ATE141804T1 - Biodegradierbare polymere zur arzneimittelverabreichung in knochen - Google Patents

Biodegradierbare polymere zur arzneimittelverabreichung in knochen

Info

Publication number
ATE141804T1
ATE141804T1 AT90909880T AT90909880T ATE141804T1 AT E141804 T1 ATE141804 T1 AT E141804T1 AT 90909880 T AT90909880 T AT 90909880T AT 90909880 T AT90909880 T AT 90909880T AT E141804 T1 ATE141804 T1 AT E141804T1
Authority
AT
Austria
Prior art keywords
bone
drug administration
biodegradable polymers
simulators
polyorthoesters
Prior art date
Application number
AT90909880T
Other languages
English (en)
Inventor
Tobin N Gerhart
Cato T Laurencin
Abraham J Domb
Robert S Langer
Wilson C Hayes
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Application granted granted Critical
Publication of ATE141804T1 publication Critical patent/ATE141804T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2027Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204Polyesters, e.g. poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001Use of materials characterised by their function or physical properties
    • A61L24/0015Medicaments; Biocides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406Antibiotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412Tissue-regenerating or healing or proliferative agents
    • A61L2300/414Growth factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602Type of release, e.g. controlled, sustained, slow
    • A61L2300/604Biodegradation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/02Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials Engineering (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polyesters Or Polycarbonates (AREA)
AT90909880T 1989-06-05 1990-06-01 Biodegradierbare polymere zur arzneimittelverabreichung in knochen ATE141804T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36122289A 1989-06-05 1989-06-05

Publications (1)

Publication Number Publication Date
ATE141804T1 true ATE141804T1 (de) 1996-09-15

Family

ID=23421153

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90909880T ATE141804T1 (de) 1989-06-05 1990-06-01 Biodegradierbare polymere zur arzneimittelverabreichung in knochen

Country Status (8)

Country Link
EP (1) EP0476045B1 (de)
JP (1) JPH05503286A (de)
AT (1) ATE141804T1 (de)
CA (1) CA2056384C (de)
DE (1) DE69028303T2 (de)
DK (1) DK0476045T3 (de)
ES (1) ES2093647T3 (de)
WO (1) WO1990015586A2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5328695A (en) * 1983-03-22 1994-07-12 Massachusetts Institute Of Technology Muscle morphogenic protein and use thereof
US5206023A (en) * 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
CA2101742C (en) * 1991-02-01 2005-04-12 Abraham J. Domb Biodegradable polymer blends for drug delivery
FR2673843B1 (fr) * 1991-03-14 1995-01-13 Centre Nat Rech Scient Composition pharmaceutique implantable, bioresorbable a base de poly(acide lactique), destinee a mettre en óoeuvre une antibiotherapie interne locale.
JP3351525B2 (ja) * 1991-06-21 2002-11-25 ジェネティックス・インスティテュート・インコーポレイテッド 骨形成性蛋白医薬処方物
US5171579A (en) * 1991-10-11 1992-12-15 Genetics Institute, Inc. Formulations of blood clot-polymer matrix for delivery of osteogenic proteins
NO940913L (no) * 1993-03-26 1994-09-27 Bristol Myers Squibb Co Preparater for kontrollert frigivelse av biologisk aktiv TGF-
CA2175049A1 (en) * 1993-10-28 1995-05-04 Timothy Ringeisen Improved process and device for treating and healing a bone void
US5981825A (en) 1994-05-13 1999-11-09 Thm Biomedical, Inc. Device and methods for in vivo culturing of diverse tissue cells
DE19521642C2 (de) * 1995-06-14 2000-11-09 Aesculap Ag & Co Kg Implantat, seine Verwendung in der Chirurgie und Verfahren zu seiner Herstellung
US6391336B1 (en) * 1997-09-22 2002-05-21 Royer Biomedical, Inc. Inorganic-polymer complexes for the controlled release of compounds including medicinals
AU760358B2 (en) * 1999-04-16 2003-05-15 Wm. Marsh Rice University Functionalized poly(propylene fumarate) and poly(propylene fumarate-co-ethylene glycol)
IL140017A (en) * 2000-11-30 2009-09-22 Abraham J Domb Polyhedra
EP1228772A1 (de) * 2001-02-01 2002-08-07 AM-Pharma B.V. Neuartiger Knochenzement mit bioaktiven Wirkstoffen
WO2006071813A2 (en) 2004-12-23 2006-07-06 Massachusetts Institute Of Technology Disposable medical supplies from hydrolytically biodegradable plastics
WO2016097358A1 (en) * 2014-12-18 2016-06-23 Universite de Bordeaux Polymer particles and biomaterials comprising the same
CA2970617C (en) 2014-12-18 2021-11-23 Dexcel Pharma Technologies Ltd. Alternating and semi-alternating poly(ester-anhydride) copolymers
EP3600438A4 (de) 2017-03-29 2020-10-28 Dexcel Pharma Technologies Ltd. Zusammensetzungen mit biologisch abbaubaren copolymeren

