ES2093647T3 - Polimeros bioerosionables para la liberacion de farmacos en los huesos. - Google Patents

Polimeros bioerosionables para la liberacion de farmacos en los huesos.

Info

Publication number
ES2093647T3
ES2093647T3 ES90909880T ES90909880T ES2093647T3 ES 2093647 T3 ES2093647 T3 ES 2093647T3 ES 90909880 T ES90909880 T ES 90909880T ES 90909880 T ES90909880 T ES 90909880T ES 2093647 T3 ES2093647 T3 ES 2093647T3
Authority
ES
Spain
Prior art keywords
polymers
bioerosionable
bones
drugs
release
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90909880T
Other languages
English (en)
Inventor
Tobin N Gerhart
Cato T Laurencin
Abraham J Domb
Robert S Langer
Wilson C Hayes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Application granted granted Critical
Publication of ES2093647T3 publication Critical patent/ES2093647T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A61L2300/604—Biodegradation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials Engineering (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polyesters Or Polycarbonates (AREA)

Abstract

POLIMEROS BIOEROSIVOS QUE SE DEGRADAN COMPLETAMENTE EN RESIDUOS NO-TOXICOS DURANTE UN PERIODO DE TIEMPO CLINICAMENTE UTIL, INCLUYE POLIANHIDRIDOS, POLIESTERES, ACIDO POLIGLICOLICO Y COPOLIMEROS DE LOS ANTERIORES, Y QUE SON UTILES PARA EL ENVIO, DIRECTAMENTE AL HUESO, DE AGENTES BIOACTIVOS, INCLUYENDO ANTIBIOTICOS, AGENTES QUIMICO-TERAPEUTICOS, INHIBIDORES DE ANTIGENESIS Y SIMULADORES DEL CRECIMIENTO DE HUESOS.
ES90909880T 1989-06-05 1990-06-01 Polimeros bioerosionables para la liberacion de farmacos en los huesos. Expired - Lifetime ES2093647T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36122289A 1989-06-05 1989-06-05

Publications (1)

Publication Number Publication Date
ES2093647T3 true ES2093647T3 (es) 1997-01-01

Family

ID=23421153

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90909880T Expired - Lifetime ES2093647T3 (es) 1989-06-05 1990-06-01 Polimeros bioerosionables para la liberacion de farmacos en los huesos.

Country Status (8)

Country Link
EP (1) EP0476045B1 (es)
JP (1) JPH05503286A (es)
AT (1) ATE141804T1 (es)
CA (1) CA2056384C (es)
DE (1) DE69028303T2 (es)
DK (1) DK0476045T3 (es)
ES (1) ES2093647T3 (es)
WO (1) WO1990015586A2 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5328695A (en) * 1983-03-22 1994-07-12 Massachusetts Institute Of Technology Muscle morphogenic protein and use thereof
US5206023A (en) * 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
WO1992013567A1 (en) * 1991-02-01 1992-08-20 Nova Pharmaceutical Corporation Biodegradable polymer blends for drug delivery
FR2673843B1 (fr) * 1991-03-14 1995-01-13 Centre Nat Rech Scient Composition pharmaceutique implantable, bioresorbable a base de poly(acide lactique), destinee a mettre en óoeuvre une antibiotherapie interne locale.
WO1993000050A1 (en) * 1991-06-21 1993-01-07 Genetics Institute, Inc. Pharmaceutical formulations of osteogenic proteins
US5171579A (en) * 1991-10-11 1992-12-15 Genetics Institute, Inc. Formulations of blood clot-polymer matrix for delivery of osteogenic proteins
CA2119090A1 (en) * 1993-03-26 1994-09-27 Wayne R. Gombotz Compositions for controlled release of biologically active tgf-.beta.
US5736160A (en) * 1993-10-28 1998-04-07 Thm Biomedical, Inc. Process and device for treating and healing a bone void
US5981825A (en) 1994-05-13 1999-11-09 Thm Biomedical, Inc. Device and methods for in vivo culturing of diverse tissue cells
DE19521642C2 (de) * 1995-06-14 2000-11-09 Aesculap Ag & Co Kg Implantat, seine Verwendung in der Chirurgie und Verfahren zu seiner Herstellung
US6391336B1 (en) * 1997-09-22 2002-05-21 Royer Biomedical, Inc. Inorganic-polymer complexes for the controlled release of compounds including medicinals
DE60043304D1 (de) * 1999-04-16 2009-12-24 Univ Wm Marsh Rice Polypropylenfumarat vernetzt mit polyethylenglykol-dimethacrylat
IL140017A (en) * 2000-11-30 2009-09-22 Abraham J Domb Polyhedra
EP1228772A1 (en) * 2001-02-01 2002-08-07 AM-Pharma B.V. Novel bone cement containing bioactive agents
US8143368B2 (en) 2004-12-23 2012-03-27 Massachusetts Institute Of Technology Disposable medical supplies from hydrolytically biodegradable plastics
WO2016097358A1 (en) * 2014-12-18 2016-06-23 Universite de Bordeaux Polymer particles and biomaterials comprising the same
AU2015365566B2 (en) 2014-12-18 2020-02-27 Dexcel Pharma Technologies Ltd. Alternating and semi-alternating poly(ester-anhydride) copolymers
WO2018178963A1 (en) 2017-03-29 2018-10-04 Dexcel Pharma Technologies Ltd. Compositions comprising biodegradable copolymers

