WO1994015902B1 - Composes a selectivite envers les recepteurs de retinoides x - Google Patents
Composes a selectivite envers les recepteurs de retinoides xInfo
- Publication number
- WO1994015902B1 WO1994015902B1 PCT/US1993/010204 US9310204W WO9415902B1 WO 1994015902 B1 WO1994015902 B1 WO 1994015902B1 US 9310204 W US9310204 W US 9310204W WO 9415902 B1 WO9415902 B1 WO 9415902B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- carbons
- acyl
- lower alkyl
- including halogen
- represents hydrogen
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 102000034577 retinoid X receptors Human genes 0.000 title abstract 5
- 108010038912 retinoid X receptors Proteins 0.000 title abstract 5
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 125000002252 acyl group Chemical group 0.000 claims 5
- -1 alkyl carboxylic acid Chemical class 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 150000001336 alkenes Chemical class 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 2
- 150000002431 hydrogen Chemical group 0.000 claims 2
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 125000000547 substituted alkyl group Chemical group 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 150000003973 alkyl amines Chemical class 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- DBTDEFJAFBUGPP-UHFFFAOYSA-N methanethione Chemical compound S=C DBTDEFJAFBUGPP-UHFFFAOYSA-N 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 150000003536 tetrazoles Chemical group 0.000 claims 1
- 150000003573 thiols Chemical class 0.000 claims 1
- 230000001404 mediated Effects 0.000 abstract 2
- 230000000051 modifying Effects 0.000 abstract 2
- 102000003702 retinoic acid receptors Human genes 0.000 abstract 2
- 108090000064 retinoic acid receptors Proteins 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003233 pyrroles Chemical class 0.000 abstract 1
- 150000004508 retinoic acid derivatives Chemical class 0.000 abstract 1
- YTPLMLYBLZKORZ-UHFFFAOYSA-N thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 1
Abstract
Composés, compositions et procédés destinés à moduler les processus induits par les récepteurs de rétinoïdes X à l'aide de composés de type rétinoïde qui activent sélectivement des membres du sous-groupe des récepteurs de rétinoïdes X (RXR), de préférence aux membres du sous-groupe des récepteurs de l'acide rétinoïque (RAR). Lesdits composés sont par exemple des dérivés de benzyle bicyclique, de pyridinyle, de thiophène, de furanyle et de pyrrole. Dans les procédés décrits, on emploie des composés destinés à moduler les processus induits sélectivement par les récepteurs de rétinoïdes X.
Priority Applications (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE69327255T DE69327255T2 (de) | 1993-01-11 | 1993-10-22 | Selektivitaet fuer retinoid x rezeptoren enthaltende verbindungen |
| AT94901195T ATE187434T1 (de) | 1993-01-11 | 1993-10-22 | Selektivitaet fuer retinoid x rezeptoren enthaltende verbindungen |
| DK94901195T DK0678086T3 (da) | 1993-01-11 | 1993-10-22 | Forbindelser med selektivitet over for retinoid-X-receptorer |
| JP6515962A JPH08505852A (ja) | 1993-01-11 | 1993-10-22 | レチノイドｘレセプターに対する選択性を有する化合物 |
| AU62258/94A AU6225894A (en) | 1993-01-11 | 1993-10-22 | Compounds having selectivity for retinoid x receptors |
| MX9306629A MX9306629A (es) | 1993-01-11 | 1993-10-22 | Compuestos que tienen actividad selectiva para receptores retinoide x, medios para modulacion de procesos mediados pr receptores de retinoide x. |
| AU55868/94A AU691477B2 (en) | 1992-04-22 | 1993-10-22 | Compounds having selectivity for retinoid X receptors |
| KR1019950702842A KR100306855B1 (ko) | 1993-01-11 | 1993-10-22 | 레티노이드x수용체에대한선택성을갖는화합물 |
| ES94901195T ES2139063T3 (es) | 1993-01-11 | 1993-10-22 | Compuestos que tienen selectividad por receptores de retinoides x. |
| EP94901195A EP0678086B1 (fr) | 1993-01-11 | 1993-10-22 | Composes a selectivite envers les recepteurs de retinoides x |
| CA002153235A CA2153235C (fr) | 1993-01-11 | 1993-10-22 | Composes selectifs pour les recepteurs de la retinoide x; moyens permettant la modulation de procedes via ces recepteurs |
| PT94901195T PT678086E (pt) | 1993-01-11 | 1993-10-22 | Compostos com selectividade para receptores de retinoides x |
