WO1994015902B1 - Composes a selectivite envers les recepteurs de retinoides x - Google Patents
Composes a selectivite envers les recepteurs de retinoides xInfo
- Publication number
- WO1994015902B1 WO1994015902B1 PCT/US1993/010204 US9310204W WO9415902B1 WO 1994015902 B1 WO1994015902 B1 WO 1994015902B1 US 9310204 W US9310204 W US 9310204W WO 9415902 B1 WO9415902 B1 WO 9415902B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- carbons
- acyl
- lower alkyl
- including halogen
- represents hydrogen
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 102000034577 retinoid X receptors Human genes 0.000 title abstract 5
- 108010038912 retinoid X receptors Proteins 0.000 title abstract 5
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 125000002252 acyl group Chemical group 0.000 claims 5
- -1 alkyl carboxylic acid Chemical class 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 150000001336 alkenes Chemical class 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 2
- 150000002431 hydrogen Chemical group 0.000 claims 2
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 125000000547 substituted alkyl group Chemical group 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 150000003973 alkyl amines Chemical class 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- DBTDEFJAFBUGPP-UHFFFAOYSA-N methanethione Chemical compound S=C DBTDEFJAFBUGPP-UHFFFAOYSA-N 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 150000003536 tetrazoles Chemical group 0.000 claims 1
- 150000003573 thiols Chemical class 0.000 claims 1
- 230000001404 mediated Effects 0.000 abstract 2
- 230000000051 modifying Effects 0.000 abstract 2
- 102000003702 retinoic acid receptors Human genes 0.000 abstract 2
- 108090000064 retinoic acid receptors Proteins 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003233 pyrroles Chemical class 0.000 abstract 1
- 150000004508 retinoic acid derivatives Chemical class 0.000 abstract 1
- YTPLMLYBLZKORZ-UHFFFAOYSA-N thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 1
Abstract
Composés, compositions et procédés destinés à moduler les processus induits par les récepteurs de rétinoïdes X à l'aide de composés de type rétinoïde qui activent sélectivement des membres du sous-groupe des récepteurs de rétinoïdes X (RXR), de préférence aux membres du sous-groupe des récepteurs de l'acide rétinoïque (RAR). Lesdits composés sont par exemple des dérivés de benzyle bicyclique, de pyridinyle, de thiophène, de furanyle et de pyrrole. Dans les procédés décrits, on emploie des composés destinés à moduler les processus induits sélectivement par les récepteurs de rétinoïdes X.
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU55868/94A AU691477B2 (en) | 1992-04-22 | 1993-10-22 | Compounds having selectivity for retinoid X receptors |
DK94901195T DK0678086T3 (da) | 1993-01-11 | 1993-10-22 | Forbindelser med selektivitet over for retinoid-X-receptorer |
PCT/US1993/010204 WO1994015902A1 (fr) | 1993-01-11 | 1993-10-22 | Composes a selectivite envers les recepteurs de retinoides x |
MX9306629A MX9306629A (es) | 1993-01-11 | 1993-10-22 | Compuestos que tienen actividad selectiva para receptores retinoide x, medios para modulacion de procesos mediados pr receptores de retinoide x. |
AT94901195T ATE187434T1 (de) | 1993-01-11 | 1993-10-22 | Selektivitaet fuer retinoid x rezeptoren enthaltende verbindungen |
ES94901195T ES2139063T3 (es) | 1993-01-11 | 1993-10-22 | Compuestos que tienen selectividad por receptores de retinoides x. |
KR1019950702842A KR100306855B1 (ko) | 1993-01-11 | 1993-10-22 | 레티노이드x수용체에대한선택성을갖는화합물 |
BR9307784A BR9307784A (pt) | 1993-01-11 | 1993-10-22 | Compostos tendo seletivamente para receptores de retinóide X |
AU62258/94A AU6225894A (en) | 1993-01-11 | 1993-10-22 | Compounds having selectivity for retinoid x receptors |
CA002153235A CA2153235C (fr) | 1993-01-11 | 1993-10-22 | Composes selectifs pour les recepteurs de la retinoide x; moyens permettant la modulation de procedes via ces recepteurs |
EP94901195A EP0678086B1 (fr) | 1993-01-11 | 1993-10-22 | Composes a selectivite envers les recepteurs de retinoides x |
