WO1991012197A1 - Unit dose assembly - Google Patents
Unit dose assembly Download PDFInfo
- Publication number
- WO1991012197A1 WO1991012197A1 PCT/US1991/000838 US9100838W WO9112197A1 WO 1991012197 A1 WO1991012197 A1 WO 1991012197A1 US 9100838 W US9100838 W US 9100838W WO 9112197 A1 WO9112197 A1 WO 9112197A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- tube
- cap
- applicator
- thin wall
- nozzle
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D51/00—Closures not otherwise provided for
- B65D51/18—Arrangements of closures with protective outer cap-like covers or of two or more co-operating closures
- B65D51/20—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing
- B65D51/22—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing having means for piercing, cutting, or tearing the inner closure
- B65D51/221—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing having means for piercing, cutting, or tearing the inner closure a major part of the inner closure being left inside the container after the opening
- B65D51/222—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing having means for piercing, cutting, or tearing the inner closure a major part of the inner closure being left inside the container after the opening the piercing or cutting means being integral with, or fixedly attached to, the outer closure
-
- A—HUMAN NECESSITIES
- A45—HAND OR TRAVELLING ARTICLES
- A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
- A45D34/00—Containers or accessories specially adapted for handling liquid toiletry or cosmetic substances, e.g. perfumes
- A45D34/04—Appliances specially adapted for applying liquid, e.g. using roller or ball
- A45D34/042—Appliances specially adapted for applying liquid, e.g. using roller or ball using a brush or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M35/00—Devices for applying media, e.g. remedies, on the human body
- A61M35/003—Portable hand-held applicators having means for dispensing or spreading integral media
- A61M35/006—Portable hand-held applicators having means for dispensing or spreading integral media using sponges, foams, absorbent pads or swabs as spreading means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D35/00—Pliable tubular containers adapted to be permanently or temporarily deformed to expel contents, e.g. collapsible tubes for toothpaste or other plastic or semi-liquid material; Holders therefor
- B65D35/24—Pliable tubular containers adapted to be permanently or temporarily deformed to expel contents, e.g. collapsible tubes for toothpaste or other plastic or semi-liquid material; Holders therefor with auxiliary devices
- B65D35/36—Pliable tubular containers adapted to be permanently or temporarily deformed to expel contents, e.g. collapsible tubes for toothpaste or other plastic or semi-liquid material; Holders therefor with auxiliary devices for applying contents to surfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67B—APPLYING CLOSURE MEMBERS TO BOTTLES JARS, OR SIMILAR CONTAINERS; OPENING CLOSED CONTAINERS
- B67B7/00—Hand- or power-operated devices for opening closed containers
- B67B7/24—Hole-piercing devices
-
- A—HUMAN NECESSITIES
- A45—HAND OR TRAVELLING ARTICLES
- A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
- A45D2200/00—Details not otherwise provided for in A45D
- A45D2200/10—Details of applicators
- A45D2200/1009—Applicators comprising a pad, tissue, sponge, or the like
- A45D2200/1018—Applicators comprising a pad, tissue, sponge, or the like comprising a pad, i.e. a cushion-like mass of soft material, with or without gripping means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D2251/00—Details relating to container closures
- B65D2251/0003—Two or more closures
- B65D2251/0006—Upper closure
- B65D2251/0015—Upper closure of the 41-type
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D2251/00—Details relating to container closures
- B65D2251/0003—Two or more closures
- B65D2251/0068—Lower closure
- B65D2251/0093—Membrane
- B65D2251/0096—Membrane integral with the container
Definitions
- This invention relates to a unit dose assembly and more particularly to a cap for use with a tube in which a unit dose is provided in the tube.
- the tube may contain a single dose of medicine, eyewash, disinfectant or other pharmaceutically related product.
- the device is particularly suitable for use with medicaments which need to be topically applied, and is ideal for use with iodine solutions which are used to sterilize and clean skin prior to injections or I-V insertions.
- Cap and tube assemblies which carry medicines and the like have obtained significant interest in the pharmaceutical industry. Not only is there a concern for resistance to undesirable tampering, such as by a child, there is increased interest in application of sterile fluids to the body for various treatment purposes.
- one object of the present invention is to provide a unit dose assembly for topical applications of the contents.
- a cap for a unit dose assembly for topical application which includes the following components.
- a tube containing a unit dose, such as a quantity of iodine for sterilizing or cleaning the skin, is provided with a nozzle having one end mounted on or part of one end of the tube and a thin end wall section on the other end of the nozzle.
- the thin wall section is puncturable to provide a discharge of the contents.
- a major part of the assembly is a cap having a first end with an inside cross section sized to engage the nozzle, the cap has an axially centered puncture means positioned to puncture the thin wall when it is moved from a first position spaced therefrom, during storage, to a second position during use.
