DE69028303D1 - Biodegradierbare polymere zur arzneimittelverabreichung in knochen - Google Patents

Biodegradierbare polymere zur arzneimittelverabreichung in knochen

Info

Publication number
DE69028303D1
DE69028303D1 DE69028303T DE69028303T DE69028303D1 DE 69028303 D1 DE69028303 D1 DE 69028303D1 DE 69028303 T DE69028303 T DE 69028303T DE 69028303 T DE69028303 T DE 69028303T DE 69028303 D1 DE69028303 D1 DE 69028303D1
Authority
DE
Germany
Prior art keywords
bones
medicinal
administration
biodegradable polymers
bone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69028303T
Other languages
English (en)
Other versions
DE69028303T2 (de
Inventor
Tobin Gerhart
Cato Laurencin
Abraham Domb
Robert Langer
Wilson Hayes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Publication of DE69028303D1 publication Critical patent/DE69028303D1/de
Application granted granted Critical
Publication of DE69028303T2 publication Critical patent/DE69028303T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A61L2300/604—Biodegradation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Materials Engineering (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
DE69028303T 1989-06-05 1990-06-01 Biodegradierbare polymere zur arzneimittelverabreichung in knochen Expired - Fee Related DE69028303T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36122289A 1989-06-05 1989-06-05
PCT/US1990/003136 WO1990015586A2 (en) 1989-06-05 1990-06-01 Bioerodible polymers for drug delivery in bone

Publications (2)

Publication Number Publication Date
DE69028303D1 true DE69028303D1 (de) 1996-10-02
DE69028303T2 DE69028303T2 (de) 1997-01-30

Family

ID=23421153

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69028303T Expired - Fee Related DE69028303T2 (de) 1989-06-05 1990-06-01 Biodegradierbare polymere zur arzneimittelverabreichung in knochen

Country Status (8)

Country Link
EP (1) EP0476045B1 (de)
JP (1) JPH05503286A (de)
AT (1) ATE141804T1 (de)
CA (1) CA2056384C (de)
DE (1) DE69028303T2 (de)
DK (1) DK0476045T3 (de)
ES (1) ES2093647T3 (de)
WO (1) WO1990015586A2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5328695A (en) * 1983-03-22 1994-07-12 Massachusetts Institute Of Technology Muscle morphogenic protein and use thereof
US5206023A (en) * 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
ATE216262T1 (de) * 1991-02-01 2002-05-15 Massachusetts Inst Technology Biologisch abbaubare polymermischungen zur arzneistoffabgabe
FR2673843B1 (fr) * 1991-03-14 1995-01-13 Centre Nat Rech Scient Composition pharmaceutique implantable, bioresorbable a base de poly(acide lactique), destinee a mettre en óoeuvre une antibiotherapie interne locale.
EP0591392B1 (de) * 1991-06-21 1996-09-11 Genetics Institute, Inc. Osteogene proteine enthaltende arzneimittel
US5171579A (en) * 1991-10-11 1992-12-15 Genetics Institute, Inc. Formulations of blood clot-polymer matrix for delivery of osteogenic proteins
NO940913L (no) * 1993-03-26 1994-09-27 Bristol Myers Squibb Co Preparater for kontrollert frigivelse av biologisk aktiv TGF-
AU8095694A (en) * 1993-10-28 1995-05-22 Thm Biomedical, Inc. Improved process and device for treating and healing a bone void
US5981825A (en) * 1994-05-13 1999-11-09 Thm Biomedical, Inc. Device and methods for in vivo culturing of diverse tissue cells
DE19521642C2 (de) * 1995-06-14 2000-11-09 Aesculap Ag & Co Kg Implantat, seine Verwendung in der Chirurgie und Verfahren zu seiner Herstellung
US6391336B1 (en) * 1997-09-22 2002-05-21 Royer Biomedical, Inc. Inorganic-polymer complexes for the controlled release of compounds including medicinals
JP2002542349A (ja) * 1999-04-16 2002-12-10 ダブリューエム・マーシュ・ライス・ユニバーシティー ポリ（プロピレンフマラート）−ジアクリレートマクロマーで交差結合された生体分解性のポリ（プロピレンフマラート）ネットワーク
IL140017A (en) * 2000-11-30 2009-09-22 Abraham J Domb Polyhedra
EP1228772A1 (de) * 2001-02-01 2002-08-07 AM-Pharma B.V. Neuartiger Knochenzement mit bioaktiven Wirkstoffen
US8143368B2 (en) 2004-12-23 2012-03-27 Massachusetts Institute Of Technology Disposable medical supplies from hydrolytically biodegradable plastics
EP3237488A1 (de) * 2014-12-18 2017-11-01 Université de Bordeaux Polymerteilchen und biomaterialien damit
EP3233964B1 (de) 2014-12-18 2020-06-17 Dexcel Pharma Technologies Ltd. Alternierende und semialternierende (poly)esteranhydrid-copolymere
AU2017406466A1 (en) 2017-03-29 2019-10-17 Dexcel Pharma Technologies Ltd. Compositions comprising biodegradable copolymers