JP6515962A JPH08505852A (ja) | 1993-01-11 | 1993-10-22 | レチノイドxレセプターに対する選択性を有する化合物 |
PT94901195T PT678086E (pt) | 1993-01-11 | 1993-10-22 | Compostos com selectividade para receptores de retinoides x |
DE69327255T DE69327255T2 (de) | 1993-01-11 | 1993-10-22 | Selektivitaet fuer retinoid x rezeptoren enthaltende verbindungen |
GR20000400533T GR3032841T3 (en) | 1993-01-11 | 2000-03-03 | Compounds having selectivity for retinoid x receptors. |
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US322393A | 1993-01-11 | 1993-01-11 | |
US08/003,223 | 1993-01-11 | ||
US2774793A | 1993-03-05 | 1993-03-05 | |
US08/027,747 | 1993-03-05 | ||
US5205193A | 1993-04-21 | 1993-04-21 | |
US08/052,051 | 1993-04-21 | ||
PCT/US1993/010204 WO1994015902A1 (fr) | 1993-01-11 | 1993-10-22 | Composes a selectivite envers les recepteurs de retinoides x |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1994015902A1 WO1994015902A1 (fr) | 1994-07-21 |
WO1994015902B1 true WO1994015902B1 (fr) | 1994-09-15 |
Family
ID=27485257
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1993/010204 WO1994015902A1 (fr) | 1992-04-22 | 1993-10-22 | Composes a selectivite envers les recepteurs de retinoides x |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0678086B1 (fr) |
JP (1) | JPH08505852A (fr) |
KR (1) | KR100306855B1 (fr) |
AT (1) | ATE187434T1 (fr) |
AU (2) | AU6225894A (fr) |
BR (1) | BR9307784A (fr) |
CA (1) | CA2153235C (fr) |
DE (1) | DE69327255T2 (fr) |
DK (1) | DK0678086T3 (fr) |
ES (1) | ES2139063T3 (fr) |
GR (1) | GR3032841T3 (fr) |
MX (1) | MX9306629A (fr) |
PT (1) | PT678086E (fr) |
WO (1) | WO1994015902A1 (fr) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5466861A (en) * | 1992-11-25 | 1995-11-14 | Sri International | Bridged bicyclic aromatic compounds and their use in modulating gene expression of retinoid receptors |
EP0933350A1 (fr) * | 1994-12-30 | 1999-08-04 | Ligand Pharmaceuticals Incorporated | Rétinoides tricycliques, procédés pour leur préparation et leur utilisation |
US7115728B1 (en) | 1995-01-30 | 2006-10-03 | Ligand Pharmaceutical Incorporated | Human peroxisome proliferator activated receptor γ |
US6028052A (en) * | 1995-09-18 | 2000-02-22 | Ligand Pharmaceuticals Incorporated | Treating NIDDM with RXR agonists |
EP1336600A3 (fr) | 1995-10-06 | 2004-07-07 | Ligand Pharmaceuticals Incorporated | Modulateurs RXR sélectifs pour les dimères et leurs méthodes d'utilisation |
US5726191A (en) * | 1995-11-16 | 1998-03-10 | Hoffmann-La Roche Inc. | Aromatic carboxylic acid esters |
US5998393A (en) * | 1996-04-05 | 1999-12-07 | Kang; Sewon | Methods for assessing 1,25(OH)2 D3 activity in skin and for enhancing the therapeutic use of 1,25(OH)2 D3 |
US7098025B1 (en) | 1997-07-25 | 2006-08-29 | Ligand Pharmaceuticals Incorporated | Human peroxisome proliferator activated receptor gamma (pparγ) gene regulatory sequences and uses therefor |
WO1999058486A1 (fr) * | 1998-05-11 | 1999-11-18 | Novo Nordisk A/S | Nouveaux composes, leur preparation et utilisation |
EP1077920A1 (fr) * | 1998-05-11 | 2001-02-28 | Novo Nordisk A/S | Nouveaux composes et leur preparation et utilisation |
AU4676999A (en) | 1998-06-12 | 1999-12-30 | Ligand Pharmaceuticals, Inc. | Treatment of anti-estrogen resistant breast cancer using rxr modulators |
FR2779720B1 (fr) * | 1998-06-12 | 2002-08-16 | Galderma Rech Dermatologique | Nouveaux composes diarylselenures et leur utilisation en medecine humaine ou veterinaire ainsi qu'en cosmetologie |
CA2355299A1 (fr) | 1998-12-14 | 2000-06-22 | Takafumi Uchida | Nouveaux ligands d'un recepteur nucleaire |
CZ2002711A3 (cs) | 1999-08-27 | 2003-11-12 | Ligand Pharmaceuticals Incorporated | Modulátory androgenních receptorů, způsoby jejich výroby a způsoby jejich použití |
US6566372B1 (en) | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
AU6941200A (en) | 1999-08-27 | 2001-03-26 | Ligand Pharmaceuticals Incorporated | 8-substituted-6-trifluoromethyl-9-pyrido(3,2-g)quinoline compounds as androgen receptor modulators |
CA2383565A1 (fr) | 1999-09-14 | 2001-03-22 | Ligand Pharmaceuticals Incorporated | Modulateurs rxr a profil pharmacologique ameliore |
