WO1990007321A3 - Sequences de guidage de recepteurs de lymphocytes et leurs emplois - Google Patents

Sequences de guidage de recepteurs de lymphocytes et leurs emplois Download PDF

Info

Publication number
WO1990007321A3
WO1990007321A3 PCT/US1989/005067 US8905067W WO9007321A3 WO 1990007321 A3 WO1990007321 A3 WO 1990007321A3 US 8905067 W US8905067 W US 8905067W WO 9007321 A3 WO9007321 A3 WO 9007321A3
Authority
WO
WIPO (PCT)
Prior art keywords
homing
proteins
lymphocyte receptor
homing sequences
inhibiting
Prior art date
Application number
PCT/US1989/005067
Other languages
English (en)
Other versions
WO1990007321A2 (fr
Inventor
Irving L. Weissman
Bernard Holzmann
Mark H. Siegelman
Original Assignee
The Board Of Trustees Of The Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Board Of Trustees Of The Leland Stanford Junior University filed Critical The Board Of Trustees Of The Leland Stanford Junior University
Publication of WO1990007321A2 publication Critical patent/WO1990007321A2/fr
Publication of WO1990007321A3 publication Critical patent/WO1990007321A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2842—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Des protéines sont identifiées comme récepteurs de guidage pour les plaques de Peyer et les ganglions lymphatiques, ces protéines pouvant s'utiliser pour inhiber le guidage des lymphocytes ou pour permettre le guidage de médicaments ou d'autres compositions pour le diagnostic ou la thérapie in vivo. En outre, des compositions d'acide nucléique peuvent s'utiliser pour l'expression des protéines ou de leurs fragments ou bien pour transformer des cellules afin de permettre une capacité de guidage accrue ou encore pour inhiber ou moduler un tel guidage.
PCT/US1989/005067 1988-12-23 1989-11-10 Sequences de guidage de recepteurs de lymphocytes et leurs emplois WO1990007321A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US28920188A 1988-12-23 1988-12-23
US289,201 1988-12-23
US31573689A 1989-02-24 1989-02-24
US315,736 1989-02-24

Publications (2)

Publication Number Publication Date
WO1990007321A2 WO1990007321A2 (fr) 1990-07-12
WO1990007321A3 true WO1990007321A3 (fr) 2010-05-27

Family

ID=26965504

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1989/005067 WO1990007321A2 (fr) 1988-12-23 1989-11-10 Sequences de guidage de recepteurs de lymphocytes et leurs emplois

Country Status (3)

Country Link
EP (1) EP0462111A4 (fr)
JP (1) JPH04504501A (fr)
WO (1) WO1990007321A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5776775A (en) * 1989-02-21 1998-07-07 Dana-Farber Cancer Institute Anti-LAM 1-3 antibody and hybridoma
US7238668B1 (en) 1989-09-01 2007-07-03 Fred Hutchinson Cancer Research Center Inhibition of lymphocyte adherence with CS-1-peptides and fragments thereof
US7750137B2 (en) 1995-09-01 2010-07-06 Millennium Pharmaceuticals, Inc. Mucosal vascular addressins
US7803904B2 (en) 1995-09-01 2010-09-28 Millennium Pharmaceuticals, Inc. Mucosal vascular addressing and uses thereof
US6551593B1 (en) 1995-02-10 2003-04-22 Millennium Pharmaceuticals, Inc. Treatment of Inflammatory bowel disease by inhibiting binding and/or signalling through α 4 β 7 and its ligands and madcam
US7147851B1 (en) 1996-08-15 2006-12-12 Millennium Pharmaceuticals, Inc. Humanized immunoglobulin reactive with α4β7 integrin
US6111090A (en) * 1996-08-16 2000-08-29 Schering Corporation Mammalian cell surface antigens; related reagents
CN101273124B (zh) * 2005-08-25 2013-05-08 亚利桑那大学董事会 干细胞融合癌发生模型
UA116189C2 (uk) 2011-05-02 2018-02-26 Мілленніум Фармасьютікалз, Інк. КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА
KR20230021758A (ko) 2011-05-02 2023-02-14 밀레니엄 파머슈티컬스 인코퍼레이티드 항-α4β7 항체에 대한 제형

