the present invention relates to topical compositions for producing healthy, youthful, attractive, natural looking human skin, and for addressing certain problem skin conditions, including aging skin, dry skin, photo aged skin, i.e., sun damaged skin, hyperpigmentation [brown and black blotches] or darkly pigmented skin [e.g. natural skin pigmentation of black persons] , acne, eczema, thin skin, which occurs commonly in Caucasian women between the ages of 25 and 40, where skin thickness is reduced, sensitive skin and composite dry-oily skin also known as T-zone oily skin.
  • the epidermal, or outer layers of human skin can be caused to peel by applying alpha hydroxy acid ("AHA") containing preparations, such as glycolic acid, in order to remove dead skin and to wound underlying living skin tissue.
  • AHA alpha hydroxy acid
  • the beneficial result of such skin peeling is that when underlying layers of skin are exposed, the underlying skin is relatively free of age lines, superficial wrinkles, acne scarring, scaliness, pigment spots, aging spots, acne lesions, and, with an appropriate topical composition, without the same relative degree of hyperpigmentation as compared to the same skin before a topical peeling composition was applied.
  • the present invention also uses AHAs, and preferably and particularly the AHA glycolic acid, as an agent to loosen the bonds between dead skin cells and underlying living tissue and stimulate the living skin tissue to form new collagen and to metabolically remove and reorganize dead cells and detritus.
  • AHAs and preferably and particularly the AHA glycolic acid, as an agent to loosen the bonds between dead skin cells and underlying living tissue and stimulate the living skin tissue to form new collagen and to metabolically remove and reorganize dead cells and detritus.
  • Exfoliation of the skin is a more gentle skin treatment process than chemical peeling, since exfoliation, unlike peeling, removes only dead skin cells from the skin surface and does not wound living cells. Peeling, in contrast, wounds living skin cells and stimulates both healing and the production of collagen and other cellular materials.
  • compositions have been described in use with salicylic acid and alcohol, as noted in U.S. patent no. 4,891,228 of Tha an.
  • alpha hydroxy acids such as glycolic acid are much better at treating skin conditions, because of their activity in relation to the removal of dead skin layers and moisturizing and treating live skin.
  • glycolic acid is the preferred alpha hydroxy acid because it penetrates the dermal layers better by virtue of its relatively smaller molecular size than other alpha hydroxy acids having larger molecular sizes, such as lactic acid.
  • glycolic acid acts at peeling and/or exfoliating skin when used synergistically in combination with relatively low concentrations of acetone.
  • U.S patent 5,133,967 to Smith for a skin toning composition which proposes the use of glycol ether instead of acetone and alcohol to degrease and de-fat the skin.
  • U.S. patent 5,154,174 describes the use of acetone as a skin drying agent in preparation for attachment of transdermal electrodes to the skin.
  • Chemical peeling can be done in varying degrees of depth, typically called light, or superficial, and medium and deep peels.
  • a light peel is generally one which is comparatively superficial in effect and a deep chemical peel is one in which peeling agents are used to produce a moderate to severe wound to the skin.
  • a deep peel achieves a much more profound effect, and does so quickly, in minutes or hours. As a result, pain and inflammation usually result.
  • Deep peeling usually produces redness lasting several days, a large and deep separation of dead skin, and the exposure of what, before the deep peel, was relatively deep living skin tissue.
  • the results of deep peeling are not equivalent to the results of light or superficial peels or exfoliation. Whereas deep peeling potentially produces undesirable redness, itching, pain, inflammation and unwanted or excessive peeling of living tissue which may last days after the deep peel treatment, light peels produce few or no such undesirable side effects.
  • the cosmetic results of deep peeling are more dramatic and more visible than the results available with light and medium peeling and exfoliation.
  • prior art peeling is accomplished by the application of high-concentration peeling agents either in a single treatment session, or, at most, over a period of repetitive treatments over several days or weeks in a professional setting, i.e., the office of a dermatologist, an aesthetician or a cosmetologist.
  • skin to be peeled has been first degreased in the prior art.
  • the peeling agents After the skin is prepared by degreasing, the peeling agents have been applied in the prior art. The peeling agents are then neutralized and/or removed after a non-standardized duration. Finally, affected skin has been topically treated with a moisturizer or other after-care preparation.
  • the results are not as beneficial as in the present invention, where alpha hydroxy acids are used.
  • the AHA's of the present invention serve not only as agents for skin peeling and/or exfoliating, but also as skin moisturizers, by virtue of their hu ectant qualities.
  • the prior art does not provide for standardization of peeling or exfoliation. For example, a professional practitioner, i.e., a dermatologist, aesthetician or cosmetologist applies skin peeling agents which the practitioner has purchased containing individual ingredients such as glycolic acid. Prior art practitioners have used a variety of application methods, with no standardized quantity of agents being applied.
  • the present invention provides a method of treatment for skin conditions, including an abrasive and absorbent applicator pad, preferably in a kit for at home use, for delivery of a composition for effective skin peeling and exfoliation as well as moisturization which is applied in concentrations of the active skin peeling ingredients far lower than that routinely used in dermatologists' offices.
  • an abrasive and absorbent applicator pad preferably in a kit for at home use, for delivery of a composition for effective skin peeling and exfoliation as well as moisturization which is applied in concentrations of the active skin peeling ingredients far lower than that routinely used in dermatologists' offices.
  • the use of the composition preferably applied with an applicator pad, provides a light at-home chemical skin peel.
  • the composition of the present invention preferably as delivered by the pad, provides an effective composition and method in that the controlled concentration of at lea ⁇ t one peeling agent permits the peeling agent to be left on the skin of the user for a relatively extensive duration.
  • peeling agents of the various embodiments of the present invention may be treatment compositions containing a single alpha hydroxy acid (AHA) or a combination of the AHAs as set forth in detail hereinafter.
  • AHA alpha hydroxy acid
  • the efficacy of the present invention substantially avoids irritating or wounding the skin in a manner perceptible to the user is a further novel advantage. Because the peeling/exfoliation treatment composition of the present invention is thus effective without skin irritation or wounding which is perceptible, the composition of the present invention may be, and is intended to be left upon the skin of the user without the neutralization or removal required in the prior art. Thus, the present invention is designed to be used at least once daily over a period of weeks to produce the same or a superior result compared to light or superficial chemical peels alone.
  • the alternate embodiment of the present invention is better than a cream containing AHAs and/or glycolic acid because the acetone in the alternate embodiment of the present invention acts as a further peeling agent in its own right and further acts as an aggressive solvent to strip the skin of oil and grease and thus allows the exfoliating agents to penetrate deeper.
  • An exfoliating agent in a cream base treatment composition which fails to employ acetone cannot penetrate as deeply and thus cannot achieve the superior results of the present invention.
  • the alternate acetone component of the present invention the exfoliating agents penetrate deeper and are more effective in exfoliating the skin.
  • the key novel aspects is the present invention's ability to deliver
  • the applicator pad which is presaturated with the AHA material, leaves the low- concentration AHA material on the skin while removing unwanted debris, dirt and oil.
  • the clearing of debris, dirt and oil and simultaneous AHA topical application allows far greater AHA efficacy than if the AHAs were applied to dirty, unprepared skin.
  • the pad enables greater AHA efficacy than if the skin had been simply cleansed prior to the application of the AHAs.
  • the pads themselves are commercially available flexible, absorbant, sponge-like cosmetic applicator pads which allow the presaturated AHAs to be expressed onto the skin with mild manual pressure and which also provide abrasion when drawn acros ⁇ the skin with mild to moderate manual pressure.
