WO1992016623A3 - Recepteur pour peptide analogue a la bombesine - Google Patents

Recepteur pour peptide analogue a la bombesine Download PDF

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Publication number
WO1992016623A3
WO1992016623A3 PCT/US1992/002091 US9202091W WO9216623A3 WO 1992016623 A3 WO1992016623 A3 WO 1992016623A3 US 9202091 W US9202091 W US 9202091W WO 9216623 A3 WO9216623 A3 WO 9216623A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptors
bombesin
peptides
disclosed
purified
Prior art date
Application number
PCT/US1992/002091
Other languages
English (en)
Other versions
WO1992016623A2 (fr
Inventor
James F Battey Jr
Martha H Corjay
Zahra Fathi
Richard I Feldman
Richard N Harkin
Timothy K Slattery
Etsuko Wada
James M Wu
Original Assignee
Berlex Lab
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Berlex Lab, Us Health filed Critical Berlex Lab
Priority to JP4510596A priority Critical patent/JPH06509940A/ja
Publication of WO1992016623A2 publication Critical patent/WO1992016623A2/fr
Publication of WO1992016623A3 publication Critical patent/WO1992016623A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/286—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against neuromediator receptors, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Des récepteurs pour des peptides analogues à la bombesine sont solubilisés et purifiés sous leur forme active. L'invention concerne des séquences d'acides aminés et l'ADN codant différents sous-types de ces récepteurs. L'invention concerne également les utilisations faites du gène récepteur et du polypeptide purifiés, y compris des moyens de criblage des agonistes et des antagonistes des ligands du récepteur, pour produire des réactifs de diagnostic ou thérapeutiques, et pour produire des anticorps. L'invention concerne en outre des kits et des réactifs de diagnostic ou thérapeutiques.
PCT/US1992/002091 1991-03-15 1992-03-13 Recepteur pour peptide analogue a la bombesine WO1992016623A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4510596A JPH06509940A (ja) 1991-03-15 1992-03-13 ボンベシン様ペプチドに対するレセプター

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US67060391A 1991-03-15 1991-03-15
US670,603 1991-03-15
US77133291A 1991-10-03 1991-10-03
US771,332 1991-10-03

Publications (2)

Publication Number Publication Date
WO1992016623A2 WO1992016623A2 (fr) 1992-10-01
WO1992016623A3 true WO1992016623A3 (fr) 1992-10-29

Family

ID=27100353

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1992/002091 WO1992016623A2 (fr) 1991-03-15 1992-03-13 Recepteur pour peptide analogue a la bombesine

Country Status (5)

Country Link
EP (1) EP0576609A1 (fr)
JP (1) JPH06509940A (fr)
AU (1) AU1793092A (fr)
CA (1) CA2105306A1 (fr)
WO (1) WO1992016623A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106132993A (zh) * 2014-03-27 2016-11-16 兹耶尔生物科学研究,开发和诊断有限公司 抗胃泌素释放肽受体(grpr)抗体,获得的过程,检测过程，抗体使用,试剂和基因构建

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6190912B1 (en) * 1998-03-31 2001-02-20 Thomas Jefferson University Blk genes and uses thereof in apoptosis
US6143521A (en) * 1998-07-22 2000-11-07 Smithkline Beecham Corporation Human bombesin receptor subtype-3sb
GB9925115D0 (en) * 1999-10-22 1999-12-22 Pfizer Ltd Novel polypeptide
AU2003240469A1 (en) * 2002-05-02 2003-11-17 Bayer Aktiengesellschaft Diagnostics and therapeutics for diseases associated with neuromedin b receptor (nmb)
US9757330B2 (en) 2013-10-18 2017-09-12 Industrial Technology Research Institute Recipe for in-situ gel, and implant, drug delivery system formed thereby

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989009232A1 (fr) * 1988-03-21 1989-10-05 Imperial Cancer Research Technology Ltd. Antagonistes aux neuropeptides
WO1991006647A1 (fr) * 1989-10-24 1991-05-16 Triton Biosciences, Inc. Recepteur de peptides a liberation de gastrine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989009232A1 (fr) * 1988-03-21 1989-10-05 Imperial Cancer Research Technology Ltd. Antagonistes aux neuropeptides
WO1991006647A1 (fr) * 1989-10-24 1991-05-16 Triton Biosciences, Inc. Recepteur de peptides a liberation de gastrine

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
MOLECULAR ENDOCRINOLOGY vol. 4, no. 12, December 1990, BALTIMORE MD, USA pages 1956 - 1963; E. SPINDEL ET AL.: 'Cloning and functional characterization of a complementary DNA encoding the murine fibroblast bombesin/gastrin-releasing peptide receptor.' *
NEURON vol. 6, no. 3, March 1991, pages 421 - 430; E. WADA ET AL.: 'cDNA cloning, characterization, and brain region-specific expression of a neuromedin-b-preferring bombesin receptor.' cited in the application *
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE USA vol. 88, no. 2, 15 January 1991, WASHINGTON DC, USA pages 395 - 399; J. BATTEY ET AL.: 'Molecular cloning of the bombesin/gastrin-releasing peptide receptor from Swiss 3T3 cells.' cited in the application *
THE JOURNAL OF BIOLOGICAL CHEMISTRY vol. 262, no. 23, 15 August 1987, BALTIMORE MD, USA pages 11215 - 11220; R. KRIS ET AL.: 'Identification of the bombesin receptor on murine and human cells by cross-linking experiments.' cited in the application *
THE JOURNAL OF BIOLOGICAL CHEMISTRY. vol. 266, no. 28, 5 October 1991, BALTIMORE MD, US pages 18771 - 18779; M. CORJAY ET AL.: 'Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells.' *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106132993A (zh) * 2014-03-27 2016-11-16 兹耶尔生物科学研究,开发和诊断有限公司 抗胃泌素释放肽受体(grpr)抗体,获得的过程,检测过程，抗体使用,试剂和基因构建

Also Published As

Publication number Publication date
EP0576609A1 (fr) 1994-01-05
AU1793092A (en) 1992-10-21
CA2105306A1 (fr) 1992-09-16
WO1992016623A2 (fr) 1992-10-01
JPH06509940A (ja) 1994-11-10

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