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0303463B1 (fr) * 1987-08-11 1994-11-30 The Board Of Trustees Of The Leland Stanford Junior University Méthode pour contrôler l'extravasation des leucocytes

Non-Patent Citations (21)

* Cited by examiner, † Cited by third party
Title
CELL, Volume 56, issued 24 March 1989, GOLDSTEIN et al., "A Human Lymphocyte Homing Receptor, the Hermes Antigen is Related to Cartilage Proteoglycan Core and Link Proteins", pages 1063-1072. *
CELL, Volume 56, issued 24 March 1989, JOHNSTON et al., "Cloning of GMP-140, a Granule Membrane Protein of Platelets and Endothelium: Sequence Similarity to Proteins Involved in Cell Adhesion and Inflammation", pages 1033-1044. *
CELL, Volume 56, issued 24 March 1989, LASKY et al., "Cloning of a Lymphocyte Homing Receptor Reveals a Lectin Domain", pages 1045-1055. *
CELL, Volume 56, issued 24 March 1989, STAMENKOVIC et al., "A Lymphocyte Molecule Implicated in Lymph Node Homing is a Member of the Cartilage Link Protein Family", pages 1057-1062. *
JOURNAL OF MOLECULAR BIOLOGY, Volume 196, issued 12 January 1987, VAN HET SCHIP et al., "Nucleotide Sequence of the Encoded Yolk Precursor Protein", pages 245-260. *
NATURE, Volume 304, issued 07 July 1983, GALLATIN et al., "A Cell-Surface Molecule Involved in Organ-Specific Homing of Lymphocytes", pages 30-34. *
NATURE, Volume 309, issued 17 May 1984, MROCZKOWSKI et al., "ATP-Stimulated Interaction Between Epidermal Growth Factor Receptor and Supercoiled DNA", pages 270-273. *
NATURE, Volume 309, issued 28 June 1984, XU et al., "Human Epidermal Growth Factor Receptor cDNA is Homologous to a Variety of RNAs Overproduced in A431 Carcinoma Cells", pages 806-810. *
NATURE, Volume 309, issued 31 May 1984, ULLRICH et al., "Human Epidermal Growth Factor Receptor cDNA Sequence and Aberrant Expression of the Amplified Gene in A431 Epidermoid Carcinoma Cells", pages 418-425. *
NATURE, Volume 320, issued 13 March 1986, NODA et al., "Existence of Distinct Sodium Channel Messenger RNAs in Rat Brain", pages 188-192. *
NUCLEIC ACIDS RESEARCH, Volume 12, No. 2, issued 1984, BURCH et al., "Identification and Sequence Analysis of the 5' End of the Major Chicken Vitellogenin Gene", pages 1117-1135. *
PROC. NATL. ACAD. SCI. U.S.A., Volume 78, No. 2, issued February 1981, SHINODA et al., "Complete Amino Acid Sequence of the Fc Region of a Human O Chain", pages 785-789. *
SCIENCE, Volume 224, issued 25 May 1984, LIN et al., "Expression Cloning of Human EGF Receptor Complementary DNA: Gene Amplification and Three Related Messenger RNA Products in A431 Cells", pages 843-848. *
SCIENCE, Volume 231, issued 21 February 1986, SIEGELMAN et al., "Cell Surface Molecule Associated with Lymphocyte Homing is Ubiquitinated Branched-Chain Glycoprotein", pages 823-829. *
SCIENCE, Volume 231, issued 21 February 1986, St. JOHN et al., "Expression Cloning of a Lymphocyte Homing Receptor cDNA: Ubiquitin is the Reactive Species", pages 845-850. *
SCIENCE, Volume 243, issued 03 March 1989, BEVILACQUA et al., "Endothelial Leukocyte Adhesion Molecule 1- an Inducible Receptor for Neutrophils Related to Complement Regulatory Proteins and Lectins", pages 1160-1165. *
SCIENCE, Volume 243, issued 03 March 1989, SIEGELMAN et al., "Mouse Lymph Node Homing Receptor cDNA Clone Encodes a Glycoprotein Revealing Tandem Interaction Domains", pages 1165-1172. *
See also references of EP0462111A1 *
THE JOURNAL OF IMMUNOLOGY, Volume 143, No. 10, issued 15 November 1989, JUTILA et al., "Function and Regulation of the Neutrophil MEL-14 Antigen In Vivo: Comparison with LFA-1 and MAC-1", pages 3318-3324. *
THE JOURNAL OF IMMUNOLOGY, Volume 143, No. 10, issued 15 November 1989, ZHOU et al., "Molecular Cloning and Expression of Pgp-1", pages 3390-3395. *
UBIQUITIN, Edited by MARTIN RECHSTEINER, issued 1988, PLENUM PUBLISHING CORPORATION, SIEGELMAN et al., "Lymphocyte Homing Receptors, Ubiquitin and Cell Surface Proteins", pages 239-269. *