  • Mildly abrasive cosmetic applicator pads are commercially available under the name SONTARA pads, described as a non-woven/spun laced pad comprised of rayon and polyester from KLEEN TEST PRODUCTS, P.O. Box 574 Milwaukee, WI.
  • Moderately abrasive cosmetic applicator pads also available from KLEEN TEST PRODUCTS are described as NOVO pads.
  • Mildly abrasive and absorbant pads e.g., SONTARA pads
  • AHA preparations which have a relatively low-viscosity liquid or liquid-like pharmaceutical vehicle.
  • the moderately abrasive NOVO pads can be used with the same relatively low-viscosity liquid or liquid-like pharmaceutical vehicle, but the NOVO pads can also be used with AHA preparations with higher viscosities, such as lotions, creams and lipid-based pharmaceutical vehicles.
  • Strongly abrasive pads such as the BUFF PUFF pad can also be presaturated with AHAs in a pharmaceutical vehicle, but strongly abrasive applicators are not preferred in the present invention.
  • the above-mentioned cosmetic applicator pads may also be manufactured in a two-sided embodiment. One side has relatively greater abrasiveness and the remaining side is less abrasive. The more abrasive side of the pad is used to debride the skin, loosening and removing dead skin cells and debris, while at the same time depo ⁇ iting a material with which the pad has been pre ⁇ aturated. Such material is typically, but not necessarily, the peeling and/or exfoliating agent of the present invention.
  • the pad, presaturated with an alternate material could be used to apply a cleanser or a skin degreasing composition.
  • the two-sided pad's less abrasive side is used to absorb dirt, skin oil and debris from the skin to be treated.
  • the user first applies the more abrasive side of the two-sided pad by gently wiping the skin to be treated with mild manual pressure using several wiping strokes while carefully avoiding harsh irritating pressure.
  • the user When debriding is complete, after several gentle wiping strokes, the user would then apply the less abrasive side of the same pad in an additional series of gentle wiping strokes.
  • the less abrasive side of the pad would absorb dirt, oil and debris from the skin to be treated which were debrided and loosened by wiping with the pad's more abrasive side.
  • the foregoing dual series of wiping strokes serves the additional function of depositing upon the skin to be treated the material with which the pad was presaturated.
  • such material is the peeling and/or exfoliating agent of the present invention, or the degreaser composition, as more fully set forth elsewhere herein.
  • Prior art professional skin peeling not done in the home has generally comprised the following sequence of steps (1) cleansing the skin; (2) application of an degreaser; (3) application of active skin peeling materials; and (4) neutralizing or removal of the active skin peeling materials.
  • the present invention may utilize at least one of the four steps, but with novel and very significant modifications.
  • An alternate modification may occur in step
  • the aforementioned conventional four steps may be accomplished in a novel manner.
  • This alternate embodiment of the present invention provides that the treatment steps be performed by applying the given material by means of a cosmetic applicator pad pre-saturated with the given material for the respective steps 1-3, the pad further being selected to provide a desired level of abrasive efficiency.
  • applicator pads of special materials and construction to apply particular skin exfoliating preparations, such as salicylic acid
  • the prior art does not teach the use of cosmetic applicator pads with specific abrasive capabilities, as does the present invention.
  • applicator pads with varying degrees of abrasive efficiency are selectively provided in order to further control and vary the depth of penetration of the degreasing, exfoliating and/or moisturizing agents.
  • a given pad abrasion level may be selected from the categories of mild and moderate abrasiveness according to the present invention. Variation in applicator pad abrasiveness is achieved by selecting suitable materials for pad construction, such as cotton, nylon, polyester, styrene and the like, singly or in combination.
  • the pad may have an applicator surface which is of fibrous consistency or otherwise suitably textured with a blend of semi-rigid and soft materials for producing an abrasive effect for scraping, removing and degreasing action.
  • the penetration depth and effectiveness of the degreasing, exfoliating and/or moisturizing agents are affected by pad abrasiveness because a given level of pad abrasive capability results in mechanical exfoliation of dead skin, thus exposing underlying living skin tis ⁇ ue more effectively.
  • the alternative ⁇ kin degreaser such as a ⁇ acetone, i ⁇ allowed to work more effectively, providing a corre ⁇ ponding level of skin degreasing efficiency when the ⁇ kin i ⁇ wiped with the pad during the degreasing steps of treatment.
  • Pad abrasive efficiency thus controls the amount of natural oil and grease left upon skin which has been prepared for topical application of the degreasing, exfoliating and/or moisturizing agent.
  • the user of a pre-saturated cosmetic applicator pad for a process of at least once per day applications gains the convenience of being apply to accurately apply a quantity of each respective materials in the 3 steps. Thus predictable and desirable results are provided by the present invention, in contrast to the prior art.
  • the exfoliating agent is: (a) applied to the skin; (b) allowed to effect its exfoliating activity; and
  • An additional novel feature of the present invention is that the exfoliating and/or degreasing or moisturizing agents, once applied by the user, and left upon the skin for at least several hour ⁇ . It is not neutralized, nor is it removed, because it is a moisturizer.
  • the present invention can be left on the skin due its low concentration of gentle exfoliating and/or moisturizing or degreasing agents.
  • the present invention is intended to be used, preferably at night before retiring, so that the exfoliating and/or moisturizing or degreasing agents would be left in contact with the user's skin until, typically, washed off by normal bathing the next morning.
  • the present invention can also be applied in the morning, and left on the ⁇ kin all day.
  • the prior art has taught away from thi ⁇ critical novel feature of the pre ⁇ ent invention.
  • the degrea ⁇ er composition of the present invention, as elsewhere set forth, is typically a mixture of alcohol, acetone and water. The concentrations of the degreaser components in the degreaser compo ⁇ ition can thu ⁇ be varied to produce a de ⁇ ired rate of skin degreasing, exfoliating and moisturizing.
  • the present invention provides an applicator pad for treating skin conditions, such as aging skin, acne, hyperpigmentation, sensitive skin, and composite dry-oily skin.
  • Applicator pads for the respective degreasing and/or peeling step ⁇ are re ⁇ pectively ⁇ aturated with a quantity of degrea ⁇ ing, and exfoliating and/or moisturizing agents.
  • the skin is degreased by the user by applying a degreaser with an applicator pad presaturated with the degreasing material.
  • the degreasing material according to the present invention is ⁇ et forth more particularly in table 3 below.
  • the degreaser contains acetone in an aqueous base, which may also contain alcohol.
  • the only neces ⁇ ary component ⁇ of the peeling/exfoliating agent of the pre ⁇ ent invention are AHAs, or mixture thereof, of which the AHA is preferably glycolic acid, and alternatively acetone as a degreaser, exfoliant and moisturizer.
  • the alpha hydroxy acids most effective for use in the present invention are glycolic acid, which is the preferred AHA, and lactic and pyruvic acids.
  • the ⁇ e AHA ⁇ are not equivalent to each other, since glycolic acid is gentler and more effective than either lactic or pyruvic acids.
  • the addition of a small amount of salicylic acid may also be useful. Lactic acid and pyruvic acid are harsher peeling and exfoliating agents than is glycolic acid.
  • lactic and pyruvic acid ⁇ in a further alternative admixture with glycolic acid in ⁇ ome embodiment ⁇ i ⁇ a feature of the present invention, since the inclusion of lactic and/or pyruvic acids can accelerate the peeling/exfoliating action of the pre ⁇ ent invention.
  • Other embodiments of the present invention as set forth above, provide a AHA selected from the group con ⁇ i ⁇ ting of glycolic, lactic and pyruvic acids and mixtures thereof.