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4186448A (en) * 1976-04-16 1980-02-05 Brekke John H Device and method for treating and healing a newly created bone void
DK154260C (da) * 1981-02-20 1989-05-22 Mundipharma Gmbh Fremgangsmaade til fremstilling af et knogleimplantat af braendt tricalciumphosphat, specielt til udfyldning af hulrum eller til sammensaetning af knogledele efter fraktur.
US4761289A (en) * 1986-10-10 1988-08-02 International Minerals & Chemical Corp. Sustained release implant and method for preparing same
US4952403A (en) * 1987-06-19 1990-08-28 President And Fellows Of Harvard College Implants for the promotion of healing of meniscal tissue
DE3734223A1 (de) * 1987-10-09 1989-04-20 Boehringer Ingelheim Kg Implantierbares, biologisch abbaubares wirkstofffreigabesystem
FI83729C (fi) * 1987-11-26 1991-08-26 Biocon Oy Kirurgisk implantat.
WO1990009783A1 (en) * 1989-02-22 1990-09-07 Massachusetts Institute Of Technology Delivery system for controlled release of bioactive factors

Also Published As

Publication number Publication date
ES2093647T3 (es) 1997-01-01
DK0476045T3 (da) 1996-09-16
WO1990015586A2 (en) 1990-12-27
CA2056384A1 (en) 1990-12-06
EP0476045A1 (de) 1992-03-25
ATE141804T1 (de) 1996-09-15
EP0476045B1 (de) 1996-08-28
WO1990015586A3 (en) 1991-03-21
CA2056384C (en) 1998-06-23
JPH05503286A (ja) 1993-06-03
DE69028303T2 (de) 1997-01-30

Similar Documents

Publication Publication Date Title
DE69028303D1 (de) Biodegradierbare polymere zur arzneimittelverabreichung in knochen
ATE357193T1 (de) Bioaktive lasttragende zusammensetzungen zum knochenverbund
FI970522A0 (fi) Koostumukset ja menetelmät pidennetyn paikallisanestesian aikaansaamiseksi
SE8803321D0 (sv) Fordrojd och styrd frigoring av vattenolosliga polypeptider
SE8902288L (sv) Farmaceutisk komposition
EP1018978A4 (de) Biologisch abbaubaresimplantatmaterial mit bioaktiver keramik
ES2183807T3 (es) Mezclas absorbibles para liberacion controlada.
ATE40519T1 (de) Implantat mit resorbierbarem schaft.
GB9814609D0 (en) Polymers
DE69026100D1 (de) Biologisch abbaubarer und resorbierbarer Formkörper für chirurgischen Gebrauch
ES2118251T3 (es) Preparaciones de microparticulas a base de copolimeros biologicamente degradables.
NZ234770A (en) 2-(n,n-di(carboxymethyl)amino)-3-cyano-4-carboxymethylthiophene-5-carboxylic acid, divalent metal salts thereof and pharmaceutical compositions
FI883594A0 (fi) Hedelmöitystä ehkäisevä implantti
ES8101886A1 (es) Procedimiento para la conformacion de colagenos
WO2004071356A3 (en) Resorbable devices
DE60126498D1 (de) Biodegradierbare chirurgische Implantate
EP1032310A4 (de) Blockcopolymere und daraus hergestellte chirurgische gegenstände
BR9106030A (pt) Composicao vitrea bioativa para implantes osseos
CA2004166A1 (en) Implant for use in bone surgery
EP1071400A4 (de) Medikamentöse verabreichung von proteinen aus polymergemischen
GB2366738A (en) Including a body of non-resorbable bioactive material implant
PT1071483E (pt) Implantacao de ossos
DE60022776D1 (de) Verfahren und material zur hämostase bei knochen
ATE221790T1 (de) Bioaktive implantate und verfahren zu deren herstellung
FR2794982B1 (fr) Materiau de greffe osseuse forme d'une ceramique phosphocalcique et de tissu osseux

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee