WO1990008457A3 - Procede pour detecter de petits carcinomes cellulaires, ainsi qu'emploi de l'hydrolase d'un peptide d'acyle et sequence de codage a cet effet - Google Patents
Procede pour detecter de petits carcinomes cellulaires, ainsi qu'emploi de l'hydrolase d'un peptide d'acyle et sequence de codage a cet effet Download PDFInfo
- Publication number
- WO1990008457A3 WO1990008457A3 PCT/US1990/000137 US9000137W WO9008457A3 WO 1990008457 A3 WO1990008457 A3 WO 1990008457A3 US 9000137 W US9000137 W US 9000137W WO 9008457 A3 WO9008457 A3 WO 9008457A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- acyl
- small cell
- cell carcinoma
- coding sequences
- detecting small
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
- Y10S436/813—Cancer
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
L'invention décrit la séquence aminoacide de l'hydrolase de peptide d'acyle. Elle concerne une molécule d'ADN encodée pour l'hydrolase d'un peptide d'acyle, un vecteur incorporant la molécule, et l'emploi de ce vecteur pour transformer un hôte. L'invention concerne également l'expression par l'hôte en vue de la production de l'hydrolase d'un peptide d'acyle, et l'utilisation d'APH pour catalyser l'hydrolyse d'un peptide ou d'une protéine Nα-acétylés ou bien la réaction entre un donneur aminoacide de Nα-acétyle et une protéine receveuse avec un groupe α-NH¿2? libre. L'invention se rapporte également à l'emploi des séquences d'encodage de l'hydrolase d'un peptide d'acyle dans la détection du cancer.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI913391A FI913391A0 (fi) | 1989-01-13 | 1991-07-12 | Foerfarande foer detektering av smaocellcarcinom och anvaendning av acylpeptidhydrolas och denna kodande sekvenser. |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29699689A | 1989-01-13 | 1989-01-13 | |
US296,996 | 1989-01-13 | ||
US07/429,935 US5268267A (en) | 1987-08-21 | 1989-11-01 | Method for diagnosing small cell carcinoma |
US429,935 | 1989-11-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1990008457A2 WO1990008457A2 (fr) | 1990-08-09 |
WO1990008457A3 true WO1990008457A3 (fr) | 1990-09-20 |
Family
ID=26969935
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1990/000137 WO1990008457A2 (fr) | 1989-01-13 | 1990-01-12 | Procede pour detecter de petits carcinomes cellulaires, ainsi qu'emploi de l'hydrolase d'un peptide d'acyle et sequence de codage a cet effet |
Country Status (15)
Country | Link |
---|---|
US (2) | US5268267A (fr) |
EP (1) | EP0378224B1 (fr) |
JP (1) | JPH04502557A (fr) |
AT (1) | ATE126830T1 (fr) |
AU (1) | AU633896B2 (fr) |
CA (1) | CA2044595A1 (fr) |
DE (1) | DE69021742T2 (fr) |
DK (1) | DK0378224T3 (fr) |
ES (1) | ES2076976T3 (fr) |
FI (1) | FI913391A0 (fr) |
GR (1) | GR3017739T3 (fr) |
IE (1) | IE900141L (fr) |
IL (1) | IL92956A0 (fr) |
PT (1) | PT92844A (fr) |
WO (1) | WO1990008457A2 (fr) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5686246A (en) * | 1995-08-03 | 1997-11-11 | Kornman; Kenneth S. | Detecting genetic predisposition to periodontal disease |
US6524795B1 (en) | 1997-03-10 | 2003-02-25 | Interleukin Genetics, Inc. | Diagnostics for cardiovascular disorders |
US7820383B2 (en) * | 1997-03-10 | 2010-10-26 | Interleukin Genetics, Inc. | Method for diagnosing myocardial infarction |
