WO1992020455A1 - Systeme a actionnement mecanique automatique pour distributeurs atomiseurs de medicaments - Google Patents

Systeme a actionnement mecanique automatique pour distributeurs atomiseurs de medicaments Download PDF

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Publication number
WO1992020455A1
WO1992020455A1 PCT/IT1992/000050 IT9200050W WO9220455A1 WO 1992020455 A1 WO1992020455 A1 WO 1992020455A1 IT 9200050 W IT9200050 W IT 9200050W WO 9220455 A1 WO9220455 A1 WO 9220455A1
Authority
WO
WIPO (PCT)
Prior art keywords
spring
bush
resilient
cylindrical
slider
Prior art date
Application number
PCT/IT1992/000050
Other languages
English (en)
Inventor
Rosaria Galli
Original Assignee
Rosaria Galli & C. S.A.S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITGE910070A external-priority patent/IT1249094B/it
Priority claimed from IT91GE98 external-priority patent/IT1253171B/it
Application filed by Rosaria Galli & C. S.A.S. filed Critical Rosaria Galli & C. S.A.S.
Publication of WO1992020455A1 publication Critical patent/WO1992020455A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/02—Membranes or pistons acting on the contents inside the container, e.g. follower pistons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/109—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle the dispensing stroke being affected by the stored energy of a spring
    • B05B11/1092—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle the dispensing stroke being affected by the stored energy of a spring automatically released from a loaded state at the end of the loading stroke