- the puncture means includes a central bore for providing access to the contents of the tube.
- the cap includes a second end in communication with the first end through that central bore.
- the second end encloses an applicator for dispensing the contents of the tube, which may be accomplished when the thin wall or membrane is pierced by the puncture means.
- the nozzle and first end of the cap have a ring and groove assembly or other arrangement by which a surface of resistance and an interference surface mutually combine to locate the cap with respect to the tube in the first position.
- the applicator means includes a material capable of expanding when fluid is transferred from the tube to the applicator.
- a preferred material is polyurethane since it can be sterilized, is soft, contains no threads and is Federal Drug Administration approved. Cotton, paper, other wicking materials, felt, sponges and other synthetic foams which have most of these same properties are also useful as applicator materials.
- the applicator and the second end include a means for preventing removal of the applicator during use.
- the entire device is intended to be sterilized.
- the sterile package may be included in a blister pack which can be opened without contacting the sterile inside, for example, and dropped onto a sterile cloth in an operating room.
- a removable cover means may be placed on the second end, such as a peel off cover, to protect the applicator from contamination.
- Fig. 1 is a perspective view of a tubular plastic unit dose assembly device of the present invention, showing a closed terminal end and a cap on the other end of the tube.
- Fig. 2 is an enlarged, fragmentary sectional elevational view taken along the line 2,2 of Fig. 1.
- Fig. 3 is a view similar to that to Fig. 2, but showing the outer cap member moved forcefully downward, upon the neck portion of the tube, driving the piercing point through the thin wall, creating an opening by which the medicament may be dispensed.
- Fig. 4 is a greatly enlarged view of the detail contained within the dot and dash circle of Fig. 3 and designated Fig. 4., showing the details of the applicator portion of the design.
- Fig. 5 is a perspective view of a preferred embodiment of this invention, shown in a package.
- a unit dose assembly for topical applications shown generally by the reference numeral 10 includes a tube portion 11 which is sealed at one end 13 after a quantity of medicament has been placed inside the tube 11.
- the tube 11 has a nozzle 15 at the other end, and the nozzle 15 is fitted with a cap 17.
- the cap 17 has an upper compartment 19 and lower compartment 21.
- the lower compartment 21 includes a piercing means 23 which is supported by the divider disc 25.
- Divider disc 25 separates the upper compartment 19 and the lower compartment 21.
- the piercer 23 includes an orifice 27 through the piercer 23, which permits transfer of the contents of the tube 11 from the lower compartment 21 to the upper compartment 19.
- the nozzle 15 is joined at one end to the tube 11 and at the other end is provided with a nozzle tip 29.
- Nozzle tip 29 includes a thin wall portion 31, which is of sufficient thickness to prevent the contents of the tube 11 from being removed until the membrane 31 is penetrated.
- the cap 17 is located in a first position on the nozzle 15 by a groove 33 and ring 35. This combination of ring and groove provides a surface of resistance in the groove and an interference surface in the ring. Of course, the ring 35 can be placed on the cap 17 and the groove on the nozzle 15 if desired.
- the upper portion 19 of the cap 17 is preferably filled with a material which is suitable for use as an applicator.
- a material which is suitable for use as an applicator Polyurethane foam and other synthetic foam materials, felt, sponges, paper and other wicking materials, cotton, and other soft materials can be used, depending upon the material contained in the tube and the use for which it is intended. It is preferred to use a polyurethane foam, or something similar, which can be sterilized, such as by gamma radiation, and which is soft, has no threads, and is FDA approved.
- the applicator material 37 will expand slightly due to its being filled with the fluid.
- a liquid has entered the urethane foam 37 and extends out beyond the end of the upper compartment 19.
- This expansion of the foam 37 can also take place in the dry form, prior to puncturing the thin wall membrane 31.
- an optional cover 39 shown in Fig. 2 can maintain the applicator material 37 under compression until it is removed and the system is activated. Then, the applicator material 37 will expand as shown in Figs. 3 and 4.
- the applicator material 37 can be bonded, by heat or adhesive for example, to the dividing wall 25 separating the upper compartment 19 from the rest of the cap 17. Care should obviously be exercised to prevent plugging the hole 27 and no adhesive materials which are not fully approved by the FDA and other agencies should be employed.
- a preferred embodiment of the present invention will incorporate the device in a package, such as a flexible, sterilizable envelope.
- a package such as a flexible, sterilizable envelope.
- the tube 11, cap 17 and exposed applicator material 37 are positioned on a substrate 43 which forms an envelope 45 using conventional technology. Instructions and advertisements can be printed on either the substrate or the blister pack as desired.