  • Such controlled and precise peeling/exfoliating efficacy i ⁇ an important novel feature of the pre ⁇ ent invention, since variations of the present invention will permit the user to select a peeling composition which has a particular combination of speed of peeling and harshne ⁇ . It i ⁇ to be noted that while it i ⁇ an object of the pre ⁇ ent invention to provide a peel for at home use which is both gradual and gentle, it is also necessary and important to vary and to control the speed with which the present invention achieves its results. Not only can ⁇ peed and efficacy be controlled as described, but speed and efficacy can also be controlled by varying the frequency of user application.
  • the present invention provides low- concentrations of AHAs and alternate ingredients, such as acetone and ⁇ alicylic acid in a co ⁇ metic applicator pad.
  • AHA ⁇ are provided in a ⁇ uitable pharmaceutical vehicle, which typically may be a composition according to the tables pre ⁇ ented below. It will be understood that a suitable pharmaceutical vehicle is merely suggested by the non-AHA ingredients, and that other suitable pharmaceutical vehicles which contain AHAs may also be used.
  • the inert, or inactive ingredients i.e., the ingredients not set forth above as being active agents of the present invention repre ⁇ ent the composition of a preferred pharmaceutical vehicle for the AHAs of the pre ⁇ ent invention.
  • the present invention provides low- concentrations of AHA ⁇ in a co ⁇ metic applicator pad.
  • the AHA ⁇ are provided in a ⁇ uitable pharmaceutical vehicle, which typically may be a compo ⁇ ition according to the table ⁇ presented below. It will be understood that a suitable pharmaceutical vehicle is merely suggested by the non-AHA ingredients, and that other suitable pharmaceutical vehicles which contain AHAs may also be u ⁇ ed.
  • the inert, or inactive ingredients i.e., the ingredients not set forth above as being active agent ⁇ of the pre ⁇ ent invention repre ⁇ ent the compo ⁇ ition of a preferred pharmaceutical vehicle for the AHAs of the present invention.
  • the alternative acetone degrea ⁇ er compo ⁇ ition is separately provided in a presaturated cosmetic applicator pad to be used prior to and separately from the cosmetic applicator pad saturated with the gentle peeling and/or exfoliating composition of the present invention.
  • Non-AHA Material ⁇ Comprising An Exemplary Preferred
  • Tables 5-8 below show specific exemplary embodiments of the present invention. Tables 5-8 are based upon Table 1, varying only in that specific AHA ⁇ are shown and are not intended to limit the scope of the present invention. Furthermore, preferred concentration ranges are shown in Table 2 above, and these preferred concentrations apply to Tables 5-8 below. Table 5 Composition Showing Glycolic Acid as the AHA of the Present Invention With Non-AHA Materials Comprising An Exemplary Preferred Pharmaceutical Vehicle
  • Polysorbate-20 0.0 10% Mixed glycolic and An effective amount 20% lactic and pyruvic acids
  • the concentrations of the acetone, alcohol and acetone may be varied, since the acetone is an aggressive solvent for removing residual oils on the skin and also acts as a peeling agent in its own right.
  • a gentler degreasing effect is achieved.
  • the peeling effect of the acetone present in the degreaser will correspondingly be controlled and reduced a ⁇ the acetone concentration i ⁇ reduced.
  • U ⁇ e of the present invention is accomplished by wiping with mild manual pressure a cosmetic applicator pad presaturated with at least one AHA compo ⁇ ition over the ⁇ kin to be treated.
  • the applicator pad debrides the skin of dead skin, dead skin cell debri ⁇ , dirt, and oil, all of which are removed by and remain upon the pad.
  • a ⁇ the pad i ⁇ wiped across the skin to be treated the mild manual pressure expresses the AHA composition and deposits the same topically upon the skin. Because the skin has been debrided and prepared by removal of debris dirt and oil, the AHAs are permitted access to penetrate the skin and thus to accomplish their peeling and/or exfoliating activity.
  • the next step is the application to the skin of exfoliating and/or peeling material according to the present invention.
  • the peeling agent i ⁇ applied with an applicator pad pre ⁇ aturated therewith applied to the skin to be treated.
  • the applicator pad is provided with a preselected level of abrasiveness selected from the group consisting of mild abrasivene ⁇ , moderate abra ⁇ ivene ⁇ and strong abrasivene ⁇ .
  • the user exercises care in the application of moderate manual pres ⁇ ure to the applicator pad a ⁇ it pa ⁇ e ⁇ over the ⁇ kin to be treated ⁇ o a ⁇ to provide a mild and/or moderate abrading of ⁇ aid ⁇ kin.
  • the preferred embodiment of the composition of the present invention is presented in Table 9 below.
  • Table 10 sets forth preferable concentrations.
  • the preferred embodiment comprises the AHA glycolic acid combined with acetone and inert ingredients.
  • the inert or inactive ingredients provide a suitable pharmaceutical ba ⁇ e for the peeling agents, but do not provide a skin peeling or exfoliating action.
  • the inert ingredients may be substituted with equivalent materials for producing a suitable pharmaceutical base.
  • compositions may be also defined as in the alternate range shown in Table 9 below, or as in an alternate preferred composition as in Table 10 below.
  • Table 9 Alternate Composition for Exfoliating and Moisturizing Agent ⁇ of the Pre ⁇ ent Invention Material ⁇ are li ⁇ ted by Weight Percentage ⁇ Material From About To About
  • kits assemblies for treating the respective skin conditions set forth above.
  • Each respective kit as ⁇ embly includes an effective and convenient in ⁇ tructional means, such as an instructional pamphlet or a videotape or other instructional means containing thereon indicia for administration of sequentially applied components according
  • a step-2 container including a ⁇ upply of applicator pad ⁇ saturated with a premea ⁇ ured quantity of degrea ⁇ er.
  • a step-3 container including a ⁇ upply of applicator pads saturated with a premeasured quantity of peeling/exfoliating exfoliating agent.
  • a step-4 container such as a tube or bottle containing a post-treatment moi ⁇ turizing and anti- inflammatory material.
  • a ⁇ tep-5 container ⁇ uch a ⁇ a tube or bottle containing a moisturizing sun screen material.
  • a suitable step 6 container such as a tube or bottle with a required material, as detailed below.
  • kits as ⁇ embly are used for both applying and removing the agents in a non-professional setting according to the aforementioned step ⁇ , which are performed at selected periodic intervals, e.g., once daily by the user as directed by the in ⁇ truction ⁇ for the particular kit for the particular respective skin condition for the particular respective number of days of that kit's embodiment [e.g., 7-day therapy phase treatment kit for aging skin] .
  • the step-wise procedure employed by the user is generally described in further detail as follows: a.
  • step 1 cleansing the ⁇ kin to be treated with a non-soaping non-detergent cleanser lotion applied with an applicator pad having a preselected level of abrasiveness, said pad being wiped across the ⁇ kin to be treated with mild manual pressure;
  • step 2 applying a suitable degreasing agent to degrease the skin to be treated, the degreasing agent being applied with an applicator pad having a preselected level of abrasivene ⁇ and the pad being presaturated with a measured quantity of degreasing agent in the manner set forth in step "a"; c.
  • step 3 applying to the skin to be treated a composition of mild skin peeling agents of a composition el ⁇ ewhere de ⁇ cribed herein, with an applicator pad presaturated with a measured quantity of said skin peeling agents in the manner set forth in step "a", the user exercising care in the application of moderate manual pres ⁇ ure to the applicator pad as it pas ⁇ es over the skin to be treated so as to provide a mild abrading of said skin; and d. step 4 - applying a suitable moisturizing anti- inflammatory cream to the skin to be treated. e. step 5 - applying a ⁇ pecial sun ⁇ creen.