| PCT/US1993/010204 WO1994015902A1 (fr) | 1993-01-11 | 1993-10-22 | Composes a selectivite envers les recepteurs de retinoides x |
| BR9307784A BR9307784A (pt) | 1993-01-11 | 1993-10-22 | Compostos tendo seletivamente para receptores de retinóide X |
| GR20000400533T GR3032841T3 (en) | 1993-01-11 | 2000-03-03 | Compounds having selectivity for retinoid x receptors. |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US322393A | 1993-01-11 | 1993-01-11 | |
| US2774793A | 1993-03-05 | 1993-03-05 | |
| US5205193A | 1993-04-21 | 1993-04-21 | |
| US08/052,051 | 1993-04-21 | ||
| US08/027,747 | 1993-04-21 | ||
| US08/003,223 | 1993-04-21 | ||
| PCT/US1993/010204 WO1994015902A1 (fr) | 1993-01-11 | 1993-10-22 | Composes a selectivite envers les recepteurs de retinoides x |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1994015902A1 WO1994015902A1 (fr) | 1994-07-21 |
| WO1994015902B1 true WO1994015902B1 (fr) | 1994-09-15 |
Family
ID=27485257
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1993/010204 WO1994015902A1 (fr) | 1992-04-22 | 1993-10-22 | Composes a selectivite envers les recepteurs de retinoides x |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0678086B1 (fr) |
| JP (1) | JPH08505852A (fr) |
| KR (1) | KR100306855B1 (fr) |
| AT (1) | ATE187434T1 (fr) |
| AU (2) | AU6225894A (fr) |
| BR (1) | BR9307784A (fr) |
| CA (1) | CA2153235C (fr) |
| DE (1) | DE69327255T2 (fr) |
| DK (1) | DK0678086T3 (fr) |
| ES (1) | ES2139063T3 (fr) |
| GR (1) | GR3032841T3 (fr) |
| MX (1) | MX9306629A (fr) |
| PT (1) | PT678086E (fr) |
| WO (1) | WO1994015902A1 (fr) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5466861A (en) * | 1992-11-25 | 1995-11-14 | Sri International | Bridged bicyclic aromatic compounds and their use in modulating gene expression of retinoid receptors |
| EP0933350A1 (fr) * | 1994-12-30 | 1999-08-04 | Ligand Pharmaceuticals Incorporated | Rétinoides tricycliques, procédés pour leur préparation et leur utilisation |
| US7115728B1 (en) | 1995-01-30 | 2006-10-03 | Ligand Pharmaceutical Incorporated | Human peroxisome proliferator activated receptor γ |
| EP0788353A1 (fr) | 1995-09-18 | 1997-08-13 | Ligand Pharmaceuticals, Inc. | Antagonistes de ppar gamma pour le traitement de l'obesite |
| CA2233888A1 (fr) * | 1995-10-06 | 1997-04-10 | Ligand Pharmaceuticals Incorporated | Modulateurs rxr selectifs pour les dimeres et leurs methodes d'utilisation |
| US5726191A (en) * | 1995-11-16 | 1998-03-10 | Hoffmann-La Roche Inc. | Aromatic carboxylic acid esters |
| US5998393A (en) * | 1996-04-05 | 1999-12-07 | Kang; Sewon | Methods for assessing 1,25(OH)2 D3 activity in skin and for enhancing the therapeutic use of 1,25(OH)2 D3 |
| WO1999005161A1 (fr) | 1997-07-25 | 1999-02-04 | Ligand Pharmaceuticals Incorporated | SEQUENCES REGULATRICES DU GENE HUMAIN PPARη (RECEPTEUR GAMMA ACTIVE DE LA PROLIFERATION DES PEROXYSOMES) ET LEURS UTILISATIONS |
| AU3700899A (en) * | 1998-05-11 | 1999-11-29 | Novo Nordisk A/S | New compounds, their preparation and use |
| EP1077919A1 (fr) * | 1998-05-11 | 2001-02-28 | Novo Nordisk A/S | Nouveaux composes, leur preparation et utilisation |
| FR2779720B1 (fr) * | 1998-06-12 | 2002-08-16 | Galderma Rech Dermatologique | Nouveaux composes diarylselenures et leur utilisation en medecine humaine ou veterinaire ainsi qu'en cosmetologie |
| EP1093362A1 (fr) | 1998-06-12 | 2001-04-25 | Ligand Pharmaceuticals Incorporated | Traitement du cancer du sein resistant aux anti-oestrogenes avec des modulateurs de rxr |
| WO2000035867A1 (fr) * | 1998-12-14 | 2000-06-22 | Nuclear Receptor Research Limited | Nouveaux ligands d'un recepteur nucleaire |
| TR200200507T2 (tr) | 1999-08-27 | 2002-10-21 | Ligand Pharmaceuticals Inc | Androjen reseptörü modülatör bileşikleri ve metotları |
| EP1212322A2 (fr) | 1999-08-27 | 2002-06-12 | Ligand Pharmaceuticals Incorporated | Composes de 6-trifluoromethyl-9-pyrido[3,2-g]quinoline 8-substitues utilises comme modulateurs de recepteurs androgenes |
| US6566372B1 (en) | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
| PE20010647A1 (es) | 1999-09-14 | 2001-06-23 | Lilly Co Eli | Moduladores de receptores de retinoide x (rxr) con perfil farmacologico mejorado |