DK1741445T3 (da) | 2000-01-21 | 2013-11-04 | Novartis Ag | Kombinationer omfattende dipeptidylpeptidase-IV-inhibitorer og antidiabetiske midler |
EP1935869A1 (fr) * | 2000-10-02 | 2008-06-25 | F. Hoffmann-La Roche Ag | Retinoides destines au traitement de l'emphyseme |
PL208665B1 (pl) * | 2000-10-02 | 2011-05-31 | Hoffmann La Roche | Związki retinoidowe, ich zastosowanie, środek farmaceutyczny i sposób wytwarzania związków retinoidowych |
WO2002071827A2 (fr) * | 2001-03-14 | 2002-09-19 | Eli Lilly And Company | Modulateurs des recepteurs x de retinoides |
AU2002333655A1 (en) * | 2001-09-25 | 2003-04-07 | Smithkline Beecham Corporation | Bicyclic heterocycles as rxr ligands |
JP5249484B2 (ja) * | 2001-12-11 | 2013-07-31 | 第一三共株式会社 | 医薬組成物 |
US9050310B2 (en) | 2004-06-25 | 2015-06-09 | Minas Theodore Coroneo | Treatment of ocular lesions |
US8652534B2 (en) | 2009-10-14 | 2014-02-18 | Berry Pharmaceuticals, LLC | Compositions and methods for treatment of mammalian skin |
AU2011218019B2 (en) * | 2010-02-19 | 2016-03-24 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University | Novel bexarotene analogs |
JP6254529B2 (ja) | 2012-11-08 | 2017-12-27 | 国立大学法人山口大学 | 角結膜障害の治療剤 |
SI3000466T1 (sl) * | 2013-05-22 | 2019-02-28 | Yamaguchi University | Inhibitor za retinohoroidalne motnje |
WO2015059632A1 (fr) | 2013-10-23 | 2015-04-30 | Acadia Pharmaceuticals Inc. | Traitement d'une maladie ou un trouble neurodégénératif |
WO2015187850A2 (fr) * | 2014-06-03 | 2015-12-10 | Duke University | Composés et méthodes destinés au traitement de troubles oculaires |
JP7178781B2 (ja) * | 2014-10-10 | 2022-11-28 | ハイ フォース リサーチ リミテッド | 蛍光合成レチノイド |
US11045441B2 (en) | 2015-10-13 | 2021-06-29 | Wisconsin Alumni Research Foundation | Use of retinoic acid and analogs thereof to treat central neural apneas |
US10238655B2 (en) | 2017-01-23 | 2019-03-26 | Arizona Board Of Regents On Behalf Of Arizona State University | Dihydroindene and tetrahydronaphthalene compounds |
US10238626B2 (en) | 2017-01-23 | 2019-03-26 | Arizona Board Of Regents On Behalf Of Arizona State University | Therapeutic compounds |
US10231947B2 (en) | 2017-01-23 | 2019-03-19 | Arizona Board Of Regents On Behalf Of Arizona State University | Isochroman compounds and methods of use thereof |
WO2019169270A1 (fr) * | 2018-03-01 | 2019-09-06 | Dawn Scientific Pharmaceuticals, Llc | Dérivés du bexarotène et leur utilisation dans le traitement du cancer |
CN113302206A (zh) | 2018-11-26 | 2021-08-24 | 戴纳立制药公司 | 治疗脂质代谢失调的方法 |
CN117285437A (zh) * | 2023-09-20 | 2023-12-26 | 沈阳药科大学 | 一种贝沙罗汀类衍生物及其制备方法和应用、一种抗肿瘤药物 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2601670B1 (fr) * | 1986-07-17 | 1988-10-07 | Cird | Nouveaux derives bicycliques aromatiques, leur procede de preparation et leur utilisation en medecine humaine et veterinaire et en cosmetique |
FR2605626B1 (fr) * | 1986-10-27 | 1989-06-02 | Oreal | Nouveaux derives aromatiques bicycliques, leur procede de preparation et leur utilisation en cosmetique et en medecine humaine et veterinaire |
-
1993
- 1993-10-22 PT PT94901195T patent/PT678086E/pt unknown
- 1993-10-22 BR BR9307784A patent/BR9307784A/pt not_active Application Discontinuation
- 1993-10-22 CA CA002153235A patent/CA2153235C/fr not_active Expired - Lifetime
- 1993-10-22 ES ES94901195T patent/ES2139063T3/es not_active Expired - Lifetime
- 1993-10-22 MX MX9306629A patent/MX9306629A/es unknown
- 1993-10-22 AT AT94901195T patent/ATE187434T1/de active
- 1993-10-22 KR KR1019950702842A patent/KR100306855B1/ko not_active IP Right Cessation
- 1993-10-22 DK DK94901195T patent/DK0678086T3/da active
- 1993-10-22 DE DE69327255T patent/DE69327255T2/de not_active Expired - Lifetime
- 1993-10-22 JP JP6515962A patent/JPH08505852A/ja active Pending
- 1993-10-22 AU AU62258/94A patent/AU6225894A/en not_active Abandoned
- 1993-10-22 AU AU55868/94A patent/AU691477B2/en not_active Expired
- 1993-10-22 EP EP94901195A patent/EP0678086B1/fr not_active Expired - Lifetime
- 1993-10-22 WO PCT/US1993/010204 patent/WO1994015902A1/fr active IP Right Grant
-
2000
- 2000-03-03 GR GR20000400533T patent/GR3032841T3/el unknown
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