Also Published As

Publication number Publication date
EP0462111A1 (fr) 1991-12-27
WO1990007321A2 (fr) 1990-07-12
EP0462111A4 (en) 1992-07-08
JPH04504501A (ja) 1992-08-13

Similar Documents

Publication Publication Date Title
WO1995016038A3 (fr) Anticorps humanises et leurs applications
AU2790292A (en) Viral recombinant vectors for expression in muscle cells
EP0853121A3 (fr) DNase humaine
EP1923467A3 (fr) Vecteurs d'adénovirus pour thérapie génétique
CA2294516A1 (fr) Proteines ikk-.beta., acides nucleiques et procedes
FI854604A0 (fi) Onkostatiini-A:n käyttö diagnostisessa menetelmässä
AU5914590A (en) Muteins of human erythropoietin, the preparation thereof and the use thereof
ATE183514T1 (de) Peptide des menschlichen proteins p53 zum gebrauch in menschlichen-zytotoxischen-t-zell- antwort-induzierenden kompositionen sowie menschliche p53-protein-spezifische t-lymphocyten
SG108208A1 (en) Connective tissue growth factor
NZ306653A (en) Isolated dna il-17 receptors
WO1987002697A1 (fr) Extraction de matieres animales en utilisant des fluides supercritiques
BR0014087A (pt) Composições com pérolas de caroteno - xantofila estáveis e métodos de uso
PT1053256E (pt) Anticorpos para o receptor de morte 4 (dr4) e utilizações destes
ATE177757T1 (de) Verbesserte immunogene zusammensetzung gegen mensliches gastrin 17
EP0128041A3 (fr) Polypeptides ayant une activité de facteur de croissance du squelette
WO1990007321A3 (fr) Sequences de guidage de recepteurs de lymphocytes et leurs emplois
WO1998058957A3 (fr) Analogues d'hormones glycoproteiques a liaison reticulee disulfite, preparation et utilisation
TR199700834T1 (xx) 1-Aril-2-Akilamino ethan bile�ikleri ve bunlar�n n�rokinin olarak �zellikle n�rokinin 1 has�mlar� olarak kullan�mlar�.
EP0228192A3 (fr) Oligopeptides-inhibiteurs de la rénine, leur préparation et leur utilisation
MA19882A1 (fr) Derives d'acides w-amines, leur preparation et utilisation ainsi que les compositions contenant ces acides.
EP1005539A4 (fr) PROTEINES IKK-$g(a), ACIDES NUCLEIQUES ET PROCEDES
IL91184A0 (en) N-2,3-butadienyl tri-and tetraaminoalkane derivatives
AU3526689A (en) Peptides that block the binding of hiv-1 to the cd4 receptor protein
DE68914700T2 (de) Polymere Zusammensetzungen und ihre Herstellung.
EP0344979A3 (fr) Antagonistes des récepteurs alpha-adrénergiques

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): JP

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE FR GB IT LU NL SE

AK Designated states

Kind code of ref document: A3

Designated state(s): JP

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH DE FR GB IT LU NL SE

CFP Corrected version of a pamphlet front page
CR1 Correction of entry in section i

Free format text: IN PAT.BUL.16/90,UNDER INID (54) TITLE REPLACE THE EXISTING TEXT BY "LYMPHOCYTE RECEPTOR HOMING SEQUENCES AND THEIR USES"

WWE Wipo information: entry into national phase

Ref document number: 1990902104

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1990902104

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1990902104

Country of ref document: EP

DPE2 Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101)