WO1992007825A1 - Derive de phenol - Google Patents

Derive de phenol Download PDF

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Publication number
WO1992007825A1
WO1992007825A1 PCT/JP1991/001506 JP9101506W WO9207825A1 WO 1992007825 A1 WO1992007825 A1 WO 1992007825A1 JP 9101506 W JP9101506 W JP 9101506W WO 9207825 A1 WO9207825 A1 WO 9207825A1
Authority
WO
WIPO (PCT)
Prior art keywords
compound
butyl
carbon atoms
formula
group
Prior art date
Application number
PCT/JP1991/001506
Other languages
English (en)
Japanese (ja)
Inventor
Masakazu Sato
Yutaka Kawashima
Katsuo Hatayama
Original Assignee
Taisho Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisho Pharmaceutical Co., Ltd. filed Critical Taisho Pharmaceutical Co., Ltd.
Publication of WO1992007825A1 publication Critical patent/WO1992007825A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms

Definitions

  • the alkyl group is a linear or branched alkyl group, for example, a methyl group, an ethyl group, a butyl group, an isopropyl group, a butyl group, an isobutyl group, a t-butyl group. It is.
  • the alkoxy group is a linear or branched alkoxy group, for example, a methoxy group, an ethoxy group, a propoxy group, an isopropoxy group, a butoxy group, an isobutoxy group, and a t-butoxy group.
  • the alkylene group is a linear or branched alkylene group, such as a dimethylene group, an ethylene group, a trimethylene group, a dimethylmethylene group, and a tetramethylene group.
  • Preferred compounds of the formula I of the present invention are the compounds shown in the examples, and more preferably N- [2- (3.5-di-tert-butyl-4-hydroxyphenylthio) acetyl] -1. 6-diisoproviraniline, N— [2- (3.5-di-tert-butyl-4-hydroxyphenylthio) acetyl] —2,4,6-trimethoxyaniline, ⁇ — [3— (3 , 5-di-tert-butyl-4-hydroxyphenylthio) provinyl] -1,2,6-diisopropylaniline, N— [2- ⁇ 6 -— ((3,5-di-tert-butyl-4-hydroxy) Enyl) thi] hexylthio ⁇ acetyl] 1,2,6-diisopropylaniline and N— [2- ⁇ 6 — [(3.5-di-t-butyl-1 4—hydroxyphenyl)] [

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un dérivé de phénol et son sel sont représentés par la formule générale (I) dans laquelle X représente un alkyle de C1 à C4 ou un alcoxy de C1 à C4; Y représente hydrogène ou un alcoxy de C1 à C4; et A représente alkylène de C1 à C4, etc. Ces composés ont une action d'inhibition de ACAT et la formation de peroxyde lipide et sont utiles comme remède pour soigner l'artériosclérose.
PCT/JP1991/001506 1990-11-05 1991-11-02 Derive de phenol WO1992007825A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP29926890 1990-11-05
JP2/299268 1990-11-05

Publications (1)

Publication Number Publication Date
WO1992007825A1 true WO1992007825A1 (fr) 1992-05-14

Family

ID=17870345

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1991/001506 WO1992007825A1 (fr) 1990-11-05 1991-11-02 Derive de phenol

Country Status (1)

Country Link
WO (1) WO1992007825A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998043626A1 (fr) * 1997-04-01 1998-10-08 Taisho Pharmaceutical Co., Ltd. Medicaments s'opposant a la reconstriction
WO1998043627A1 (fr) * 1997-04-01 1998-10-08 Taisho Pharmaceutical Co., Ltd. Medicaments preventifs contre des affections d'ischemie cardiaque
EP0987254A1 (fr) * 1997-05-26 2000-03-22 Kowa Co., Ltd. Nouveaux composes de diamine cycliques et medicament contenant ces composes
WO2001025193A1 (fr) * 1999-10-04 2001-04-12 Nippon Soda Co., Ltd. Composes phenoliques et supports d'enregistrement les contenant
US6969711B2 (en) 1997-05-26 2005-11-29 Kowa Company, Ltd. Cyclic diamine compounds and medicine containing the same
JP2021512879A (ja) * 2018-01-30 2021-05-20 デモテック．インコーポレイテッド プロブコール誘導体及びその調製方法と使用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61197554A (ja) * 1985-02-04 1986-09-01 ジー．デイ．サール　アンド　コンパニー 新規アニリド
JPH0395154A (ja) * 1989-06-29 1991-04-19 Shionogi & Co Ltd ［ジ―ｔｅｒｔ―ブチル（ヒドロキシ）フェニルチオ］置換ヒドロキサム酸誘導体

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61197554A (ja) * 1985-02-04 1986-09-01 ジー．デイ．サール　アンド　コンパニー 新規アニリド
JPH0395154A (ja) * 1989-06-29 1991-04-19 Shionogi & Co Ltd ［ジ―ｔｅｒｔ―ブチル（ヒドロキシ）フェニルチオ］置換ヒドロキサム酸誘導体

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998043626A1 (fr) * 1997-04-01 1998-10-08 Taisho Pharmaceutical Co., Ltd. Medicaments s'opposant a la reconstriction
WO1998043627A1 (fr) * 1997-04-01 1998-10-08 Taisho Pharmaceutical Co., Ltd. Medicaments preventifs contre des affections d'ischemie cardiaque
EP0987254A1 (fr) * 1997-05-26 2000-03-22 Kowa Co., Ltd. Nouveaux composes de diamine cycliques et medicament contenant ces composes
EP0987254A4 (fr) * 1997-05-26 2000-09-13 Kowa Co Nouveaux composes de diamine cycliques et medicament contenant ces composes
US6969711B2 (en) 1997-05-26 2005-11-29 Kowa Company, Ltd. Cyclic diamine compounds and medicine containing the same
WO2001025193A1 (fr) * 1999-10-04 2001-04-12 Nippon Soda Co., Ltd. Composes phenoliques et supports d'enregistrement les contenant
US7012159B1 (en) 1999-10-04 2006-03-14 Nippon Soda Co., Ltd. Phenolic compounds and recording materials containing the same
JP4583688B2 (ja) * 1999-10-04 2010-11-17 日本曹達株式会社 フェノール性化合物及びそれを用いた記録材料
JP2021512879A (ja) * 2018-01-30 2021-05-20 デモテック．インコーポレイテッド プロブコール誘導体及びその調製方法と使用
JP7146159B2 (ja) 2018-01-30 2022-10-04 デモテック．インコーポレイテッド プロブコール誘導体及びその調製方法と使用

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