Definitions

  • the container/dispenser packs being marketed presently are based on manually-actuated mechanical systems wherein the user's depression of the slider which transfers the thrust to the pump mainly affects the quality of the dispensation. If, for example, the slider is depressed slowly, the dispensation is unsuitable, i.e. dropwise, with a not atomized jet or the like, which compromises the uniform distribution over the nose mucosa and is detrimental to the absorption of the medicament. Therefore, the problem to be solved is how to render the quality of dispensation independent of the amount and the speed of depression exerted by the user onto the slider of the control head; the article of the invention aims to solve this problem.
  • control head of the present invention constitutes the control and atomization manual system for the assembly of the medicament administering pack; the container and the pump arranged therein, with the sealed portion provided with a protruding cylindrical attachment neck, are unchanged.
  • the proposed control assembly will be normally introduced into said neck in ⁇ gu of any other known assembly; however, thanks to a self-actuated and self-loaded snap system, it has the peculiarity of ensuring a perfect atomized and dosed dispensation as desired, regardless of the pressure or actuation speed on the slider.
  • the basic principle of the invention is based on the use of a spring-loaded self- actuated mechanical system which during the actuation stroke comprises a first spring-loading step and a successive automatic snap-release of the stored energy, which actuates the dispensing and dosing pump automatically, constantly and independently.
  • the mechanism developed for this automatic snap-release at the end of the stroke comprises a resilient elastic element which tends, or is forced, to change its shape and position to permit the unlocking and release of the tension stored in the spring while being loaded.
  • This resilient element can be provided with different shapes, as under described, while mantaining its detent function unchanged.
  • Fig. 1 is a fragmentary axial sectional view of the ultidose container/dispenser assembly being concerned, with a manually-controlled and automatically snap-actuated head according to the invention;
  • Fig. 2 is a fragmentary enlarged axial sectional view of the head of Fig. 1 prior to the actuating stroke and loading of the compression coil spring;
  • Fig. 3 is a view similar to Fig. 2, with the system in the position when the snap actuation for dispensation has occurred;
  • Fig. 4 is a fragmentary side elevational and partly axial sectional view similar to Fig. 1, of a modified embodiment with a resilient self-release expansion- effective member, in its rest condition;
  • Fig. 5 is a view similar to Fig. 4 at the end of the dispensing step effected by the snap-release of the spring as a result of the compression, through the supporting bush, of the resilient member so as to eliminate its opposing action;
  • Fig. 6 is a view similar to Fig. 4 of a slightly modified embodiment, i.e. comprising an outer sleeve in the form of an internal annular ridge integral with the body constituting the slider of the atomizing assembly and adapted to compress the resilient member;
  • Fig. 7 is a view similar to Fig. 6, with the parts in the condition at the end of the dispensing step, i.e. after the self-release of the previously-loaded spring;
  • Fig. 8 is a fragmentary side elevational and partly axial sectional view of an atomizing head according to the present invention, as a modification for application on single-use atomizers, the components being in the rest condition, i.e. before the spring is loaded;
  • Fig. 9 is a view similar to Fig. 8, the components being in the position occurring at the end of the dispensing step, i.e. after the self-release of the previously-loaded spring;
  • Fig. 10 is a fragmentary side elevational view of a guide bush wherein, as a detail modification, the resilient member is molded integral with said bush;
  • Fig. 11 is a sectional plan view on the line B-B of the Fig. 10;
  • Fig. 12 is a view similar to Fig. 8 of a single-use atomizing head with a modified release system based on the use of an opposing resilient member in the form of shaped slitted bush instead of a ring;
  • Fig. 13 is a fragmentary side sectional view of the resilient shaped bush of Fig. 12;
  • the container/dispenser for multi-dose endo-nasal administration substantially comprises a container 1 having inserted therein a conventional sealed pump with a protruding cylindrical neck 2 and a feeding tube 3 for the solution to be dispensed; on said cylindrical neck there can be locked any known system of control and atomization head.
  • a head which is constructed as proposed by the invention, said head comprising a cylindrical tubular body 4 having the atomizing nozzle 12 on the top thereof, a supporting bush 6, an outer sleeve 7 provided with depending resilient projections 8, a compression spring 9 and, finally, a slider 10 with depression and grip radial planar extensions 11.
  • a head which is constructed as proposed by the invention, said head comprising a cylindrical tubular body 4 having the atomizing nozzle 12 on the top thereof, a supporting bush 6, an outer sleeve 7 provided with depending resilient projections 8, a compression spring 9 and, finally, a slider 10 with depression and grip radial planar extensions 11.
  • the compression spring 9 which rests on a lower shoulder of the tubular body 4 is released though having, anyway, the capability of keeping the slider 10 in the raised position.
  • the bush 6 has a resilient abutment element 5, operating in a slotted groove in "Seeger” ring fashion, in a protruding position wherein it opposes the descent of the cylindrical tubular body 4.
  • the resilient ring 5, in this position is obliged to protrude inwardly of the sleeve 7.Therefore, by depressing the slider 10 downwards for use, at the beginning of the stroke thereof, thanks to the pre- established clearance indicated at "A", the spring 9 is depressed and is loaded, while the other parts keep still due to the locking action of the ring 5.
  • the inside planar portion of the slider 10 which is of cup-shape, abuts against the circular top end of the sleeve 7 and moves it downwards.
  • said sleeve 7 is formed with a circular enlargement which, as seen in Fig. 3, upon reaching the level of the resilient ring 5, permits the latter to expand.
  • the inward protruding portion of the ring is retracted and the cylindrical tubular body 4, due to the action of the loaded spring 9, moves downwards with a strong snap action and causes the dispensation through the atomizing nozzle 12, said dispensation being always constant and independent of how the user has depressed the slider 10 of the head.
  • a threaded sleeve 13 or any other means having the same effect is fitted on the end of the cylindrical tubular body 4.
  • the sleeve 7 is provided at the bottom with an inwardly protruding rim 7a which, in detent fashion, engages a corresponding shoulder on the supporting bush 6.
  • Figs. 4 and 5 show a modification wherein the resilient element 105 is normally in an expanded position and is accomodated in a circular groove made on the lower collar of the cylindrical tubular body 104.
  • the outer sleeve 107 is provided with an upper inner edge.
  • Figs. 6 and 7 show a further detail modification wherein an annular ridge 207 molded integrally in the interior of the slider 210 substitutes for the outer sleeve 107.
  • Said ridge 207 has the same outline as the upper inner edge of the sleeve 107 and ensure the same function thereof, with the advantage of eliminating a separate component.
  • the system can be applied, still in the field of atomizing dispensers for medicaments to be administered in endo-nasal manner, with the same advantages, to the kwown single-dose or single-use packs.
  • the main body 312 of the dispenser and the cylindrical housing 310 associated therewith constitute the basic portions and enclose the tubular member 303 having at the top the atomizing nozzle and at the bottom the pumping plunger operating in the container 301 containing the dose of solution to be dispensed and which is axially slidably inserted in the tubular member 303. Externally thereof is also axially mounted the bush 306 having the task of guiding the housing 310 with respect to the container 301 with a stroke which is limited by suitable stops.
  • a coil spring 309 Arranged between the bottom of the cup-shaped housing 310 and the closed end of the container 301 is a coil spring 309 having the function to effect, after the manual loading and as a result of the self-release, the snap-release for the atomized dispensation of the packed substance.
  • the self-release occurs according to the basic principle of the invention, i.e. by the action of a resilient annular member 305 accomodated in a suitable seat in the bush 306 and tending to protrude towards the inner wall 307 of the housing 310 which, however, in the rest condition and successively in the loaded condition (Fig. 8), opposes its expansion.
  • the resilient member 305 in this instance of flattened round section, protrudes inwardly and prevents the centering cup 304 for the spring 309 mounted on the container 301, from advancing and effecting the dispensing stroke.
  • the single-use pack is grasped as usual, with the thumb against the bottom of the housing 310.
  • the latter is moved as shown by the arrow and the spring 309 is loaded until (Fig. 9) the member 305 may expand into the larger diameter chamber of the housing inner wall 307 and, therefore, ceases protruding inwardly, thus releasing immediately the components 305 and 304 which, urged by the loade spring 309, will be advanced suddenly and will cause an energetic dispensation and a perfect atomization.
  • Figs. 10 and 11 show a modification wherein the annular resilient member is molded integrally with the guiding sleeve.
  • the bush 406 similar to the original bush indicated at 6 in the Figs. 1,2,3 and at 306 in the Figs.
  • a suitable level has two slits to form integrally, in the thickness of the wall, two resilient ring segments 405 which are provided at the respective free ends, with a suitable protrusion 400 each having the function of bearing against the sleeve 7 or the housing wall 307, or against the cylindrical tubular element 4 or the cup 304 so as to act like the resilient member or ring 5 or 305 and substitute for it.
  • the bush 306 and the resilient element 305 are replaced with a slitted resilient tubular member 506 shown in the detail Figs. 13 and 14, which thanks to a shaped edge 505,- in the rest condition, bears against the inner side of the slider 512.
  • the member 506 has fitted axially slidably thereon the mouth of the housing 510 and the spring 509 bears against said housing.
  • the operation of the self- release is simple: upon depression for use against the bottom of the housing 510 to cause it to advance along the cylindrical portion of the member 506, the spring 509 is loaded. On completion of this stroke, the edge 507 of the mouth of the housing 510 engages the outer shaped slitted collar 505 of the resilient member and depresses it up to a 5 level to make it lose its abutted condition, whereupon the assembly is snapped forward and causes the finely atomized dispensation as required.
  • the slitted resilient tubular member 506 may be constructed of different shapes and with a larger number of sectors and
  • the resilient member 506 is replaced with a cylindrical sleeve 606 on the upper end of which rests a slitted annular resilient member 605 having a shaped and externally conical edge which