  • the pre ⁇ ent invention provides three types of moisturizing sun screen ⁇ .
  • Type 1 - employ ⁇ a hydro-alcoholic gel for acne patients, because this is a drying-type sun screen.
  • Type 2 - employs a rich moisturizing sun screen for the photo aging skin and aging skin.
  • Type 3 - employs a bleaching agent - hydroquinone - for hyperpigmented and darkly pigmented skin.
  • Skin bleaching is separately provided by the present invention as a ⁇ eparate step for the pigmented skin, i.e., hyperpigmented skin and darkly pigmented skin.
  • Bleaching would be done by applying a hydroquinone bleach-containing material in the evening.
  • the hydroquinone bleach as described in more detail below, is applied after the peeling agent ha ⁇ been applied and before the moi ⁇ turizer is applied.
  • the peeling/exfoliating exfoliating agent, the hydroquinone bleach, and the moi ⁇ turizer are all left on the ⁇ kin to be treated all night long.
  • the present invention provides two type ⁇ of anti- inflammatory moisturizer materials. Both have hydrocortisone in them.
  • Type 1 - anhydrous preparation employed for aging skin.
  • Type 2 - hydrous preparation used for all other skin type ⁇
  • the skin peeling/exfoliating exfoliating agents provided in step 3 of the present invention include low concentrations of, preferably, acetone, glycolic acid, ⁇ alicylic acid, and lactic acid according to the Table ⁇ set forth below.
  • a low- concentration quantity of resorcinol is provided as a peeling/exfoliating exfoliating agent in combination with the aforementioned preferable peeling agent ⁇ .
  • the preferred embodiment of the composition of the peeling/exfoliating exfoliating agent of the present invention is presented in Table 1 below, and the alternate embodiment composition containing resorcinol is presented in Table 2 below.
  • Tables 1.1 and 2.1 respectively, set forth ranges and preferable concentrations for the therapeutic phase of the present invention, namely the 15-2-2 peeling/exfoliating exfoliating compo ⁇ ition.
  • 15-2-2 refers to preferably 15% glycolic acid, 2% lactic acid and 2% ⁇ alicylic acid.
  • the Maintenance phase preferably utilizes 5-2-2, i.e., one- third the concentrations of the aforementioned peeling/exfoliating exfoliating agents.
  • the composition ⁇ and concentration ⁇ of the maintenance phase peeling/exfoliating exfoliating agents are not here set forth because they are the same as those set forth in
  • Material ⁇ are listed by Weight Percentages Material Preferably About Witch Hazel 2.5% Propylene Glycol 3.0% Camphor 0.1% Acetone 5.0%
  • step 1 clean ⁇ er i ⁇ li ⁇ ted a ⁇ provided in ⁇ aturated pad ⁇ in a 2 ounce quantity.
  • step 1 clean ⁇ er i ⁇ li ⁇ ted a ⁇ provided in ⁇ aturated pad ⁇ in a 2 ounce quantity.
  • all other li ⁇ ted component quantities are similarly divided evenly into subquantities for pad saturation for the relevant number of days.
  • the sixth ⁇ tep being application of a sun screen in the morning and the fifth step being application of a moisturizer and anti-inflammatory combination in the evening.
  • the active anti-inflammatory ingredient of the present invention is hydrocortisone.
  • the individual treatments of the respective skin conditions in some cases require more than four steps.
  • the individual skin conditions are treated generally as follows.
  • Cleansing twice daily is accomplished with a soap- free cleansing lotion designed to cleanse efficiently without exces ⁇ ive drying or irritation of the skin.
  • a cleanser such as DEA lauryl sulfate in an emollient ba ⁇ e and i ⁇ used twice per day.
  • the degreaser is applied to deep clean the skin and remove exces ⁇ ⁇ ebum, which may reduce the effectivene ⁇ s of the treatment pads.
  • the degreaser is a hydro-alcoholic solution containing acetone in the concentration range of 0.1% to 10% but preferably 5% .
  • 3 15-2-2 Treatment Pads contain the peeling/ exfoliating agent combination glycolic acid [preferably 15%, but over the possible range of 1-20%], salicylic acid [preferably 2%, but over the pos ⁇ ible range of 0.1% to 5%], and lactic acid [preferable 2%, but over a possible range of 0.1% to 20%].
  • the 15-2-2 combination works synergistically with acetone as a peeling agent [preferably 5% but over the possible range of 0.1% to 10%].
  • the peeling/exfoliating agent combination i ⁇ provided in a penetrating hydro-alcoholic vehicle containing acetone as a co-solvent to insure proper delivery of the peeling/ exfoliating agent to the skin area to be treated. See Tables 1 and 2 for co position ⁇ and concentration ranges.
  • the hydrocortisone balm for night-time use only is applied, containing the well-known anti-inflammatory and anti- pruritic drug hydrocortisone in the concentration range 0.1% to 2.5%, preferably 1%, in an anhydrous base.
  • a moisturizing sun screen i ⁇ provided for morning application and day-time use to replenish moisture to the skin and maintain the moisture balance of the skin.
  • the moisturizing sun screen is further provided with broad spectrum UV screens [i.e., screens for UVA and UVB] for protection from sunlight after therapy.
  • the moisturizing sun screen contains octyl methoxycinnamate in the concentration range of 1.5% - 7.5%, preferably 7.5% and benzophenone-3 in the range from 0.1% to 6%, preferably 4%.
  • Cleansing twice daily is accomplished with a ⁇ oap- free clean ⁇ ing lotion de ⁇ igned to cleanse efficiently without excessive drying or irritation of the skin.
  • a clean ⁇ er such as DEA lauryl sulfate in an emollient ba ⁇ e and is used twice per day.
  • the degreaser i ⁇ applied twice daily to deep clean the skin and remove excess sebum, which may reduce the effectivenes ⁇ of the treatment pads.
  • the degreaser is a hydro-alcoholic solution containing acetone in the concentration range of 0.1% to 10% but preferably 5% .
  • Gentle twice daily peeling/exfoliation is accomplished by the use of the 5-2-2 treatment pad during the maintenance phase.
  • the 5-2-2 pad contains glycolic acid [preferably 5%, but over a possible range of 1-20%], salicylic acid [preferably 2%, but over a possible range of 0.1% to 5%], and lactic acid [preferably 2%, but over a pos ⁇ ible range of 0.1% to 20%].
  • the peeling/ exfoliating agent combination i ⁇ carried in a penetrating hydro- alcoholic vehicle containing acetone in the concentration range of 0.1% to 10% but preferably 5% as a co-solvent to insure proper delivery of the peeling/ exfoliating agent to the skin area to be treated. See Tables 1 and 2 for composition ⁇ and concentration range ⁇ .
  • the hydrocortisone balm is applied at night time, containing the well-known anti-inflammatory and anti-pruritic drug hydrocortisone in the concentration range 0.1% to 2.5% , preferably 1% in a hydrous base.
  • a moisturizing sun screen i ⁇ provided for morning application and day-time u ⁇ e to repleni ⁇ h moi ⁇ ture to the skin and maintain the moisture balance of the skin.
  • the moisturizing sun screen is further provided with broad spectrum UV screens [i.e., screens for UVA and UVB] for protection from sunlight after therapy.
  • the moisturizing sun screen contains octyl methoxycinnamate in the concentration range of 1.5% - 7.5%, preferably 7.5% and benzophenone-3 in the range from 0.1% to 6%, preferably 4%.
