WO1994006438A1 - Analogues de l'adenosine et procede d'intensification de la liberation de l'adenosine - Google Patents

Analogues de l'adenosine et procede d'intensification de la liberation de l'adenosine Download PDF

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Publication number
WO1994006438A1
WO1994006438A1 PCT/US1993/008284 US9308284W WO9406438A1 WO 1994006438 A1 WO1994006438 A1 WO 1994006438A1 US 9308284 W US9308284 W US 9308284W WO 9406438 A1 WO9406438 A1 WO 9406438A1
Authority
WO
WIPO (PCT)
Prior art keywords
aryl
compound
alkyl
aroyl
ribofuranosyl
Prior art date
Application number
PCT/US1993/008284
Other languages
English (en)
Inventor
Dennis A. Carson
Howard B. Cottam
Original Assignee
The Regents Of The University Of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Regents Of The University Of California filed Critical The Regents Of The University Of California
Priority to AU48451/93A priority Critical patent/AU4845193A/en
Publication of WO1994006438A1 publication Critical patent/WO1994006438A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals

Abstract

L'invention se rapporte à des analogues de nucléosides tels que des composés de ribofuranosyl-β-D-pyrrolopyrimidine et des composés de ribofuranosyl pyrrolopyrimidine N-oxyde et des sels pharmaceutiquement acceptables et des mélanges de ceux-ci. L'invention se rapporte également à des compositions comprenant ces composés et ces excipients pharmaceutiquement acceptables. L'invention comprend en outre des composés de ribofuranosyl ayant la position anomérique substituée par des substituants sélectionnés parmi le groupe constitué par -O-(C1-C18)alkyle, -O-(C1-C18)acyle, halogène, O-tosyle, ou -OSO2R11 dans lequel R11 représente -(C¿1?-C18)alkyle ou -(C6-C24)aryle. Des procédé de préparation de ces composés sont également décrits. Des procédés pour traiter d'une maladie ou un état pathologique, tel qu'une inflammation, certaines maladies du coeur, des ulcères gastriques, l'arthrose, la fonction neutrophile ou pour faciliter la vasodilatation, notamment, consistent à administrer à un sujet nécessitant ce traitement une quantité efficace inhibitrice de l'activité de l'adénosine kinase des composés revendiqués ou des compositions de ceux-ci.
PCT/US1993/008284 1992-09-11 1993-08-31 Analogues de l'adenosine et procede d'intensification de la liberation de l'adenosine WO1994006438A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU48451/93A AU4845193A (en) 1992-09-11 1993-08-31 Adenosine analogues and method of increasing adenosine release

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94413492A 1992-09-11 1992-09-11
US07/944,134 1992-09-11

Publications (1)

Publication Number Publication Date
WO1994006438A1 true WO1994006438A1 (fr) 1994-03-31

Family

ID=25480854

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1993/008284 WO1994006438A1 (fr) 1992-09-11 1993-08-31 Analogues de l'adenosine et procede d'intensification de la liberation de l'adenosine

Country Status (2)

Country Link
AU (1) AU4845193A (fr)
WO (1) WO1994006438A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0682519A1 (fr) * 1993-02-03 1995-11-22 Gensia, Inc. Inhibiteurs de l'adenosine kinase
US5573772A (en) * 1993-03-15 1996-11-12 Gensia, Inc. Methods for protecting tissues and organs from ischemic damage
US5589467A (en) * 1993-09-17 1996-12-31 Novo Nordisk A/S 2,5',N6-trisubstituted adenosine derivatives
US5665721A (en) * 1995-06-07 1997-09-09 Abbott Laboratories Heterocyclic substituted cyclopentane compounds
US6143749A (en) * 1995-06-07 2000-11-07 Abbott Laboratories Heterocyclic substituted cyclopentane compounds
WO2009044886A1 (fr) 2007-10-05 2009-04-09 Api Corporation Procédé de production de dérivés de ribofuranose
US7601501B2 (en) 2006-08-11 2009-10-13 The Scripps Research Institute Controlling osteogenesis by inhibition of osteogenic suppressors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4455420A (en) * 1983-01-13 1984-06-19 Hoffmann-La Roche Inc. 4-Amino-7-(5-deoxy-beta-D-ribofuranosyl)-5-iodo-7H-pyrrolo[2,3-d] pyrimidine
US5132424A (en) * 1988-07-21 1992-07-21 The Upjohn Company Pyrazolo-pyrrolo-pyrimidine-diones

