WO1994007507A1 - Method for antagonizing inositol 1,4,5-triphosphate - Google Patents

Method for antagonizing inositol 1,4,5-triphosphate Download PDF

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Publication number
WO1994007507A1
WO1994007507A1 PCT/US1993/008168 US9308168W WO9407507A1 WO 1994007507 A1 WO1994007507 A1 WO 1994007507A1 US 9308168 W US9308168 W US 9308168W WO 9407507 A1 WO9407507 A1 WO 9407507A1
Authority
WO
WIPO (PCT)
Prior art keywords
inositol
triphosphate
binding
calcium
release
Prior art date
Application number
PCT/US1993/008168
Other languages
English (en)
French (fr)
Inventor
Kenneth A. Stauderman
Original Assignee
Merrell Dow Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc. filed Critical Merrell Dow Pharmaceuticals Inc.
Priority to JP6509054A priority Critical patent/JPH08502068A/ja
Priority to KR1019950701166A priority patent/KR950703347A/ko
Priority to EP93921252A priority patent/EP0661982A1/en
Priority to AU48417/93A priority patent/AU670962B2/en
Publication of WO1994007507A1 publication Critical patent/WO1994007507A1/en
Priority to NO951163A priority patent/NO951163L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/795—Polymers containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
PCT/US1993/008168 1992-09-28 1993-08-30 Method for antagonizing inositol 1,4,5-triphosphate WO1994007507A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP6509054A JPH08502068A (ja) 1992-09-28 1993-08-30 イノシトール１，４，５‐トリスホスフェートを拮抗する方法
KR1019950701166A KR950703347A (ko) 1992-09-28 1993-08-30 이노시톨 1,4,5-트리포스페이트의 길항 방법(Method for Antagonizing Inositol 1,4,5-Triphosphate)
EP93921252A EP0661982A1 (en) 1992-09-28 1993-08-30 Method for antagonizing inositol 1,4,5-triphosphate
AU48417/93A AU670962B2 (en) 1992-09-28 1993-08-30 Method for antagonizing inositol 1,4,5-triphosphate
NO951163A NO951163L (no) 1992-09-28 1995-03-27 Metode for antagonisering av inositol-1,4,5-trifosfat

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95239392A 1992-09-28 1992-09-28
US07/952,393 1992-09-28

Publications (1)

Publication Number Publication Date
WO1994007507A1 true WO1994007507A1 (en) 1994-04-14

Family

ID=25492868

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1993/008168 WO1994007507A1 (en) 1992-09-28 1993-08-30 Method for antagonizing inositol 1,4,5-triphosphate

Country Status (13)

Country Link
EP (1) EP0661982A1 (zh)
JP (1) JPH08502068A (zh)
KR (1) KR950703347A (zh)
AU (1) AU670962B2 (zh)
CA (1) CA2145681A1 (zh)
HU (1) HUT70192A (zh)
IL (1) IL107066A (zh)
MX (1) MX9305933A (zh)
NO (1) NO951163L (zh)
NZ (1) NZ256178A (zh)
TW (1) TW260663B (zh)
WO (1) WO1994007507A1 (zh)
ZA (1) ZA936978B (zh)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996000586A2 (en) * 1994-06-30 1996-01-11 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Methods for treating cell proliferative disorders by modulating signal transduction
WO1997022251A1 (en) * 1995-12-21 1997-06-26 Ayurcore, Inc. Compositions for modulating intracellular inositol trisphosphate concentration and uses thereof
US5780483A (en) * 1995-02-17 1998-07-14 Smithkline Beecham Corporation IL-8 receptor antagonists
US5886044A (en) * 1995-02-17 1999-03-23 Smithkline Beecham Corporation IL-8 receptor antagonists
US6005008A (en) * 1996-02-16 1999-12-21 Smithkline Beecham Corporation IL-8 receptor antagonists
US6133319A (en) * 1996-06-27 2000-10-17 Smithkline Beecham Corporation IL-8 receptor antagonists
US6211373B1 (en) 1996-03-20 2001-04-03 Smithkline Beecham Corporation Phenyl urea antagonists of the IL-8 receptor
US6262113B1 (en) 1996-03-20 2001-07-17 Smithkline Beecham Corporation IL-8 receptor antagonists
US6271261B1 (en) 1996-06-27 2001-08-07 Smithkline Beecham Corporation IL-8 receptor antagonists
WO2002038140A2 (en) * 2000-11-09 2002-05-16 Contrimmune Biotechnology Inc Therapeutic uses for ip3 receptor-mediated calcium channel modulators
US9771430B2 (en) 2011-09-02 2017-09-26 The Trustees Of Columbia University In The City Of New York Method of treating a metabolic disorder induced by obesity in a subject in need thereof by administering MK2/3 inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB781479A (en) * 1953-08-27 1957-08-21 Ciba Ltd New polyureas and process for making them
EP0467185A2 (en) * 1990-07-09 1992-01-22 The Dow Chemical Company Oligomers, their uses and formulations

