WO1990015586A3 - Polymeres pouvant s'eroder biologiquement pour liberation de medicaments dans les os - Google Patents

Polymeres pouvant s'eroder biologiquement pour liberation de medicaments dans les os Download PDF

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Publication number
WO1990015586A3
WO1990015586A3 PCT/US1990/003136 US9003136W WO9015586A3 WO 1990015586 A3 WO1990015586 A3 WO 1990015586A3 US 9003136 W US9003136 W US 9003136W WO 9015586 A3 WO9015586 A3 WO 9015586A3
Authority
WO
WIPO (PCT)
Prior art keywords
bone
bioerodible polymers
drug delivery
delivery
simulators
Prior art date
Application number
PCT/US1990/003136
Other languages
English (en)
Other versions
WO1990015586A2 (fr
Inventor
Tobin N Gerhart
Cato T Laurencin
Abraham J Domb
Robert S Langer
Wilson C Hayes
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Priority to EP90909880A priority Critical patent/EP0476045B1/fr
Priority to DE69028303T priority patent/DE69028303T2/de
Publication of WO1990015586A2 publication Critical patent/WO1990015586A2/fr
Publication of WO1990015586A3 publication Critical patent/WO1990015586A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A61L2300/604—Biodegradation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

Polymères pouvant s'éroder biologiquement se décomposant totalement en des résidus non toxiques pendant une période appropriée aux besoins cliniques. Lesdits polymères, qui comprennent les polyanhydrides, les polyorthoesters, l'acide polyglycolique, l'acide polylactique et leurs copolymères, sont utiles pour introduire directement dans l'os des agents bioactifs, y compris les antibiotiques, les agents chimiothérapeutiques, les inhibiteurs d'angiogénèse, et les simulateurs de croissance osseuse.
PCT/US1990/003136 1989-06-05 1990-06-01 Polymeres pouvant s'eroder biologiquement pour liberation de medicaments dans les os WO1990015586A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP90909880A EP0476045B1 (fr) 1989-06-05 1990-06-01 Polymeres pouvant s'eroder biologiquement pour liberation de medicaments dans les os
DE69028303T DE69028303T2 (de) 1989-06-05 1990-06-01 Biodegradierbare polymere zur arzneimittelverabreichung in knochen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36122289A 1989-06-05 1989-06-05
US361,222 1989-06-05

Publications (2)

Publication Number Publication Date
WO1990015586A2 WO1990015586A2 (fr) 1990-12-27
WO1990015586A3 true WO1990015586A3 (fr) 1991-03-21

Family

ID=23421153

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1990/003136 WO1990015586A2 (fr) 1989-06-05 1990-06-01 Polymeres pouvant s'eroder biologiquement pour liberation de medicaments dans les os

Country Status (8)

Country Link
EP (1) EP0476045B1 (fr)
JP (1) JPH05503286A (fr)
AT (1) ATE141804T1 (fr)
CA (1) CA2056384C (fr)
DE (1) DE69028303T2 (fr)
DK (1) DK0476045T3 (fr)
ES (1) ES2093647T3 (fr)
WO (1) WO1990015586A2 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5328695A (en) * 1983-03-22 1994-07-12 Massachusetts Institute Of Technology Muscle morphogenic protein and use thereof
US5206023A (en) * 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
EP0568651B1 (fr) * 1991-02-01 2002-04-17 Massachusetts Institute Of Technology Melanges de polymeres biodegradables pour apport medicamenteux
FR2673843B1 (fr) * 1991-03-14 1995-01-13 Centre Nat Rech Scient Composition pharmaceutique implantable, bioresorbable a base de poly(acide lactique), destinee a mettre en óoeuvre une antibiotherapie interne locale.
EP0591392B1 (fr) * 1991-06-21 1996-09-11 Genetics Institute, Inc. Compositions pharmaceutiques de proteines osteogeniques
US5171579A (en) * 1991-10-11 1992-12-15 Genetics Institute, Inc. Formulations of blood clot-polymer matrix for delivery of osteogenic proteins
CA2119090A1 (fr) * 1993-03-26 1994-09-27 Wayne R. Gombotz Compositions pour la liberation controlee de tgf-.beta. biologiquement actif
AU8095694A (en) * 1993-10-28 1995-05-22 Thm Biomedical, Inc. Improved process and device for treating and healing a bone void
US5981825A (en) 1994-05-13 1999-11-09 Thm Biomedical, Inc. Device and methods for in vivo culturing of diverse tissue cells
DE19521642C2 (de) * 1995-06-14 2000-11-09 Aesculap Ag & Co Kg Implantat, seine Verwendung in der Chirurgie und Verfahren zu seiner Herstellung
US6391336B1 (en) * 1997-09-22 2002-05-21 Royer Biomedical, Inc. Inorganic-polymer complexes for the controlled release of compounds including medicinals
ATE357468T1 (de) * 1999-04-16 2007-04-15 Univ Wm Marsh Rice Bioabbaubare mit polypropylenfumaratdiacrylat- makromonomeren vernetzte polypropylenfumarat- netzwerke
IL140017A (en) * 2000-11-30 2009-09-22 Abraham J Domb Polyhedra
EP1228772A1 (fr) * 2001-02-01 2002-08-07 AM-Pharma B.V. Nouveau ciment osseux contenant des principes actifs
US8143368B2 (en) 2004-12-23 2012-03-27 Massachusetts Institute Of Technology Disposable medical supplies from hydrolytically biodegradable plastics
EP3237488A1 (fr) * 2014-12-18 2017-11-01 Université de Bordeaux Particules polymères et biomatériaux les comprenant
WO2016097848A1 (fr) 2014-12-18 2016-06-23 Dexcel Pharma Technologies Ltd. Copolymères de poly(ester-anhydride) alternés et semi-alternés
WO2018178963A1 (fr) 2017-03-29 2018-10-04 Dexcel Pharma Technologies Ltd. Compositions contenant des copolymères biodégradables