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  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)

Abstract

L'invention se rapporte à un système à actionnement mécanique automatique pour des emballages de produits pharmaceutiques particuliers dont le contenu doit être administré sous la forme d'un spray atomisé en petites doses précises. Généralement, ces emballages sont soit du type à usage multiple soit du type jetable et contiennent une pompe doseuse qu'on actionne manuellement avec une force donnée pour assurer une parfaite atomisation. Toutefois, tous les patients ne parviennent pas à exercer ou à mesurer cette force avec précision, ce qui entraîne des décharges insuffisantes ou pas suffisamment atomisées. Le système de la présente invention vise à éviter cet inconvénient en utilisant une tête à actionnement automatique sollicitée par ressort présentant une première phase d'actionnement manuel pour charger le ressort (9) et une phase suivante de déclenchement par déclic sous l'action d'un organe de déclenchement mécanique automatique (5, 6, 7) situé à l'extrémité de la course d'actionnement de la pompe de décharge, laquelle peut par conséquent être actionnée avec la force nécessaire exacte pour une atomisation optimale, cette force ne dépendant que du bon choix du ressort (9).
PCT/IT1992/000050 1991-05-17 1992-05-15 Systeme a actionnement mecanique automatique pour distributeurs atomiseurs de medicaments WO1992020455A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
ITGE91A000070 1991-05-17
ITGE910070A IT1249094B (it) 1991-05-17 1991-05-17 "testina di azionamento per erogatore-nebulizzatore di farmaci con sistema meccanico incorporato di autocomando per spinta e dosaggio della pompa inserita nel contenitore"
ITGE91A000098 1991-07-25
IT91GE98 IT1253171B (it) 1991-07-25 1991-07-25 Sistema meccanico di autoazionamento per erogatori-nebulizzatori di farmaci confezionati in contenitori provvisti di pompa incorporata.

Publications (1)

Publication Number Publication Date
WO1992020455A1 true WO1992020455A1 (fr) 1992-11-26

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PCT/IT1992/000050 WO1992020455A1 (fr) 1991-05-17 1992-05-15 Systeme a actionnement mecanique automatique pour distributeurs atomiseurs de medicaments

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Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993018812A1 (fr) * 1992-03-25 1993-09-30 Tebro S.A. Distributeur a jet de poudre pour traitements par inhalation de medicament
GB2291135A (en) * 1994-07-06 1996-01-17 Boehringer Ingelheim Kg Device for dispensing fluid
WO1997020590A1 (fr) * 1995-12-05 1997-06-12 Boehringer Ingelheim International Gmbh Mecanisme de blocage destine a un dispositif actionne par un ressort
US5819730A (en) * 1993-06-09 1998-10-13 Glaxo Wellcome Australia Ltd. Device for administering pharmaceutical substances
NL1008999C2 (nl) * 1998-04-24 1999-10-26 Vendor Bv Vloeistofverstuiver.
EP0925799A3 (fr) * 1997-12-18 2000-03-08 Daniel Py Dispositif d'actionnement pour diffuseur de médicament
WO2002030503A1 (fr) * 2000-10-11 2002-04-18 Astrazeneca Ab Dispositif de distribution
WO2002030504A1 (fr) * 2000-10-11 2002-04-18 Astrazeneca Ab Dispositif d'administration
US6510847B1 (en) 1999-07-12 2003-01-28 Astrazeneca Ab Delivery device
EP1616629A1 (fr) * 2004-07-13 2006-01-18 Ing. Erich Pfeiffer GmbH Dispositif d'actionnement pour distributeur de fluides
US7070071B2 (en) 2002-09-23 2006-07-04 Agouron Pharmaceuticals, Inc. Dispensing apparatus and method for liquid products, particularly medicinal products
WO2013054076A1 (fr) * 2011-10-11 2013-04-18 Consort Medical Plc Dispositif de distribution de fluide
US10272213B2 (en) 2013-07-19 2019-04-30 Consort Medical Plc Fluid delivery device
US10370175B2 (en) 2012-07-30 2019-08-06 P.C.O.A. Devices Ltd. Receptacle for containing and dispensing solid medicinal pills
US10399725B2 (en) 2012-07-05 2019-09-03 P.C.O.A. Devices Ltd. Medication dispenser
US10456332B2 (en) 2014-06-22 2019-10-29 P.C.O.A. Devices Ltd. Controlled dosage form-dispensing system
US10952928B2 (en) 2015-04-20 2021-03-23 Dosentrix Ltd. Medication dispenser depilling mechanism
US11264125B2 (en) 2015-10-15 2022-03-01 Dosentrx, Ltd. Image recognition-based dosage form dispensers
US11458072B2 (en) 2015-11-02 2022-10-04 Dosentrx Ltd. Lockable advanceable oral dosage form dispenser containers

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3140803A (en) * 1961-02-20 1964-07-14 Felton W Ebersole Liquid pump adapted for fireextinguishing, etc.
DE1804838A1 (de) * 1968-10-24 1970-06-11 Schlossar Edmund Fluessigkeitszerstaeuber mit handbetaetigter Druckerzeugungseinrichtung
US4083476A (en) * 1973-11-30 1978-04-11 Boehringer Ingelheim Gmbh Snap device for manually actuated liquid-atomizing pumps
EP0021123B1 (fr) * 1979-06-08 1983-07-20 Hoechst Aktiengesellschaft Pulvérisateur
EP0127573A1 (fr) * 1983-04-15 1984-12-05 Cws Ag Générateur d'aérosol

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3140803A (en) * 1961-02-20 1964-07-14 Felton W Ebersole Liquid pump adapted for fireextinguishing, etc.
DE1804838A1 (de) * 1968-10-24 1970-06-11 Schlossar Edmund Fluessigkeitszerstaeuber mit handbetaetigter Druckerzeugungseinrichtung
US4083476A (en) * 1973-11-30 1978-04-11 Boehringer Ingelheim Gmbh Snap device for manually actuated liquid-atomizing pumps
EP0021123B1 (fr) * 1979-06-08 1983-07-20 Hoechst Aktiengesellschaft Pulvérisateur
EP0127573A1 (fr) * 1983-04-15 1984-12-05 Cws Ag Générateur d'aérosol