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB781479A (en) * 1953-08-27 1957-08-21 Ciba Ltd New polyureas and process for making them
EP0467185A2 (en) * 1990-07-09 1992-01-22 The Dow Chemical Company Oligomers, their uses and formulations

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
F. O'ROURKE ET AL.: "THE INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR BINDING SITES OF PLATELET MEMBRANES", THE BIOCHEMICAL JOURNAL, vol. 267, no. 2, 1990, pages 297 - 302 *
M.A. TONES ET AL.: "THE EFFECT OF HEPARIN ON THE INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR IN RAT LIVER MICROSOMES", FEBS LETTERS, vol. 252, no. 1,2, 1989, pages 105 - 108, XP025605443, DOI: doi:10.1016/0014-5793(89)80898-1 *
See also references of EP0661982A1 *
T.K. GHOSH ET AL.: "COMPETITIVE, REVERSIBLE, AND POTENT ANTAGONISM OF INOSITOL 1,4,5-TRISPHOSPHATE-ACTIVATED CALCIUM RELEASE BY HEPARIN", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 263, no. 23, 1988, pages 11075 - 11079 *

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996000586A2 (en) * 1994-06-30 1996-01-11 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Methods for treating cell proliferative disorders by modulating signal transduction
WO1996000586A3 (en) * 1994-06-30 1996-02-15 Max Planck Gesellschaft Methods for treating cell proliferative disorders by modulating signal transduction
US6180675B1 (en) 1995-02-17 2001-01-30 Smithkline Beecham Corporation IL-8 receptor antagonists
US5780483A (en) * 1995-02-17 1998-07-14 Smithkline Beecham Corporation IL-8 receptor antagonists
US5886044A (en) * 1995-02-17 1999-03-23 Smithkline Beecham Corporation IL-8 receptor antagonists
US6083920A (en) * 1995-12-21 2000-07-04 Ayurcore, Inc. Compositions for modulating intracellular inositol trisphosphate concentration
WO1997022251A1 (en) * 1995-12-21 1997-06-26 Ayurcore, Inc. Compositions for modulating intracellular inositol trisphosphate concentration and uses thereof
US6005008A (en) * 1996-02-16 1999-12-21 Smithkline Beecham Corporation IL-8 receptor antagonists
US6211373B1 (en) 1996-03-20 2001-04-03 Smithkline Beecham Corporation Phenyl urea antagonists of the IL-8 receptor
US6262113B1 (en) 1996-03-20 2001-07-17 Smithkline Beecham Corporation IL-8 receptor antagonists
US6133319A (en) * 1996-06-27 2000-10-17 Smithkline Beecham Corporation IL-8 receptor antagonists
US6271261B1 (en) 1996-06-27 2001-08-07 Smithkline Beecham Corporation IL-8 receptor antagonists
WO2002038140A2 (en) * 2000-11-09 2002-05-16 Contrimmune Biotechnology Inc Therapeutic uses for ip3 receptor-mediated calcium channel modulators
WO2002038140A3 (en) * 2000-11-09 2003-03-13 Contrimmune Biotechnology Inc Therapeutic uses for ip3 receptor-mediated calcium channel modulators
US9771430B2 (en) 2011-09-02 2017-09-26 The Trustees Of Columbia University In The City Of New York Method of treating a metabolic disorder induced by obesity in a subject in need thereof by administering MK2/3 inhibitors

Also Published As

Publication number Publication date
IL107066A0 (en) 1993-12-28
ZA936978B (en) 1994-04-18
NO951163D0 (no) 1995-03-27
JPH08502068A (ja) 1996-03-05
CA2145681A1 (en) 1994-04-14
MX9305933A (es) 1994-04-29
AU4841793A (en) 1994-04-26
HU9500891D0 (en) 1995-05-29
EP0661982A1 (en) 1995-07-12
HUT70192A (en) 1995-09-28
IL107066A (en) 1998-01-04
TW260663B (zh) 1995-10-21
KR950703347A (ko) 1995-09-20
AU670962B2 (en) 1996-08-08
NO951163L (no) 1995-03-27
NZ256178A (en) 1997-03-24

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