| PT1248604E (pt) | 2000-01-21 | 2007-01-31 | Novartis Ag | Associações compreendendo inibidor de dipeptidilpeptidase-iv |
| PL208665B1 (pl) * | 2000-10-02 | 2011-05-31 | Hoffmann La Roche | Związki retinoidowe, ich zastosowanie, środek farmaceutyczny i sposób wytwarzania związków retinoidowych |
| EP1935869A1 (fr) * | 2000-10-02 | 2008-06-25 | F. Hoffmann-La Roche Ag | Retinoides destines au traitement de l'emphyseme |
| DE60204674T2 (de) | 2001-03-14 | 2006-05-18 | Eli Lilly And Co., Indianapolis | Retinoid x rezeptormodulatoren |
| EP1430042A2 (fr) * | 2001-09-25 | 2004-06-23 | SmithKline Beecham Corporation | Ligands selectifs du recepteur x retinoide |
| JP5249484B2 (ja) * | 2001-12-11 | 2013-07-31 | 第一三共株式会社 | 医薬組成物 |
| US9050310B2 (en) | 2004-06-25 | 2015-06-09 | Minas Theodore Coroneo | Treatment of ocular lesions |
| US8652534B2 (en) | 2009-10-14 | 2014-02-18 | Berry Pharmaceuticals, LLC | Compositions and methods for treatment of mammalian skin |
| US9174917B2 (en) | 2010-02-19 | 2015-11-03 | Arizona Board Of Regents On Behalf Of Arizona State University | Bexarotene analogs |
| US9492431B2 (en) | 2012-11-08 | 2016-11-15 | Yamaguchi University | Therapeutic agent for keratoconjunctive disorders |
| BR112015029114B1 (pt) * | 2013-05-22 | 2020-11-24 | Yamaguchi University | composição |
| US20160263189A1 (en) | 2013-10-23 | 2016-09-15 | Acadia Pharmaceuticals Inc. | Treatment of a neurodegenerative disease or disorder |
| WO2015187850A2 (fr) * | 2014-06-03 | 2015-12-10 | Duke University | Composés et méthodes destinés au traitement de troubles oculaires |
| ES2909874T3 (es) * | 2014-10-10 | 2022-05-10 | High Force Res Limited | Retinoides sintéticos fluorescentes |
| US11045441B2 (en) | 2015-10-13 | 2021-06-29 | Wisconsin Alumni Research Foundation | Use of retinoic acid and analogs thereof to treat central neural apneas |
| US10238626B2 (en) | 2017-01-23 | 2019-03-26 | Arizona Board Of Regents On Behalf Of Arizona State University | Therapeutic compounds |
| US10238655B2 (en) | 2017-01-23 | 2019-03-26 | Arizona Board Of Regents On Behalf Of Arizona State University | Dihydroindene and tetrahydronaphthalene compounds |
| US10231947B2 (en) | 2017-01-23 | 2019-03-19 | Arizona Board Of Regents On Behalf Of Arizona State University | Isochroman compounds and methods of use thereof |
| CA3092682A1 (fr) * | 2018-03-01 | 2019-09-06 | DJ Therapeutics LLC | Derives du bexarotene et leur utilisation dans le traitement du cancer |
| CA3120970A1 (fr) | 2018-11-26 | 2020-06-04 | Denali Therapeutics Inc. | Procedes de traitement du metabolisme lipidique deregule |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2601670B1 (fr) * | 1986-07-17 | 1988-10-07 | Cird | Nouveaux derives bicycliques aromatiques, leur procede de preparation et leur utilisation en medecine humaine et veterinaire et en cosmetique |
| FR2605626B1 (fr) * | 1986-10-27 | 1989-06-02 | Oreal | Nouveaux derives aromatiques bicycliques, leur procede de preparation et leur utilisation en cosmetique et en medecine humaine et veterinaire |
-
1993
- 1993-10-22 JP JP6515962A patent/JPH08505852A/ja active Pending
- 1993-10-22 KR KR1019950702842A patent/KR100306855B1/ko not_active IP Right Cessation
- 1993-10-22 MX MX9306629A patent/MX9306629A/es unknown
- 1993-10-22 CA CA002153235A patent/CA2153235C/fr not_active Expired - Lifetime
- 1993-10-22 ES ES94901195T patent/ES2139063T3/es not_active Expired - Lifetime
- 1993-10-22 DK DK94901195T patent/DK0678086T3/da active
- 1993-10-22 AU AU62258/94A patent/AU6225894A/en not_active Abandoned
- 1993-10-22 AU AU55868/94A patent/AU691477B2/en not_active Expired
- 1993-10-22 WO PCT/US1993/010204 patent/WO1994015902A1/fr active IP Right Grant
- 1993-10-22 EP EP94901195A patent/EP0678086B1/fr not_active Expired - Lifetime
- 1993-10-22 AT AT94901195T patent/ATE187434T1/de active
- 1993-10-22 PT PT94901195T patent/PT678086E/pt unknown
- 1993-10-22 DE DE69327255T patent/DE69327255T2/de not_active Expired - Lifetime
- 1993-10-22 BR BR9307784A patent/BR9307784A/pt not_active Application Discontinuation
-
2000
- 2000-03-03 GR GR20000400533T patent/GR3032841T3/el unknown
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