WO1992022527A3 - Derives de pyrrolidine 3-substitues comme antagonistes du calcium - Google Patents

Derives de pyrrolidine 3-substitues comme antagonistes du calcium Download PDF

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Publication number
WO1992022527A3
WO1992022527A3 PCT/GB1992/001088 GB9201088W WO9222527A3 WO 1992022527 A3 WO1992022527 A3 WO 1992022527A3 GB 9201088 W GB9201088 W GB 9201088W WO 9222527 A3 WO9222527 A3 WO 9222527A3
Authority
WO
WIPO (PCT)
Prior art keywords
calcium channel
channel antagonists
pyrrolidine derivatives
phenyl
substituted pyrrolidine
Prior art date
Application number
PCT/GB1992/001088
Other languages
English (en)
Other versions
WO1992022527A2 (fr
Inventor
Thomas Henry Brown
David Gwynn Cooper
Ronald Joseph King
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Priority to JP4511090A priority Critical patent/JPH06508353A/ja
Priority to EP92912277A priority patent/EP0589971A1/fr
Publication of WO1992022527A2 publication Critical patent/WO1992022527A2/fr
Publication of WO1992022527A3 publication Critical patent/WO1992022527A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Composés de la structure (I): où R représente alkyle C1-8, alkyl(phényle)C1-8, alcényl(phényle)p C2-8, alcynyl(phényle)p C2-8, cycloalkyle C3-8 ou alkyle C1-8 cycloalkyle C3-8; p vaut de 0 à 2; n vaut de 0 à 6; A représente une liaison, -CH=CH-, -C=C-, oxygène, soufre ou NR1; R1 représente hydrogène, alkyle C¿1-8?, ou phényle alkyle C1-4; m vaut de 0 à 3; et Ar représente aryle ou hétéroaryle, dont chacun peut être éventuellement substitué, et sels pharmaceutiquement acceptables de ces composés, lesquels peuvent être utilisés comme antagonistes du calcium. De nouveaux composés de la structure (I), des procédés de préparation et des compositions pharmaceutiques les contenant sont aussi décrits.
PCT/GB1992/001088 1991-06-17 1992-06-17 Derives de pyrrolidine 3-substitues comme antagonistes du calcium WO1992022527A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP4511090A JPH06508353A (ja) 1991-06-17 1992-06-17 化合物
EP92912277A EP0589971A1 (fr) 1991-06-17 1992-06-17 Composes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919113031A GB9113031D0 (en) 1991-06-17 1991-06-17 Compounds
GB9113031.0 1991-06-17

Publications (2)

Publication Number Publication Date
WO1992022527A2 WO1992022527A2 (fr) 1992-12-23
WO1992022527A3 true WO1992022527A3 (fr) 1993-02-18

Family

ID=10696812

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1992/001088 WO1992022527A2 (fr) 1991-06-17 1992-06-17 Derives de pyrrolidine 3-substitues comme antagonistes du calcium

Country Status (5)

Country Link
EP (1) EP0589971A1 (fr)
JP (1) JPH06508353A (fr)
AU (1) AU1975092A (fr)
GB (1) GB9113031D0 (fr)
WO (1) WO1992022527A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT70031A (en) * 1992-11-30 1995-09-28 Sankyo Co Alfa, omega-diarylalkane derivatives, their preparation and pharmaceutical compositions containing them
GB9226111D0 (en) * 1992-12-15 1993-02-10 Smithkline Beecham Plc Madicaments
GB9314973D0 (en) * 1993-07-20 1993-09-01 Smithkline Beecham Plc Medicaments
US5849760A (en) * 1993-12-09 1998-12-15 Institut De Recherche Jouveinal 2-(arylalkenyl)azacycloalkane derivatives as ligands for sigma receptors
WO1995024390A1 (fr) * 1994-03-11 1995-09-14 Smithkline Beecham Plc Nouvelles piperidines substituees par phenyl(-alkyl/alkoxy)-1-aminoalkyle et pyrolidines utilisees comme antagonistes des canaux calciques
GB9411052D0 (en) * 1994-06-02 1994-07-20 Smithkline Beecham Plc Medicaments
GB9411045D0 (en) * 1994-06-02 1994-07-20 Smithkline Beecham Plc Compounds and use
GB9518572D0 (en) * 1995-09-12 1995-11-15 Smithkline Beecham Plc Compounds
AU713236B2 (en) * 1996-02-15 1999-11-25 Sankyo Company Limited Diarly alkane derivatives containing an alicyclic group, their preparation and their theraputic and prophylactic uses
JP3593037B2 (ja) * 1998-11-20 2004-11-24 エフ．ホフマン−ラ ロシュ アーゲー ピロリジン誘導体ｃｃｒ−３受容体アンタゴニスト
GB0002100D0 (en) 2000-01-28 2000-03-22 Novartis Ag Organic compounds
MXPA05012899A (es) 2003-05-30 2006-06-23 Neuromed Tech Inc 3-aminometil-pirrolidinas como bloqueadores del canal de calcio tipo n.
BRPI0715355A2 (pt) 2006-08-09 2013-06-18 Smithkline Beecham Corp anilinas pirrolidonas com moduladores de recepÇço de progesteronas
JP2010513568A (ja) * 2006-12-19 2010-04-30 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー ピロリジンアニリン類