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4455420A (en) * 1983-01-13 1984-06-19 Hoffmann-La Roche Inc. 4-Amino-7-(5-deoxy-beta-D-ribofuranosyl)-5-iodo-7H-pyrrolo[2,3-d] pyrimidine
US5132424A (en) * 1988-07-21 1992-07-21 The Upjohn Company Pyrazolo-pyrrolo-pyrimidine-diones

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BIOCHEMICAL PHARMACOLOGY, Volume 35, Number 18, issued 1986, DAVIES et al., "Studies on Several Pyrrolo[2,3-d] Pyrimidine Analogues of Adenosine which Lack Significant Agonist Activity at A1 and A2 Receptors but have Potent Pharmacoligical Activity In Vivo", pages 3021-3029. *
CHEMICAL ABSTRACTS, Volume 115, No. 21, issued 25 November 1991, BICHARD et al., "Acetonides of Alpha-Hydroxy-Delta-Altronolacetones", page 1914, Abstract No. 232714g; & TETRAHEDRON: ASYMMETRY, 2(9), 901-12. *
CHEMICAL ABSTRACTS, Volume 116, No. 15, issued 13 April 1992, CORIZZI et al., "Stereoselective Synthesis of the 6-Phosphono Analog of Fructose -Phosphate", see page 4723, Abstract No. 152177q; & J. CHEM. SOC. COMMUN., (2), 189-90. *
CHEMICAL ABSTRACTS, Volume 88, No. 1, issued 02 January 1978, "Nucleosides, Ribosylation of 6-Substituted 2,4-Diamino-5-Nitropyrimidines and their Transformation into Pteridine Ribosides", page 626, Column 1, Abstract No. 7281t. *
JOURNAL OF MEDICINAL CHEMISTRY, Volume 31, issued 1988, MOSS et al., "Synthesis, Intramolecular Hydrogen Bonding, and Biochemical Studies of Clitocine, a Naturally Occuring Exocyclic Amino Nucleoside", pages 786-790. *
P. TS'O, "Basic Principles in Nucleic Acid Chemistry", published 1974, by ACADEMIC PRESS (N.Y.), pages 122-129. *
TETRAHEDRON LETTERS, Volume 31, Number 2, issued 1990, PALMER et al., "Synthesis of Carbocyclic Clitocine" pages 279-282. *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0682519A1 (fr) * 1993-02-03 1995-11-22 Gensia, Inc. Inhibiteurs de l'adenosine kinase
EP0682519A4 (fr) * 1993-02-03 1997-12-17 Gensia Inc Inhibiteurs de l'adenosine kinase.
US5573772A (en) * 1993-03-15 1996-11-12 Gensia, Inc. Methods for protecting tissues and organs from ischemic damage
US5589467A (en) * 1993-09-17 1996-12-31 Novo Nordisk A/S 2,5',N6-trisubstituted adenosine derivatives
US5665721A (en) * 1995-06-07 1997-09-09 Abbott Laboratories Heterocyclic substituted cyclopentane compounds
US6143749A (en) * 1995-06-07 2000-11-07 Abbott Laboratories Heterocyclic substituted cyclopentane compounds
US7601501B2 (en) 2006-08-11 2009-10-13 The Scripps Research Institute Controlling osteogenesis by inhibition of osteogenic suppressors
WO2009044886A1 (fr) 2007-10-05 2009-04-09 Api Corporation Procédé de production de dérivés de ribofuranose
JPWO2009044886A1 (ja) * 2007-10-05 2011-02-10 株式会社エーピーアイ コーポレーション リボフラノース誘導体の製造方法

Also Published As

Publication number Publication date
AU4845193A (en) 1994-04-12

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