WO1992011866A1 - SEQUENCE DE LAMININE UTILES COMME ACTIVATEUR DE tPA - Google Patents

SEQUENCE DE LAMININE UTILES COMME ACTIVATEUR DE tPA Download PDF

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Publication number
WO1992011866A1
WO1992011866A1 PCT/US1992/000353 US9200353W WO9211866A1 WO 1992011866 A1 WO1992011866 A1 WO 1992011866A1 US 9200353 W US9200353 W US 9200353W WO 9211866 A1 WO9211866 A1 WO 9211866A1
Authority
WO
WIPO (PCT)
Prior art keywords
sequence
peptide
laminin
tpa
plasminogen activator
Prior art date
Application number
PCT/US1992/000353
Other languages
English (en)
Inventor
Salvatore V. Pizzo
Sharon Stack
Original Assignee
Duke University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duke University filed Critical Duke University
Publication of WO1992011866A1 publication Critical patent/WO1992011866A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/12—Polypeptides, proteins or derivatives thereof, e.g. degradation products thereof
    • A61L33/128—Other specific proteins or polypeptides not covered by A61L33/122 - A61L33/126

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Materials Engineering (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Une séquence de laminine de C-S-R-A-R-K-Q-A-A-S-I-K-V-A-V-S-A-D-R-NH2 ou ses analogues sont utilisés en association avec le tPA pour augmenter considérablement l'activation de plasminogène par le tPA. Des formulations combinent le fragment de laminine ou son analogue avec le tPA ou son analogue fonctionnel pour être administré à des niveaux sensiblement inférieurs à ceux requis par le tPA lui-même tout en assurant une protection contre les embolies.
PCT/US1992/000353 1991-01-14 1992-01-14 SEQUENCE DE LAMININE UTILES COMME ACTIVATEUR DE tPA WO1992011866A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64061691A 1991-01-14 1991-01-14
US640,616 1991-01-14

Publications (1)

Publication Number Publication Date
WO1992011866A1 true WO1992011866A1 (fr) 1992-07-23

Family

ID=24568983

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1992/000353 WO1992011866A1 (fr) 1991-01-14 1992-01-14 SEQUENCE DE LAMININE UTILES COMME ACTIVATEUR DE tPA

Country Status (1)

Country Link
WO (1) WO1992011866A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009033731A3 (fr) * 2007-09-11 2009-09-03 Mondobiotech Laboratories Ag Utilisation d'un peptide comme agent thérapeutique

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4839169A (en) * 1986-08-05 1989-06-13 Burroughs Wellcome Co. Synergistic combination of t-PA and prostacyclin
US4968617A (en) * 1985-05-28 1990-11-06 Burroughs Wellcome Co. Solid hydrochloride salt of t-PA

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4968617A (en) * 1985-05-28 1990-11-06 Burroughs Wellcome Co. Solid hydrochloride salt of t-PA
US4839169A (en) * 1986-08-05 1989-06-13 Burroughs Wellcome Co. Synergistic combination of t-PA and prostacyclin

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BIOCHEMISTRY, Vol. 29, issued 02 May 1990, STACK et al., "Regulation of Plasminogen Activation by Components of the Extracellular Matrix", pages 4966-4970. *
FEBS, Vol. 172, issued June 1984, SALONEN et al., "Laminin Interacts with Plasminogen and its Tissue-type Activators", pages 29-32. *
JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 260, No. 18, issued 25 August 1985, SILVERSTEIN el al., "Activation of Immobilized Plasminogen by Tissue Activator", pages 10346-10352. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009033731A3 (fr) * 2007-09-11 2009-09-03 Mondobiotech Laboratories Ag Utilisation d'un peptide comme agent thérapeutique

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