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1964511A1 (de) * 1968-12-23 1970-07-09 Robins Co Inc A H 1-substituierte-3-Phenoxypyrrolidine und Verfahren zu ihrer Herstellung
EP0030526A1 (fr) * 1979-12-05 1981-06-17 Astra Läkemedel Aktiebolag Phényl-azacycloalcanes, procédés de préparation et préparations pharmaceutiques contenant ces composés
EP0218249A2 (fr) * 1985-10-11 1987-04-15 Tokyo Kasei Kogyo Co., Ltd Procédé de préparationdes 3-aminopyrrolidines
EP0229623A2 (fr) * 1986-01-09 1987-07-22 Hoechst Aktiengesellschaft Alkylamines diaryl-substituées, procédé pour leur préparation, leur application et médicaments les contenant
EP0244739A2 (fr) * 1986-05-02 1987-11-11 BASF Aktiengesellschaft Dérivés de la pyrrolidine et de la pipéridine N-substituées et leurs sels
EP0290958A2 (fr) * 1987-05-12 1988-11-17 Hoechst Aktiengesellschaft Alkylamines substituées par des groupes diarylalkyles, leur procédé de préparation, leur utilisation ainsi que médicaments les contenant
EP0309913A2 (fr) * 1987-09-30 1989-04-05 BASF Aktiengesellschaft Dérivés de 3-aryl-pyrrolidine N-substitués à activité fongicide
EP0360685A1 (fr) * 1988-09-23 1990-03-28 Lipha, Lyonnaise Industrielle Pharmaceutique "[(diarylméthoxy) alcoyl] - 1 pyrrolidines et piperidines, procédés de préparation et médicaments les contenant"
EP0466585A1 (fr) * 1990-07-10 1992-01-15 Adir Et Compagnie Nouveaux dérivés de la pipéridine, de la tétrahydropyridine et de la pyrrolidine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1964511A1 (de) * 1968-12-23 1970-07-09 Robins Co Inc A H 1-substituierte-3-Phenoxypyrrolidine und Verfahren zu ihrer Herstellung
EP0030526A1 (fr) * 1979-12-05 1981-06-17 Astra Läkemedel Aktiebolag Phényl-azacycloalcanes, procédés de préparation et préparations pharmaceutiques contenant ces composés
EP0218249A2 (fr) * 1985-10-11 1987-04-15 Tokyo Kasei Kogyo Co., Ltd Procédé de préparationdes 3-aminopyrrolidines
EP0229623A2 (fr) * 1986-01-09 1987-07-22 Hoechst Aktiengesellschaft Alkylamines diaryl-substituées, procédé pour leur préparation, leur application et médicaments les contenant
EP0244739A2 (fr) * 1986-05-02 1987-11-11 BASF Aktiengesellschaft Dérivés de la pyrrolidine et de la pipéridine N-substituées et leurs sels
EP0290958A2 (fr) * 1987-05-12 1988-11-17 Hoechst Aktiengesellschaft Alkylamines substituées par des groupes diarylalkyles, leur procédé de préparation, leur utilisation ainsi que médicaments les contenant
EP0309913A2 (fr) * 1987-09-30 1989-04-05 BASF Aktiengesellschaft Dérivés de 3-aryl-pyrrolidine N-substitués à activité fongicide
EP0360685A1 (fr) * 1988-09-23 1990-03-28 Lipha, Lyonnaise Industrielle Pharmaceutique "[(diarylméthoxy) alcoyl] - 1 pyrrolidines et piperidines, procédés de préparation et médicaments les contenant"
EP0466585A1 (fr) * 1990-07-10 1992-01-15 Adir Et Compagnie Nouveaux dérivés de la pipéridine, de la tétrahydropyridine et de la pyrrolidine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF MEDICINAL CHEMISTRY, Vol. 12, No. 3, May 1969, pages 442-444; R.L. DUNCAN et al., "Synthesis and Biological Properties of Some 1-Substituted 3-(o-Methoxyphenoxy)Pyrrolidines", Compounds of Formula III, page 442. *

Also Published As

Publication number Publication date
JPH06508353A (ja) 1994-09-22
GB9113031D0 (en) 1991-08-07
WO1992022527A2 (fr) 1992-12-23
AU1975092A (en) 1993-01-12
EP0589971A1 (fr) 1994-04-06

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