Cited By (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5546932A (en) * 1992-03-25 1996-08-20 Tebro Sa Powder jet dispenser for medicament inhalation therapies
WO1993018812A1 (fr) * 1992-03-25 1993-09-30 Tebro S.A. Distributeur a jet de poudre pour traitements par inhalation de medicament
US5819730A (en) * 1993-06-09 1998-10-13 Glaxo Wellcome Australia Ltd. Device for administering pharmaceutical substances
GB2291135A (en) * 1994-07-06 1996-01-17 Boehringer Ingelheim Kg Device for dispensing fluid
GB2291135B (en) * 1994-07-06 1998-02-25 Boehringer Ingelheim Kg Device for dispensing fluid
AU716773B2 (en) * 1995-12-05 2000-03-09 Boehringer Ingelheim International Gmbh Locking/stressing mechanism for a spring-actuated device
US6453795B1 (en) 1995-12-05 2002-09-24 Boehringer Ingelheim International Gmbh Locking mechanism for a spring-actuated device
KR100448746B1 (ko) * 1995-12-05 2004-12-23 베링거 인겔하임 인터내셔날 게엠베하 스프링작동식장치용록킹메카니즘
WO1997020590A1 (fr) * 1995-12-05 1997-06-12 Boehringer Ingelheim International Gmbh Mecanisme de blocage destine a un dispositif actionne par un ressort
EP0925799A3 (fr) * 1997-12-18 2000-03-08 Daniel Py Dispositif d'actionnement pour diffuseur de médicament
USRE45589E1 (en) 1997-12-18 2015-06-30 Dr. Py Institute Llc One-way actuation release mechanism for a system for applying medicament
EP2058023A3 (fr) * 1997-12-18 2011-01-05 PY, Daniel Mécanisme d'actionnement pour distributeur de médicaments
USRE43329E1 (en) 1997-12-18 2012-04-24 Medical Instill Technologies, Inc. One-way actuation release mechanism for a system for applying medicament
NL1008999C2 (nl) * 1998-04-24 1999-10-26 Vendor Bv Vloeistofverstuiver.
US6510847B1 (en) 1999-07-12 2003-01-28 Astrazeneca Ab Delivery device
WO2002030503A1 (fr) * 2000-10-11 2002-04-18 Astrazeneca Ab Dispositif de distribution
WO2002030504A1 (fr) * 2000-10-11 2002-04-18 Astrazeneca Ab Dispositif d'administration
US7070071B2 (en) 2002-09-23 2006-07-04 Agouron Pharmaceuticals, Inc. Dispensing apparatus and method for liquid products, particularly medicinal products
EP1616629A1 (fr) * 2004-07-13 2006-01-18 Ing. Erich Pfeiffer GmbH Dispositif d'actionnement pour distributeur de fluides
CN103889587A (zh) * 2011-10-11 2014-06-25 和谐医疗有限公司 流体输送装置
WO2013054076A1 (fr) * 2011-10-11 2013-04-18 Consort Medical Plc Dispositif de distribution de fluide
US9314808B2 (en) 2011-10-11 2016-04-19 Consort Medical Plc Fluid delivery device
US10399725B2 (en) 2012-07-05 2019-09-03 P.C.O.A. Devices Ltd. Medication dispenser
US10370175B2 (en) 2012-07-30 2019-08-06 P.C.O.A. Devices Ltd. Receptacle for containing and dispensing solid medicinal pills
US10272213B2 (en) 2013-07-19 2019-04-30 Consort Medical Plc Fluid delivery device
US10456332B2 (en) 2014-06-22 2019-10-29 P.C.O.A. Devices Ltd. Controlled dosage form-dispensing system
US10952928B2 (en) 2015-04-20 2021-03-23 Dosentrix Ltd. Medication dispenser depilling mechanism
US11264125B2 (en) 2015-10-15 2022-03-01 Dosentrx, Ltd. Image recognition-based dosage form dispensers
US11458072B2 (en) 2015-11-02 2022-10-04 Dosentrx Ltd. Lockable advanceable oral dosage form dispenser containers

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