WO1990012488A3 - A clone of double-stranded rna virus applied to antibody production, study of retrovirus-like frameshifting and production of proteins in yeast - Google Patents

A clone of double-stranded rna virus applied to antibody production, study of retrovirus-like frameshifting and production of proteins in yeast Download PDF

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Publication number
WO1990012488A3
WO1990012488A3 PCT/US1990/001717 US9001717W WO9012488A3 WO 1990012488 A3 WO1990012488 A3 WO 1990012488A3 US 9001717 W US9001717 W US 9001717W WO 9012488 A3 WO9012488 A3 WO 9012488A3
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WO
WIPO (PCT)
Prior art keywords
frameshifting
production
yeast
double
stranded rna
Prior art date
Application number
PCT/US1990/001717
Other languages
French (fr)
Other versions
WO1990012488A2 (en
Inventor
Reed B Wickner
Jonathan D Dinman
Tateo Icho
Original Assignee
Us Commerce
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Commerce filed Critical Us Commerce
Publication of WO1990012488A2 publication Critical patent/WO1990012488A2/en
Publication of WO1990012488A3 publication Critical patent/WO1990012488A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/00022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A recombinant DNA molecule is described which is useful for determining the effect of an agent on translational frameshifting that is directed by a viral nucleotide sequence as a means of regulation of viral gene expression. This DNA molecule comprises an indicator gene for detection of frameshifting during translation and a DNA segment that encodes that portion of the double-stranded RNA genome of the L-A virus of yeast that directs translational frameshifting between the reading frame for the major coat protein and the reading frame for the RNA polymerase.
PCT/US1990/001717 1989-04-05 1990-04-04 A clone of double-stranded rna virus applied to antibody production, study of retrovirus-like frameshifting and production of proteins in yeast WO1990012488A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US31121789A 1989-04-05 1989-04-05
US311,217 1989-04-05
US49236490A 1990-03-09 1990-03-09
US492,364 1990-03-09

Publications (2)

Publication Number Publication Date
WO1990012488A2 WO1990012488A2 (en) 1990-11-01
WO1990012488A3 true WO1990012488A3 (en) 1990-11-29

Family

ID=26977785

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1990/001717 WO1990012488A2 (en) 1989-04-05 1990-04-04 A clone of double-stranded rna virus applied to antibody production, study of retrovirus-like frameshifting and production of proteins in yeast

Country Status (2)

Country Link
AU (1) AU5630590A (en)
WO (1) WO1990012488A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9102939B2 (en) 1997-12-23 2015-08-11 The Carnegie Institution Of Washington Genetic inhibition by double-stranded RNA

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPP249298A0 (en) 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
DK1624060T3 (en) 1998-03-20 2012-04-10 Commw Scient Ind Res Org Control of gene expression
WO2000044914A1 (en) 1999-01-28 2000-08-03 Medical College Of Georgia Research Institute, Inc. Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna
US6423885B1 (en) 1999-08-13 2002-07-23 Commonwealth Scientific And Industrial Research Organization (Csiro) Methods for obtaining modified phenotypes in plant cells
US20020132257A1 (en) 2001-01-31 2002-09-19 Tony Giordano Use of post-transcriptional gene silencing for identifying nucleic acid sequences that modulate the function of a cell

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
CELL, Volume 35, issued December 1983, J.T. LIS et al.: "New heat shock puffs and beta-galactosidase activity resulting from transformation of drosophila with an hsp70-lacZ hybrid gene", pages 403-410. See entire article. *
CELL, Volume 55, issued 18 November 1988, T. FUJIMURA et al.: "Gene overlap results in a viral protein having an RNA binding domain and a major coat protein domain", pp. 663-671. See entire article. *
CELL, Volume 55, issued 23 December 1988, W. WILSON et al.: "HIV Expression Strategies Ribosomal frameshifting is directed by a short sequence in both mammalian and yeast systems", pp. 1159-1169. See entire document. *
GenBank and UEMBL nucleotide sequence data bases. Sequence provided to GenBank data base on 08 September 1988 by R.B. WICKNER. (93% sequence homology with nucleotides 4041 to 4500 of the instant application). *
J. BIOL. CHEM., Volume 264, No. 12, issued 25 April 1989, T. ICHO et al.: "The double-stranded RNA genome of yeast virus encodes its own putative RNA polymerase by fusing two open reading frames", pp. 6716-6723. See the entire document. *
MOL. CELL. BIOL., Volume 4, Number 1, issued January 1984, D.J. THIELE et al.: "Multiple L double-stranded RNA species of Saccharomyces cerevisiae: evidence for separate encapsidation", pp. 92-100. See entire article. *
NUCL. ACID. RES., Volume 13, Nunber 5, issued April 1985, J. BRUENN et al.: "Long internal inverted repeat in a yeast double-stranded RNA", pp. 1575-1591. See entire document. *
PROC. NATL. ACAD. SCI. USA, Volume 85, issued June 1988, R. ESTEBAN et al.: "Site-specific binding of viral plus single-stranded RNA to replicase-containing open virus-like particles of yeast", pages 4411-4415. See entire article. *
YEAST, Volume 4, special issue, issued 07 August 1988, W. WILSON et al.: "Human Immunodeficiency virus (HIV-1) gene expression: ribosomal frameshifting requires a short sequence and no secondary structure in yeast and mammalian systems", pp. S177. See the entire abstract. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9102939B2 (en) 1997-12-23 2015-08-11 The Carnegie Institution Of Washington Genetic inhibition by double-stranded RNA

Also Published As

Publication number Publication date
WO1990012488A2 (en) 1990-11-01
AU5630590A (en) 1990-11-16

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