WO1994016104B1 - Systeme d'imagerie couleur utilise en biologie moleculaire - Google Patents

Systeme d'imagerie couleur utilise en biologie moleculaire

Info

Publication number
WO1994016104B1
WO1994016104B1 PCT/US1994/000340 US9400340W WO9416104B1 WO 1994016104 B1 WO1994016104 B1 WO 1994016104B1 US 9400340 W US9400340 W US 9400340W WO 9416104 B1 WO9416104 B1 WO 9416104B1
Authority
WO
WIPO (PCT)
Prior art keywords
dna
color
image
color image
vectors
Prior art date
Application number
PCT/US1994/000340
Other languages
English (en)
Other versions
WO1994016104A1 (fr
Filing date
Publication date
Application filed filed Critical
Priority to CA002165980A priority Critical patent/CA2165980C/fr
Publication of WO1994016104A1 publication Critical patent/WO1994016104A1/fr
Publication of WO1994016104B1 publication Critical patent/WO1994016104B1/fr

Links

Abstract

La présente invention se rapporte généralement aux domaines de l'analyse et de l'interprétation d'images macromoléculaires. Elle se rapporte plus particulièrement à des moyens de sélection d'une image, et à l'utilisation d'une automatisation unique par ordinateur, à vecteur de couleur, pour déterminer la forme, la longueur, et les caractéristiques physiques d'une bissectrice d'image d'ADN à coloration, en fonction du contour global. L'invention se rapporte également à des procédés permettant d'étirer de manière gravitationnelle l'ADN en une forme essentiellement linéaire, à deux dimensions, présentant une distance entre les paires de kilobases comprise entre 0,34 νm et 0,65 νm par paire de kilobase. Des exemples d'images couleurs analysées sont présentés, lesquels comprennent la cartographie des distances, de l'orientation et d'éléments de marquage d'ADN à coloration par hybridation à visualisation directe (DIRVISH).
PCT/US1994/000340 1993-01-08 1994-01-10 Systeme d'imagerie couleur utilise en biologie moleculaire WO1994016104A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002165980A CA2165980C (fr) 1993-06-21 1994-06-21 Methode et appareil pour localiser les structures fonctionnelles de la partie inferieure de la jambe pendant la chirurgie du genou

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US278193A 1993-01-08 1993-01-08
US08/002,781 1993-01-08

Publications (2)

Publication Number Publication Date
WO1994016104A1 WO1994016104A1 (fr) 1994-07-21
WO1994016104B1 true WO1994016104B1 (fr) 1994-08-18

Family

ID=21702481

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1994/000340 WO1994016104A1 (fr) 1993-01-08 1994-01-10 Systeme d'imagerie couleur utilise en biologie moleculaire

Country Status (2)