- the packaging can be a paper-mylar envelope or a blister pack or other packing which can be sterilized by steam, gamma radiation and the like.
- the device of the present invention will be sterilized prior to use. While there are a variety of ways for sterilizing, such as might be employed in the assembly of the device in its marketable form, it is preferred that the device be assembled and thereafter be sterilized using gamma ray sterilization techniques. Unless the contents of the tube 11 are sensitive to gamma ray sterilization, this is the most effective way to ensure that the entire device is sterile.
- one of the preferred uses for the present invention is to dispense iodine solutions which themselves are used to sterilize and clean skin prior to injection or other surgical procedures, it is contemplated that these devices will be used in an operating room facility.
- the device In the blister pack embodiment, the device has been sterilized and is maintained sterile until it is time for use.
- the exterior envelope 45 and the substrate 43 may be contaminated, however slightly, by the environment, it is contemplated that someone in the operating room will be directly responsible for opening the package and allowing the tube 11 and cap 17 assembly to be removed and placed on a sterile tray without the tube assembly 11 being touched. This is often done by a perimeter nurse.
- the surgeons and assistants who have been sterilized and are wearing sterilized gloves will then pick up the tube 11 in a sterile condition and will not have had to have contacted the outside of a tube that could have been contaminated in any way.
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Health & Medical Sciences (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Closures For Containers (AREA)
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE69108717T DE69108717T2 (en) | 1990-02-08 | 1991-02-07 | SINGLE PORTION PACK. |
BR919105997A BR9105997A (en) | 1990-02-08 | 1991-02-07 | BISNAGA AND COVER SET DEVICE |
EP91904431A EP0513197B1 (en) | 1990-02-08 | 1991-02-07 | Unit dose assembly |
FI923572A FI923572A (en) | 1990-02-08 | 1992-08-10 | ANORDNING FOER ENHETSDOSERING. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US476,689 | 1990-02-08 | ||
US07/476,689 US5042690A (en) | 1990-02-08 | 1990-02-08 | Unit dose assembly |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1991012197A1 true WO1991012197A1 (en) | 1991-08-22 |
Family
ID=23892858
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1991/000838 WO1991012197A1 (en) | 1990-02-08 | 1991-02-07 | Unit dose assembly |
Country Status (8)
Country | Link |
---|---|
US (1) | US5042690A (en) |
EP (1) | EP0513197B1 (en) |
JP (1) | JPH05504319A (en) |
BR (1) | BR9105997A (en) |
CA (1) | CA2075473A1 (en) |
DE (1) | DE69108717T2 (en) |
FI (1) | FI923572A (en) |
WO (1) | WO1991012197A1 (en) |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5307953A (en) * | 1991-12-03 | 1994-05-03 | Glaxo Group Limited | Single dose dispenser having a piercing member |
FR2720281A1 (en) * | 1994-05-26 | 1995-12-01 | Karl Andre Leopold Penalba | Medicinal liquid applicator |
US5819730A (en) * | 1993-06-09 | 1998-10-13 | Glaxo Wellcome Australia Ltd. | Device for administering pharmaceutical substances |
FR2770410A1 (en) * | 1997-10-30 | 1999-05-07 | Aspir | SKIN LIQUID APPLICATOR, CARE KIT, AND CARE DEVICE COMPRISING SAME |
EP0922645A1 (en) * | 1997-12-11 | 1999-06-16 | Gurit-Essex AG | Applicator for low viscosity products |
EP1044625A1 (en) * | 1999-04-16 | 2000-10-18 | L'oreal | Applying capsule and applicator assembly with such a capsule |
WO2000071198A1 (en) | 1999-05-21 | 2000-11-30 | Aspir | Cutaneous applicator with a liquid storage cartridge |
US6942412B2 (en) | 2000-11-07 | 2005-09-13 | L'oréal | Product application device including a dip tube |
US7066674B2 (en) | 2000-11-07 | 2006-06-27 | L'oreal, S.A. | Application device, system, and method |
