WO1993018764A3 - Verapamil hcl formulation and other ophthalmic solutions with buffer system for ocular administration - Google Patents

Verapamil hcl formulation and other ophthalmic solutions with buffer system for ocular administration Download PDF

Info

Publication number
WO1993018764A3
WO1993018764A3 PCT/US1993/002549 US9302549W WO9318764A3 WO 1993018764 A3 WO1993018764 A3 WO 1993018764A3 US 9302549 W US9302549 W US 9302549W WO 9318764 A3 WO9318764 A3 WO 9318764A3
Authority
WO
WIPO (PCT)
Prior art keywords
verapamil hcl
buffer system
ocular administration
ophthalmic solutions
hcl formulation
Prior art date
Application number
PCT/US1993/002549
Other languages
French (fr)
Other versions
WO1993018764A2 (en
Inventor
Richard L Giovanoni
Original Assignee
Coopervision Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coopervision Pharma filed Critical Coopervision Pharma
Priority to SK1438-93A priority Critical patent/SK143893A3/en
Priority to JP5516746A priority patent/JPH06511014A/en
Priority to CZ932600A priority patent/CZ260093A3/en
Publication of WO1993018764A2 publication Critical patent/WO1993018764A2/en
Publication of WO1993018764A3 publication Critical patent/WO1993018764A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

An aqueous ophthalmic solution is disclosed in which one or more acive ingredients in ionized form are gradually brought to undissociated, free base form by lacrimal solution acting against the affect of a plurality of buffers. The affect of each buffer is overcome sequentially by the lacrimal fluid. A preferred formulation includes verapamil HCl as the active ingredient in ionized form and includes as buffers: boric acid at 2.8 %, disodium edetate at 0.18 %, dextrose at 0.3 %, and polyvinylpyrrolidone at 2.0 %.
PCT/US1993/002549 1992-03-18 1993-03-18 VERAPAMIL HCl FORMULATION AND OTHER OPHTHALMIC SOLUTIONS WITH BUFFER SYSTEM FOR OCULAR ADMINISTRATION WO1993018764A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
SK1438-93A SK143893A3 (en) 1992-03-18 1993-03-18 Verapamil hci formulation and other opthalmic solutions with buffer system for ocular administration
JP5516746A JPH06511014A (en) 1992-03-18 1993-03-18 Ophthalmic solutions, such as verapamil hydrochloride formulations containing a buffer system, for administration to the eye
CZ932600A CZ260093A3 (en) 1992-03-18 1993-03-18 VERAPAMIL HCl PREPARATION AND OTHER OPHTHALMIC SOLUTIONS WITH A BUFFER SYSTEM FOR EYE ADMINISTRATION

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US85324692A 1992-03-18 1992-03-18
US07/853,246 1992-03-18
US99199592A 1992-12-17 1992-12-17
US07/991,995 1992-12-17

Publications (2)

Publication Number Publication Date
WO1993018764A2 WO1993018764A2 (en) 1993-09-30
WO1993018764A3 true WO1993018764A3 (en) 1993-11-25

Family

ID=27127128

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1993/002549 WO1993018764A2 (en) 1992-03-18 1993-03-18 VERAPAMIL HCl FORMULATION AND OTHER OPHTHALMIC SOLUTIONS WITH BUFFER SYSTEM FOR OCULAR ADMINISTRATION

Country Status (7)

Country Link
EP (1) EP0589020A4 (en)
AU (1) AU3926093A (en)
CA (1) CA2102110A1 (en)
CZ (1) CZ260093A3 (en)
HU (1) HUT67631A (en)
SK (1) SK143893A3 (en)
WO (1) WO1993018764A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001097852A1 (en) * 2000-06-19 2001-12-27 Santen Pharmaceutical Co., Ltd. Aseptics
US7022740B2 (en) 2004-04-29 2006-04-04 Leonard Mackles Lubricious ophthalmic solutions

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4981871A (en) * 1987-05-15 1991-01-01 Abelson Mark B Treatment of ocular hypertension with class I calcium channel blocking agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4470965A (en) * 1982-10-27 1984-09-11 Usv Pharmaceutical Corporation Celiprolol for the treatment of glaucoma
TW200402B (en) * 1990-08-13 1993-02-21 Senju Pharma Co