Country Link
US (1) US5707797A (fr)
WO (1) WO1994016104A1 (fr)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5936731A (en) * 1991-02-22 1999-08-10 Applied Spectral Imaging Ltd. Method for simultaneous detection of multiple fluorophores for in situ hybridization and chromosome painting
FR2755149B1 (fr) * 1996-10-30 1999-01-15 Pasteur Institut Procede de diagnostic de maladies genetiques par peignage moleculaire et coffret de diagnostic
IL156002A0 (en) 1997-02-12 2003-12-23 Eugene Y Chan Methods and products for analyzing polymers
US6289229B1 (en) 1998-01-20 2001-09-11 Scimed Life Systems, Inc. Readable probe array for in vivo use
CA2328609A1 (fr) * 1998-05-16 1999-11-25 Pe Corporation (Ny) Instrument servant a surveiller l'amplification en chaine par polymerase (pcr) d'adn
US7498164B2 (en) 1998-05-16 2009-03-03 Applied Biosystems, Llc Instrument for monitoring nucleic acid sequence amplification reaction
US6270730B1 (en) 1998-06-16 2001-08-07 Northwest Engineering Inc. Multi-well rotary synthesizer
US6271042B1 (en) * 1998-08-26 2001-08-07 Alpha Innotech Corporation Biochip detection system
US6248537B1 (en) * 1999-05-28 2001-06-19 Institut Pasteur Use of the combing process for the identification of DNA origins of replication
US6927065B2 (en) * 1999-08-13 2005-08-09 U.S. Genomics, Inc. Methods and apparatus for characterization of single polymers
US6696022B1 (en) 1999-08-13 2004-02-24 U.S. Genomics, Inc. Methods and apparatuses for stretching polymers
US6762059B2 (en) * 1999-08-13 2004-07-13 U.S. Genomics, Inc. Methods and apparatuses for characterization of single polymers
US6235483B1 (en) 2000-01-31 2001-05-22 Agilent Technologies, Inc. Methods and kits for indirect labeling of nucleic acids
WO2002044425A2 (fr) 2000-12-01 2002-06-06 Visigen Biotechnologies, Inc. Synthese d'acides nucleiques d'enzymes, et compositions et methodes modifiant la fidelite d'incorporation de monomeres
US7473767B2 (en) * 2001-07-03 2009-01-06 The Institute For Systems Biology Methods for detection and quantification of analytes in complex mixtures
US7668697B2 (en) * 2006-02-06 2010-02-23 Andrei Volkov Method for analyzing dynamic detectable events at the single molecule level
JP2005504275A (ja) * 2001-09-18 2005-02-10 ユー．エス． ジェノミクス， インコーポレイテッド 高分解能線形解析用のポリマーの差示的タグ付け
US7383134B2 (en) * 2002-01-15 2008-06-03 Piper James R Method and/or system for analyzing biological samples using a computer system
WO2003091455A1 (fr) * 2002-04-23 2003-11-06 U.S.Genomics, Inc. Compositions et procedes relatifs a des sondes d'acides nucleiques a deux bras
US7371520B2 (en) * 2002-05-28 2008-05-13 U.S. Genomics, Inc. Methods and apparati using single polymer analysis
US7282330B2 (en) * 2002-05-28 2007-10-16 U.S. Genomics, Inc. Methods and apparati using single polymer analysis
US20040214211A1 (en) * 2003-01-23 2004-10-28 U.S. Genomics, Inc. Methods for analyzing polymer populations
EP1620203A2 (fr) * 2003-04-10 2006-02-01 U.S. Genomics, Inc. Structures microfluidiques avancees
US20040241659A1 (en) * 2003-05-30 2004-12-02 Applera Corporation Apparatus and method for hybridization and SPR detection
WO2005012575A1 (fr) * 2003-08-01 2005-02-10 U.S. Genomics, Inc. Procedes et compositions lies a l'utilisation d'endonucleases specifiques d'une sequence pour analyser des acides nucleiques dans des conditions de non-clivage
US7977048B2 (en) 2004-01-13 2011-07-12 Pathogenetix, Inc. Detection and quantification of analytes in solution using polymers
US20050196790A1 (en) * 2004-02-05 2005-09-08 U.S. Genomics, Inc. Methods for detection and quantitation of minimum length polymers
JP2007529758A (ja) * 2004-03-19 2007-10-25 ユー．エス． ジェノミクス， インコーポレイテッド 単一分子の検出のための組成物および方法
US20060041385A1 (en) * 2004-08-18 2006-02-23 Bauer Kenneth D Method of quantitating proteins and genes in cells using a combination of immunohistochemistry and in situ hybridization
US7351538B2 (en) * 2004-08-23 2008-04-01 U.S. Genomics Systems and methods for detecting and analyzing polymers
WO2006098772A2 (fr) * 2004-10-13 2006-09-21 U.S. Genomics, Inc. Systemes et procedes d'optimisation de mesures
US20060160231A1 (en) * 2004-11-24 2006-07-20 U.S. Genomics, Inc. Linear analysis of polymers
US20070128083A1 (en) * 2005-07-18 2007-06-07 U.S. Genomics, Inc. Microfluidic methods and apparatuses for sample preparation and analysis
WO2007056250A2 (fr) * 2005-11-04 2007-05-18 U.S. Genomics, Inc. Analyse heterogene d'analytes en solution au moyen de polymeres
EP1963531B1 (fr) 2005-12-23 2011-09-21 Nanostring Technologies, Inc. Nanorapporteurs et procedes de production et d'utilisation de ceux-ci
US8986926B2 (en) * 2005-12-23 2015-03-24 Nanostring Technologies, Inc. Compositions comprising oriented, immobilized macromolecules and methods for their preparation
WO2009052214A2 (fr) * 2007-10-15 2009-04-23 Complete Genomics, Inc. Analyse de séquence à l'aide d'acides nucléiques décorés
US8446463B2 (en) 2008-08-22 2013-05-21 Genprime, Inc. Apparatus, method and article to perform assays using assay strips
US9028776B2 (en) 2012-04-18 2015-05-12 Toxic Report Llc Device for stretching a polymer in a fluid sample
US9069358B2 (en) 2013-06-24 2015-06-30 Biolytic Lab Performance, Inc. System for controlling and optimizing reactions in solid phase synthesis of small molecules
US10576475B2 (en) 2016-09-15 2020-03-03 Genprime, Inc. Diagnostic assay strip cassette

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4994373A (en) * 1983-01-27 1991-02-19 Enzo Biochem, Inc. Method and structures employing chemically-labelled polynucleotide probes
US4710465A (en) * 1984-04-19 1987-12-01 Yale University Junction-fragment DNA probes and probe clusters
US4741043B1 (en) * 1985-11-04 1994-08-09 Cell Analysis Systems Inc Method of and apparatus for image analyses of biological specimens
US5192683A (en) * 1987-02-19 1993-03-09 The Royal Institution For The Advancement Of Learning (Mcgill University) Monoclonal antibodies to cruciform DNA structure
AU647741B2 (en) * 1989-12-01 1994-03-31 Regents Of The University Of California, The Methods and compositions for chromosome-specific staining
US5405747A (en) * 1991-09-25 1995-04-11 The Regents Of The University Of California Office Of Technology Transfer Method for rapid base sequencing in DNA and RNA with two base labeling
CA2078377A1 (fr) * 1992-09-16 1994-03-17 Henry H. Q. Heng Cartographie des genes par hybridation in situ a la chromatine libre
US5470710A (en) * 1993-10-22 1995-11-28 University Of Utah Automated hybridization/imaging device for fluorescent multiplex DNA sequencing

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