  • Sen ⁇ itive Skin - Therapy Pha ⁇ e For sensitive skin, the therapy phase is comprised of the following steps:
  • a cleanser such as DEA lauryl sulfate in an emollient base and is used twice per day.
  • the skin is degreased gently, without exce ⁇ sive abrasion or further u ⁇ e of detergents or solvent ⁇ .
  • the skin further cleansed using ultra pure rehydrated aloe vera juice and a blend of sodium PCA and other humectant ⁇ , ⁇ uch a ⁇ methyl glyceth-20 in a water-ba ⁇ ed vehicle.
  • 15-2-2 Treatment Pads contain the peeling/exfoliating agent combination glycolic acid [preferably 15%, but over the possible range of 1-20%], salicylic acid [preferably 2%, but over the pos ⁇ ible range of 0.1% to 5%], and lactic acid [preferable 2%, but over a po ⁇ ible range of 0.1% to 20%].
  • the peeling/exfoliating agent combination i ⁇ provided in a penetrating hydro- alcoholic vehicle containing acetone as a co-solvent to insure proper delivery of the peeling/exfoliating agent to the skin area to be treated.
  • the 15-2-2 combination works synergistically with acetone a ⁇ a peeling agent [preferably 5% but over the po ⁇ ible range of 0.1% to 10%]. See Table ⁇ 1 and 2 for compo ⁇ itions and range ⁇ .
  • the penetrating effect refer ⁇ to the ability of the vehicle to cause deep, even di ⁇ per ⁇ ion throughout the skin.
  • a hydro-alcoholic vehicle is one containing both water and alcohol, comprising a two-solvent system. 4.
  • the therapeutic balm which is applied twice daily contains the well-known anti-inflammatory and anti-pruritic drug hydrocortisone in the range of 0.1% to 2.5% in a hydrou ⁇ base.
  • the therapeutic balm serves to promote hydration and reduce inflammation to increase user comfort, as may be needed with frequent treatment of sensitive skin.
  • Moisturization and Ultraviolet light [UV] protection is provided for morning and daytime use on sensitive skin by applying a quick absorbing oil free emulsion which is light in consi ⁇ tency and does not have a heavy or oily base.
  • UVA and UVB protection is provided without the use of oxybenzone, lanolins, glycols, etc.
  • the UV filters are Octyl Methoxycinnamate in the range of 1.5% to 7.5% and Menthyl Anthranilate in the range of 1% to 10% and the oil-free emulsion itself is a water-based emulsion compri ⁇ ed of a water-ba ⁇ ed vehicle and an e ⁇ ter-ba ⁇ ed emollient pha ⁇ e.
  • the Maintenance phase is comprised of the following:
  • Soap-free cleansing twice daily is done during the maintenance phase. Cleansing is accomplished with a soap- free cleansing lotion as in the therapy phase, the cleanser being designed to cleanse efficiently without exces ⁇ ive drying or irritation of the skin.
  • the skin is degreased gently twice daily, without excessive abrasion or further use of detergents or solvents.
  • the skin further cleansed using ultra pure rehydrated aloe vera juice and a blend of sodium PCA and other humectant ⁇ , ⁇ uch a ⁇ methyl glyceth-20 in a water- based vehicle.
  • the 5-2-2 pad contains glycolic acid [preferably 5%, but over a possible range of 1-20%], salicylic acid [preferably 2%, but over a pos ⁇ ible range of 0.1% to 5%], and lactic acid [preferably 2%, but over a possible range of 0.1% to 20%].
  • the peeling/ exfoliating agent combination is carried in a penetrating hydro- alcoholic vehicle containing acetone in the concentration range of 0.1% to 10% as a co-solvent to insure proper delivery of the peeling/ exfoliating agent to the skin area to be treated.
  • the 5-2-2 combination works synergistically with acetone as a peeling agent [preferably 5% but over the possible range of 0.1% to 10%]. See Table ⁇ 1 and 2 for compo ⁇ ition ⁇ and concentration ranges.
  • the therapeutic hydrocortisone balm is applied, containing the well-known anti-inflammatory and anti-pruritic drug hydrocortisone in the concentration range 0.1% to 2.5% but preferably 1%, in a hydrous base.
  • Sun protector is applied in the morning for day time use via quick absorbing, oil-free emulsion for sensitive skin.
  • Broad spectrum [UVA and UVB] protection i ⁇ provided without the u ⁇ e of oxybenzone, lanolins, glycols, etc.
  • the UV filter ⁇ are Octyl Methoxycinnamate in the range of 1.5% to 7.5% and Menthyl Anthranilate in the range of 1% to 10% and the oil-free e ul ⁇ ion it ⁇ elf is a water- based emulsion comprised of a water-based vehicle and an ester-based emollient phase.
  • Cleansing twice daily is accomplished with a soap- free cleansing lotion designed to cleanse efficiently without excessive drying or irritation of the skin.
  • a cleanser such as DEA lauryl sulfate in an emollient ba ⁇ e and i ⁇ u ⁇ ed twice per day.
  • the degrea ⁇ er is applied to deep clean the skin and remove excess sebum, which may reduce the effectiveness of the treatment pads.
  • the degreaser is a hydro-alcoholic solution containing acetone in the concentration range of 0.1% to 10% but preferably 5% .
  • 15-2-2 Treatment Pads contain the peeling/exfoliating agent combination glycolic acid [preferably 15%, but over the pos ⁇ ible range of 1-20%], salicylic acid [preferably 2%, but over the possible range of 0.1% to 5%], and lactic acid [preferable 2%, but over a possible range of 0.1% to 20%].
  • the peeling/exfoliating agent combination is provided in a penetrating hydro- alcoholic vehicle containing acetone as a co-solvent to insure proper delivery of the peeling/exfoliating agent to the skin area to be treated.
  • the 15-2-2 combination works synergistically with acetone as a peeling agent [preferably 5% but over the po ⁇ ible range of 0.1% to 10%]. See Table ⁇ 1 and 2 for compo ⁇ itions and concentration ranges.
  • a hydrocortisone moisturizer therapeutic balm is applied which is used at night time. This material use ⁇ the well-known anti-inflammatory hydrocortisone in a water- based emulsion.
  • a gel containing a topical acne preparation or group of preparations such as benzoyl peroxide is then applied in the morning, but not at night. Appropriate directions are provided in the kit of the present invention. The use of benzoyl peroxide to treat acne is well documented. This gel provides benzoyl peroxide U.S.P. in a non-irritating water based gel.
  • An acne treatment UV screen for morning application and daytime use is provided to reduce the user's UV exposure.
  • the acne UV screen is a non- comedogenic, oil-free preparation containing octyl methoxycinnamate in the concentration range of 1.5% - 7.5% , preferably 7.5%; homosalate 1-10%, preferably 5%; octyl salicylate 1.5-5%, preferably 5%; and benzophenone-3 in the range from 0.1% to 6%, preferably 4% to provide broad spectrum UVA and UVB protection in a hydro-alcoholic base.
  • the user is in ⁇ tructed to u ⁇ e the acne UV screen liberally, i.e., to totally cover the area of therapy with the UV screen.
  • An antiseptic acne cleanser i ⁇ provided which contain ⁇ mild detergent ⁇ to cleanse the skin and remove excess oil. The user is instructed to cleanse the skin at regular periodic intervals, preferably twice per day. 2. Gentle twice daily peeling/exfoliation is accomplished by the use of the 5-2-2 treatment pad during the maintenance phase.