WO2007070420A1 (en) * | 2005-12-09 | 2007-06-21 | Chemence Inc. | Applicator and tube dispenser for low and high viscosity adhesive components |
US9688444B2 (en) | 2012-11-21 | 2017-06-27 | R.P. Scherer Technologies, Llc | Single use container with dispenser |
AU2016340898B2 (en) * | 2015-10-21 | 2019-08-15 | Boehringer lngelheim Vetmedica GMBH | Storage and dispenser device |
Families Citing this family (95)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5226562A (en) * | 1991-09-11 | 1993-07-13 | Norbert Kirk | Dispenser for glue cartridge |
WO1993009058A1 (en) * | 1991-10-29 | 1993-05-13 | The West Company, Incorporated | Improved tamper evident closure |
US5577851A (en) * | 1993-02-24 | 1996-11-26 | Painter's Products Inc. | Tube dispenser with sponge applicator |
US5469980A (en) | 1994-01-26 | 1995-11-28 | Wheaton Holding, Inc. | Child resistant container closure assembly |
US6379069B1 (en) * | 1994-12-12 | 2002-04-30 | James Alexander Corporation | Dispenser and process |
FR2729920B1 (en) * | 1995-02-01 | 1997-06-06 | Kerplas Snc | BOTTLE BODY AND BOTTLE FOR DISPENSING A PRODUCT |
US5590780A (en) * | 1995-06-22 | 1997-01-07 | Wheaton Holding, Inc. | Unit dose assembly |
US5769552A (en) * | 1996-05-06 | 1998-06-23 | Creative Products, Inc. | Fluid product holding and dispensing system |
US5992668A (en) * | 1996-07-11 | 1999-11-30 | Aptargroup, Inc. | Sealed dispensing closure with a sealed penetrator |
US6488665B1 (en) | 1997-04-08 | 2002-12-03 | Allegiance Corporation | Antimicrobial alcohol gel pre-operative skin-preparation delivery system |
US6126037A (en) * | 1997-09-09 | 2000-10-03 | Merck & Co., Inc. | Flow control orifice |
SE514699C2 (en) * | 1997-09-29 | 2001-04-02 | Asept Int Ab | Portioning device and packaging from which a liquid product, preferably liquid food, is to be dispensed with the aid of the dispensing device and coupling device in said package |
SE515112C2 (en) * | 1997-09-29 | 2001-06-11 | Asept Int Ab | Packaging, ways of making this and coupling for the same |
USD418413S (en) * | 1997-09-29 | 2000-01-04 | Asept International Ab | Connection member for plastic packings |
SE515113C2 (en) | 1997-09-29 | 2001-06-11 | Asept Int Ab | Packaging, ways of making this and coupling for the same |
CA2314900C (en) * | 1997-12-19 | 2009-02-24 | United States Surgical Corporation | Fibrin mixture and dispenser assembly |
US5927549A (en) * | 1998-03-20 | 1999-07-27 | Aptargroup, Inc. | Dispensing structure with frangible membrane for separating two products |
US6045004A (en) * | 1998-03-20 | 2000-04-04 | Aptargroup, Inc. | Dispensing structure with dispensing valve and barrier penetrator |
US5853109A (en) * | 1998-04-29 | 1998-12-29 | Aptargroup, Inc. | Dispensing structure with displaceable penetrator and bistable cover actuator |
US5938363A (en) * | 1998-07-02 | 1999-08-17 | Timms; Lisa R. | Lotion dispensing system |
US6003728A (en) * | 1998-10-22 | 1999-12-21 | Aptargroup, Inc. | Dispensing structure with an openable member for separating two products |
US6372816B1 (en) | 1999-06-25 | 2002-04-16 | Dentsply Detrey Gmbh | Dental materials packaging and method of use |
US6228354B1 (en) | 1999-07-02 | 2001-05-08 | Allegiance Corporation | Water resistant film-forming antimicrobial skin-preparation |
EP1078880B1 (en) | 1999-08-05 | 2003-03-19 | The Procter & Gamble Company | Dispensing device comprising a reservoir and attachment means provided with protected piercing means |
US6386392B1 (en) | 1999-11-02 | 2002-05-14 | The Procter & Gamble Company | Reservoirs for use with cleaning devices |
US6321941B1 (en) | 2000-04-20 | 2001-11-27 | The Procter & Gamble Company | Consumer safe fitment for connecting a reservoir to a dispensing appliance |
US6474506B2 (en) * | 2000-05-12 | 2002-11-05 | Gary Mawby | Dispensing container |
FR2811872B1 (en) * | 2000-07-24 | 2003-02-14 | Oreal | DEVICE FOR APPLYING A PRODUCT, ESPECIALLY A COSMETIC OR A CARE PRODUCT |
US6666216B2 (en) | 2000-07-24 | 2003-12-23 | L'oreal S.A. | Device for applying a product to a surface |