US6720141B1 (en) * | 1999-11-01 | 2004-04-13 | Interleukin Genetics, Inc. | Diagnostics and therapeutics for restenosis |
US6210877B1 (en) | 1997-03-10 | 2001-04-03 | Interleukin Genetics, Inc. | Prediction of coronary artery disease |
GB9723553D0 (en) * | 1997-11-07 | 1998-01-07 | Duff Gordon W | Prediction of the risk of chronic obstructive airway disease |
US6746839B1 (en) | 1998-01-12 | 2004-06-08 | Interleukin Genetics, Inc. | Diagnostics and therapeutics for an obstructive airway disease |
US6733967B1 (en) | 1998-04-21 | 2004-05-11 | Interleukin Genetics, Inc. | Fetal testing for prediction of low birth weight |
US6225069B1 (en) | 2000-02-29 | 2001-05-01 | The Board Of Trustees Of The University Of Arkansas | Methods to identify genetic predisposition to alzheimer's disease |
US8551704B2 (en) | 2007-02-16 | 2013-10-08 | Pacific Biosciences Of California, Inc. | Controllable strand scission of mini circle DNA |
CA2693979A1 (fr) * | 2007-07-26 | 2009-02-05 | Pacific Biosciences Of California, Inc. | Sequencage moleculaire redondant |
BR112013014479B1 (pt) | 2010-12-09 | 2020-10-27 | Orig3N, Inc. | métodos para determinar a gravidade e progressão de doença periodontal |
US20140141410A1 (en) * | 2011-07-08 | 2014-05-22 | Universitat Zurich | Feline leukemia virus trans-membrane protein p15e for diagnosis of felv infection |
CA2930693A1 (fr) | 2013-11-15 | 2015-05-21 | The Board Of Trustees Of The Leland Stanford Junior Unversity | Procedes de traitement d'une insuffisance cardiaque avec des agonistes de recepteur 2 d'hypocretine |
US11590165B2 (en) | 2014-12-17 | 2023-02-28 | Bausch Health Companies Inc. | Formulations of calcium and phosphate for oral inflammation |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4438032A (en) * | 1981-01-30 | 1984-03-20 | The Regents Of The University Of California | Unique T-lymphocyte line and products derived therefrom |
US4601980A (en) * | 1979-07-05 | 1986-07-22 | Genentech Inc. | Microbial expression of a gene for human growth hormone |
US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4879214A (en) * | 1988-11-15 | 1989-11-07 | E. I. Du Pont De Nemours And Company | Differentiation of nucleic acid segments on the basis of nucleotide differences |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB200362A (en) * | 1922-07-12 | 1923-07-12 | Gen Electric | Improvements in and relating to casings for liquid-cooled electrical apparatus, such as transformers |
GB303997A (en) * | 1927-12-14 | 1929-01-17 | Rover Co Ltd | Improvements in exhaust silencers for internal combustion engines |
GB293266A (en) * | 1927-12-28 | 1928-07-05 | James Bryant Roberts | Improvements in trolley sheaves |
JPS6339237B2 (fr) * | 1979-04-06 | 1988-08-04 | Karuruberugu Baiotekunorojii Ltd As | |
US4623619A (en) * | 1982-03-03 | 1986-11-18 | Nordisk Insulinlaboratorium | Method for the determination of liability in human individuals to develop atherosclerosis |
US4675285A (en) * | 1984-09-19 | 1987-06-23 | Genetics Institute, Inc. | Method for identification and isolation of DNA encoding a desired protein |
DK171161B1 (da) * | 1985-03-28 | 1996-07-08 | Hoffmann La Roche | Fremgangsmåde til påvisning af forekomst eller fravær af mindst én specifik nukleinsyresekvens i en prøve eller til skelnen mellem to forskellige nukleinsyresekvenser i denne prøve |
GB8712646D0 (en) * | 1987-05-29 | 1987-07-01 | Clayton Found Res | Structural evidence |