  • the 5-2-2 pad contain ⁇ glycolic acid [preferably 5%, but over a po ⁇ ible range of 1-20%], salicylic acid [preferably 2%, but over a possible range of 0.1. to 5.], and lactic acid [preferably 2%, but over a possible range of 0.1% to 20%].
  • the peeling/exfoliating agent combination is carried in a penetrating hydro- alcoholic vehicle containing acetone in the concentration range of 0.1% to 10% as a co-solvent to insure proper delivery of the peeling/exfoliating agent to the skin area to be treated.
  • the 5-2-2 combination works synergi ⁇ tically with acetone a ⁇ a peeling agent [preferably 5% but over the po ⁇ ible range of 0.1% to 10%]. See Tables 1 and 2 for composition ⁇ and concentration range ⁇ . 3.
  • An acne treatment UV screen for morning application and daytime use is provided to reduce the user's UV exposure.
  • the acne UV ⁇ creen i ⁇ a non- comedogenic, oil-free preparation containing octyl methoxycinnamate in the concentration range of 1.5% - 7.5% , preferably 7.5%; homo ⁇ alate 1-10%, preferably 5%; octyl salicylate 1.5-5%, preferably 5%; and benzophenone-3 in the range from 0.1% to 6%, preferably 4% to provide broad spectrum UVA and UVB protection in a hydro-alcoholic base.
  • the user is instructed to use the acne UV screen liberally, i.e., to totally cover the area of therapy with the UV screen.
  • Cleansing twice daily is provided by the soap-free cleanser during the maintenance phase. Cleansing is accomplished with a soap-free cleansing lotion as in the therapy phase, the cleanser being designed to cleanse efficiently without excessive drying or irritation of the skin.
  • the degreaser is applied to deep clean the skin and remove excess sebum, which may reduce the effectiveness of the treatment pads.
  • the degreaser is a hydro-alcoholic ⁇ olution containing acetone in the concentration range of 0.1% to 10% but preferably 5% .
  • Treatment Pads contain the peeling/ exfoliating agent combination glycolic acid [preferably
  • the peeling/exfoliating agent combination i ⁇ provided in a penetrating hydro-alcoholic vehicle containing acetone as a co-solvent to insure proper delivery of the peeling/exfoliating agent to the skin area to be treated.
  • the 15-2-2 combination works synergistically with acetone as a peeling agent [preferably 5% but over the pos ⁇ ible range of 0.1% to 10%]. See Table ⁇ 1 and 2 for compositions and concentration ranges.
  • Hydroquinone screen cream is provided for application to area ⁇ of hyperpigmentation or generally to darkly pigmented ⁇ kin at a selected interval, between two and four times daily, preferably three times.
  • An alternate embodiment includes a hydro-alcoholic vehicle at night with the hydroquinone screen used in the morning.
  • Thi ⁇ hydroquinone ⁇ creen cream contains hydroquinone in the range of 0.1% to 2%, preferably 2% as a skin bleach in a non-comedogenic water ba ⁇ ed emulsion.
  • hydroquinone screen cream i ⁇ a broad ⁇ pectrum [UVA and UVB] ⁇ unscreen, preferably octylmethoxycinna ate, and preferably about 7.5% and benzophenone-3 , preferably about 1.5%. and emollients and moisturizers .
  • the therapeutic hydrocortisone balm is applied at night time, containing the well-known anti-inflammatory and anti-pruritic drug hydrocortisone in the concentration range 0.1% to 2.5% , preferably 1% in a hydrous base.
  • UV protection is provided for sen ⁇ itive ⁇ kin by applying a quick absorbing oil free emulsion which i ⁇ light in con ⁇ istency and does not have a heavy or oily base.
  • Broad spectrum [UVA and UVB] protection is provided without the use of oxybenzone, lanolins, glycols, etc.
  • the UV filters are Octyl Methoxycinnamate in the range of 1.5% to 7.5% and Menthyl Anthranilate in the range of 1% to 10% and the oil- free emulsion it ⁇ elf i ⁇ a water-ba ⁇ ed emulsion comprised of a water-based vehicle and an ester-based emollient phase.
  • Hyper Pigmented Skin and Darkly Pigmented Skin - Maintenance Phase 1 Cleansing twice daily is provided by the soap-free cleanser during the maintenance phase. Cleansing i ⁇ accomplished with a ⁇ oap-free cleansing lotion as in the therapy phase, the cleanser being designed to cleanse efficiently without excessive drying or irritation of the skin.
  • the degrea ⁇ er i ⁇ applied twice daily to deep clean the ⁇ kin and remove exce ⁇ ⁇ ebum, which may reduce the effectiveness of the treatment pads.
  • the degreaser is a hydro-alcoholic solution containing acetone in the concentration range of 0.1% to 10% but preferably 5% .
  • the 5-2-2 pad contains glycolic acid [preferably 5%, but over a possible range of 1-20%], salicylic acid [preferably 2%, but over a possible range of 0.1% to 5%], and lactic acid [preferably 2%, but over a possible range of 0.1% to 20%].
  • the peeling/exfoliating agent combination is carried in a penetrating hydro- alcoholic vehicle containing acetone in the concentration range of 0.1% to 10% as a co-solvent to insure proper delivery of the peeling/ exfoliating agent to the skin area to be treated.
  • the 5-2-2 combination works synergistically with acetone as a peeling agent [preferably 5% but over the possible range of 0.1% to 10%]. See Tables 1 and 2 for compositions and concentration ranges.
  • Hydroquinone screen cream is provided for application at a ⁇ elected interval, between two and four times daily, preferably three times to pigmented area ⁇ .
  • An alternate embodiment include ⁇ a hydro-alcoholic vehicle at night with the hydroquinone ⁇ creen u ⁇ ed in the morning.
  • Thi ⁇ hydroquinone ⁇ creen cream contain ⁇ hydroquinone in the range of 0.1% to 2%, preferably 2% as a skin bleach in a non-comedogenic water based emulsion.
  • a broad spectrum [UVA and UVB] sunscreen and emollients and moisturizer ⁇ are also provided in the hydroquinone screen cream.
  • Sun protector is applied in the morning for day time use via quick absorbing, oil-free emulsion for sensitive skin.
  • Broad spectrum [UVA and UVB] protection is provided without the use of oxybenzone, lanolin ⁇ , glycols, etc.
  • the UV filters are Octyl Methoxycinnamate in the range of 1.5% to 7.5%, preferably 7.5% and Menthyl Anthranilate in the range of 1% to 10% and the oil-free emulsion it ⁇ elf is a water-based emul ⁇ ion compri ⁇ ed of a water-ba ⁇ ed vehicle and an ester-ba ⁇ ed emollient pha ⁇ e.
  • Cleansing twice daily is provided by the soap-free cleanser during the maintenance pha ⁇ e. Cleansing is accomplished with a soap-free cleansing lotion as in the therapy phase, the clean ⁇ er being de ⁇ igned to cleanse efficiently without exces ⁇ ive drying or irritation of the skin.
  • the degreaser is applied twice daily to deep clean the skin and remove exces ⁇ ⁇ ebum, which may reduce the effectivene ⁇ s of the treatment pad ⁇ .
  • the degrea ⁇ er is applied in the morning only to the areas of T-zone oiliness.
  • the degrea ⁇ er i ⁇ a hydro-alcoholic ⁇ olution containing acetone in the concentration range of 0.1% to 10% but preferably 5% .
  • 15-2-2 Treatment Pad ⁇ contain the peeling/exfoliating agent combination glycolic acid [preferably 15%, but over the possible range of 1-20%], salicylic acid [preferably 2%, but over the possible range of 0.1% to 5%] , and lactic acid [preferable 2%, but over a possible range of 0.1% to 20%].