US6439789B1 (en) * | 2000-09-27 | 2002-08-27 | Closure Medical Corporation | Polymerizable 1, 1-disubstituted ethylene monomer formulation applicators, applicator tips, applicator kits and methods |
US6918710B2 (en) * | 2000-12-01 | 2005-07-19 | The Procter & Gamble Company | Disposable package for a volatile liquid |
US6779657B2 (en) | 2001-06-06 | 2004-08-24 | Closure Medical Corporation | Single-use applicators, dispensers and methods for polymerizable monomer compound |
CA2449925C (en) * | 2001-06-08 | 2010-03-09 | F. Hoffmann-La Roche Ag | Control solution packets and methods for calibrating bodily fluid sampling devices |
WO2003016834A1 (en) * | 2001-08-16 | 2003-02-27 | Closure Medical Corporation | Multiple-component combining |
US6533484B1 (en) | 2001-09-13 | 2003-03-18 | Allegiance Corporation | Solution applicator |
US6474508B1 (en) | 2002-01-24 | 2002-11-05 | Saint-Gobain Calmar Inc. | Unit dose tube and cap assembly |
US20050019089A1 (en) * | 2002-08-28 | 2005-01-27 | Gary Ashe | Disposable single-use applicator with seal opening cap |
US20040127861A1 (en) * | 2002-12-26 | 2004-07-01 | Bradley Pharmaceuticals, Inc. | Method and apparatus for dispensing a composition |
US6929152B2 (en) * | 2003-04-23 | 2005-08-16 | L'oreal | Assembly for the packaging and application of a fluid product |
US7017782B2 (en) | 2003-09-12 | 2006-03-28 | Harrold John E | Child resistant safety cap for applicator tubes |
US20050067316A1 (en) * | 2003-09-25 | 2005-03-31 | Garry Tsaur | Sealed container with enclosed opening means |
ITMO20030283A1 (en) * | 2003-10-21 | 2005-04-22 | Lameplast Spa | BOTTLE FOR FLUID PRODUCTS, PARTICULARLY PHARMACEUTICAL, |
ITMO20040184A1 (en) * | 2004-07-16 | 2004-10-16 | Lameplast Spa | 'APPLICATOR FOR FLUID SUBSTANCES FOR MEDICAL AND COSMETIC USE'. |
US20050111900A1 (en) * | 2004-11-30 | 2005-05-26 | Francesca Fazzolari | Ampoule and method of use |
US7581899B2 (en) * | 2004-11-30 | 2009-09-01 | James Alexander Corporation | Dispenser and process |
US7458742B2 (en) * | 2005-04-27 | 2008-12-02 | Edward J. Stropkay | Door handle dispenser for sanitizing liquids |
KR200392852Y1 (en) * | 2005-06-01 | 2005-08-18 | 이재수 | Medicine container |
WO2007039120A1 (en) * | 2005-09-20 | 2007-04-12 | Georg-August-Universität Göttingen | Disinfection system |
US7572079B2 (en) * | 2006-02-24 | 2009-08-11 | Hammond Wong | Apparatus or method for applying a solvent |
US7976234B2 (en) | 2006-04-28 | 2011-07-12 | James Alexander Corporation | Multi-chambered dispenser and process |
US8668400B2 (en) * | 2007-04-05 | 2014-03-11 | The Hartz Mountain Corporation | Fluid applicator |
US8109236B2 (en) * | 2007-04-05 | 2012-02-07 | Sumitomo Corporation Of America | Fluid delivery assembly |
US20080267689A1 (en) * | 2007-04-27 | 2008-10-30 | Soller Douglas A | Liquid applicator |
US8729121B2 (en) | 2007-06-25 | 2014-05-20 | Adhezion Biomedical, Llc | Curing accelerator and method of making |
US8070014B2 (en) | 2007-08-24 | 2011-12-06 | Seaquist Closures L.L.C. | Liner piercing twist closure |
EP2742875B1 (en) | 2007-11-14 | 2016-02-24 | Adhezion Biomedical, LLC | Cyanoacrylate tissue adhesives |
US8910830B2 (en) * | 2007-12-18 | 2014-12-16 | James Alexander Corporation | Container assembly |
US8100294B2 (en) * | 2007-12-18 | 2012-01-24 | James Alexander Corporation | Container assembly |
US8403178B2 (en) * | 2007-12-18 | 2013-03-26 | James Alexander Corporation | Container assembly |
EP2234897B1 (en) * | 2008-01-29 | 2012-03-07 | James Alexander Corporation | Dispenser |
US8293838B2 (en) | 2008-06-20 | 2012-10-23 | Adhezion Biomedical, Llc | Stable and sterile tissue adhesive composition with a controlled high viscosity |
US8198344B2 (en) | 2008-06-20 | 2012-06-12 | Adhezion Biomedical, Llc | Method of preparing adhesive compositions for medical use: single additive as both the thickening agent and the accelerator |