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4186448A (en) * 1976-04-16 1980-02-05 Brekke John H Device and method for treating and healing a newly created bone void
EP0058867A1 (fr) * 1981-02-20 1982-09-01 mundipharma GmbH Procédé pour fabriquer une céramique d'os de tricalciumphosphate à utiliser comme implantation d'os, en particulier pour remplir des espaces vides ou pour fixer des éclats d'os après une fracture et les corps moulés de céramique de tricalciumphosphate fabriqués d'après ce procédé
US4761289A (en) * 1986-10-10 1988-08-02 International Minerals & Chemical Corp. Sustained release implant and method for preparing same
EP0295721A2 (fr) * 1987-06-19 1988-12-21 The President And Fellows Of Harvard College Stimulation de la guérison du tissu méniscal
EP0311065A1 (fr) * 1987-10-09 1989-04-12 Boehringer Ingelheim Kg Système implantable biodégradable pour la délivrance d'un agent actif
WO1989004674A1 (fr) * 1987-11-26 1989-06-01 Biocon Oy Articles destines a entrer en contact avec des tissus du corps et contenant un agent anti-microbien
WO1990009783A1 (fr) * 1989-02-22 1990-09-07 Massachusetts Institute Of Technology Systeme d'acheminement a liberation regulee de facteurs bioactifs

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4186448A (en) * 1976-04-16 1980-02-05 Brekke John H Device and method for treating and healing a newly created bone void
EP0058867A1 (fr) * 1981-02-20 1982-09-01 mundipharma GmbH Procédé pour fabriquer une céramique d'os de tricalciumphosphate à utiliser comme implantation d'os, en particulier pour remplir des espaces vides ou pour fixer des éclats d'os après une fracture et les corps moulés de céramique de tricalciumphosphate fabriqués d'après ce procédé
US4761289A (en) * 1986-10-10 1988-08-02 International Minerals & Chemical Corp. Sustained release implant and method for preparing same
EP0295721A2 (fr) * 1987-06-19 1988-12-21 The President And Fellows Of Harvard College Stimulation de la guérison du tissu méniscal
EP0311065A1 (fr) * 1987-10-09 1989-04-12 Boehringer Ingelheim Kg Système implantable biodégradable pour la délivrance d'un agent actif
WO1989004674A1 (fr) * 1987-11-26 1989-06-01 Biocon Oy Articles destines a entrer en contact avec des tissus du corps et contenant un agent anti-microbien
WO1990009783A1 (fr) * 1989-02-22 1990-09-07 Massachusetts Institute Of Technology Systeme d'acheminement a liberation regulee de facteurs bioactifs

Also Published As

Publication number Publication date
WO1990015586A2 (fr) 1990-12-27
DE69028303D1 (de) 1996-10-02
DK0476045T3 (da) 1996-09-16
DE69028303T2 (de) 1997-01-30
CA2056384A1 (fr) 1990-12-06
EP0476045A1 (fr) 1992-03-25
JPH05503286A (ja) 1993-06-03
ES2093647T3 (es) 1997-01-01
CA2056384C (fr) 1998-06-23
ATE141804T1 (de) 1996-09-15
EP0476045B1 (fr) 1996-08-28

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