  • the peeling/exfoliating agent combination is provided in a penetrating hydro- alcoholic vehicle containing acetone as a co-solvent to insure proper delivery of the peeling/exfoliating agent to the skin area to be treated.
  • the 15-2-2 combination works synergistically with acetone as a peeling agent [preferably 5% but over the pos ⁇ ible range of 0.1% to 10%]. See Table ⁇ 1 and 2 for compositions and concentration ranges.
  • the therapeutic hydrocortisone balm is applied, containing the well-known anti-inflammatory and anti-pruritic drug hydrocortisone in the concentration range 0.1% to 2.5%, preferably 1% in a hydrous base.
  • UVA and UVB are Octyl Methoxycinnamate in the range of 1.5% to 7.5% and Menthyl Anthranilate in the range of 1% to 10%.
  • Cleansing twice daily is provided by the ⁇ oap-free clean ⁇ er during the maintenance phase. Cleansing is accomplished with a soap-free cleansing lotion a ⁇ in the therapy pha ⁇ e, the cleanser being designed to clean ⁇ e efficiently without excessive drying or irritation of the skin.
  • the degreaser is applied twice daily to deep clean the skin and remove excess sebum, which may reduce the effectivenes ⁇ of the treatment pads.
  • the degrea ⁇ er is applied in the morning only to the areas of T-zone oiliness and in the evening to the entire face or other skin area to be treated.
  • the degreaser is a hydro-alcoholic solution containing acetone in the concentration range of 0.1% to 10% but preferably 5%
  • the 5-2-2 pad contains glycolic acid [preferably 5%, but over a possible range of 1-20%], salicylic acid [preferably 2%, but over a pos ⁇ ible range of 0.1% to 5%], and lactic acid [preferably 2%, but over a po ⁇ sible range of 0.1% to 20%].
  • the peeling/exfoliating agent combination i ⁇ carried in a penetrating hydro- alcoholic vehicle containing acetone in the concentration range of 0.1% to 10% a ⁇ a co- ⁇ olvent to in ⁇ ure proper delivery of the peeling/ exfoliating agent to the ⁇ kin area to be treated.
  • the 5-2-2 combination work ⁇ ⁇ ynergi ⁇ tically with acetone as a peeling agent [preferably 5% but over the pos ⁇ ible range of 0.1% to 10%]. See Table ⁇ 1 and 2 for compositions and concentration ranges.
  • the therapeutic balm i ⁇ applied in the evening containing the well-known anti-inflammatory and anti-pruritic drug hydrocortisone in the concentration range 0.1% to 2.5%, preferably 1% in a hydrous base.
  • Sun protector is applied in the morning for day time use via quick absorbing, oil-free emulsion for sensitive skin.
  • Broad spectrum [UVA and UVB] protection is provided without the use of oxybenzone, lanolins, glycols, etc.
  • the UV filters are Octyl Methoxycinnamate in the range of 1.5% to 7.5% and Menthyl Anthranilate in the range of 1% to 10% and the oil-free emulsion itself i ⁇ a water- based emulsion comprised of a water-based vehicle and an ester-based emollient phase.
  • the present invention provides a novel home skin peel composition, method and kit for producing healthy and attractive skin.
  • Other modifications may be made to the present invention, without departing from the spirit and scope of the present invention, as noted in the appended claims.

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Abstract

Un procédé consistant à utiliser une nouvelle combinaison d'une composition de soins pour la peau et d'un tampon applicateur permet de dégraisser, desquamer et/ou exfolier, et hydrater la peau à domicile. Ce procédé est doux dans la mesure où les concentrations de l'ingrédient actif de desquamation et/ou de dégraissage, d'exfoliation et d'hydratation de la peau, principalement composé d'un acide alpha hydroxy ou d'un mélange d'acides alpha hydroxy, et comprenant de préférence de l'acétone, sont considérablement inférieures à celles d'habitude destinées à un usage professionnel dans les cabinets de dermatologues, d'esthéticiens et/ou de cosmétologues professionnels. La composition de la présente invention est présentée dans un excipient pharmaceutique approprié et pré-saturé dans un tampon applicateur commode.
PCT/US1994/006443 1993-06-01 1994-06-01 Procede de traitement cutane au moyen d'une composition et d'un tampon WO1994027569A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU70568/94A AU7056894A (en) 1993-06-01 1994-06-01 Skin treatment method utilizing a composition and a pad
EP94919412A EP0703775A4 (fr) 1993-06-01 1994-06-01 Procede de traitement cutane au moyen d'une composition et d'un tampon
CA002164229A CA2164229C (fr) 1993-06-01 1994-06-01 Methode de traitement de la peau utilisant un composition d'alphahydroxyacide et un tampon d'application

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US7056093A 1993-06-01 1993-06-01
US7055393A 1993-06-01 1993-06-01
US08/070,553 1993-06-01
US08/070,559 1993-06-01
US08/070,559 US5505948A (en) 1993-06-01 1993-06-01 Home skin peel composition for producing healthy and attractive skin
US08/070,560 1993-06-01
US11013393A 1993-08-20 1993-08-20
US10982593A 1993-08-20 1993-08-20
US10982493A 1993-08-20 1993-08-20
US10982193A 1993-08-20 1993-08-20
US08/109,821 1993-08-20
US08/109,825 1993-08-20
US08/110,133 1993-08-20
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AU (1) AU7056894A (fr)
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EP0660720A1 (fr) * 1992-09-14 1995-07-05 SMITH, Walter, P. Composition de conditionnement de la peau, son application et sa production
FR2732215A1 (fr) * 1995-03-28 1996-10-04 Sederma Sa Nouvelles compositions cosmetiques depigmentantes
DE19518815A1 (de) * 1995-05-23 1996-11-28 Beiersdorf Ag Kosmetische oder dermatologische Zubereitungen mit einem Gehalt an alpha-Hydroxyfettsäuren
EP0756479A1 (fr) * 1995-03-03 1997-02-05 Avon Products, Inc. Composition anti-acneique douce
EP0868908A2 (fr) * 1997-03-19 1998-10-07 Kabushiki Kaisha Yakult Honsha Composition cosmétique
US5951991A (en) * 1997-05-22 1999-09-14 The Procter & Gamble Company Cleansing products with improved moisturization
US5972361A (en) * 1996-10-25 1999-10-26 The Procter & Gamble Company Cleansing products
US5980931A (en) * 1996-10-25 1999-11-09 The Procter & Gamble Company Cleansing products having a substantially dry substrate
US6063397A (en) * 1996-10-25 2000-05-16 The Procter & Gamble Company Disposable cleansing products for hair and skin
US6132746A (en) * 1997-05-22 2000-10-17 The Procter & Gamble Company Cleansing products with improved moisturization
US6153208A (en) * 1997-09-12 2000-11-28 The Procter & Gamble Company Cleansing and conditioning article for skin or hair
US6190678B1 (en) 1997-09-05 2001-02-20 The Procter & Gamble Company Cleansing and conditioning products for skin or hair with improved deposition of conditioning ingredients