ZA885915B (en) * | 1987-08-21 | 1989-04-26 | Gen Hospital Corp | Acyl-peptide hydrolase and methods of production and use |
-
1989
- 1989-11-01 US US07/429,935 patent/US5268267A/en not_active Expired - Fee Related
-
1990
- 1990-01-03 IL IL92956A patent/IL92956A0/xx unknown
- 1990-01-11 PT PT92844A patent/PT92844A/pt not_active Application Discontinuation
- 1990-01-12 ES ES90100575T patent/ES2076976T3/es not_active Expired - Lifetime
- 1990-01-12 JP JP2505428A patent/JPH04502557A/ja active Pending
- 1990-01-12 IE IE900141A patent/IE900141L/xx unknown
- 1990-01-12 EP EP90100575A patent/EP0378224B1/fr not_active Expired - Lifetime
- 1990-01-12 WO PCT/US1990/000137 patent/WO1990008457A2/fr active Application Filing
- 1990-01-12 DE DE69021742T patent/DE69021742T2/de not_active Expired - Fee Related
- 1990-01-12 AU AU53569/90A patent/AU633896B2/en not_active Ceased
- 1990-01-12 CA CA002044595A patent/CA2044595A1/fr not_active Abandoned
- 1990-01-12 AT AT90100575T patent/ATE126830T1/de not_active IP Right Cessation
- 1990-01-12 DK DK90100575.1T patent/DK0378224T3/da active
-
1991
- 1991-07-12 FI FI913391A patent/FI913391A0/fi not_active Application Discontinuation
-
1993
- 1993-07-15 US US08/091,445 patent/US5512467A/en not_active Expired - Fee Related
-
1995
- 1995-10-16 GR GR950402838T patent/GR3017739T3/el unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4601980A (en) * | 1979-07-05 | 1986-07-22 | Genentech Inc. | Microbial expression of a gene for human growth hormone |
US4438032A (en) * | 1981-01-30 | 1984-03-20 | The Regents Of The University Of California | Unique T-lymphocyte line and products derived therefrom |
US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4683195B1 (fr) * | 1986-01-30 | 1990-11-27 | Cetus Corp | |
US4879214A (en) * | 1988-11-15 | 1989-11-07 | E. I. Du Pont De Nemours And Company | Differentiation of nucleic acid segments on the basis of nucleotide differences |
Non-Patent Citations (3)
Title |
---|
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, (Duluth, Minnesota, USA), Volume 126, 31 January 1985, JONES et al., "Acylpeptide Hydrolase Activity From Erythrocytes", pages 933-940. * |
JOURNAL OF BIOCHEMISTRY, (Tokyo, Japan), Volume 77, No. 1, issued 1975, TSUNASAWA et al., "Purification and Properties of Acylamino Acid-Releasing Enzyme from Rat Liver", page 89-102. * |
THE JOURNAL OF BIOLOGICAL CHEMISTRY, (Baltimore, Maryland, USA), Volume 262, No. 24, issued 25 August 1987, KOBAYASHI et al., "Acyl-Peptide Hydrolase from Rat Liver", pages 11435-11445. * |
Also Published As
Publication number | Publication date |
---|---|
EP0378224A3 (fr) | 1991-11-27 |
EP0378224A2 (fr) | 1990-07-18 |
US5512467A (en) | 1996-04-30 |
JPH04502557A (ja) | 1992-05-14 |
CA2044595A1 (fr) | 1990-07-14 |
AU5356990A (en) | 1990-08-24 |
FI913391A0 (fi) | 1991-07-12 |
GR3017739T3 (en) | 1996-01-31 |
DK0378224T3 (da) | 1996-01-15 |
IE900141L (en) | 1990-07-13 |
DE69021742T2 (de) | 1996-02-22 |
WO1990008457A2 (fr) | 1990-08-09 |
US5268267A (en) | 1993-12-07 |
PT92844A (pt) | 1990-07-31 |
ATE126830T1 (de) | 1995-09-15 |
AU633896B2 (en) | 1993-02-11 |
DE69021742D1 (de) | 1995-09-28 |
ES2076976T3 (es) | 1995-11-16 |
IL92956A0 (en) | 1990-09-17 |
EP0378224B1 (fr) | 1995-08-23 |
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