US20110117047A1 (en) | 2008-06-23 | 2011-05-19 | Adhezion Biomedical, Llc | Cyanoacrylate tissue adhesives with desirable permeability and tensile strength |
US9254133B2 (en) | 2008-10-31 | 2016-02-09 | Adhezion Biomedical, Llc | Sterilized liquid compositions of cyanoacrylate monomer mixtures |
US8609128B2 (en) | 2008-10-31 | 2013-12-17 | Adhezion Biomedical, Llc | Cyanoacrylate-based liquid microbial sealant drape |
US8652510B2 (en) | 2008-10-31 | 2014-02-18 | Adhezion Biomedical, Llc | Sterilized liquid compositions of cyanoacrylate monomer mixtures |
WO2010133671A1 (en) * | 2009-05-20 | 2010-11-25 | Sanofi-Aventis Deutschland Gmbh | Assembly for use in a drug delivery device |
US20100318041A1 (en) * | 2009-06-11 | 2010-12-16 | C Smart Products, Llc | Method and apparatus for single-use cream or liquid applicator |
FR2951884B1 (en) | 2009-10-26 | 2013-01-18 | Valeo Equip Electr Moteur | CURRENT RECTIFIER MODULE FOR ROTATING ELECTRIC MACHINE AND ROTATING ELECTRIC MACHINE COMPRISING SUCH A MODULE |
US9309019B2 (en) | 2010-05-21 | 2016-04-12 | Adhezion Biomedical, Llc | Low dose gamma sterilization of liquid adhesives |
US9427560B2 (en) * | 2010-08-11 | 2016-08-30 | Innovative Pharmaceutical Comcepts (Ipc) Inc. | Active agent delivery device |
EP2608895A4 (en) | 2010-08-27 | 2017-12-27 | Razmik Margoosian | Liquid dispensing applicator with breakable projection and locking system |
US8550737B2 (en) * | 2010-09-20 | 2013-10-08 | Adhezion Biomedical, Llc | Applicators for dispensing adhesive or sealant material |
CH703940A2 (en) * | 2010-10-13 | 2012-04-13 | Rm Beteiligungs Ag | Plastic closure with the capsule for delivering active substances. |
CN102502047A (en) * | 2011-09-30 | 2012-06-20 | 吴宪明 | Cleaning bottle neck, cleaning bottle neck with bottle neck sleeve as well as cleaning bottle |
US9066711B2 (en) | 2011-11-02 | 2015-06-30 | Adhezion Biomedical, Llc | Applicators for storing sterilizing, and dispensing an adhesive |
USD713931S1 (en) | 2013-01-09 | 2014-09-23 | Central Garden & Pet Company | Sprayer |
WO2015020659A1 (en) | 2013-08-08 | 2015-02-12 | Colgate-Palmolive Company | Deodorant dispenser and refill cartridge therefor |
US9421297B2 (en) | 2014-04-02 | 2016-08-23 | Adhezion Biomedical, Llc | Sterilized compositions of cyanoacrylate monomers and naphthoquinone 2,3-oxides |
MX2016014914A (en) | 2014-05-22 | 2017-04-06 | Colgate Palmolive Co | Pump dispenser and system comprising a refill cartridge and the pump dispenser. |
JP6359391B2 (en) * | 2014-09-12 | 2018-07-18 | ユニ・チャーム株式会社 | Fluid container |
WO2016179679A1 (en) | 2015-05-13 | 2016-11-17 | Razmik Margoosian | Medical liquid dispensing applicators and methods of manufacture |
EP3147034A1 (en) * | 2015-09-25 | 2017-03-29 | Sulzer Mixpac AG | Applicator for ejecting doses of a flowable component |
FR3044653B1 (en) * | 2015-12-08 | 2017-12-01 | 10-Vins | APPARATUS FOR THE PREPARATION OF BEVERAGE TASTING AND METHOD OF OPENING A BEVERAGE CONTAINER USING SUCH AN INSTALLATION |
ES2886263T3 (en) * | 2016-08-19 | 2021-12-16 | Becton Dickinson Co | Adapter set for attachment to a bottle |
FR3056121B1 (en) * | 2016-09-16 | 2018-11-30 | Christian Cautiello | DEVICE FOR APPLYING A FLUID TO A SURFACE. |
US9987474B2 (en) * | 2016-10-05 | 2018-06-05 | iMed Technology, Inc. | Antiseptic swab |
USD843193S1 (en) | 2017-08-04 | 2019-03-19 | Ethicon, Inc. | Container support frame |
US10219793B2 (en) * | 2017-08-04 | 2019-03-05 | Ethicon, Inc. | Delivery systems for flowable substances stored in squeezable containers |
FR3075022B1 (en) | 2017-12-18 | 2021-08-06 | Oreal | PACKAGING AND APPLICATION DEVICE FOR A COSMETIC PRODUCT ON KERATINIC MATERIALS |
US10478602B2 (en) | 2018-01-24 | 2019-11-19 | iMed Technology, Inc. | Antiseptic swab with activation button |
USD864382S1 (en) | 2018-01-24 | 2019-10-22 | iMed Technology, Inc. | Antiseptic swab |
US11090506B2 (en) * | 2018-05-15 | 2021-08-17 | Omm Imports, Inc. | Disposable product cap and assembly having a manually usable thermo-optical device for skin care |