US6280757B1 (en) 1997-05-22 2001-08-28 The Procter & Gamble Company Cleansing articles for skin or hair
EP1161518A2 (fr) 1999-03-18 2001-12-12 Unilever Plc Serviette
US6338855B1 (en) 1996-10-25 2002-01-15 The Procter & Gamble Company Cleansing articles for skin and/or hair which also deposit skin care actives
US6616641B2 (en) 1993-12-22 2003-09-09 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Impregnated matrix and method for making same
WO2006040570A1 (fr) * 2004-10-16 2006-04-20 Paul George Welfle Composition d'exfoliant et kit comprenant un tampon recouvert de particules de metal
WO2008112964A1 (fr) * 2007-03-15 2008-09-18 The Procter & Gamble Company Trousse de soin personnel ayant des compositions de soin pour la peau avec une différence aisément perceptible
WO2008120113A2 (fr) * 2007-03-30 2008-10-09 Kimberly-Clark Worldwide, Inc. Système de soins cosmétiques pour la peau
WO2009063158A2 (fr) * 2007-11-14 2009-05-22 Reckitt Benckiser (Uk) Limited Article de soin personnel
ITMI20091647A1 (it) * 2009-09-25 2011-03-26 Skinfit Technologies S R L Composizione cosmetica in forma di maschera e kit per la sua preparazione
FR2997846A1 (fr) * 2012-11-09 2014-05-16 Oreal Composition comprenant un derive dicarbonyle et un acide, le procede de lissage des fibres keratiniques a partir de cette composition
JP2014526561A (ja) * 2011-09-23 2014-10-06 アラーガン、インコーポレイテッド 皮膚剥脱のための組成物およびその使用
WO2014086544A3 (fr) * 2012-12-06 2015-01-15 Beiersdorf Ag Préparations cosmétiques ou dermatologiques comportant des combinaisons de 4-n-butylrésorcine avec une ou plusieurs matières premières de parfum non terpénoïdes
WO2016050626A1 (fr) * 2014-09-29 2016-04-07 Koninklijke Philips N.V. Dispositif et procédé de nettoyage de la peau
US10426723B2 (en) 2014-12-03 2019-10-01 Mary Kay Inc. Cosmetic compositions

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US5091171B1 (en) * 1986-12-23 1995-09-26 Ruey J Yu Amphoteric compositions and polymeric forms of alpha hydroxyacids, and their therapeutic use
US5091171B2 (en) * 1986-12-23 1997-07-15 Tristrata Inc Amphoteric compositions and polymeric forms of alpha hydroxyacids and their therapeutic use
US4891228A (en) * 1988-02-02 1990-01-02 Richardson-Vicks Inc. Medicated cleansing pads

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Cited By (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0660720A4 (fr) * 1992-09-14 1996-12-27 Walter P Smith Composition de conditionnement de la peau, son application et sa production.
EP0660720A1 (fr) * 1992-09-14 1995-07-05 SMITH, Walter, P. Composition de conditionnement de la peau, son application et sa production
US6616641B2 (en) 1993-12-22 2003-09-09 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Impregnated matrix and method for making same
EP0756479A1 (fr) * 1995-03-03 1997-02-05 Avon Products, Inc. Composition anti-acneique douce
EP0756479A4 (fr) * 1995-03-03 1997-05-07 Avon Prod Inc Composition anti-acneique douce
FR2732215A1 (fr) * 1995-03-28 1996-10-04 Sederma Sa Nouvelles compositions cosmetiques depigmentantes
DE19518815A1 (de) * 1995-05-23 1996-11-28 Beiersdorf Ag Kosmetische oder dermatologische Zubereitungen mit einem Gehalt an alpha-Hydroxyfettsäuren
US5980931A (en) * 1996-10-25 1999-11-09 The Procter & Gamble Company Cleansing products having a substantially dry substrate
US5972361A (en) * 1996-10-25 1999-10-26 The Procter & Gamble Company Cleansing products
US6063397A (en) * 1996-10-25 2000-05-16 The Procter & Gamble Company Disposable cleansing products for hair and skin
US6074655A (en) * 1996-10-25 2000-06-13 The Procter & Gamble Company Cleansing products
US6338855B1 (en) 1996-10-25 2002-01-15 The Procter & Gamble Company Cleansing articles for skin and/or hair which also deposit skin care actives
EP0868908A2 (fr) * 1997-03-19 1998-10-07 Kabushiki Kaisha Yakult Honsha Composition cosmétique
EP0868908A3 (fr) * 1997-03-19 2000-02-23 Kabushiki Kaisha Yakult Honsha Composition cosmétique
US6280757B1 (en) 1997-05-22 2001-08-28 The Procter & Gamble Company Cleansing articles for skin or hair
US6132746A (en) * 1997-05-22 2000-10-17 The Procter & Gamble Company Cleansing products with improved moisturization
US6495151B2 (en) 1997-05-22 2002-12-17 The Procter & Gamble Company Cleansing articles for skin or hair
US5951991A (en) * 1997-05-22 1999-09-14 The Procter & Gamble Company Cleansing products with improved moisturization
US6190678B1 (en) 1997-09-05 2001-02-20 The Procter & Gamble Company Cleansing and conditioning products for skin or hair with improved deposition of conditioning ingredients
US6153208A (en) * 1997-09-12 2000-11-28 The Procter & Gamble Company Cleansing and conditioning article for skin or hair
EP1161518A2 (fr) 1999-03-18 2001-12-12 Unilever Plc Serviette
WO2006040570A1 (fr) * 2004-10-16 2006-04-20 Paul George Welfle Composition d'exfoliant et kit comprenant un tampon recouvert de particules de metal
WO2008112964A1 (fr) * 2007-03-15 2008-09-18 The Procter & Gamble Company Trousse de soin personnel ayant des compositions de soin pour la peau avec une différence aisément perceptible
WO2008120113A3 (fr) * 2007-03-30 2009-08-13 Kimberly Clark Co Système de soins cosmétiques pour la peau
WO2008120113A2 (fr) * 2007-03-30 2008-10-09 Kimberly-Clark Worldwide, Inc. Système de soins cosmétiques pour la peau
WO2009063158A2 (fr) * 2007-11-14 2009-05-22 Reckitt Benckiser (Uk) Limited Article de soin personnel
WO2009063158A3 (fr) * 2007-11-14 2010-07-15 Reckitt & Colman (Overseas) Limited Article de soin personnel
ITMI20091647A1 (it) * 2009-09-25 2011-03-26 Skinfit Technologies S R L Composizione cosmetica in forma di maschera e kit per la sua preparazione
JP2014526561A (ja) * 2011-09-23 2014-10-06 アラーガン、インコーポレイテッド 皮膚剥脱のための組成物およびその使用
FR2997846A1 (fr) * 2012-11-09 2014-05-16 Oreal Composition comprenant un derive dicarbonyle et un acide, le procede de lissage des fibres keratiniques a partir de cette composition
WO2014086544A3 (fr) * 2012-12-06 2015-01-15 Beiersdorf Ag Préparations cosmétiques ou dermatologiques comportant des combinaisons de 4-n-butylrésorcine avec une ou plusieurs matières premières de parfum non terpénoïdes
WO2016050626A1 (fr) * 2014-09-29 2016-04-07 Koninklijke Philips N.V. Dispositif et procédé de nettoyage de la peau
US10426723B2 (en) 2014-12-03 2019-10-01 Mary Kay Inc. Cosmetic compositions
US11103445B2 (en) 2014-12-03 2021-08-31 Mary Kay Inc. Cosmetic compositions
US11786453B2 (en) 2014-12-03 2023-10-17 Mary Kay Inc. Cosmetic compositions

Also Published As

Publication number Publication date
CA2164229A1 (fr) 1994-12-08
EP0703775A4 (fr) 1997-02-26
CA2164229C (fr) 2008-04-08
AU7056894A (en) 1994-12-20
EP0703775A1 (fr) 1996-04-03

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