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4186448A (en) * 1976-04-16 1980-02-05 Brekke John H Device and method for treating and healing a newly created bone void
DK154260C (da) * 1981-02-20 1989-05-22 Mundipharma Gmbh Fremgangsmaade til fremstilling af et knogleimplantat af braendt tricalciumphosphat, specielt til udfyldning af hulrum eller til sammensaetning af knogledele efter fraktur.
US4761289A (en) * 1986-10-10 1988-08-02 International Minerals & Chemical Corp. Sustained release implant and method for preparing same
US4952403A (en) * 1987-06-19 1990-08-28 President And Fellows Of Harvard College Implants for the promotion of healing of meniscal tissue
DE3734223A1 (de) * 1987-10-09 1989-04-20 Boehringer Ingelheim Kg Implantierbares, biologisch abbaubares wirkstofffreigabesystem
FI83729C (fi) * 1987-11-26 1991-08-26 Biocon Oy Kirurgisk implantat.
WO1990009783A1 (en) * 1989-02-22 1990-09-07 Massachusetts Institute Of Technology Delivery system for controlled release of bioactive factors

Also Published As

Publication number Publication date
ATE141804T1 (de) 1996-09-15
DK0476045T3 (da) 1996-09-16
DE69028303D1 (de) 1996-10-02
WO1990015586A2 (en) 1990-12-27
WO1990015586A3 (en) 1991-03-21
JPH05503286A (ja) 1993-06-03
EP0476045B1 (en) 1996-08-28
DE69028303T2 (de) 1997-01-30
CA2056384C (en) 1998-06-23
CA2056384A1 (en) 1990-12-06
EP0476045A1 (en) 1992-03-25

Similar Documents

Publication Publication Date Title
ES2093647T3 (es) Polimeros bioerosionables para la liberacion de farmacos en los huesos.
BR9402861A (pt) Composição adesiva, biocompatível, biodegradável e não tóxica, biomaterial e material adesivo
EP1018978A4 (en) BIODEGRADABLE IMPLANT MATERIAL WITH BIOACTIVE CERAMICS
ES2183807T3 (es) Mezclas absorbibles para liberacion controlada.
BR0107942A (pt) Polìmeros de proteìna de liberação lenta
DE69026100D1 (de) Biologisch abbaubarer und resorbierbarer Formkörper für chirurgischen Gebrauch
DE69010764D1 (de) Verfahren für chirurgische Implantate.
BR9702234A (pt) Prótese aperfeiçoada para reparo de hérnia e reconstrução de tecido mole
DE69011137D1 (de) Femurkopf-Osteomielehre für Kniegelenksimplantate.
FI883594A0 (fi) Hedelmöitystä ehkäisevä implantti
DE69023444D1 (de) Absorbierbare chirurgische Klammer.
ATE40519T1 (de) Implantat mit resorbierbarem schaft.
DE69426740D1 (de) Antibakterielle Gefässprothese und chirurgisches Nahtmaterial
DE69113367D1 (de) Verpackte künstliche resorbierbare chirurgische Elemente.
WO2004071356A3 (en) Resorbable devices
ES2063333T3 (es) Implante para uso en cirugia de huesos.
ATA60289A (de) Knochenimplantat
FR2659224B1 (fr) Repere chirurgical, et mesureur, notamment pour prothese de hanche, mettant en óoeuvre un tel repere.
BR9703112A (pt) Sutura cirúrgica tendo uma ponta formada termicamente e aparelho e método para fabricação ma mesma
IT8821119A0 (it) Protesi chirurgiche canalicolari assorbibili.
GB2253566B (en) Surgical article for artificial joints
IT1241478B (it) Composizioni farmaceutiche a base di calcitonina, somministrabili per via endonasale, per il controllo del calcio sierico e del dismetabolismo osseo.
ES2074956B1 (es) Protesis de cadera que sustituye la parte proximal del femur.
IT8921608A0 (it) Composizioni a base di tessuti vegetali od animali e procedimento per la loro preparazione.
ES1026574Y (es) Cotillo acetabular perfeccionado para protesis de cadera.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 476045

Country of ref document: ES