WO2023112696A1 (en) * | 2021-12-15 | 2023-06-22 | 株式会社資生堂 | Spout structure, and fluid accommodating container |
US20240197303A1 (en) * | 2022-12-20 | 2024-06-20 | Becton, Dickinson And Company | Brush/Foam-Based Applicator for Dispensing Tissue Adhesive |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3414360A (en) * | 1966-02-01 | 1968-12-03 | Schwartzman Gilbert | Sealing means for applicator |
US3454196A (en) * | 1967-07-20 | 1969-07-08 | Polytop Corp | Fixed spout closure with auxiliary cap |
US3481676A (en) * | 1968-02-08 | 1969-12-02 | Gilbert Schwartzman | Disposable self-container applicator |
DE1961542A1 (en) * | 1969-12-08 | 1971-07-22 | Gilbert Schwartzmann | Fluid applicator |
CH641359A5 (en) * | 1980-01-09 | 1984-02-29 | Louis Troesch | Device for moistening an object with a liquid |
US4723687A (en) * | 1981-03-16 | 1988-02-09 | Franz Kutterer | Tube with screw cap |
US4867326A (en) * | 1988-08-25 | 1989-09-19 | Cp Packaging | Child resistant cap and tube assembly |
US4875602A (en) * | 1988-06-15 | 1989-10-24 | Triad Direct Incorporated | Self-contained liquid dispensing device |
US4884703A (en) * | 1988-09-27 | 1989-12-05 | Cp Packaging Inc. | Container and closure assembly |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2771218A (en) * | 1954-05-19 | 1956-11-20 | Henderson Edward | Closure assembly |
US3349966A (en) * | 1966-04-25 | 1967-10-31 | Schwartzman Gilbert | Two-part mixture package and applicator |
US3922099A (en) * | 1974-06-26 | 1975-11-25 | William C Christine | Applicator dispenser |
US4271982A (en) * | 1979-09-14 | 1981-06-09 | Dynatron/Bondo Corporation | Glue dispenser |
US4296786A (en) * | 1979-09-28 | 1981-10-27 | The West Company | Transfer device for use in mixing a primary solution and a secondary or additive substance |
US4456150A (en) * | 1981-03-25 | 1984-06-26 | Yang Wei Lu | Tube's cap and the pierce structure of a sealed opening |
US4681243A (en) * | 1984-03-07 | 1987-07-21 | Colpo Co., Ltd. | Cartridge with plug opening mechanism |
-
1990
- 1990-02-08 US US07/476,689 patent/US5042690A/en not_active Expired - Lifetime
-
1991
- 1991-02-07 WO PCT/US1991/000838 patent/WO1991012197A1/en active IP Right Grant
- 1991-02-07 DE DE69108717T patent/DE69108717T2/en not_active Expired - Fee Related
- 1991-02-07 CA CA002075473A patent/CA2075473A1/en not_active Abandoned
- 1991-02-07 EP EP91904431A patent/EP0513197B1/en not_active Expired - Lifetime
- 1991-02-07 JP JP3504934A patent/JPH05504319A/en active Pending
- 1991-02-07 BR BR919105997A patent/BR9105997A/en not_active IP Right Cessation
-
1992
- 1992-08-10 FI FI923572A patent/FI923572A/en not_active Application Discontinuation
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3414360A (en) * | 1966-02-01 | 1968-12-03 | Schwartzman Gilbert | Sealing means for applicator |
US3454196A (en) * | 1967-07-20 | 1969-07-08 | Polytop Corp | Fixed spout closure with auxiliary cap |
US3481676A (en) * | 1968-02-08 | 1969-12-02 | Gilbert Schwartzman | Disposable self-container applicator |
DE1961542A1 (en) * | 1969-12-08 | 1971-07-22 | Gilbert Schwartzmann | Fluid applicator |
CH641359A5 (en) * | 1980-01-09 | 1984-02-29 | Louis Troesch | Device for moistening an object with a liquid |
US4723687A (en) * | 1981-03-16 | 1988-02-09 | Franz Kutterer | Tube with screw cap |
US4875602A (en) * | 1988-06-15 | 1989-10-24 | Triad Direct Incorporated | Self-contained liquid dispensing device |
US4867326A (en) * | 1988-08-25 | 1989-09-19 | Cp Packaging | Child resistant cap and tube assembly |
US4884703A (en) * | 1988-09-27 | 1989-12-05 | Cp Packaging Inc. | Container and closure assembly |
Cited By (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5307953A (en) * | 1991-12-03 | 1994-05-03 | Glaxo Group Limited | Single dose dispenser having a piercing member |
US5819730A (en) * | 1993-06-09 | 1998-10-13 | Glaxo Wellcome Australia Ltd. | Device for administering pharmaceutical substances |