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4186448A (en) * 1976-04-16 1980-02-05 Brekke John H Device and method for treating and healing a newly created bone void
DK154260C (da) * 1981-02-20 1989-05-22 Mundipharma Gmbh Fremgangsmaade til fremstilling af et knogleimplantat af braendt tricalciumphosphat, specielt til udfyldning af hulrum eller til sammensaetning af knogledele efter fraktur.
US4761289A (en) * 1986-10-10 1988-08-02 International Minerals & Chemical Corp. Sustained release implant and method for preparing same
US4952403A (en) * 1987-06-19 1990-08-28 President And Fellows Of Harvard College Implants for the promotion of healing of meniscal tissue
DE3734223A1 (de) * 1987-10-09 1989-04-20 Boehringer Ingelheim Kg Implantierbares, biologisch abbaubares wirkstofffreigabesystem
FI83729C (fi) * 1987-11-26 1991-08-26 Biocon Oy Kirurgisk implantat.
WO1990009783A1 (en) * 1989-02-22 1990-09-07 Massachusetts Institute Of Technology Delivery system for controlled release of bioactive factors

Also Published As

Publication number Publication date
CA2056384C (en) 1998-06-23
EP0476045B1 (de) 1996-08-28
WO1990015586A2 (en) 1990-12-27
DK0476045T3 (da) 1996-09-16
DE69028303T2 (de) 1997-01-30
DE69028303D1 (de) 1996-10-02
JPH05503286A (ja) 1993-06-03
WO1990015586A3 (en) 1991-03-21
CA2056384A1 (en) 1990-12-06
EP0476045A1 (de) 1992-03-25
ES2093647T3 (es) 1997-01-01

Similar Documents

Publication Publication Date Title
ATE141804T1 (de) Biodegradierbare polymere zur arzneimittelverabreichung in knochen
SE8803321D0 (sv) Fordrojd och styrd frigoring av vattenolosliga polypeptider
FI970522A (fi) Koostumukset ja menetelmät pidennetyn paikallisanestesian aikaansaamiseksi
SE8902288D0 (sv) Farmaceutisk komposition
DE69636989D1 (de) Bioaktive lasttragende zusammensetzungen zum knochenverbund
EP1018978A4 (de) Biologisch abbaubaresimplantatmaterial mit bioaktiver keramik
ES2118251T3 (es) Preparaciones de microparticulas a base de copolimeros biologicamente degradables.
BR9402861A (pt) Composição adesiva, biocompatível, biodegradável e não tóxica, biomaterial e material adesivo
DE69429048D1 (de) Biologisch erodierbare Vorrichtung zur Verabreichung von Wirkstoffen
DK1137400T3 (da) Præparater indeholdende et peptid og polymælkesyre-glycolsyre egnet til fremstilling af subkutane implantater med en forlænget frigivelsesperiode
ZA899943B (en) Absorbable coating and blend
FI883594A0 (fi) Hedelmöitystä ehkäisevä implantti
EP0815853A3 (de) Langsam freisetzende Zubereitung für bioaktive Substanz mit einer sauren Gruppe
GB9814609D0 (en) Polymers
DE69026100D1 (de) Biologisch abbaubarer und resorbierbarer Formkörper für chirurgischen Gebrauch
FR2693108B3 (fr) Matériau chirurgical résorbable en particulier fil de suture résorbable.
EP1032310A4 (de) Blockcopolymere und daraus hergestellte chirurgische gegenstände
FI972890A0 (fi) Ny plastbaserad komposit och dess anvaendning
EP1071400A4 (de) Medikamentöse verabreichung von proteinen aus polymergemischen
EP0647669A3 (de) Copolymere aus (p-Dioxanone/Glycolide und/oder Lactid) und p-Dioxanon.
EP1133240A4 (de) Biologisch abbaubare kaugummigrundstoffe enthaltend weichgemachte poly(d,l)milchsaeure sowie deren copolymere
GB2366738A (en) Including a body of non-resorbable bioactive material implant
FR2794982B1 (fr) Materiau de greffe osseuse forme d'une ceramique phosphocalcique et de tissu osseux
ATE221790T1 (de) Bioaktive implantate und verfahren zu deren herstellung
Schwartz Biomaterials: the French Bet on Natural Products

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time