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4981871A (en) * 1987-05-15 1991-01-01 Abelson Mark B Treatment of ocular hypertension with class I calcium channel blocking agents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Physician's Desk Reference for Ophthamology, 16 Edition, 1988, pp. 14, 68, 88 and 90. *
See also references of EP0589020A4 *

Also Published As

Publication number Publication date
WO1993018764A2 (en) 1993-09-30
EP0589020A4 (en) 1994-07-06
AU3926093A (en) 1993-10-21
HUT67631A (en) 1995-04-28
CZ260093A3 (en) 1994-07-13
CA2102110A1 (en) 1993-09-19
EP0589020A1 (en) 1994-03-30
SK143893A3 (en) 1994-05-11

Similar Documents

Publication Publication Date Title
US6479556B2 (en) Ophthalmic compositions for soft contact lens, method of enhancing wettability of soft contact lens and method of inhibiting terpenoid adsorption
CA2101189A1 (en) Agglomerated hydrophilic complexes with multi-phasic release characteristics
KR890004691A (en) Antiseptic system for ophthalmic preparations
CA2013188A1 (en) Preservative system for ophthalmic formulations
ES2088385T3 (en) LIPOSOME FORMULATIONS WITH A HIGH ANTINEOPLASTIC AGENT / LIPID AGENT.
CA2004598A1 (en) Medicinal aerosol formulations
MXPA03011947A (en) Olopatadine formulations for topical administration.
ATE154239T1 (en) SPHEROUIDIC DRUG FORMULATION
CA2392050A1 (en) Pharmaceutical formulations containing zolmitriptan
KR100260061B1 (en) Vitamin e drop
BR9401199A (en) Drug preparations, process for the preparation of a medicine preparation, process for the preparation of a medicine formulation.
CA2000763A1 (en) Dispersable formulation
CA2020877A1 (en) Stable tretinoin emulsified cream formulations
CA2340898A1 (en) Compositions and methods for treating intracellular infections
CA2023563A1 (en) Stable injectable pharmaceutical formulation for folic acid and leucovorin salts and method
IT1255968B (en) PHARMACEUTICAL COMPOSITIONS CONTAINING URSODESOXICOLIC ACID
WO1993018764A3 (en) Verapamil hcl formulation and other ophthalmic solutions with buffer system for ocular administration
ITRM20010438A1 (en) N-ACETYLCISTEIN-BASED OPHTHALMIC PREPARATION FOR THE TREATMENT OF DRY EYE SYNDROME.
NO980058L (en) Ophthalmic preparations
NO950950L (en) Pharmaceutical preparation
KR100392481B1 (en) Dexamethasone gel
EP0056681A3 (en) Levonantradol and n-methyllevonantradol formulations
IE890275L (en) Pharmaceutical composition for 4-aroylimidazol-2-ones
GB2264639B (en) Modified Release Formulation
IT1254707B (en) TOPICAL USE OF CALCITONE FOR THE PREPARATION OF MEDICATIONS IN THE IDIOPATHIC SENILE CATARACT AND A PHARMACEUTICAL COMPOSITION THAT CONTAINS IT

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AT AU BB BG BR CA CH CZ DE DK ES FI GB HU JP KP KR LK LU MG MN MW NL NO NZ PL PT RO RU SD SE SK UA

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 2102110

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 1993908438

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 251570

Country of ref document: NZ

AK Designated states

Kind code of ref document: A3

Designated state(s): AT AU BB BG BR CA CH CZ DE DK ES FI GB HU JP KP KR LK LU MG MN MW NL NO NZ PL PT RO RU SD SE SK UA

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR SN TD TG

WWE Wipo information: entry into national phase

Ref document number: PV1993-2600

Country of ref document: CZ

WWE Wipo information: entry into national phase

Ref document number: 143893

Country of ref document: SK

WWP Wipo information: published in national office

Ref document number: 1993908438

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: PV1993-2600

Country of ref document: CZ

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWW Wipo information: withdrawn in national office

Ref document number: 1993908438

Country of ref document: EP

WWR Wipo information: refused in national office

Ref document number: PV1993-2600

Country of ref document: CZ