FR2720281A1 (en) * | 1994-05-26 | 1995-12-01 | Karl Andre Leopold Penalba | Medicinal liquid applicator |
FR2770410A1 (en) * | 1997-10-30 | 1999-05-07 | Aspir | SKIN LIQUID APPLICATOR, CARE KIT, AND CARE DEVICE COMPRISING SAME |
WO1999022801A1 (en) * | 1997-10-30 | 1999-05-14 | Aspir | Liquid applicator for the skin |
US6299377B1 (en) | 1997-10-30 | 2001-10-09 | Aspir | Liquid applicator for the skin |
EP0922645A1 (en) * | 1997-12-11 | 1999-06-16 | Gurit-Essex AG | Applicator for low viscosity products |
US6604879B2 (en) | 1999-04-16 | 2003-08-12 | L'oreal | Applicator and applicator assembly equipped with such an applicator |
EP1044625A1 (en) * | 1999-04-16 | 2000-10-18 | L'oreal | Applying capsule and applicator assembly with such a capsule |
FR2792296A1 (en) * | 1999-04-16 | 2000-10-20 | Oreal | APPLICATOR CAPSULE AND APPLICATION ASSEMBLY PROVIDED WITH SUCH APPLICATOR CAPSULE |
US6334727B1 (en) | 1999-04-16 | 2002-01-01 | L'oreal | Applicator and applicator assembly equipped with such an applicator |
WO2000071198A1 (en) | 1999-05-21 | 2000-11-30 | Aspir | Cutaneous applicator with a liquid storage cartridge |
US6942412B2 (en) | 2000-11-07 | 2005-09-13 | L'oréal | Product application device including a dip tube |
US7066674B2 (en) | 2000-11-07 | 2006-06-27 | L'oreal, S.A. | Application device, system, and method |
WO2007070420A1 (en) * | 2005-12-09 | 2007-06-21 | Chemence Inc. | Applicator and tube dispenser for low and high viscosity adhesive components |
US7918621B2 (en) | 2005-12-09 | 2011-04-05 | Clast Trading Ltd. | Applicator and tube dispenser for low and high viscosity adhesive components |
US9688444B2 (en) | 2012-11-21 | 2017-06-27 | R.P. Scherer Technologies, Llc | Single use container with dispenser |
AU2016340898B2 (en) * | 2015-10-21 | 2019-08-15 | Boehringer lngelheim Vetmedica GMBH | Storage and dispenser device |
Also Published As
Publication number | Publication date |
---|---|
FI923572A0 (en) | 1992-08-10 |
FI923572A (en) | 1992-08-10 |
BR9105997A (en) | 1992-11-10 |
EP0513197A4 (en) | 1993-03-10 |
US5042690A (en) | 1991-08-27 |
DE69108717T2 (en) | 1995-10-05 |
EP0513197B1 (en) | 1995-04-05 |
DE69108717D1 (en) | 1995-05-11 |
CA2075473A1 (en) | 1991-08-09 |
EP0513197A1 (en) | 1992-11-19 |
JPH05504319A (en) | 1993-07-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US5042690A (en) | Unit dose assembly | |
KR100232689B1 (en) | Device | |
AU2005334794B2 (en) | Medical skin applicator apparatus | |
AU718754B2 (en) | Two-chamber cartridge for propellant-free metered aerosols | |
US3908654A (en) | Dispensing package for a dry biological and a liquid diluent | |
US6398031B1 (en) | Vial for packaging a liquid for medical use | |
US20030086747A1 (en) | Surgical prep solution applicator system and methods | |
HU219520B (en) | Parenteral injection kit-has pharmaceutical liquid preparation container with applicator and cannulae for number of doses | |
US20040162533A1 (en) | Applicator device | |
JP4759232B2 (en) | Method for manufacturing packaged prefilled syringe | |
CN114728737B (en) | Vapor coolant device | |
JPH0788151A (en) | Drug-containing vessel | |
US20200253354A1 (en) | Multi-purpose touch free applicator with reservoir | |
BRPI0801949A2 (en) | bellows disposable ampoule for injection of medicated fluid and the like | |
JPH0377557A (en) | Medicine-filled container | |
PH26430A (en) | Liquid droplet dispensing apparatus | |
GB1579282A (en) | Unit dose |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): BR CA FI JP |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IT LU NL SE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1991904431 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2075473 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 923572 Country of ref document: FI |
|
WWP | Wipo information: published in national office |
Ref document number: 1991904431 Country of ref document: EP |
|
WWG | Wipo information: grant in national office |
Ref document number: 1991904431 Country of ref document: EP |